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Method: We review the relevant literature related to the difficult airway and thyroid surgery. Comments: Endothoracic goiter, deformity of the airway, compression of the airway and thyroid cancer do not appear to have an influence on the difficulty for intubation. Classical parameters have a better predictive value: mouth opening less than 35 mm, Mallampati II-IV, short neck, neck movility less than 80 degrees, thyromental distance less than 60 mm, retrognathia, Cormack index III-IV, macroglossia, inability to protude the teeth and body mass index (BMI) greater than 35 Kg/m2. Conclusions: According to the literature, thyroid disease does not increase the risk for a difficult airway (ventilation / intubation). The risk of an unexpected difficult airway (false negative) cannot be eliminated. 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