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authorBryan Newbold <bnewbold@robocracy.org>2019-03-05 14:27:31 -0800
committerBryan Newbold <bnewbold@robocracy.org>2019-03-05 14:27:31 -0800
commitbee73c6adb8eea919e5581a5050ba0311dd5ed22 (patch)
treebd34dd968246fd39c48762270fa5888b4389bcba
parent30a8fc5f78eb15f641d6e8da0e7c0741d3f82b13 (diff)
downloadfatcat-bee73c6adb8eea919e5581a5050ba0311dd5ed22.tar.gz
fatcat-bee73c6adb8eea919e5581a5050ba0311dd5ed22.zip
basic pubmed parser
Diffstat
-rw-r--r--python/parse_pubmed_xml.py370
-rw-r--r--python/tests/files/pubmedsample_2019.xml36822
2 files changed, 37192 insertions, 0 deletions
diff --git a/python/parse_pubmed_xml.py b/python/parse_pubmed_xml.py
new file mode 100644
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--- /dev/null
+++ b/python/parse_pubmed_xml.py
@@ -0,0 +1,370 @@
+
+import sys
+import json
+import datetime
+from bs4 import BeautifulSoup
+from bs4.element import NavigableString
+
+# from: https://www.ncbi.nlm.nih.gov/books/NBK3827/table/pubmedhelp.T.publication_types/?report=objectonly
+PUBMED_RELEASE_TYPE_MAP = {
+ #Adaptive Clinical Trial
+ "Address": "speech",
+ "Autobiography": "book",
+ #Bibliography
+ "Biography": "book",
+ #Case Reports
+ "Classical Article": "article-journal",
+ #Clinical Conference
+ #Clinical Study
+ #Clinical Trial
+ #Clinical Trial, Phase I
+ #Clinical Trial, Phase II
+ #Clinical Trial, Phase III
+ #Clinical Trial, Phase IV
+ #Clinical Trial Protocol
+ #Clinical Trial, Veterinary
+ #Collected Works
+ #Comparative Study
+ #Congress
+ #Consensus Development Conference
+ #Consensus Development Conference, NIH
+ #Controlled Clinical Trial
+ "Dataset": "dataset",
+ #Dictionary
+ #Directory
+ #Duplicate Publication
+ "Editorial": "editorial",
+ #English Abstract # doesn't indicate that this is abstract-only
+ #Equivalence Trial
+ #Evaluation Studies
+ #Expression of Concern
+ #Festschrift
+ #Government Document
+ #Guideline
+ "Historical Article": "article-journal",
+ #Interactive Tutorial
+ "Interview": "interview",
+ "Introductory Journal Article": "article-journal",
+ "Journal Article": "article-journal",
+ "Lecture": "speech",
+ "Legal Case": "legal_case",
+ "Legislation": "legislation",
+ "Letter": "letter",
+ #Meta-Analysis
+ #Multicenter Study
+ #News
+ "Newspaper Article": "article-newspaper",
+ #Observational Study
+ #Observational Study, Veterinary
+ #Overall
+ #Patient Education Handout
+ #Periodical Index
+ #Personal Narrative
+ #Portrait
+ #Practice Guideline
+ #Pragmatic Clinical Trial
+ #Publication Components
+ #Publication Formats
+ #Publication Type Category
+ #Randomized Controlled Trial
+ #Research Support, American Recovery and Reinvestment Act
+ #Research Support, N.I.H., Extramural
+ #Research Support, N.I.H., Intramural
+ #Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.
+ #Research Support, U.S. Gov't, P.H.S.
+ #Review # in the "literature review" sense, not "product review"
+ #Scientific Integrity Review
+ #Study Characteristics
+ #Support of Research
+ #Systematic Review
+ "Technical Report": "report",
+ #Twin Study
+ #Validation Studies
+ #Video-Audio Media
+ #Webcasts
+}
+
+MONTH_ABBR_MAP = {
+ "Jan": 1, "01": 1,
+ "Feb": 2, "02": 2,
+ "Mar": 3, "03": 3,
+ "Apr": 4, "04": 4,
+ "May": 5, "05": 5,
+ "Jun": 6, "06": 6,
+ "Jul": 7, "07": 7,
+ "Aug": 8, "08": 8,
+ "Sep": 9, "09": 9,
+ "Oct": 10, "10": 10,
+ "Nov": 11, "11": 11,
+ "Dec": 12, "12": 12,
+}
+
+class PubMedParser():
+ """
+ Converts PubMed/MEDLINE XML into in release entity (which can dump as JSON)
+
+ TODO: MEDLINE doesn't include PMC/OA license; could include in importer?
+ TODO: clean (ftfy) title, original title, etc
+ """
+
+ def __init__(self):
+ pass
+
+ def parse_file(self, handle):
+
+ # 1. open with beautiful soup
+ soup = BeautifulSoup(handle, "xml")
+
+ # 2. iterate over articles, call parse_article on each
+ for article in soup.find_all("PubmedArticle"):
+ resp = self.parse_article(article)
+ print(json.dumps(resp))
+ #sys.exit(-1)
+
+ def parse_article(self, a):
+
+ medline = a.MedlineCitation
+ # PubmedData isn't required by DTD, but seems to always be present
+ pubmed = a.PubmedData
+ extra = dict()
+ extra_pubmed = dict()
+
+ identifiers = pubmed.ArticleIdList
+ doi = identifiers.find("ArticleId", IdType="doi")
+ if doi:
+ doi = doi.string.lower()
+
+ pmcid = identifiers.find("ArticleId", IdType="pmc")
+ if pmcid:
+ pmcid = pmcid.string
+
+ release_type = None
+ for pub_type in medline.Article.PublicationTypeList.find_all("PublicationType"):
+ if pub_type.string in PUBMED_RELEASE_TYPE_MAP:
+ release_type = PUBMED_RELEASE_TYPE_MAP[pub_type.string]
+ break
+ if medline.Article.PublicationTypeList.find(string="Retraction of Publication"):
+ release_type = "retraction"
+ retraction_of = medline.find("CommentsCorrections", RefType="RetractionOf")
+ if retraction_of:
+ extra_pubmed['retraction_of_raw'] = retraction_of.RefSource.string
+ extra_pubmed['retraction_of_pmid'] = retraction_of.PMID.string
+
+ # everything in medline is published
+ release_status = "published"
+ if medline.Article.PublicationTypeList.find(string="Corrected and Republished Article"):
+ release_status = "updated"
+ if medline.Article.PublicationTypeList.find(string="Retracted Publication"):
+ release_status = "retracted"
+
+ pages = medline.find('MedlinePgn')
+ if pages:
+ pages = pages.string
+
+ title = medline.Article.ArticleTitle.string, # always present
+ if type(title) is tuple:
+ title = ': '.join(title)
+ if title.endswith('.'):
+ title = title[:-1]
+ # this hides some "special" titles, but the vast majority are
+ # translations; translations don't always include the original_title
+ if title.startswith('[') and title.endswith(']'):
+ title = title[1:-1]
+
+ original_title = medline.Article.find("VernacularTitle", recurse=False)
+ if original_title:
+ original_title = original_title.string
+ if original_title.endswith('.'):
+ original_title = original_title[:-1]
+
+ # TODO: happening in alpha order, not handling multi-language well.
+ # also need to convert lang codes: https://www.nlm.nih.gov/bsd/language_table.html
+ language = medline.Article.Language
+ if language:
+ language = language.string
+ # TODO: map to two-letter
+ if language in ("und", "un"):
+ # "undetermined"
+ language = None
+
+ ### Journal/Issue Metadata
+ # MedlineJournalInfo is always present
+ container = dict()
+ container_extra = dict()
+ mji = medline.MedlineJournalInfo
+ if mji.find("Country"):
+ container_extra['country_name'] = mji.Country.string
+ if mji.find("ISSNLinking"):
+ container['issnl'] = mji.ISSNLinking.string
+
+ journal = medline.Article.Journal
+ issnp = journal.find("ISSN", IssnType="Print")
+ if issnp:
+ container_extra['issnp'] = issnp.string
+
+ pub_date = journal.PubDate
+ release_date = None
+ if pub_date.find("MedlineDate"):
+ release_year = int(pub_date.MedlineDate.string.split()[0][:4])
+ else:
+ release_year = int(pub_date.Year.string)
+ if pub_date.find("Day") and pub_date.find("Month"):
+ release_date = datetime.date(
+ release_year,
+ MONTH_ABBR_MAP[pub_date.Month.string],
+ int(pub_date.Day.string))
+ release_date = release_date.isoformat()
+
+ ji = journal.JournalIssue
+ volume = None
+ if ji.find("Volume"):
+ volume = ji.Volume.string
+ issue = None
+ if ji.find("Issue"):
+ issue = ji.Issue.string
+ if journal.find("Title"):
+ container['name'] = journal.Title.string
+
+ if extra_pubmed:
+ extra['pubmed'] = extra_pubmed
+ if not extra:
+ extra = None
+
+ ### Abstracts
+ # "All abstracts are in English"
+ abstracts = []
+ first_abstract = medline.find("AbstractText")
+ if first_abstract and first_abstract.get('NlmCategory'):
+ joined = "\n".join([m.get_text() for m in medline.find_all("AbstractText")])
+ abstracts.append(dict(
+ content=joined,
+ mimetype="text/plain",
+ lang="en",
+ ))
+ else:
+ for abstract in medline.find_all("AbstractText"):
+ abstracts.append(dict(
+ content=abstract.get_text().strip(),
+ mimetype="text/plain",
+ lang="en",
+ ))
+ if abstract.find('math'):
+ abstracts.append(dict(
+ # strip the <AbstractText> tags
+ content=str(abstract)[14:-15],
+ mimetype="application/mathml+xml",
+ lang="en",
+ ))
+ if not abstracts:
+ abstracts = None
+
+ ### Contribs
+ contribs = []
+ if medline.AuthorList:
+ for author in medline.AuthorList.find_all("Author"):
+ contrib = dict(
+ role="author",
+ )
+ if author.ForeName:
+ contrib['raw_name'] = "{} {}".format(author.ForeName.string, author.LastName.string)
+ elif author.LastName:
+ contrib['raw_name'] = author.LastName.string
+ contrib_extra = dict()
+ orcid = author.find("Identifier", Source="ORCID")
+ if orcid:
+ # needs re-formatting from, eg, "0000000179841889"
+ orcid = orcid.string
+ if orcid.startswith("http://orcid.org/"):
+ orcid = orcid.replace("http://orcid.org/", "")
+ elif orcid.startswith("https://orcid.org/"):
+ orcid = orcid.replace("https://orcid.org/", "")
+ elif not '-' in orcid:
+ orcid = "{}-{}-{}-{}".format(
+ orcid[0:4],
+ orcid[4:8],
+ orcid[8:12],
+ orcid[12:16],
+ )
+ contrib_extra['orcid'] = orcid
+ affiliation = author.find("Affiliation")
+ if affiliation:
+ contrib['raw_affiliation'] = affiliation.string
+ if author.find("EqualContrib"):
+ # TODO: schema for this?
+ contrib_extra['equal_contrib'] = True
+ if contrib_extra:
+ contrib['extra'] = contrib_extra
+ contribs.append(contrib)
+
+ if medline.AuthorList['CompleteYN'] == 'N':
+ contribs.append(dict(raw_name="et al."))
+ if not contribs:
+ contribs = None
+
+ ### References
+ refs = []
+ if pubmed.ReferenceList:
+ for ref in pubmed.ReferenceList.find_all('Reference'):
+ ref_obj = dict()
+ ref_extra = dict()
+ ref_pmid = ref.find("ArticleId", IdType="pubmed")
+ if ref_pmid:
+ ref_extra['pmid'] = ref_pmid.string
+ ref_raw = ref.Citation
+ if ref_raw:
+ ref_extra['raw'] = ref_raw.string
+ if ref_extra:
+ ref_obj['extra'] = ref_extra
+ refs.append(ref_obj)
+ if not refs:
+ refs = None
+
+ re = dict(
+ work_id=None,
+ title=title,
+ original_title=original_title,
+ release_type=release_type,
+ release_status=release_status,
+ release_date=release_date,
+ release_year=release_year,
+ doi=doi,
+ pmid=int(medline.PMID.string), # always present
+ pmcid=pmcid,
+ #isbn13 # never in Article
+ volume=volume,
+ issue=issue,
+ pages=pages,
+ #publisher # not included?
+ language=language,
+ #license_slug # not in MEDLINE
+
+ # content, mimetype, lang
+ abstracts=abstracts,
+
+ # raw_name, role, raw_affiliation, extra
+ contribs=contribs,
+
+ # key, year, container_name, title, locator
+ # extra: volume, authors, issue, publisher, identifiers
+ refs=refs,
+
+ # name, type, publisher, issnl
+ # extra: issnp, issne, original_name, languages, country
+ container=container,
+
+ # extra:
+ # withdrawn_date
+ # translation_of
+ # subtitle
+ # aliases
+ # container_name
+ # group-title
+ # pubmed: retraction refs
+ extra=extra,
+ )
+
+ return re
+
+if __name__=='__main__':
+ parser = PubMedParser()
+ parser.parse_file(open(sys.argv[1]))
diff --git a/python/tests/files/pubmedsample_2019.xml b/python/tests/files/pubmedsample_2019.xml
new file mode 100644
index 00000000..27126b85
--- /dev/null
+++ b/python/tests/files/pubmedsample_2019.xml
@@ -0,0 +1,36822 @@
+<?xml version="1.0" encoding="utf-8"?>
+<!DOCTYPE PubmedArticleSet PUBLIC "-//NLM//DTD PubMedArticle, 1st January 2019//EN" "https://dtd.nlm.nih.gov/ncbi/pubmed/out/pubmed_190101.dtd">
+<PubmedArticleSet>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">973217</PMID>
+ <DateCompleted>
+ <Year>1976</Year>
+ <Month>12</Month>
+ <Day>03</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2002</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0095-3814</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>3</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1976</Year>
+ <Season>Fall</Season>
+ </PubDate>
+ </JournalIssue>
+ <Title>Topics in health care financing</Title>
+ <ISOAbbreviation>Top Health Care Financ</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Hospital debt management and cost reimbursement.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>69-81</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Blume</LastName>
+ <ForeName>F R</ForeName>
+ <Initials>FR</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Top Health Care Financ</MedlineTA>
+ <NlmUniqueID>7509107</NlmUniqueID>
+ <ISSNLinking>0095-3814</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000066" MajorTopicYN="N">Accounting</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004469" MajorTopicYN="Y">Economics, Hospital</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006739" MajorTopicYN="Y">Hospital Administration</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1976</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1976</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1976</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">973217</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">1669026</PMID>
+ <DateCompleted>
+ <Year>1993</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>30</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0377-8231</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>Anniv No Pt 1</Volume>
+ <PubDate>
+ <Year>1991</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Bulletin et memoires de l'Academie royale de medecine de Belgique</Title>
+ <ISOAbbreviation>Bull. Mem. Acad. R. Med. Belg.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[150th Anniversary Celebration of the Royal Academy of Medicine of Belgium. Part 1. Bruxelles, 26-28 September 1991].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1-191</MedlinePgn>
+ </Pagination>
+ <Language>fre</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016423">Congress</PublicationType>
+ <PublicationType UI="D016424">Overall</PublicationType>
+ <PublicationType UI="D019477">Portrait</PublicationType>
+ </PublicationTypeList>
+ <VernacularTitle>Célébration du CL Anniversaire de l'Académie Royal de Médecine de Belgique. Première partie. Bruxelles, 26-28 septembre 1991.</VernacularTitle>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Belgium</Country>
+ <MedlineTA>Bull Mem Acad R Med Belg</MedlineTA>
+ <NlmUniqueID>7608462</NlmUniqueID>
+ <ISSNLinking>0377-8231</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000047" MajorTopicYN="Y">Academies and Institutes</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001530" MajorTopicYN="N" Type="Geographic">Belgium</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1991</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1991</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1991</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">1669026</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">1875346</PMID>
+ <DateCompleted>
+ <Year>1991</Year>
+ <Month>09</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0022-2623</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>34</Volume>
+ <Issue>8</Issue>
+ <PubDate>
+ <Year>1991</Year>
+ <Month>Aug</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal of medicinal chemistry</Title>
+ <ISOAbbreviation>J. Med. Chem.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivatives.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>2489-95</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Modification of the hexahydronaphthalene ring 5-position in simvastatin 2a via oxygenation and oxa replacement afforded two series of derivatives which were evaluated in vitro for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and acutely in vivo for oral effectiveness as inhibitors of cholesterogenesis in the rat. Of the compounds selected for further biological evaluation, the 6 beta-methyl-5-oxa 10 and 5 alpha-hydroxy 16 derivatives of 3,4,4a,5-tetrahydro 2a, as well as, the 6 beta-epimer 14 of 16 proved orally active as hypocholesterolemic agents in cholestyramine-primed dogs. Subsequent acute oral metabolism studies in dogs demonstrated that compounds 14 and 16 evoke lower peak plasma drug activity and area-under-the-curve values than does compound 10 and led to the selection of 14 and 16 for toxicological evaluation.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="N">
+ <Author ValidYN="Y">
+ <LastName>Duggan</LastName>
+ <ForeName>M E</ForeName>
+ <Initials>ME</Initials>
+ <AffiliationInfo>
+ <Affiliation>Merck Sharp &amp; Dohme Research Laboratories, West Point, Pennsylvania 19486.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Alberts</LastName>
+ <ForeName>A W</ForeName>
+ <Initials>AW</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bostedor</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Chao</LastName>
+ <ForeName>Y S</ForeName>
+ <Initials>YS</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Germershausen</LastName>
+ <ForeName>J I</ForeName>
+ <Initials>JI</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Gilfillan</LastName>
+ <ForeName>J L</ForeName>
+ <Initials>JL</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Halczenko</LastName>
+ <ForeName>W</ForeName>
+ <Initials>W</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hartman</LastName>
+ <ForeName>G D</ForeName>
+ <Initials>GD</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hunt</LastName>
+ <ForeName>V</ForeName>
+ <Initials>V</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Imagire</LastName>
+ <ForeName>J S</ForeName>
+ <Initials>JS</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Med Chem</MedlineTA>
+ <NlmUniqueID>9716531</NlmUniqueID>
+ <ISSNLinking>0022-2623</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C070477">6-(2-(8-(2,2-dimethylbutyryl)oxy)-2,6-dimethyl-5-hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthyl-1-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000085">Acetates</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000924">Anticholesteremic Agents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D019161">Hydroxymethylglutaryl-CoA Reductase Inhibitors</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>97C5T2UQ7J</RegistryNumber>
+ <NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>9LHU78OQFD</RegistryNumber>
+ <NameOfSubstance UI="D008148">Lovastatin</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>AGG2FN16EV</RegistryNumber>
+ <NameOfSubstance UI="D019821">Simvastatin</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>S88TT14065</RegistryNumber>
+ <NameOfSubstance UI="D010100">Oxygen</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000085" MajorTopicYN="N">Acetates</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000924" MajorTopicYN="N">Anticholesteremic Agents</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D055598" MajorTopicYN="N">Chemical Phenomena</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002621" MajorTopicYN="N">Chemistry</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002784" MajorTopicYN="N">Cholesterol</DescriptorName>
+ <QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019161" MajorTopicYN="Y">Hydroxymethylglutaryl-CoA Reductase Inhibitors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008148" MajorTopicYN="N">Lovastatin</DescriptorName>
+ <QualifierName UI="Q000031" MajorTopicYN="Y">analogs &amp; derivatives</QualifierName>
+ <QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008968" MajorTopicYN="N">Molecular Conformation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010100" MajorTopicYN="Y">Oxygen</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019821" MajorTopicYN="N">Simvastatin</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1991</Year>
+ <Month>8</Month>
+ <Day>1</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1991</Year>
+ <Month>8</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>1991</Year>
+ <Month>8</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
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+ </History>
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+ <ArticleIdList>
+ <ArticleId IdType="pubmed">1875346</ArticleId>
+ </ArticleIdList>
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+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">3549656</PMID>
+ <DateCompleted>
+ <Year>1987</Year>
+ <Month>05</Month>
+ <Day>15</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2014</Year>
+ <Month>11</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0021-8820</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>40</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1987</Year>
+ <Month>Jan</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Journal of antibiotics</Title>
+ <ISOAbbreviation>J. Antibiot.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Semisynthetic beta-lactam antibiotics. III. Effect on antibacterial activity and comt-susceptibility of chlorine-introduction into the catechol nucleus of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2- phenylacetamido]penicillanic acid.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>22-8</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The resistance of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2- phenylacetamido]penicillanic acid (1a) to metabolism by catechol-O-methyl-transferase (COMT) was increased by introduction of the chlorine atom into the catechol moiety. Penicillins (1b-1d) having one or two chlorine atoms at the positions adjacent to the hydroxyl group were found to have greater stability to COMT. This resulted in greater efficiency in vivo in experimental Pseudomonas aeruginosa and Escherichia coli infections. In vitro activities were essentially unchanged.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Ohi</LastName>
+ <ForeName>N</ForeName>
+ <Initials>N</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Aoki</LastName>
+ <ForeName>B</ForeName>
+ <Initials>B</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kuroki</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Matsumoto</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kojima</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Nehashi</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D003160">Comparative Study</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Japan</Country>
+ <MedlineTA>J Antibiot (Tokyo)</MedlineTA>
+ <NlmUniqueID>0151115</NlmUniqueID>
+ <ISSNLinking>0021-8820</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D065098">Catechol O-Methyltransferase Inhibitors</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D007202">Indicators and Reagents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D010406">Penicillins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D047090">beta-Lactams</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>88852-54-4</RegistryNumber>
+ <NameOfSubstance UI="C052009">6-(2-(3-(5-chloro-3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>92773-65-4</RegistryNumber>
+ <NameOfSubstance UI="C052008">6-(2-(3-(2-chloro-3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>92773-66-5</RegistryNumber>
+ <NameOfSubstance UI="C052007">6-(2-(3-(2,5-dichloro-3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001419" MajorTopicYN="N">Bacteria</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D065098" MajorTopicYN="Y">Catechol O-Methyltransferase Inhibitors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004927" MajorTopicYN="N">Escherichia coli Infections</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007202" MajorTopicYN="N">Indicators and Reagents</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008815" MajorTopicYN="N">Mice, Inbred Strains</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010406" MajorTopicYN="N">Penicillins</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011552" MajorTopicYN="N">Pseudomonas Infections</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D047090" MajorTopicYN="N">beta-Lactams</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1987</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1987</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1987</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">3549656</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">5757641</PMID>
+ <DateCompleted>
+ <Year>1970</Year>
+ <Month>03</Month>
+ <Day>22</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2003</Year>
+ <Month>11</Month>
+ <Day>14</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <JournalIssue CitedMedium="Print">
+ <Volume>15</Volume>
+ <PubDate>
+ <Year>1968</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Trudy Instituta fiziologii, Akademiia nauk Gruzinskoi SSR</Title>
+ <ISOAbbreviation>Tr Inst Fiz Akad Nauk Gruz Ssr</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[The effect of immediate stimulation of the hippocampus on reflex reactions in animals].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>86-96</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Tevzadze</LastName>
+ <ForeName>V G</ForeName>
+ <Initials>VG</Initials>
+ </Author>
+ </AuthorList>
+ <Language>geo</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <VernacularTitle>O vliianii neposredstvennogo razdrazheniia gippokampa na reflektornye reaktsii zhivotnykh.</VernacularTitle>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Georgia (Republic)</Country>
+ <MedlineTA>Tr Inst Fiz Akad Nauk Gruz Ssr</MedlineTA>
+ <NlmUniqueID>7507618</NlmUniqueID>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004558" MajorTopicYN="N">Electric Stimulation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006624" MajorTopicYN="N">Hippocampus</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012018" MajorTopicYN="Y">Reflex</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1968</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1968</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1968</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">5757641</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">8119288</PMID>
+ <DateCompleted>
+ <Year>1994</Year>
+ <Month>04</Month>
+ <Day>01</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0014-2956</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>220</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1994</Year>
+ <Month>Feb</Month>
+ <Day>15</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>European journal of biochemistry</Title>
+ <ISOAbbreviation>Eur. J. Biochem.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Purification and characterisation of a water-soluble ferrochelatase from Bacillus subtilis.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>201-8</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Bacillus subtilis ferrochelatase is encoded by the hemH gene of the hemEHY gene cluster and catalyses the incorporation of Fe2+ into protoporphyrin IX. B. subtilis ferrochelatase produced in Escherichia coli was purified. It was found to be a monomeric, water-soluble enzyme of molecular mass 35 kDa which in addition to Fe2+ can incorporate Zn2+ and Cu2+ into protoporphyrin IX. Chemical modification experiments indicated that the single cysteine residue in the ferrochelatase is required for enzyme activity although it is not a conserved residue compared to other ferrochelatases. In growing B. subtilis, the ferrochelatase constitutes approximately 0.05% (by mass) of the total cell protein, which corresponds to some 600 ferrochelatase molecules/cell. The turnover number of isolated ferrochelatase, 18-29 min-1, was found to be consistent with the rate of haem synthesis in exponentially growing cells (0.2 mol haem formed/min/mol enzyme). It is concluded that the B. subtilis ferrochelatase has enzymic properties which are similar to those of other characterised ferrochelatases of known primary structure, i.e. ferrochelatases of the mitochondrial inner membrane of yeast and mammalian cells. However, in contrast to these enzymes the B. subtilis enzyme is a water-soluble protein and should be more amenable to structural analysis.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Hansson</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Microbiology, Lund University, Sweden.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hederstedt</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Eur J Biochem</MedlineTA>
+ <NlmUniqueID>0107600</NlmUniqueID>
+ <ISSNLinking>0014-2956</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>059QF0KO0R</RegistryNumber>
+ <NameOfSubstance UI="D014867">Water</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 4.99.1.1</RegistryNumber>
+ <NameOfSubstance UI="D005294">Ferrochelatase</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <GeneSymbolList>
+ <GeneSymbol>hemE</GeneSymbol>
+ <GeneSymbol>hemH</GeneSymbol>
+ <GeneSymbol>hemY</GeneSymbol>
+ </GeneSymbolList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001412" MajorTopicYN="N">Bacillus subtilis</DescriptorName>
+ <QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002384" MajorTopicYN="N">Catalysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003001" MajorTopicYN="N">Cloning, Molecular</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName>
+ <QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005294" MajorTopicYN="N">Ferrochelatase</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000302" MajorTopicYN="Y">isolation &amp; purification</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017353" MajorTopicYN="N">Gene Deletion</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005798" MajorTopicYN="N">Genes, Bacterial</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008970" MajorTopicYN="N">Molecular Weight</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012995" MajorTopicYN="N">Solubility</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014867" MajorTopicYN="N">Water</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1994</Year>
+ <Month>2</Month>
+ <Day>15</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1994</Year>
+ <Month>2</Month>
+ <Day>15</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1994</Year>
+ <Month>2</Month>
+ <Day>15</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">8119288</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">8219565</PMID>
+ <DateCompleted>
+ <Year>1993</Year>
+ <Month>12</Month>
+ <Day>08</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>11</Month>
+ <Day>23</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1051-0443</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>4</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <MedlineDate>1993 Sep-Oct</MedlineDate>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal of vascular and interventional radiology : JVIR</Title>
+ <ISOAbbreviation>J Vasc Interv Radiol</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Transcatheter manipulation of asymmetrically opened titanium Greenfield filters.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>687-90</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The problem of asymmetric opening of the modified hook titanium Greenfield inferior vena cava filter necessitating transcatheter manipulation was evaluated in a retrospective study.</AbstractText>
+ <AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Titanium Greenfield filters were placed in 166 patients over a 36-month period. The radiographic reports of all patients were reviewed to identify cases in which the filter failed to open symmetrically after deployment and catheter or wire manipulation of the filter was performed. The reports and angiograms from these patients were reviewed with respect to the circumstances surrounding filter placement and methods to achieve more symmetric opening.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">Transcatheter manipulation of asymmetrically opened filters was performed in 15 of 166 cases (9%). In 12 of these patients, acceptable and uneventful opening of the filter was achieved with a guide wire, pigtail catheter, or occlusion balloon catheter. In one case manipulation only partly improved orientation of the limbs, while in another case successful manipulation was complicated by distal migration. In the final case, the asymmetric filter covered only part of the lumen of the vena cava despite manipulations and a second filter was placed for optimal caval interruption. No specific cause for incomplete expansion was identified in any case.</AbstractText>
+ <AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Marked asymmetry in opening of the modified hook titanium Greenfield filter that warrants manipulation occurs infrequently, but recognition and proper management may be important to ensure optimal caval interruption.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Moore</LastName>
+ <ForeName>B S</ForeName>
+ <Initials>BS</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Radiology, University of California at San Diego 92103.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Valji</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Roberts</LastName>
+ <ForeName>A C</ForeName>
+ <Initials>AC</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bookstein</LastName>
+ <ForeName>J J</ForeName>
+ <Initials>JJ</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Vasc Interv Radiol</MedlineTA>
+ <NlmUniqueID>9203369</NlmUniqueID>
+ <ISSNLinking>1051-0443</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>D1JT611TNE</RegistryNumber>
+ <NameOfSubstance UI="D014025">Titanium</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>J Vasc Interv Radiol. 1994 May-Jun;5(3):526-7</RefSource>
+ <PMID Version="1">8054760</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>J Vasc Interv Radiol. 1994 May-Jun;5(3):528-32</RefSource>
+ <PMID Version="1">8054761</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>J Vasc Interv Radiol. 1993 Sep-Oct;4(5):617-20</RefSource>
+ <PMID Version="1">8219555</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D002405" MajorTopicYN="Y">Catheterization, Central Venous</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011859" MajorTopicYN="N">Radiography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014025" MajorTopicYN="N">Titanium</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016306" MajorTopicYN="Y">Vena Cava Filters</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014682" MajorTopicYN="N">Vena Cava, Inferior</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1993</Year>
+ <Month>9</Month>
+ <Day>1</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1993</Year>
+ <Month>9</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1993</Year>
+ <Month>9</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">8219565</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">8655018</PMID>
+ <DateCompleted>
+ <Year>1996</Year>
+ <Month>07</Month>
+ <Day>30</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2017</Year>
+ <Month>03</Month>
+ <Day>03</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0017-0011</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>67</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1996</Year>
+ <Month>Jan</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Ginekologia polska</Title>
+ <ISOAbbreviation>Ginekol. Pol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[Effect of fetal and neonatal growth on the occurrence of some diseases in adults].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>34-6</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The findings of many authors show that reduced fetal growth is followed by increased mortality from cardiovascular disease in adult life. They are further evidence that cardiovascular disease originates, among other risk factors, through programming of the bodies structure and metabolism during fetal and early post-natal life. Wrong maternal nutrition may have an important influence on programming.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Jendryczko</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Katedry i Zakładu Chemii i Analizy Leków, AM w Katowicach.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Poreba</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ </AuthorList>
+ <Language>pol</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D004740">English Abstract</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016441">Retracted Publication</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ <VernacularTitle>Wpływ przebiegu rozwoju płodu i noworodka na ujawnienie sie niektórych chorób okresu dorosłego.</VernacularTitle>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Poland</Country>
+ <MedlineTA>Ginekol Pol</MedlineTA>
+ <NlmUniqueID>0374641</NlmUniqueID>
+ <ISSNLinking>0017-0011</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Ginekol Pol. 1998 Jul;69(7):561</RefSource>
+ <PMID Version="1">9867475</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="RetractionIn">
+ <RefSource>Ginekol Pol. 1998 Jul;69(7):559-60</RefSource>
+ <PMID Version="1">9867474</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002657" MajorTopicYN="N">Child Development</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005314" MajorTopicYN="N">Embryonic and Fetal Development</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005317" MajorTopicYN="N">Fetal Growth Retardation</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
+ <QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009747" MajorTopicYN="N">Nutritional Physiological Phenomena</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>11</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1996</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1996</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1996</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">8655018</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">8863847</PMID>
+ <DateCompleted>
+ <Year>1996</Year>
+ <Month>11</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2014</Year>
+ <Month>11</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0026-895X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>50</Volume>
+ <Issue>4</Issue>
+ <PubDate>
+ <Year>1996</Year>
+ <Month>Oct</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Molecular pharmacology</Title>
+ <ISOAbbreviation>Mol. Pharmacol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1000-9</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The mitogenic effect of extracellular ATP was examined in cultured rat aortic smooth muscle cells (VSMCs). ATP, 2-methylthio-ATP, and ADP stimulated [3H]thymidine and [3H]leucine incorporation and cell growth. AMP, adenosine, UTP, and P2x agonists showed little of these effects. Reactive blue 2, a P2Y purinoceptor antagonist, was effective in suppressing the mitogenic effect of ATP and 2-methylthio-ATP, indicating that extracellular ATP-induced VSMC proliferation is mediated by P2Y purinoceptors. The P2Y purinoceptor activation was coupled to a pertussis toxin (PTX)-insensitive G protein (Gq) and triggered phosphoinositide hydrolysis with subsequent activation of protein kinase C (PKC), Raf-1, and mitogen-activated protein kinase (MAPK) in VSMCs. In response to ATP, both 42-and 44-kDa MAPKs were activated, and tyrosine was phosphorylated. Western blot analysis using PKC isozyme-specific antibodies indicated that VSMCs express PKC-alpha, PKC-delta, and PKC-zeta. A complete down-regulation of PKC-alpha and PKC-delta was seen after 24-hr treatment with 12-O-tetradecanoylphorbol-13-acetate. When cells were pretreated with 12-O-tetradecanoyl-phorbol-13-acetate for 24 hr and subsequently challenged with ATP, Raf-1 activation and 42-kDa as well as 44-kDa MAPK tyrosine phosphorylation failed to be induced. These results demonstrate that ATP-induced Raf-1 and MAPK activations involve the activation of PKC-alpha and PKC-delta. P2Y purinoceptor stimulation with ATP also caused accumulation of c-fos and c-myc mRNAs. Both Reactive blue 2 and staurosporine significantly blocked this increase by ATP. In conclusion, the mitogenic effect of ATP seemed to be triggered by activation of the Gq protein-coupled P2Y purinoceptor that led to the formation of inositol trisphosphate and activation of PKC. PKC and, in turn, Raf-1 and MAPK were then activated, leading eventually to DNA synthesis and cell proliferation.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Yu</LastName>
+ <ForeName>S M</ForeName>
+ <Initials>SM</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Pharmacology, Chang Gung College of Medicine and Technology, Kwei-San, Tao-Yuan, Taiwan. smyu@cguaplo.cgu.edu</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Chen</LastName>
+ <ForeName>S F</ForeName>
+ <Initials>SF</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lau</LastName>
+ <ForeName>Y T</ForeName>
+ <Initials>YT</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Yang</LastName>
+ <ForeName>C M</ForeName>
+ <Initials>CM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Chen</LastName>
+ <ForeName>J C</ForeName>
+ <Initials>JC</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ <PublicationType UI="D016441">Retracted Publication</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Mol Pharmacol</MedlineTA>
+ <NlmUniqueID>0035623</NlmUniqueID>
+ <ISSNLinking>0026-895X</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D011518">Proto-Oncogene Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D018048">Receptors, Purinergic P2</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>10028-17-8</RegistryNumber>
+ <NameOfSubstance UI="D014316">Tritium</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>8L70Q75FXE</RegistryNumber>
+ <NameOfSubstance UI="D000255">Adenosine Triphosphate</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>9007-49-2</RegistryNumber>
+ <NameOfSubstance UI="D004247">DNA</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 2.7.11.1</RegistryNumber>
+ <NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 2.7.11.1</RegistryNumber>
+ <NameOfSubstance UI="D019908">Proto-Oncogene Proteins c-raf</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 2.7.11.13</RegistryNumber>
+ <NameOfSubstance UI="D011493">Protein Kinase C</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 2.7.11.17</RegistryNumber>
+ <NameOfSubstance UI="D017871">Calcium-Calmodulin-Dependent Protein Kinases</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 3.6.1.-</RegistryNumber>
+ <NameOfSubstance UI="D019204">GTP-Binding Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>GMW67QNF9C</RegistryNumber>
+ <NameOfSubstance UI="D007930">Leucine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>VC2W18DGKR</RegistryNumber>
+ <NameOfSubstance UI="D013936">Thymidine</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="ErratumIn">
+ <RefSource>Mol Pharmacol 1997 Mar;51(3):533</RefSource>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="RetractionIn">
+ <RefSource>Wu D, Yang CM, Lau YT, Chen JC. Mol Pharmacol. 1998 Feb;53(2):346</RefSource>
+ <PMID Version="1">9499167</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000255" MajorTopicYN="N">Adenosine Triphosphate</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001011" MajorTopicYN="N">Aorta</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017871" MajorTopicYN="N">Calcium-Calmodulin-Dependent Protein Kinases</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002455" MajorTopicYN="N">Cell Division</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName>
+ <QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004789" MajorTopicYN="N">Enzyme Activation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005110" MajorTopicYN="N">Extracellular Space</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019204" MajorTopicYN="N">GTP-Binding Proteins</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007930" MajorTopicYN="N">Leucine</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009131" MajorTopicYN="N">Muscle, Smooth, Vascular</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
+ <QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011493" MajorTopicYN="N">Protein Kinase C</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011518" MajorTopicYN="N">Proto-Oncogene Proteins</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019908" MajorTopicYN="N">Proto-Oncogene Proteins c-raf</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018048" MajorTopicYN="N">Receptors, Purinergic P2</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013268" MajorTopicYN="N">Stimulation, Chemical</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013936" MajorTopicYN="N">Thymidine</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
+ <QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014316" MajorTopicYN="N">Tritium</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1996</Year>
+ <Month>10</Month>
+ <Day>1</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1996</Year>
+ <Month>10</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1996</Year>
+ <Month>10</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">8863847</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">8941094</PMID>
+ <DateCompleted>
+ <Year>1997</Year>
+ <Month>01</Month>
+ <Day>02</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>11</Month>
+ <Day>24</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0009-7322</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>94</Volume>
+ <Issue>11</Issue>
+ <PubDate>
+ <Year>1996</Year>
+ <Month>Dec</Month>
+ <Day>01</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Circulation</Title>
+ <ISOAbbreviation>Circulation</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Assessment of myocardial viability in patients with chronic coronary artery disease. Rest-4-hour-24-hour 201Tl tomography versus dobutamine echocardiography.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>2712-9</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">To date, late redistribution after resting 201Tl injection has not been evaluated. In addition, the concordance between resting 201Tl imaging and dobutamine echocardiography in identifying viable myocardium has not been assessed.</AbstractText>
+ <AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Forty patients with coronary artery disease underwent rest-4-hour-24-hour 201Tl tomography and dobutamine echocardiography (5 to 10 micrograms.kg-1.min-1). Late redistribution occurred in 46 (21%) of 219 persistent defects at 4 hours. Systolic function and contractile reserve were similar among persistent defects at 4 hours with and without late redistribution. Contractile reserve was more frequent in segments with normal 201Tl uptake (59%), completely reversible defects (53%), or mild to moderate defects at 4 hours (56%) compared with severe defects (14%; P &lt; .02 versus all). Of 105 hypokinetic segments, 99 (94%) were viable by 201Tl, and 88 (84%) showed contractile reserve. In contrast, of 155 akinetic segments, 119 (77%) were viable by 201Tl, but only 34 (22%) had contractile reserve. Concordance between 201Tl and dobutamine was 82% in hypokinetic segments but 43% in akinetic segments. In 109 revascularized segments, positive accuracy for functional recovery was 72% for 201Tl and 92% for dobutamine, whereas negative accuracy was 100% and 65%, respectively. Sensitivity was 100% for 201Tl and 79% for dobutamine.</AbstractText>
+ <AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Late redistribution occurs in one fifth of persistent defects at 4 hours, and it does not correlate to systolic function or contractile reserve. Dobutamine and 201Tl yield concordant information in the majority of hypokinetic segments, whereas concordance is low in akinetic segments. Dobutamine demonstrates higher positive accuracy and sensitivity in predicting recovery of dysfunctional myocardium, whereas 201Tl shows higher negative predictive accuracy but reduced positive accuracy.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Perrone-Filardi</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ <AffiliationInfo>
+ <Affiliation>Division of Cardiology, Federico II University Medical School, Naples, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Pace</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Prastaro</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Squame</LastName>
+ <ForeName>F</ForeName>
+ <Initials>F</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Betocchi</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Soricelli</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Piscione</LastName>
+ <ForeName>F</ForeName>
+ <Initials>F</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Indolfi</LastName>
+ <ForeName>C</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Crisci</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Salvatore</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Chiariello</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Circulation</MedlineTA>
+ <NlmUniqueID>0147763</NlmUniqueID>
+ <ISSNLinking>0009-7322</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D013794">Thallium Radioisotopes</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>3S12J47372</RegistryNumber>
+ <NameOfSubstance UI="D004280">Dobutamine</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Circulation. 1996 Dec 1;94(11):2674-80</RefSource>
+ <PMID Version="1">8941085</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Circulation. 1996 Dec 1;94(11):2681-4</RefSource>
+ <PMID Version="1">8941086</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Circulation. 1996 Dec 1;94(11):2685-8</RefSource>
+ <PMID Version="1">8941087</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Circulation. 1997 Oct 21;96(8):2740-2</RefSource>
+ <PMID Version="1">9355926</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002940" MajorTopicYN="N">Circadian Rhythm</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003327" MajorTopicYN="N">Coronary Disease</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
+ <QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004280" MajorTopicYN="Y">Dobutamine</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004452" MajorTopicYN="Y">Echocardiography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006321" MajorTopicYN="N">Heart</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009200" MajorTopicYN="N">Myocardial Contraction</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009204" MajorTopicYN="N">Myocardial Revascularization</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011877" MajorTopicYN="N">Radionuclide Imaging</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012146" MajorTopicYN="N">Rest</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013599" MajorTopicYN="N">Systole</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013794" MajorTopicYN="Y">Thallium Radioisotopes</DescriptorName>
+ <QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018487" MajorTopicYN="N">Ventricular Dysfunction, Left</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1996</Year>
+ <Month>12</Month>
+ <Day>1</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1996</Year>
+ <Month>12</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1996</Year>
+ <Month>12</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">8941094</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">9110943</PMID>
+ <DateCompleted>
+ <Year>1996</Year>
+ <Month>10</Month>
+ <Day>23</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2011</Year>
+ <Month>11</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1059-2725</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>Doc No 200-201</Volume>
+ <PubDate>
+ <Year>1996</Year>
+ <Month>Jul</Month>
+ <Day>30</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Online journal of current clinical trials</Title>
+ <ISOAbbreviation>Online J Curr Clin Trials</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Conservative management of mechanical neck disorders. A systematic overview and meta-analysis.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>[34457 words; 185 paragraphs]</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">This overview reports the efficacy of conservative treatments (drug therapy, manual therapy, patient education, physical medicine modalities) in reducing pain in adults with mechanical neck disorders.</AbstractText>
+ <AbstractText Label="METHODS" NlmCategory="METHODS">Computerized bibliographic database searches from 1985 to December 1993, information requests from authors, and bibliography screenings were used to identify published and unpublished research. Applying strict criteria, two investigators independently reviewed the blinded articles. Each selected trial was evaluated independently for methodologic quality.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">Twenty-four randomized controlled trials (RCTs) and eight before-after studies met our selection criteria. Twenty RCTs rated moderately strong or better in terms of methodologic quality. Five trials using manual therapy in combination with other treatments were clinically similar, were statistically not heterogeneous (p = 0.98), and were combined to yield an effect size of -0.6 (95% CI: -0.9, -0.4), equivalent to a 16 point improvement on a 100 point pain scale. Four RCTs using physical medicine modalities were combined using the inverse chi-square method: two using electromagnetic therapy produced a significant reduction in pain (p &lt; 0.01); and two using laser therapy did not differ significantly from a placebo (p = 0.63). Little or no scientific evidence exists for other therapies, including such commonly used treatments as medication, rest and exercise.</AbstractText>
+ <AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Within the limits of methodologic quality, the best available evidence supports the use of manual therapies in combination with other treatments for short-term relief of neck pain. There is some support for the use of electromagnetic therapy and against the use of laser therapy. In general, other interventions have not been studied in enough detail adequately to assess efficacy or effectiveness. This overview provides the foundation for an evidence-based approach to practice. More robust design and methodology should be used in future research, in particular, the use of valid and reliable outcomes measures.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Gross</LastName>
+ <ForeName>A R</ForeName>
+ <Initials>AR</Initials>
+ <AffiliationInfo>
+ <Affiliation>Chedoke-McMaster Hospitals &amp; Schools of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Aker</LastName>
+ <ForeName>P D</ForeName>
+ <Initials>PD</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Goldsmith</LastName>
+ <ForeName>C H</ForeName>
+ <Initials>CH</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Peloso</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D017418">Meta-Analysis</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Online J Curr Clin Trials</MedlineTA>
+ <NlmUniqueID>9300367A</NlmUniqueID>
+ <ISSNLinking>1059-2725</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D015670" MajorTopicYN="N">Acupuncture Therapy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002684" MajorTopicYN="N">Chiropractic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016206" MajorTopicYN="N">Databases, Bibliographic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008349" MajorTopicYN="N">Manipulation, Orthopedic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019838" MajorTopicYN="Y">Neck Injuries</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010146" MajorTopicYN="N">Pain</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000534" MajorTopicYN="N">rehabilitation</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D059408" MajorTopicYN="Y">Pain Management</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010353" MajorTopicYN="N">Patient Education as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D026741" MajorTopicYN="Y">Physical Therapy Modalities</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014947" MajorTopicYN="N">Wounds and Injuries</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000534" MajorTopicYN="N">rehabilitation</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1996</Year>
+ <Month>7</Month>
+ <Day>30</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1996</Year>
+ <Month>7</Month>
+ <Day>30</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1996</Year>
+ <Month>7</Month>
+ <Day>30</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">9110943</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">9394824</PMID>
+ <DateCompleted>
+ <Year>1998</Year>
+ <Month>01</Month>
+ <Day>02</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0014-2980</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>27</Volume>
+ <Issue>11</Issue>
+ <PubDate>
+ <Year>1997</Year>
+ <Month>Nov</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>European journal of immunology</Title>
+ <ISOAbbreviation>Eur. J. Immunol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>2959-64</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>In this work we have microdissected lamina propria plasma cells and used polymerase chain reaction and sequencing to investigate immunoglobulin (Ig) gene rearrangements and mutations in human intestine. In addition, specific primers were designed for individual Ig gene rearrangements to analyze the distribution of related B cell and plasma cell clones at different sites along the bowel. Confirming our earlier work, intestinal IgVH genes were highly mutated in plasma cells from older individuals (&gt; 30 years). IgVH genes were significantly less mutated in samples taken from patients aged 11-30 years, and there were fewer mutations again in samples from young children (&lt; 11 years). In age-matched specimens the number of mutations was equivalent in the duodenum and colon. Using complementarity-determining region 3 primers to amplify specific Ig gene rearrangements, evidence was also found for the existence of related lamina propria plasma cells along the small bowel and colon, although these were quite scarce. In addition, analysis of the numbers of related clones in a random sampling from discrete areas of lamina propria indicates that the local population is diverse. These results suggest that the highly mutated IgVH genes in adult intestinal plasma cells are a consequence of chronic antigen exposure with age. Duodenal plasma cells are as highly mutated as colonic plasma cells, despite the fact that the upper bowel has no indigenous microbial flora (the stimulus for intestinal plasma cells). They also show that the plasma cell population is diverse and can be widely disseminated along the bowel.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Dunn-Walters</LastName>
+ <ForeName>D K</ForeName>
+ <Initials>DK</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Histopathology, UMDS, London, Great Britain.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Boursier</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Spencer</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <DataBankList CompleteYN="N">
+ <DataBank>
+ <DataBankName>GENBANK</DataBankName>
+ <AccessionNumberList>
+ <AccessionNumber>Z93128</AccessionNumber>
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+ <AccessionNumber>Z93156</AccessionNumber>
+ <AccessionNumber>Z93157</AccessionNumber>
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+ </DataBankList>
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+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Germany</Country>
+ <MedlineTA>Eur J Immunol</MedlineTA>
+ <NlmUniqueID>1273201</NlmUniqueID>
+ <ISSNLinking>0014-2980</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D007143">Immunoglobulin Heavy Chains</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D007135">Immunoglobulin Variable Region</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003106" MajorTopicYN="N">Colon</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004386" MajorTopicYN="N">Duodenum</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015321" MajorTopicYN="N">Gene Rearrangement</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005803" MajorTopicYN="N">Genes, Immunoglobulin</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007143" MajorTopicYN="N">Immunoglobulin Heavy Chains</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007135" MajorTopicYN="N">Immunoglobulin Variable Region</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007413" MajorTopicYN="N">Intestinal Mucosa</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
+ <QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009928" MajorTopicYN="N">Organ Specificity</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010950" MajorTopicYN="N">Plasma Cells</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1997</Year>
+ <Month>12</Month>
+ <Day>12</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1997</Year>
+ <Month>12</Month>
+ <Day>12</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1997</Year>
+ <Month>12</Month>
+ <Day>12</Day>
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+ <PublicationStatus>ppublish</PublicationStatus>
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+ <ArticleId IdType="pubmed">9394824</ArticleId>
+ <ArticleId IdType="doi">10.1002/eji.1830271131</ArticleId>
+ </ArticleIdList>
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+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">9482442</PMID>
+ <DateCompleted>
+ <Year>1998</Year>
+ <Month>03</Month>
+ <Day>18</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>11</Month>
+ <Day>24</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0140-6736</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>351</Volume>
+ <Issue>9101</Issue>
+ <PubDate>
+ <Year>1998</Year>
+ <Month>Feb</Month>
+ <Day>14</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Lancet (London, England)</Title>
+ <ISOAbbreviation>Lancet</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>A woman with nodules in her lungs.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>494</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Järveläinen</LastName>
+ <ForeName>H</ForeName>
+ <Initials>H</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Medicine, Turku University Central Hospital, Finland.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Vainionpää</LastName>
+ <ForeName>H</ForeName>
+ <Initials>H</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kuopio</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lehtonen</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D002363">Case Reports</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Lancet</MedlineTA>
+ <NlmUniqueID>2985213R</NlmUniqueID>
+ <ISSNLinking>0140-6736</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D011208">Powders</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>7631-86-9</RegistryNumber>
+ <NameOfSubstance UI="D012822">Silicon Dioxide</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="ErratumIn">
+ <RefSource>Lancet 1998 Jun 27;351(9120):1968</RefSource>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="ErratumIn">
+ <RefSource>Lancet 1998 Mar 7;351(9104):760</RefSource>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009324" MajorTopicYN="N">Naturopathy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011208" MajorTopicYN="N">Powders</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011859" MajorTopicYN="N">Radiography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012822" MajorTopicYN="N">Silicon Dioxide</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="Y">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012829" MajorTopicYN="N">Silicosis</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1998</Year>
+ <Month>3</Month>
+ <Day>3</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1998</Year>
+ <Month>3</Month>
+ <Day>3</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1998</Year>
+ <Month>3</Month>
+ <Day>3</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">9482442</ArticleId>
+ <ArticleId IdType="pii">S0140673697104913</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">9505772</PMID>
+ <DateCompleted>
+ <Year>1998</Year>
+ <Month>03</Month>
+ <Day>24</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>01</Month>
+ <Day>26</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0007-0912</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>80</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1998</Year>
+ <Month>Jan</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>British journal of anaesthesia</Title>
+ <ISOAbbreviation>Br J Anaesth</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Myocardial ischaemia after coronary artery bypass grafting: early vs late extubation.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>20-5</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The technique of early extubation after coronary artery bypass grafting is increasing in popularity, but its safety and effect on myocardial ischaemia remain to be established. In a randomized, prospective study, patients undergoing routine elective coronary artery bypass grafting were managed with either early or late tracheal extubation. The incidence and severity of electrocardiographic myocardial ischaemia were compared. Data were analysed from 85 patients (43 early extubation; 42 late extubation). Median time to extubation was 110 min in the early extubation patients and 757 min in the late extubation patients. After correction for randomization bias, there were no significant differences between groups in ischaemic burden, maximal ST-segment deviation, incidence of ischaemia and area under the ST deviation-time curve (integral of ST deviation and time). Similarly, there were no differences between groups in postoperative creatine kinase MB-isoenzyme concentrations and duration of stay in the ICU or hospital. Therefore, this study provides evidence for the safety of early extubation after routine coronary artery bypass grafting.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Berry</LastName>
+ <ForeName>P D</ForeName>
+ <Initials>PD</Initials>
+ <AffiliationInfo>
+ <Affiliation>Cardiothoracic Centre Liverpool-NHS Trust.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Thomas</LastName>
+ <ForeName>S D</ForeName>
+ <Initials>SD</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Mahon</LastName>
+ <ForeName>S P</ForeName>
+ <Initials>SP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Jackson</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fox</LastName>
+ <ForeName>M A</ForeName>
+ <Initials>MA</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fabri</LastName>
+ <ForeName>B</ForeName>
+ <Initials>B</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Weir</LastName>
+ <ForeName>W I</ForeName>
+ <Initials>WI</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Russell</LastName>
+ <ForeName>G N</ForeName>
+ <Initials>GN</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016430">Clinical Trial</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Br J Anaesth</MedlineTA>
+ <NlmUniqueID>0372541</NlmUniqueID>
+ <ISSNLinking>0007-0912</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="ErratumIn">
+ <RefSource>Br J Anaesth 1998 Apr;80(4):572</RefSource>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="ErratumIn">
+ <RefSource>Br J Anaesth 1998 Jul;81(1):111</RefSource>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001026" MajorTopicYN="N">Coronary Artery Bypass</DescriptorName>
+ <QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004562" MajorTopicYN="N">Electrocardiography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007442" MajorTopicYN="N">Intubation, Intratracheal</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017202" MajorTopicYN="N">Myocardial Ischemia</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011182" MajorTopicYN="N">Postoperative Care</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011184" MajorTopicYN="N">Postoperative Period</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1998</Year>
+ <Month>3</Month>
+ <Day>20</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1998</Year>
+ <Month>3</Month>
+ <Day>20</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1998</Year>
+ <Month>3</Month>
+ <Day>20</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">9505772</ArticleId>
+ <ArticleId IdType="pii">S0007-0912(17)40574-5</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">9575322</PMID>
+ <DateCompleted>
+ <Year>1998</Year>
+ <Month>05</Month>
+ <Day>12</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2007</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0002-838X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>57</Volume>
+ <Issue>8</Issue>
+ <PubDate>
+ <Year>1998</Year>
+ <Month>Apr</Month>
+ <Day>15</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>American family physician</Title>
+ <ISOAbbreviation>Am Fam Physician</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Lumbar spine stenosis: a common cause of back and leg pain.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1825-34, 1839-40</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Lumbar spine stenosis most commonly affects the middle-aged and elderly population. Entrapment of the cauda equina roots by hypertrophy of the osseous and soft tissue structures surrounding the lumbar spinal canal is often associated with incapacitating pain in the back and lower extremities, difficulty ambulating, leg paresthesias and weakness and, in severe cases, bowel or bladder disturbances. The characteristic syndrome associated with lumbar stenosis is termed neurogenic intermittent claudication. This condition must be differentiated from true claudication, which is caused by atherosclerosis of the pelvofemoral vessels. Although many conditions may be associated with lumbar canal stenosis, most cases are idiopathic. Imaging of the lumbar spine performed with computed tomography or magnetic resonance imaging often demonstrates narrowing of the lumbar canal with compression of the cauda equina nerve roots by thickened posterior vertebral elements, facet joints, marginal osteophytes or soft tissue structures such as the ligamentum flavum or herniated discs. Treatment for symptomatic lumbar stenosis is usually surgical decompression. Medical treatment alternatives, such as bed rest, pain management and physical therapy, should be reserved for use in debilitated patients or patients whose surgical risk is prohibitive as a result of concomitant medical conditions.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Alvarez</LastName>
+ <ForeName>J A</ForeName>
+ <Initials>JA</Initials>
+ <AffiliationInfo>
+ <Affiliation>University Hospitals of Cleveland/Case Western Reserve University, Cleveland, Ohio, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hardy</LastName>
+ <ForeName>R H</ForeName>
+ <Initials>RH</Initials>
+ <Suffix>Jr</Suffix>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Am Fam Physician</MedlineTA>
+ <NlmUniqueID>1272646</NlmUniqueID>
+ <ISSNLinking>0002-838X</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Am Fam Physician. 1999 Jan 15;59(2):280, 283-4</RefSource>
+ <PMID Version="1">9930124</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017116" MajorTopicYN="N">Low Back Pain</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008161" MajorTopicYN="N">Lumbosacral Region</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010146" MajorTopicYN="N">Pain</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010353" MajorTopicYN="N">Patient Education as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013130" MajorTopicYN="N">Spinal Stenosis</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
+ <QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013664" MajorTopicYN="N">Teaching Materials</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>13</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1998</Year>
+ <Month>5</Month>
+ <Day>12</Day>
+ <Hour>2</Hour>
+ <Minute>2</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>3</Month>
+ <Day>28</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1998</Year>
+ <Month>5</Month>
+ <Day>12</Day>
+ <Hour>2</Hour>
+ <Minute>2</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">9575322</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">9626910</PMID>
+ <DateCompleted>
+ <Year>1998</Year>
+ <Month>08</Month>
+ <Day>12</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2015</Year>
+ <Month>11</Month>
+ <Day>19</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0047-1828</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>62</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <Year>1998</Year>
+ <Month>May</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Japanese circulation journal</Title>
+ <ISOAbbreviation>Jpn. Circ. J.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Hepatitis C virus infection and heart diseases: a multicenter study in Japan.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>389-91</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>As a collaborative research project of the Committees for the Study of Idiopathic Cardiomyopathy, a questionnaire was sent out to 19 medical institutions in Japan in order to examine the possible association between hepatitis C virus (HCV) infection and cardiomyopathies. Hepatitis C virus antibody was found in 74 of 697 patients (10.6%) with hypertrophic cardiomyopathy (mean age, 57.7 years) and in 42 of 663 patients (6.3%) with dilated cardiomyopathy (mean age, 56.5 years); these prevalences were significantly higher than that found in volunteer blood donors in Japan (2.4%, 50-59 years of age, each p&lt;0.0001). The prevalence was significantly higher in patients suffering from hypertrophic cardiomyopathy as opposed to those with dilated cardiomyopathy (p&lt;0.01). The presence of HCV antibody was detected in 650 of 11,967 patients (5.4%) patients seeking care in 5 academic hospitals. Various cardiac abnormalities were found among these patients, arrhythmias being the most frequent. These observations suggest that HCV infection is an important cause of a variety of otherwise unexplained heart diseases.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="N">
+ <Author ValidYN="Y">
+ <LastName>Matsumori</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Kyoto University, Japan.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ohashi</LastName>
+ <ForeName>N</ForeName>
+ <Initials>N</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hasegawa</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sasayama</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Eto</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Imaizumi</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Izumi</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kawamura</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kawana</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kimura</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kitabatake</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Matsuzaki</LastName>
+ <ForeName>M</ForeName>
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+ </Author>
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+ <LastName>Nagai</LastName>
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+ <LastName>Yokoyama</LastName>
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+ <DescriptorName UI="D009202" MajorTopicYN="N">Cardiomyopathies</DescriptorName>
+ <QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
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+ <DescriptorName UI="D006321" MajorTopicYN="N">Heart</DescriptorName>
+ <QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006331" MajorTopicYN="N">Heart Diseases</DescriptorName>
+ <QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016174" MajorTopicYN="N">Hepacivirus</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006526" MajorTopicYN="N">Hepatitis C</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018937" MajorTopicYN="N">Hepatitis C Antibodies</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
+ </MeshHeading>
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+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007564" MajorTopicYN="N" Type="Geographic">Japan</DescriptorName>
+ <QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009206" MajorTopicYN="N">Myocardium</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
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+ <History>
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+ <Month>6</Month>
+ <Day>17</Day>
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+ <Year>1998</Year>
+ <Month>6</Month>
+ <Day>17</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>1998</Year>
+ <Month>6</Month>
+ <Day>17</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
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+ </History>
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+ <ArticleId IdType="pubmed">9626910</ArticleId>
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+ <PMID Version="1">9627170</PMID>
+ <DateCompleted>
+ <Year>1998</Year>
+ <Month>08</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1435-2443</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>383</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1998</Year>
+ <Month>Mar</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Langenbeck's archives of surgery</Title>
+ <ISOAbbreviation>Langenbecks Arch Surg</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Outcome of patients with sepsis and septic shock after ICU treatment.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>44-8</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Today, sepsis syndrome is the leading cause of death in adult, non-coronary intensive care units (ICUs) and is of great clinical importance. The purpose of this review was to evaluate recent prospective studies concerning the short- and long-term prognosis of patients suffering from systemic inflammatory-response syndrome (SIRS), sepsis, severe sepsis and septic shock. It has been shown in multicentre prospective surveys that 1% and 0.3% of all patients admitted to hospitals suffer, respectively, from bacteraemia alone and bacteraemia with severe sepsis. This rate increases, of course, when only admissions to the ICUs are considered: the above-mentioned rates increase then by a factor of 8 and 30, respectively. Thus, approximately 10% of patients in the ICU suffer from sepsis, 6% from severe sepsis and 2-3% from septic shock. SIRS occurs more frequently and its occurrence ranges from 40% to 70% of all patients admitted to ICUs. Thereby, 40-70% suffering from SIRS progress to a more severe septic-disease state. The overall prognosis is still poor, despite the recent advances in ICU treatment. The mortality rate of SIRS ranges from 6% to 7% and in septic shock amounts to over 50%. In particular, abdominal sepsis exhibits the highest mortality rate with 72%. The long-term prognosis is equally poor; only approximately 30% survived the first year after hospital admission.</AbstractText>
+ <AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The prognosis of sepsis and septic shock remains poor, despite the advances in ICU treatment. Although prognostic factors have been identified for some patients, groups have not yet been able to identify the immediate or long-term prognosis for the majority of these septic patients.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Schoenberg</LastName>
+ <ForeName>M H</ForeName>
+ <Initials>MH</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of General Surgery, University of Ulm, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Weiss</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Radermacher</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
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+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
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+ <Country>Germany</Country>
+ <MedlineTA>Langenbecks Arch Surg</MedlineTA>
+ <NlmUniqueID>9808285</NlmUniqueID>
+ <ISSNLinking>1435-2443</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016470" MajorTopicYN="N">Bacteremia</DescriptorName>
+ <QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002423" MajorTopicYN="N">Cause of Death</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003422" MajorTopicYN="Y">Critical Care</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012772" MajorTopicYN="N">Shock, Septic</DescriptorName>
+ <QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013530" MajorTopicYN="N">Surgical Wound Infection</DescriptorName>
+ <QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018746" MajorTopicYN="N">Systemic Inflammatory Response Syndrome</DescriptorName>
+ <QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>21</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1998</Year>
+ <Month>6</Month>
+ <Day>17</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1998</Year>
+ <Month>6</Month>
+ <Day>17</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1998</Year>
+ <Month>6</Month>
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+ <Hour>0</Hour>
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+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">9634358</PMID>
+ <DateCompleted>
+ <Year>1998</Year>
+ <Month>06</Month>
+ <Day>18</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2004</Year>
+ <Month>03</Month>
+ <Day>31</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0022-1899</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>177</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>1998</Year>
+ <Month>Jun</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Journal of infectious diseases</Title>
+ <ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Retraction: A rabbit model for human cytomeglovirus--induced chorioretinal disease (J Infect Dis 1993;168:336-44).</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1778</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Dunkel</LastName>
+ <ForeName>E C</ForeName>
+ <Initials>EC</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Scheer</LastName>
+ <ForeName>D I</ForeName>
+ <Initials>DI</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Zhu</LastName>
+ <ForeName>Q</ForeName>
+ <Initials>Q</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Whitley</LastName>
+ <ForeName>R J</ForeName>
+ <Initials>RJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Schaffer</LastName>
+ <ForeName>P A</ForeName>
+ <Initials>PA</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Pavan-Langston</LastName>
+ <ForeName>D</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="N">
+ <LastName>Whitely</LastName>
+ <ForeName>R J</ForeName>
+ <Initials>RJ</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016440">Retraction of Publication</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Infect Dis</MedlineTA>
+ <NlmUniqueID>0413675</NlmUniqueID>
+ <ISSNLinking>0022-1899</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="RetractionOf">
+ <RefSource>Dunkel EC, de Freitas D, Scheer DI, Siegel ML, Zhu Q, Whitley RJ, Schaffer PA, Pavan-Langston D. J Infect Dis. 1993 Aug;168(2):336-44</RefSource>
+ <PMID Version="1">8393056</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="ErratumIn">
+ <RefSource>J Infect Dis 1998 Aug;178(2):601</RefSource>
+ <Note>Whitely RJ [corrected to Whitley RJ]</Note>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1998</Year>
+ <Month>6</Month>
+ <Day>20</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1998</Year>
+ <Month>6</Month>
+ <Day>20</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1998</Year>
+ <Month>6</Month>
+ <Day>20</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
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+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
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+ <ArticleId IdType="pubmed">9634358</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">9861576</PMID>
+ <DateCompleted>
+ <Year>1999</Year>
+ <Month>03</Month>
+ <Day>29</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0268-1315</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>13</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>1998</Year>
+ <Month>Nov</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>International clinical psychopharmacology</Title>
+ <ISOAbbreviation>Int Clin Psychopharmacol</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Cardiac side-effects of two selective serotonin reuptake inhibitors in middle-aged and elderly depressed patients.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>263-7</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Selective serotonin reuptake inhibitors (SSRIs) are the 'new' drugs of first choice for the treatment of depression in the older patient. Systematic studies on the effects of SSRIs on cardiac function are scarce, despite the high prevalence of cardiac disorders in the older depressed patient. This is a study which systematically assessed cardiac function by echocardiography in middle-aged and elderly depressed patients treated with SSRI. In a double-blind randomized trial, 20 patients were assigned to receive fluvoxamine 100 mg/day [DOSAGE ERROR CORRECTED] or fluoxetine 20 mg/day [DOSAGE ERROR CORRECTED] for 6 weeks. Cardiac function was assessed by left ventricle ejection fraction, aortic flow integral and early or passive/late or active mitral inflow, and electrocardiography. Neither SSRI significantly affected cardiac function. Compared with patients without a history of myocardial infarction and/or hypertension, patients with such a history showed a significant improvement in left ventricular ejection fraction. Despite our small study sample, these data indicate that both fluoxetine and fluvoxamine do not affect cardiac function adversely.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Strik</LastName>
+ <ForeName>J J</ForeName>
+ <Initials>JJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Psychiatry, Maastricht University Hospital, The Netherlands.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Honig</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lousberg</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cheriex</LastName>
+ <ForeName>E C</ForeName>
+ <Initials>EC</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Van Praag</LastName>
+ <ForeName>H M</ForeName>
+ <Initials>HM</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016430">Clinical Trial</PublicationType>
+ <PublicationType UI="D003160">Comparative Study</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Int Clin Psychopharmacol</MedlineTA>
+ <NlmUniqueID>8609061</NlmUniqueID>
+ <ISSNLinking>0268-1315</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D017367">Serotonin Uptake Inhibitors</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>01K63SUP8D</RegistryNumber>
+ <NameOfSubstance UI="D005473">Fluoxetine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>O4L1XPO44W</RegistryNumber>
+ <NameOfSubstance UI="D016666">Fluvoxamine</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="ErratumIn">
+ <RefSource>Int Clin Psychopharmacol 1999 Mar;14(2):138</RefSource>
+ <Note>Dosage error in published abstract; MEDLINE/PubMed abstract corrected</Note>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName>
+ <QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName>
+ <QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003866" MajorTopicYN="N">Depressive Disorder</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004452" MajorTopicYN="N">Echocardiography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004562" MajorTopicYN="N">Electrocardiography</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005473" MajorTopicYN="N">Fluoxetine</DescriptorName>
+ <QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016666" MajorTopicYN="N">Fluvoxamine</DescriptorName>
+ <QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017367" MajorTopicYN="N">Serotonin Uptake Inhibitors</DescriptorName>
+ <QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
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+ <ISSN IssnType="Print">0893-133X</ISSN>
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+ <Volume>20</Volume>
+ <Issue>2</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>Feb</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</Title>
+ <ISOAbbreviation>Neuropsychopharmacology</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Antipsychotic potential of CCK-based treatments: an assessment using the prepulse inhibition model of psychosis.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>141-9</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Systemic injections of cholecystokinin (CCK), a "gut-brain" peptide, have been shown to modulate brain dopamine function and produce neuroleptic-like effects on such dopamine-regulated behaviors as locomotor activity. However, clinical trials of CCK agonists in schizophrenia patients showed mixed results. To re-examine the antipsychotic potential of CCK-based treatments, we examined systemic injections of CCK analogs in an animal model with strong face and construct validity for sensorimotor-gating deficits seen in schizophrenia patients and with strong predictive validity for antipsychotic drug activity. Prepulse inhibition (PPI) occurs when a weak acoustic lead stimulus ("prepulse") inhibits the startle response to a sudden loud sound ("pulse"). PPI is significantly reduced in schizophrenia patients and rats treated with dopamine agonists. Antipsychotics reverse decreased PPI in rats to a degree highly correlated with their clinical efficacy. Subcutaneous (s.c.) injections of caerulein (10 micrograms/kg) a mixed CCKA/B agonist, partially reversed amphetamine-induced reduction of PPI; whereas, s.c. haloperidol (0.5 mg/kg) totally reversed amphetamine-induced disruption of PPI. Caerulein's effect on PPI was blocked by pretreatment with a CCKA antagonist (devazepide) but not a CCKB antagonist (L-365,260). CCK-4, a preferential CCKB agonist, had no significant effect on PPI. These results suggest that caerulein produces a weak neuroleptic-like effect on PPI that is mediated by stimulation of CCKA receptors. Possible circuities in this effect are discussed. In a separate experiment, s.c. caerulein produced to a more potent neuroleptic-like profile on amphetamine-induced hyperlocomotion, suggesting that selection of preclinical paradigms may be important in evaluating the antipsychotic potential of CCK-based treatments.</AbstractText>
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+ <LastName>Feifel</LastName>
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+ <Affiliation>Department of Psychiatry, University of California, San Diego, La Jolla 92093-8620, USA.</Affiliation>
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+ <RegistryNumber>888Y08971B</RegistryNumber>
+ <NameOfSubstance UI="D002108">Ceruletide</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>9011-97-6</RegistryNumber>
+ <NameOfSubstance UI="D002766">Cholecystokinin</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>J6292F8L3D</RegistryNumber>
+ <NameOfSubstance UI="D006220">Haloperidol</NameOfSubstance>
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+ <CitationSubset>IM</CitationSubset>
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+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D001522" MajorTopicYN="N">Behavior, Animal</DescriptorName>
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+ <DescriptorName UI="D002766" MajorTopicYN="N">Cholecystokinin</DescriptorName>
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+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D011618" MajorTopicYN="N">Psychotic Disorders</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName>
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+ <DescriptorName UI="D013758" MajorTopicYN="N">Tetragastrin</DescriptorName>
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+ <ISSN IssnType="Print">0041-0101</ISSN>
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+ <Volume>37</Volume>
+ <Issue>2</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>Feb</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Toxicon : official journal of the International Society on Toxinology</Title>
+ <ISOAbbreviation>Toxicon</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Bibliography of toxinology.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>399-404</MedlinePgn>
+ </Pagination>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016417">Bibliography</PublicationType>
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+ <Country>England</Country>
+ <MedlineTA>Toxicon</MedlineTA>
+ <NlmUniqueID>1307333</NlmUniqueID>
+ <ISSNLinking>0041-0101</ISSNLinking>
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+ <NameOfSubstance UI="D014118">Toxins, Biological</NameOfSubstance>
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+ <CitationSubset>IM</CitationSubset>
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+ <DescriptorName UI="D014118" MajorTopicYN="Y">Toxins, Biological</DescriptorName>
+ </MeshHeading>
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+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1999</Year>
+ <Month>3</Month>
+ <Day>17</Day>
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+ <Year>1999</Year>
+ <Month>3</Month>
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+ <Year>2018</Year>
+ <Month>07</Month>
+ <Day>10</Day>
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+ <ISSN IssnType="Print">0300-2896</ISSN>
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+ <Volume>34</Volume>
+ <Issue>11</Issue>
+ <PubDate>
+ <Year>1998</Year>
+ <Month>Dec</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Archivos de bronconeumologia</Title>
+ <ISOAbbreviation>Arch. Bronconeumol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[Tobacco control in children, adolescents and young people: knowledge, prevention and action].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>564</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>de Granda Orive</LastName>
+ <ForeName>J I</ForeName>
+ <Initials>JI</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Peña Miguel</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Morato Arnáiz</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ </AuthorList>
+ <Language>spa</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016422">Letter</PublicationType>
+ <PublicationType UI="D016420">Comment</PublicationType>
+ </PublicationTypeList>
+ <VernacularTitle>La lucha contra el tabaco en los niños, adolescentes y jóvenes: conocimiento, prevención y actuación.</VernacularTitle>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Spain</Country>
+ <MedlineTA>Arch Bronconeumol</MedlineTA>
+ <NlmUniqueID>0354720</NlmUniqueID>
+ <ISSNLinking>0300-2896</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentOn">
+ <RefSource>Arch Bronconeumol. 1998 Apr;34(4):199-203</RefSource>
+ <PMID Version="1">9611655</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007722" MajorTopicYN="N">Health Knowledge, Attitudes, Practice</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D000074606" MajorTopicYN="Y">Smoking Prevention</DescriptorName>
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+ <Year>2004</Year>
+ <Month>11</Month>
+ <Day>17</Day>
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+ <ISSN IssnType="Print">0832-610X</ISSN>
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+ <Volume>46</Volume>
+ <Issue>2</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>Feb</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Canadian journal of anaesthesia = Journal canadien d'anesthesie</Title>
+ <ISOAbbreviation>Can J Anaesth</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Complete airway obstruction.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>99-104</MedlinePgn>
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+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Crosby</LastName>
+ <ForeName>E T</ForeName>
+ <Initials>ET</Initials>
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+ <Language>eng</Language>
+ <Language>fre</Language>
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+ <MedlineTA>Can J Anaesth</MedlineTA>
+ <NlmUniqueID>8701709</NlmUniqueID>
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+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000779">Anesthetics, Local</NameOfSubstance>
+ </Chemical>
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+ <CitationSubset>IM</CitationSubset>
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+ <RefSource>Can J Anaesth. 1999 Feb;46(2):176-8</RefSource>
+ <PMID Version="1">10083999</PMID>
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+ <DescriptorName UI="D000402" MajorTopicYN="N">Airway Obstruction</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
+ <QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000776" MajorTopicYN="N">Anesthesiology</DescriptorName>
+ <QualifierName UI="Q000193" MajorTopicYN="N">education</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D000779" MajorTopicYN="N">Anesthetics, Local</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002574" MajorTopicYN="N">Cervical Vertebrae</DescriptorName>
+ <QualifierName UI="Q000293" MajorTopicYN="N">injuries</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016292" MajorTopicYN="N">Conscious Sedation</DescriptorName>
+ <QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007442" MajorTopicYN="N">Intubation, Intratracheal</DescriptorName>
+ <QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
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+ <DescriptorName UI="D020704" MajorTopicYN="N">Laryngoscopes</DescriptorName>
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+ <DescriptorName UI="D007828" MajorTopicYN="N">Laryngoscopy</DescriptorName>
+ <QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
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+ </MeshHeading>
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+ <Year>1999</Year>
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+ <Day>20</Day>
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+ <Year>1999</Year>
+ <Month>3</Month>
+ <Day>20</Day>
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+ <Year>1999</Year>
+ <Month>3</Month>
+ <Day>20</Day>
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+ </History>
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+ <PMID Version="1">10101342</PMID>
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+ <Year>1999</Year>
+ <Month>04</Month>
+ <Day>15</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>06</Month>
+ <Day>05</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0733-8627</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>17</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>Feb</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Emergency medicine clinics of North America</Title>
+ <ISOAbbreviation>Emerg. Med. Clin. North Am.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Evaluation of the patient with extremity trauma: an evidence based approach.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>77-95, viii</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>This article reviews relevant literature to provide evidence based guidelines for the evaluation of patients with extremity trauma in the emergency department. The development of clinical decision rules for extremity trauma in the ankle and knee, and guidelines for obtaining postreduction radiographs of shoulder dislocations and nursemaid's elbows are discussed.</AbstractText>
+ </Abstract>
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+ <Author ValidYN="Y">
+ <LastName>Kaufman</LastName>
+ <ForeName>D</ForeName>
+ <Initials>D</Initials>
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+ <Affiliation>Division of Emergency Medicine, Northwestern University Medical School, Chicago, Illinois, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Leung</LastName>
+ <ForeName>J</ForeName>
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+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D003661" MajorTopicYN="N">Decision Support Techniques</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D005121" MajorTopicYN="N">Extremities</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
+ <QualifierName UI="Q000293" MajorTopicYN="Y">injuries</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D050723" MajorTopicYN="N">Fractures, Bone</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D007718" MajorTopicYN="N">Knee Injuries</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
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+ <DescriptorName UI="D011859" MajorTopicYN="N">Radiography</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D012783" MajorTopicYN="N">Shoulder Dislocation</DescriptorName>
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+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
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+ <Year>1999</Year>
+ <Month>Mar</Month>
+ <Day>30</Day>
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+ <Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
+ <ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation>
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+ <ArticleTitle>Thermal adaptation analyzed by comparison of protein sequences from mesophilic and extremely thermophilic Methanococcus species.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>3578-83</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The genome sequence of the extremely thermophilic archaeon Methanococcus jannaschii provides a wealth of data on proteins from a thermophile. In this paper, sequences of 115 proteins from M. jannaschii are compared with their homologs from mesophilic Methanococcus species. Although the growth temperatures of the mesophiles are about 50 degrees C below that of M. jannaschii, their genomic G+C contents are nearly identical. The properties most correlated with the proteins of the thermophile include higher residue volume, higher residue hydrophobicity, more charged amino acids (especially Glu, Arg, and Lys), and fewer uncharged polar residues (Ser, Thr, Asn, and Gln). These are recurring themes, with all trends applying to 83-92% of the proteins for which complete sequences were available. Nearly all of the amino acid replacements most significantly correlated with the temperature change are the same relatively conservative changes observed in all proteins, but in the case of the mesophile/thermophile comparison there is a directional bias. We identify 26 specific pairs of amino acids with a statistically significant (P &lt; 0.01) preferred direction of replacement.</AbstractText>
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+ <Author ValidYN="Y">
+ <LastName>Haney</LastName>
+ <ForeName>P J</ForeName>
+ <Initials>PJ</Initials>
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+ <Affiliation>Department of Microbiology, University of Illinois, B103 Chemical and Life Sciences Laboratory, 601 South Goodwin Avenue, Urbana, IL 61801, USA.</Affiliation>
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+ <LastName>Badger</LastName>
+ <ForeName>J H</ForeName>
+ <Initials>JH</Initials>
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+ <LastName>Buldak</LastName>
+ <ForeName>G L</ForeName>
+ <Initials>GL</Initials>
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+ <LastName>Reich</LastName>
+ <ForeName>C I</ForeName>
+ <Initials>CI</Initials>
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+ <ForeName>C R</ForeName>
+ <Initials>CR</Initials>
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+ <LastName>Olsen</LastName>
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+ <GrantID>T32 GM007283</GrantID>
+ <Acronym>GM</Acronym>
+ <Agency>NIGMS NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>GM07283</GrantID>
+ <Acronym>GM</Acronym>
+ <Agency>NIGMS NIH HHS</Agency>
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+ <DescriptorName UI="D000064" MajorTopicYN="N">Acclimatization</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019943" MajorTopicYN="N">Amino Acid Substitution</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001426" MajorTopicYN="N">Bacterial Proteins</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017017" MajorTopicYN="N">Methanococcus</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011487" MajorTopicYN="N">Protein Conformation</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013696" MajorTopicYN="N">Temperature</DescriptorName>
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+ <KeywordList Owner="NASA">
+ <Keyword MajorTopicYN="N">NASA Discipline Exobiology</Keyword>
+ <Keyword MajorTopicYN="N">Non-NASA Center</Keyword>
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+ <Investigator ValidYN="Y">
+ <LastName>Woese</LastName>
+ <ForeName>C R</ForeName>
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+ <MedlineCitation Status="MEDLINE" Owner="NLM">
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+ <DateCompleted>
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+ </DateCompleted>
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+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
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+ <ArticleTitle>Health technology assessment: decentralized and fragmented in the US compared to other countries.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>177-98</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>This paper presents the results of the first comprehensive international survey to catalogue health technology assessment (HTA) activities. By 1995, there were formal HTA programs in 24 countries established mostly in the late 1980s and early 1990s. European countries generally have one or two federal or provincial HTA programs each, Canada has an extensive network of federal and regional organizations coordinated by a central body and the US has 53 HTA organizations, the vast majority of which are in the private sector. While the commitment of the US government to HTA has been erratic, the private sector has been witness to an expansion of HTA activities by insurance companies, hospitals, medical/device manufacturers, consulting firms and health professional societies. In contrast to other developed countries, the current state of technology assessment in the US is decentralized, fragmented and duplicative. We conclude by discussing the importance of a US HTA agency at the national level.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Perry</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
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+ <Affiliation>Medical Technology and Practice Patterns Institute, WHO Collaborating Center on Health Technology Assessment, Washington, DC 20007, USA.</Affiliation>
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+ <ISSN IssnType="Print">0031-7144</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>54</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>Mar</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Die Pharmazie</Title>
+ <ISOAbbreviation>Pharmazie</ISOAbbreviation>
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+ <ArticleTitle>Antimicrobial activity of some Nepalese medicinal plants.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>232-4</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Rajbhandari</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
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+ <Affiliation>Institute of Pharmacy, Ernst-Moritz-Arndt-University, Greifswald, Germany.</Affiliation>
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+ <Author ValidYN="Y">
+ <LastName>Schöpke</LastName>
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+ <Initials>T</Initials>
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+ <MedlineTA>Pharmazie</MedlineTA>
+ <NlmUniqueID>9800766</NlmUniqueID>
+ <ISSNLinking>0031-7144</ISSNLinking>
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+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
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+ <DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
+ <QualifierName UI="Q000302" MajorTopicYN="Y">isolation &amp; purification</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006094" MajorTopicYN="N">Gram-Positive Bacteria</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009390" MajorTopicYN="N" Type="Geographic">Nepal</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010946" MajorTopicYN="N">Plants, Medicinal</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
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+ <ISSN IssnType="Print">0031-9023</ISSN>
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+ <Volume>79</Volume>
+ <Issue>5</Issue>
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+ <Month>May</Month>
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+ <Title>Physical therapy</Title>
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+ <ArticleTitle>Looking for the Forrest.</ArticleTitle>
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+ <MedlinePgn>454-5</MedlinePgn>
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+ <LastName>Rothstein</LastName>
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+ <NlmUniqueID>0022623</NlmUniqueID>
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+ <DescriptorName UI="D004645" MajorTopicYN="Y">Empathy</DescriptorName>
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+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D019359" MajorTopicYN="N">Knowledge</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D026741" MajorTopicYN="N">Physical Therapy Modalities</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D011369" MajorTopicYN="Y">Professional-Patient Relations</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D012922" MajorTopicYN="Y">Social Change</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014754" MajorTopicYN="N">Violence</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
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+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1999</Year>
+ <Month>5</Month>
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+ <Year>1999</Year>
+ <Month>5</Month>
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+ <Month>06</Month>
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+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0031-7144</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>54</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>Mar</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Die Pharmazie</Title>
+ <ISOAbbreviation>Pharmazie</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Different kinetics of hydroquinone depletion in various medicinal plant tissue cultures producing arbutin.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>234-5</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Jahodár</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dusková</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Polásek</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Papugová</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Germany</Country>
+ <MedlineTA>Pharmazie</MedlineTA>
+ <NlmUniqueID>9800766</NlmUniqueID>
+ <ISSNLinking>0031-7144</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D006873">Hydroquinones</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>C5INA23HXF</RegistryNumber>
+ <NameOfSubstance UI="D001104">Arbutin</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001104" MajorTopicYN="N">Arbutin</DescriptorName>
+ <QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
+ <QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D046508" MajorTopicYN="N">Culture Techniques</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017022" MajorTopicYN="N">Flow Injection Analysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006873" MajorTopicYN="N">Hydroquinones</DescriptorName>
+ <QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010946" MajorTopicYN="N">Plants, Medicinal</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
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+ <Month>4</Month>
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+ <Year>1999</Year>
+ <Month>4</Month>
+ <Day>7</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1999</Year>
+ <Month>4</Month>
+ <Day>7</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
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+ <ArticleId IdType="pubmed">10192115</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">10331749</PMID>
+ <DateCompleted>
+ <Year>1999</Year>
+ <Month>06</Month>
+ <Day>01</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2009</Year>
+ <Month>11</Month>
+ <Day>11</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0031-9023</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>79</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>May</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Physical therapy</Title>
+ <ISOAbbreviation>Phys Ther</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Effects of side lying on lung function in older individuals.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>456-66</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">Body positioning exerts a strong effect on pulmonary function, but its effect on other components of the oxygen transport pathway are less well understood, especially the effects of side-lying positions. This study investigated the interrelationships between side-lying positions and indexes of lung function such as spirometry, alveolar diffusing capacity, and inhomogeneity of ventilation in older individuals.</AbstractText>
+ <AbstractText Label="SUBJECTS AND METHODS" NlmCategory="METHODS">Nineteen nonsmoking subjects (mean age=62.8 years, SD=6.8, range=50-74) with no history of cardiac or pulmonary disease were tested over 2 sessions. The test positions were sitting and left side lying in one session and sitting and right side lying in the other session. In each of the positions, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), single-breath pulmonary diffusing capacity (DLCO/VA), and the slope of phase III (DN2%/L) of the single-breath nitrogen washout test to determine inhomogeneity of ventilation were measured.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared with measurements obtained in the sitting position, FVC and FEV1 were decreased equally in the side-lying positions, but no change was observed in DLCO/VA or DN2%/L.</AbstractText>
+ <AbstractText Label="CONCLUSION AND DISCUSSION" NlmCategory="CONCLUSIONS">Side-lying positions resulted in decreases in FVC and FEV1, which is consistent with the well-documented effects of the supine position. These findings further support the need for prescriptive rather than routine body positioning of patients with risks of cardiopulmonary compromise and the need to use upright positions in which lung volumes and capacities are maximized.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Manning</LastName>
+ <ForeName>F</ForeName>
+ <Initials>F</Initials>
+ <AffiliationInfo>
+ <Affiliation>Family Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dean</LastName>
+ <ForeName>E</ForeName>
+ <Initials>E</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ross</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Abboud</LastName>
+ <ForeName>R T</ForeName>
+ <Initials>RT</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
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+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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+ <Country>United States</Country>
+ <MedlineTA>Phys Ther</MedlineTA>
+ <NlmUniqueID>0022623</NlmUniqueID>
+ <ISSNLinking>0031-9023</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CitationSubset>S</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001944" MajorTopicYN="N">Breath Tests</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005541" MajorTopicYN="N">Forced Expiratory Volume</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006331" MajorTopicYN="N">Heart Diseases</DescriptorName>
+ <QualifierName UI="Q000517" MajorTopicYN="N">prevention &amp; control</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008171" MajorTopicYN="N">Lung Diseases</DescriptorName>
+ <QualifierName UI="Q000517" MajorTopicYN="N">prevention &amp; control</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011187" MajorTopicYN="N">Posture</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011653" MajorTopicYN="N">Pulmonary Diffusing Capacity</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013147" MajorTopicYN="N">Spirometry</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014797" MajorTopicYN="N">Vital Capacity</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1999</Year>
+ <Month>5</Month>
+ <Day>20</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1999</Year>
+ <Month>5</Month>
+ <Day>20</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1999</Year>
+ <Month>5</Month>
+ <Day>20</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
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+ </History>
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+ <ArticleId IdType="pubmed">10331749</ArticleId>
+ </ArticleIdList>
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+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">10389168</PMID>
+ <DateCompleted>
+ <Year>1999</Year>
+ <Month>07</Month>
+ <Day>15</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0869-8139</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>85</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>Jan</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova</Title>
+ <ISOAbbreviation>Ross Fiziol Zh Im I M Sechenova</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[Ethanol modifies the ion selectivity of sodium channels in the rat sensory neurons].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>110-8</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Ethanol was shown to decrease the reversal potential of tetrodotoxin-resistant (TTXr) and TTX-sensitive channels in short-term culture of the dorsal root ganglion cells. The ethanol led to alterations in ionic selectivity of the TTXr channels (its shifting from the X-th Eisenmann selectivity sequence to the XI-th one). The data obtained suggest that the findings were due to selectivity filter modification because of disturbed hydrogen bounds in the channel macromolecule.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Krylov</LastName>
+ <ForeName>B V</ForeName>
+ <Initials>BV</Initials>
+ <AffiliationInfo>
+ <Affiliation>I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, Russia.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Vilin</LastName>
+ <ForeName>Iu Iu</ForeName>
+ <Initials>IuIu</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Katina</LastName>
+ <ForeName>I E</ForeName>
+ <Initials>IE</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Podzorova</LastName>
+ <ForeName>S A</ForeName>
+ <Initials>SA</Initials>
+ </Author>
+ </AuthorList>
+ <Language>rus</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D004740">English Abstract</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <VernacularTitle>Etanol modifitsiruet ionnuiu izbiratel'nost' natrievykh kanalov sensornykh neĭronov krysy.</VernacularTitle>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Russia (Federation)</Country>
+ <MedlineTA>Ross Fiziol Zh Im I M Sechenova</MedlineTA>
+ <NlmUniqueID>9715665</NlmUniqueID>
+ <ISSNLinking>0869-8139</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D002412">Cations</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D015222">Sodium Channels</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>3K9958V90M</RegistryNumber>
+ <NameOfSubstance UI="D000431">Ethanol</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>4368-28-9</RegistryNumber>
+ <NameOfSubstance UI="D013779">Tetrodotoxin</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002412" MajorTopicYN="N">Cations</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000431" MajorTopicYN="N">Ethanol</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005727" MajorTopicYN="N">Ganglia, Spinal</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015640" MajorTopicYN="N">Ion Channel Gating</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009475" MajorTopicYN="N">Neurons, Afferent</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018408" MajorTopicYN="N">Patch-Clamp Techniques</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015222" MajorTopicYN="N">Sodium Channels</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013779" MajorTopicYN="N">Tetrodotoxin</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1999</Year>
+ <Month>7</Month>
+ <Day>2</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1999</Year>
+ <Month>7</Month>
+ <Day>2</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1999</Year>
+ <Month>7</Month>
+ <Day>2</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">10389168</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">10540283</PMID>
+ <DateCompleted>
+ <Year>1999</Year>
+ <Month>12</Month>
+ <Day>17</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0950-382X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>34</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>Oct</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Molecular microbiology</Title>
+ <ISOAbbreviation>Mol. Microbiol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>24-36</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The nirIX gene cluster of Paracoccus denitrificans is located between the nir and nor gene clusters encoding nitrite and nitric oxide reductases respectively. The NirI sequence corresponds to that of a membrane-bound protein with six transmembrane helices, a large periplasmic domain and cysteine-rich cytoplasmic domains that resemble the binding sites of [4Fe-4S] clusters in many ferredoxin-like proteins. NirX is soluble and apparently located in the periplasm, as judged by the predicted signal sequence. NirI and NirX are homologues of NosR and NosX, proteins involved in regulation of the expression of the nos gene cluster encoding nitrous oxide reductase in Pseudomonas stutzeri and Sinorhizobium meliloti. Analysis of a NirI-deficient mutant strain revealed that NirI is involved in transcription activation of the nir gene cluster in response to oxygen limitation and the presence of N-oxides. The NirX-deficient mutant transiently accumulated nitrite in the growth medium, but it had a final growth yield similar to that of the wild type. Transcription of the nirIX gene cluster itself was controlled by NNR, a member of the family of FNR-like transcriptional activators. An NNR binding sequence is located in the middle of the intergenic region between the nirI and nirS genes with its centre located at position -41.5 relative to the transcription start sites of both genes. Attempts to complement the NirI mutation via cloning of the nirIX gene cluster on a broad-host-range vector were unsuccessful, the ability to express nitrite reductase being restored only when the nirIX gene cluster was reintegrated into the chromosome of the NirI-deficient mutant via homologous recombination in such a way that the wild-type nirI gene was present directly upstream of the nir operon.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Saunders</LastName>
+ <ForeName>N F</ForeName>
+ <Initials>NF</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Molecular Cell Physiology, Faculty of Biology, BioCentrum Amsterdam, Vrije Universiteit, De Boelelaan 1087, NL-1081 HV Amsterdam, The Netherlands.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Houben</LastName>
+ <ForeName>E N</ForeName>
+ <Initials>EN</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Koefoed</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>de Weert</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Reijnders</LastName>
+ <ForeName>W N</ForeName>
+ <Initials>WN</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Westerhoff</LastName>
+ <ForeName>H V</ForeName>
+ <Initials>HV</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>De Boer</LastName>
+ <ForeName>A P</ForeName>
+ <Initials>AP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Van Spanning</LastName>
+ <ForeName>R J</ForeName>
+ <Initials>RJ</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <DataBankList CompleteYN="Y">
+ <DataBank>
+ <DataBankName>GENBANK</DataBankName>
+ <AccessionNumberList>
+ <AccessionNumber>AF005358</AccessionNumber>
+ <AccessionNumber>U47133</AccessionNumber>
+ <AccessionNumber>U94899</AccessionNumber>
+ </AccessionNumberList>
+ </DataBank>
+ <DataBank>
+ <DataBankName>PDB</DataBankName>
+ <AccessionNumberList>
+ <AccessionNumber>P33943</AccessionNumber>
+ </AccessionNumberList>
+ </DataBank>
+ </DataBankList>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Mol Microbiol</MedlineTA>
+ <NlmUniqueID>8712028</NlmUniqueID>
+ <ISSNLinking>0950-382X</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C120062">NNR protein, Paracoccus denitrificans</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C401644">NirI protein, Paracoccus denitrificans</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C401643">NirX protein, Paracoccus denitrificans</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 1.7.-</RegistryNumber>
+ <NameOfSubstance UI="D009572">Nitrite Reductases</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001426" MajorTopicYN="Y">Bacterial Proteins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004268" MajorTopicYN="Y">DNA-Binding Proteins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015964" MajorTopicYN="N">Gene Expression Regulation, Bacterial</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005816" MajorTopicYN="N">Genetic Complementation Test</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005810" MajorTopicYN="N">Multigene Family</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009572" MajorTopicYN="N">Nitrite Reductases</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010231" MajorTopicYN="N">Paracoccus denitrificans</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017433" MajorTopicYN="N">Protein Structure, Secondary</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017386" MajorTopicYN="N">Sequence Homology, Amino Acid</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014158" MajorTopicYN="Y">Transcription, Genetic</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1999</Year>
+ <Month>12</Month>
+ <Day>14</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1999</Year>
+ <Month>12</Month>
+ <Day>14</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1999</Year>
+ <Month>12</Month>
+ <Day>14</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">10540283</ArticleId>
+ <ArticleId IdType="pii">mmi1563</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">10612833</PMID>
+ <DateCompleted>
+ <Year>2000</Year>
+ <Month>01</Month>
+ <Day>20</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2012</Year>
+ <Month>07</Month>
+ <Day>11</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1098-1004</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>15</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2000</Year>
+ <Month>Jan</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Human mutation</Title>
+ <ISOAbbreviation>Hum. Mutat.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Erratum: analysis of DNA elements that modulate myosin VIIa expression in humans.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>114-5</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Usher syndromeIb (USH1B), an autosomal recessive disorder caused by mutations in myosin VIIa (MYO7A), is characterized by congenital profound hearing loss, vestibular abnormalities and retinitis pigmentosa. Promoter elements in the 5 kb upstream of the translation start were identified using adult retinal pigment epithelium cells (ARPE-19) as a model system. A 160 bp minimal promoter within the first intron was active in ARPE-19 cells, but not in HeLa cells that do not express MYO7A. A 100 bp sequence, 5' of the first exon, and repeated with 90% homology within the first intron, appeared to modulate expression in both cell lines. Segments containing these elements were screened by heteroduplex analysis. No heteroduplexes were detected in the minimal promoter, suggesting that this sequence is conserved. A -2568 A&gt;T transversion in the 5' 100 bp repeat, eliminating a CCAAT element, was found only in USH1B patients. However, in all 5 families, -2568 A&gt;T was in cis with the same missense mutation in the myosin VIIa tail (Arg1240Gln), and 4 of the 5 families were Dutch. These observations suggest either 1) linkage disequilibrium or 2)that a combination of a promoter mutation with a less active myosin VIIa protein results in USH1B.</AbstractText>
+ <CopyrightInformation>Copyright 2000 Wiley-Liss, Inc.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Orten</LastName>
+ <ForeName>D J</ForeName>
+ <Initials>DJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Center for Hereditary Communication Disorders, Boys Town National Research Hospital Omaha, NE, USA. ortend@boystown.org</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Weston</LastName>
+ <ForeName>M D</ForeName>
+ <Initials>MD</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kelley</LastName>
+ <ForeName>P M</ForeName>
+ <Initials>PM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cremers</LastName>
+ <ForeName>C W</ForeName>
+ <Initials>CW</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wagenaar</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Jacobson</LastName>
+ <ForeName>S G</ForeName>
+ <Initials>SG</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kimberling</LastName>
+ <ForeName>W J</ForeName>
+ <Initials>WJ</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <GrantList CompleteYN="N">
+ <Grant>
+ <GrantID>DC00677</GrantID>
+ <Acronym>DC</Acronym>
+ <Agency>NIDCD NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>DC00982</GrantID>
+ <Acronym>DC</Acronym>
+ <Agency>NIDCD NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>DC03351</GrantID>
+ <Acronym>DC</Acronym>
+ <Agency>NIDCD NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ </GrantList>
+ <PublicationTypeList>
+ <PublicationType UI="D016439">Corrected and Republished Article</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ <PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Hum Mutat</MedlineTA>
+ <NlmUniqueID>9215429</NlmUniqueID>
+ <ISSNLinking>1059-7794</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>EC 3.6.4.1</RegistryNumber>
+ <NameOfSubstance UI="D009218">Myosins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 3.6.4.1</RegistryNumber>
+ <NameOfSubstance UI="C096109">myosin VIIa</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 3.6.4.2</RegistryNumber>
+ <NameOfSubstance UI="D004398">Dyneins</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="RepublishedFrom">
+ <RefSource>Hum Mutat. 1999 Oct;14(4):354</RefSource>
+ <PMID Version="1">10502787</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D019943" MajorTopicYN="N">Amino Acid Substitution</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004398" MajorTopicYN="N">Dyneins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005786" MajorTopicYN="Y">Gene Expression Regulation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006319" MajorTopicYN="N">Hearing Loss, Sensorineural</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015810" MajorTopicYN="N">Linkage Disequilibrium</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020125" MajorTopicYN="N">Mutation, Missense</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009218" MajorTopicYN="N">Myosins</DescriptorName>
+ <QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010375" MajorTopicYN="N">Pedigree</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010857" MajorTopicYN="N">Pigment Epithelium of Eye</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012150" MajorTopicYN="N">Polymorphism, Restriction Fragment Length</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011401" MajorTopicYN="Y">Promoter Regions, Genetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012174" MajorTopicYN="N">Retinitis Pigmentosa</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013577" MajorTopicYN="N">Syndrome</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015837" MajorTopicYN="N">Vestibular Diseases</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1999</Year>
+ <Month>12</Month>
+ <Day>29</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1999</Year>
+ <Month>12</Month>
+ <Day>29</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1999</Year>
+ <Month>12</Month>
+ <Day>29</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">10612833</ArticleId>
+ <ArticleId IdType="pii">10.1002/(SICI)1098-1004(200001)15:1&lt;114::AID-HUMU21&gt;3.0.CO;2-4</ArticleId>
+ <ArticleId IdType="doi">10.1002/(SICI)1098-1004(200001)15:1&lt;114::AID-HUMU21&gt;3.0.CO;2-4</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">10737756</PMID>
+ <DateCompleted>
+ <Year>2000</Year>
+ <Month>04</Month>
+ <Day>13</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>30</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0022-2623</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>43</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>2000</Year>
+ <Month>Mar</Month>
+ <Day>23</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal of medicinal chemistry</Title>
+ <ISOAbbreviation>J. Med. Chem.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1234-41</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The regioselective dibenzylphosphorylation of 2 followed by catalytic reduction in the presence of N-methyl-D-glucamine afforded 2-(S)-(1-(R)-(3, 5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-(2- phosphoryl-3-oxo-4H,-1,2,4-triazolo)methylmorpholine, bis(N-methyl-D-glucamine) salt, 11. Incubation of 11 in rat, dog, and human plasma and in human hepatic subcellular fractions in vitro indicated that conversion to 2 would be expected to occur in vivo most readily in humans during hepatic circulation. Conversion of 11 to 2 occurred rapidly in vivo in the rat and dog with the levels of 11 being undetectable within 5 min after 1 and 8 mg/kg doses iv in the rat and within 15 min after 0.5, 2, and 32 mg/kg doses iv in the dog. Compound 11 has a 10-fold lower affinity for the human NK-1 receptor as compared to 2, but it is functionally equivalent to 2 in preclinical models of NK-1-mediated inflammation in the guinea pig and cisplatin-induced emesis in the ferret, indicating that 11 acts as a prodrug of 2. Based in part on these data, 11 was identified as a novel, water-soluble prodrug of the clinical candidate 2 suitable for intravenous administration in humans.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Hale</LastName>
+ <ForeName>J J</ForeName>
+ <Initials>JJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Merck, Sharp &amp; Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K. jeffrey_hale@merck.com</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Mills</LastName>
+ <ForeName>S G</ForeName>
+ <Initials>SG</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>MacCoss</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dorn</LastName>
+ <ForeName>C P</ForeName>
+ <Initials>CP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Finke</LastName>
+ <ForeName>P E</ForeName>
+ <Initials>PE</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Budhu</LastName>
+ <ForeName>R J</ForeName>
+ <Initials>RJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Reamer</LastName>
+ <ForeName>R A</ForeName>
+ <Initials>RA</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Huskey</LastName>
+ <ForeName>S E</ForeName>
+ <Initials>SE</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Luffer-Atlas</LastName>
+ <ForeName>D</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dean</LastName>
+ <ForeName>B J</ForeName>
+ <Initials>BJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>McGowan</LastName>
+ <ForeName>E M</ForeName>
+ <Initials>EM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Feeney</LastName>
+ <ForeName>W P</ForeName>
+ <Initials>WP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Chiu</LastName>
+ <ForeName>S H</ForeName>
+ <Initials>SH</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cascieri</LastName>
+ <ForeName>M A</ForeName>
+ <Initials>MA</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Chicchi</LastName>
+ <ForeName>G G</ForeName>
+ <Initials>GG</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kurtz</LastName>
+ <ForeName>M M</ForeName>
+ <Initials>MM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sadowski</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ber</LastName>
+ <ForeName>E</ForeName>
+ <Initials>E</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tattersall</LastName>
+ <ForeName>F D</ForeName>
+ <Initials>FD</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Rupniak</LastName>
+ <ForeName>N M</ForeName>
+ <Initials>NM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Williams</LastName>
+ <ForeName>A R</ForeName>
+ <Initials>AR</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Rycroft</LastName>
+ <ForeName>W</ForeName>
+ <Initials>W</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hargreaves</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Metzger</LastName>
+ <ForeName>J M</ForeName>
+ <Initials>JM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>MacIntyre</LastName>
+ <ForeName>D E</ForeName>
+ <Initials>DE</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Med Chem</MedlineTA>
+ <NlmUniqueID>9716531</NlmUniqueID>
+ <ISSNLinking>0022-2623</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C406348">2-(1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluoro)phenyl-4-(5-(2-phosphoryl-3-oxo-4H,-1,2,4-triazolo))methylmorpholine, bis(N-methylglucamine) salt</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000080">Acetals</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000894">Anti-Inflammatory Agents, Non-Steroidal</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000932">Antiemetics</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D009025">Morpholines</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D064729">Neurokinin-1 Receptor Antagonists</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D011355">Prodrugs</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>059QF0KO0R</RegistryNumber>
+ <NameOfSubstance UI="D014867">Water</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>1NF15YR6UY</RegistryNumber>
+ <NameOfSubstance UI="C114556">aprepitant</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>Q20Q21Q62J</RegistryNumber>
+ <NameOfSubstance UI="D002945">Cisplatin</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000080" MajorTopicYN="N">Acetals</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000894" MajorTopicYN="N">Anti-Inflammatory Agents, Non-Steroidal</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000932" MajorTopicYN="N">Antiemetics</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002945" MajorTopicYN="N">Cisplatin</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004353" MajorTopicYN="N">Drug Evaluation, Preclinical</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005289" MajorTopicYN="N">Ferrets</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006168" MajorTopicYN="N">Guinea Pigs</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009025" MajorTopicYN="N">Morpholines</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D064729" MajorTopicYN="Y">Neurokinin-1 Receptor Antagonists</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011355" MajorTopicYN="N">Prodrugs</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012995" MajorTopicYN="N">Solubility</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013237" MajorTopicYN="N">Stereoisomerism</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014839" MajorTopicYN="N">Vomiting</DescriptorName>
+ <QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014867" MajorTopicYN="N">Water</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2000</Year>
+ <Month>3</Month>
+ <Day>29</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2000</Year>
+ <Month>4</Month>
+ <Day>15</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2000</Year>
+ <Month>3</Month>
+ <Day>29</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">10737756</ArticleId>
+ <ArticleId IdType="pii">jm990617v</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">10854512</PMID>
+ <DateCompleted>
+ <Year>2000</Year>
+ <Month>06</Month>
+ <Day>29</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2004</Year>
+ <Month>11</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">1432-2218</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>14</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2000</Year>
+ <Month>Jan</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Surgical endoscopy</Title>
+ <ISOAbbreviation>Surg Endosc</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Inflammatory fibroid polyp of the duodenum.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>86</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Duodenal inflammatory fibroid polyps (IFP) are extemely rare lesions indistinguishable from submucosal tumors by endoscopic inspection alone. Like gastric inflammatory fibroid polyps, they can be managed by endoscopic polypectomy or mucosectomy. However, preoperative diagnosis of this benign lesion is difficult. Here we present a case of duodenal IFP causing gastrointestinal bleeding that was evaluated by endoscopic ultrasound before surgical removal. On endosonography, the duodenal IFP appeared as a coarsely heterogeneous isoechoic and hypoechoic mass circumscribed by a distinct margin and arising from the third layer of the duodenal wall. The endosonographic appearance of this lesion was in marked contrast to that previously reported for gastric IFPs, which have tended to appear as hypoechoic homogeneous lesions with indistinct margins. Endosonographic evaluation of suspected IFPs before endoscopic or surgical treatment is useful. However, the endosonographic appearances of duodenal and gastric IFPs may be significantly different, possibly because of differences in the makeup of the duodenal and gastric walls.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Soon</LastName>
+ <ForeName>M S</ForeName>
+ <Initials>MS</Initials>
+ <AffiliationInfo>
+ <Affiliation>Division of Gastroenterology, ChangHua Christian Medical Center, ChangHua, Taiwan.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lin</LastName>
+ <ForeName>O S</ForeName>
+ <Initials>OS</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D002363">Case Reports</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>1999</Year>
+ <Month>11</Month>
+ <Day>25</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Germany</Country>
+ <MedlineTA>Surg Endosc</MedlineTA>
+ <NlmUniqueID>8806653</NlmUniqueID>
+ <ISSNLinking>0930-2794</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D004379" MajorTopicYN="N">Duodenal Neoplasms</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ <QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004382" MajorTopicYN="N">Duodenitis</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ <QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016099" MajorTopicYN="N">Endoscopy, Gastrointestinal</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019160" MajorTopicYN="N">Endosonography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005350" MajorTopicYN="N">Fibroma</DescriptorName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ <QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005753" MajorTopicYN="N">Gastric Mucosa</DescriptorName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006471" MajorTopicYN="N">Gastrointestinal Hemorrhage</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ <QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007417" MajorTopicYN="N">Intestinal Polyps</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ <QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>1999</Year>
+ <Month>07</Month>
+ <Day>22</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="accepted">
+ <Year>1999</Year>
+ <Month>08</Month>
+ <Day>10</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2000</Year>
+ <Month>6</Month>
+ <Day>16</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2000</Year>
+ <Month>7</Month>
+ <Day>6</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2000</Year>
+ <Month>6</Month>
+ <Day>16</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">10854512</ArticleId>
+ <ArticleId IdType="doi">10.1007/s004649901204</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">10972993</PMID>
+ <DateCompleted>
+ <Year>2000</Year>
+ <Month>09</Month>
+ <Day>26</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2008</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0899-1987</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>28</Volume>
+ <Issue>4</Issue>
+ <PubDate>
+ <Year>2000</Year>
+ <Month>Aug</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Molecular carcinogenesis</Title>
+ <ISOAbbreviation>Mol. Carcinog.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>236-46</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Germline mutations of BRCA1 and BRCA2 predispose to hereditary breast, ovarian, and possibly prostate cancer, yet structural mutations in these genes are infrequent in sporadic cancer cases. To better define the involvement of these genes in sporadic cancers, we characterized expression levels of BRCA1 and BRCA2 transcripts in cancer cell lines derived from neoplasms of the ovary, prostate, and breast and compared them with those expressed in primary cultures of normal epithelial cells established from these organs. We observed upregulation of BRCA1 and/or BRCA2 expression in six of seven ovarian cancer cell lines (OVCA420, OVCA429, OVCA432, ALST, DOV13, and SKOV3) when compared with levels found in normal ovary surface epithelial cells. Furthermore, five cancerous or immortalized prostatic epithelial cell lines (BPH-1, TSU-Pr1, LNCaP, PC-3, and DU145) also expressed higher levels of BRCA1 and/or BRCA2 mRNA than did primary cultures of normal prostatic epithelial cells. In contrast, only the estrogen receptor-positive MCF-7 cell line overexpressed these messages, whereas the estrogen receptor-negative breast cancer cell lines Hs578T, MDA-MB-231, and MDA-MB-468 showed no change in expression levels when compared with normal breast epithelial cells. In addition, expanding on our recent identification of a novel BRCA2 transcript variant carrying an in-frame exon 12 deletion (BRCA2 delta 12), we report increased expression of this variant in several ovarian, prostate, and mammary cancer cell lines (OVCA420, OVCA433, ALST, DOV13, SKOV3, TSU-Pr1, DU145, and MDA-MB-468). Most notably, high levels of BRCA2 delta 12 mRNA were detected in an estrogen receptor-positive breast cancer cell line, MCF-7, and in an androgen-independent prostate cancer cell line, DU-145. Interestingly, the wild-type BRCA2 transcript was barely detectable in DU145, which could be used as a model system for future investigations on BRCA2 delta 12 function. Taken together, our data suggest disruption of BRCA1 and/or BRCA2 gene expression in certain epithelial cancer cell lines of the ovary, prostate, and breast. Because wild-type BRCA1 and BRCA2 gene products increase during cell-cycle progression and are believed to exert growth-inhibitory action, enhanced expression of these genes in cancer cells may represent a negative feedback mechanism for curbing proliferation in fast-growing cells. At present, the functionality of BRCA2 delta 12 remains elusive.</AbstractText>
+ <CopyrightInformation>Copyright 2000 Wiley-Liss, Inc.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Rauh-Adelmann</LastName>
+ <ForeName>C</ForeName>
+ <Initials>C</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Biology, Tufts University, Medford, Massachusetts, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lau</LastName>
+ <ForeName>K M</ForeName>
+ <Initials>KM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sabeti</LastName>
+ <ForeName>N</ForeName>
+ <Initials>N</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Long</LastName>
+ <ForeName>J P</ForeName>
+ <Initials>JP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Mok</LastName>
+ <ForeName>S C</ForeName>
+ <Initials>SC</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ho</LastName>
+ <ForeName>S M</ForeName>
+ <Initials>SM</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <GrantList CompleteYN="N">
+ <Grant>
+ <GrantID>C69453</GrantID>
+ <Agency>PHS HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>CA15576</GrantID>
+ <Acronym>CA</Acronym>
+ <Agency>NCI NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>CA62269</GrantID>
+ <Acronym>CA</Acronym>
+ <Agency>NCI NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ </GrantList>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ <PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Mol Carcinog</MedlineTA>
+ <NlmUniqueID>8811105</NlmUniqueID>
+ <ISSNLinking>0899-1987</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D019313">BRCA1 Protein</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D024682">BRCA2 Protein</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D009363">Neoplasm Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D019313" MajorTopicYN="N">BRCA1 Protein</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D024682" MajorTopicYN="N">BRCA2 Protein</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001940" MajorTopicYN="N">Breast</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005091" MajorTopicYN="N">Exons</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015972" MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019398" MajorTopicYN="Y">Genes, BRCA1</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009363" MajorTopicYN="N">Neoplasm Proteins</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010051" MajorTopicYN="N">Ovarian Neoplasms</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011471" MajorTopicYN="N">Prostatic Neoplasms</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017384" MajorTopicYN="N">Sequence Deletion</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014158" MajorTopicYN="Y">Transcription, Genetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014407" MajorTopicYN="N">Tumor Cells, Cultured</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2000</Year>
+ <Month>9</Month>
+ <Day>6</Day>
+ <Hour>11</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2000</Year>
+ <Month>9</Month>
+ <Day>30</Day>
+ <Hour>11</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2000</Year>
+ <Month>9</Month>
+ <Day>6</Day>
+ <Hour>11</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">10972993</ArticleId>
+ <ArticleId IdType="pii">10.1002/1098-2744(200008)28:4&lt;236::AID-MC6&gt;3.0.CO;2-H</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11025314</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>01</Month>
+ <Day>05</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0108-2701</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>56 ( Pt 10)</Volume>
+ <PubDate>
+ <Year>2000</Year>
+ <Month>Oct</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Acta crystallographica. Section C, Crystal structure communications</Title>
+ <ISOAbbreviation>Acta Crystallogr C</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Multicentre hydrogen bonds in a 2:1 arylsulfonylimidazolone hydrochloride salt.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1247-50</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The title compound, (S)-(+)-4-[5-(2-oxo-4, 5-dihydroimidazol-1-ylsulfonyl)indolin-1 -ylcarbonyl ]anilinium chloride (S)-(+)-1-[1-(4-aminobenzoyl)indoline-5- sulfonyl]-4-phenyl-4, 5-dihydroimidazol-2-one, C(24)H(23)N(4)O(4)S(+).Cl(-). C(24)H(22)N(4)O(4)S, crystallizes in space group C2 from a CH(3)OH/CH(2)Cl(2) solution. In the crystal structure, there are two different conformers with their terminal C(6) aromatic rings mutually oriented at angles of 67.69 (14) and 61.16 (15) degrees. The distances of the terminal N atoms (of the two conformers) from the chloride ion are 3.110 (4) and 3.502 (4) A. There are eight distinct hydrogen bonds, i.e. four N-H...Cl, three N-H...O and one N-H...N, with one N-H group involved in a bifurcated hydrogen bond with two acceptors sharing the H atom. C-H...O contacts assist in the overall hydrogen-bonding process.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Park</LastName>
+ <ForeName>K L</ForeName>
+ <Initials>KL</Initials>
+ <AffiliationInfo>
+ <Affiliation>College of Pharmacy, Chungnam National University, Taejeon 305-764, Korea. parki@cnu.ac.kr.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Moon</LastName>
+ <ForeName>B G</ForeName>
+ <Initials>BG</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Jung</LastName>
+ <ForeName>S H</ForeName>
+ <Initials>SH</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kim</LastName>
+ <ForeName>J G</ForeName>
+ <Initials>JG</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Suh</LastName>
+ <ForeName>I H</ForeName>
+ <Initials>IH</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Acta Crystallogr C</MedlineTA>
+ <NlmUniqueID>8305826</NlmUniqueID>
+ <ISSNLinking>0108-2701</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C417516">1-(1-(4-aminobenzoyl)indoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazol-2-one</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D007093">Imidazoles</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D013450">Sulfones</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018360" MajorTopicYN="N">Crystallography, X-Ray</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006860" MajorTopicYN="N">Hydrogen Bonding</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007093" MajorTopicYN="N">Imidazoles</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008968" MajorTopicYN="N">Molecular Conformation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013237" MajorTopicYN="N">Stereoisomerism</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013450" MajorTopicYN="N">Sulfones</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>2000</Year>
+ <Month>05</Month>
+ <Day>17</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="accepted">
+ <Year>2000</Year>
+ <Month>07</Month>
+ <Day>03</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2000</Year>
+ <Month>10</Month>
+ <Day>12</Day>
+ <Hour>11</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>2</Month>
+ <Day>28</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2000</Year>
+ <Month>10</Month>
+ <Day>12</Day>
+ <Hour>11</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11025314</ArticleId>
+ <ArticleId IdType="pii">S0108270100009495</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11034741</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>08</Month>
+ <Day>02</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>06</Month>
+ <Day>28</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1469-493X</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Issue>4</Issue>
+ <PubDate>
+ <Year>2000</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Cochrane database of systematic reviews</Title>
+ <ISOAbbreviation>Cochrane Database Syst Rev</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Parent-training programmes for improving maternal psychosocial health.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>CD002020</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The prevalence of mental health problems in women is 1:3 and such problems tend to be persistent. There is evidence from a range of studies to suggest that a number of factors relating to maternal psychosocial health can have a significant effect on the mother-infant relationship, and that this can have consequences for the psychological health of the child. It is now thought that parenting programmes may have an important role to play in the improvement of maternal psychosocial health.</AbstractText>
+ <AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The objective of this review is to address whether group-based parenting programmes are effective in improving maternal psychosocial health including anxiety, depression and self-esteem.</AbstractText>
+ <AbstractText Label="SEARCH STRATEGY" NlmCategory="METHODS">A range of biomedical, social science, educational and general reference electronic databases were searched including MEDLINE, EMBASE CINAHL, PsychLIT, ERIC, ASSIA, Sociofile and the Social Science Citation Index. Other sources of information included the Cochrane Library (SPECTR, CENTRAL), and the National Research Register (NRR).</AbstractText>
+ <AbstractText Label="SELECTION CRITERIA" NlmCategory="METHODS">Only randomised controlled trials were included in which participants had been randomly allocated to an experimental and a control group, the latter being either a waiting-list, no-treatment or a placebo control group. Studies had to include at least one group-based parenting programme, and one standardised instrument measuring maternal psychosocial health.</AbstractText>
+ <AbstractText Label="DATA COLLECTION AND ANALYSIS" NlmCategory="METHODS">A systematic critical appraisal of all included studies was undertaken using the Journal of the American Medical Association (JAMA) published criteria. The data were summarised using effect sizes but were not combined in a meta-analysis due to the small number of studies within each group and the presence of significant heterogeneity.</AbstractText>
+ <AbstractText Label="MAIN RESULTS" NlmCategory="RESULTS">A total of 22 studies were included in the review but only 17 provided sufficient data to calculate effect sizes. These 17 studies reported on a total of 59 outcomes including depression, anxiety, stress, self-esteem, social competence, social support, guilt, mood, automatic thoughts, dyadic adjustment, psychiatric morbidity, irrationality, anger and aggression, mood, attitude, personality, and beliefs. Approximately 22% of the outcomes measured suggested significant differences favouring the intervention group. A further 40% showed differences favouring the intervention group but which failed to achieve conventional levels of statistical significance, in some cases due to the small numbers that were used. Approximately 38% of outcomes suggested no evidence of effectiveness.</AbstractText>
+ <AbstractText Label="REVIEWER'S CONCLUSIONS" NlmCategory="CONCLUSIONS">It is suggested that parenting programmes can make a significant contribution to the improvement of psychosocial health in mothers. While the critical appraisal suggests some variability in the quality of the included studies, it is concluded that there is sufficient evidence to support their use with diverse groups of parents. However, it is also suggested that some caution should be exercised before the results are generalised to parents irrespective of the level of pathology present, and that further research is still required.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Barlow</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ <AffiliationInfo>
+ <Affiliation>Health Services Research Unit, University of Oxford, Institute of Health Sciences, Old Road, Oxford, UK, OX3 7LF. esther.coren@dphpc.ox.ac.uk</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Coren</LastName>
+ <ForeName>E</ForeName>
+ <Initials>E</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Cochrane Database Syst Rev</MedlineTA>
+ <NlmUniqueID>100909747</NlmUniqueID>
+ <ISSNLinking>1361-6137</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="UpdateIn">
+ <RefSource>Cochrane Database Syst Rev. 2001;(2):CD002020</RefSource>
+ <PMID Version="1">11406024</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008425" MajorTopicYN="N">Maternal Behavior</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009034" MajorTopicYN="Y">Mother-Child Relations</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016487" MajorTopicYN="Y">Parenting</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015397" MajorTopicYN="Y">Program Evaluation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012649" MajorTopicYN="N">Self Concept</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>99</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2000</Year>
+ <Month>10</Month>
+ <Day>18</Day>
+ <Hour>11</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>3</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2000</Year>
+ <Month>10</Month>
+ <Day>18</Day>
+ <Hour>11</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11034741</ArticleId>
+ <ArticleId IdType="pii">CD002020</ArticleId>
+ <ArticleId IdType="doi">10.1002/14651858.CD002020</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">11056631</PMID>
+ <DateCompleted>
+ <Year>2016</Year>
+ <Month>03</Month>
+ <Day>08</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2000</Year>
+ <Month>12</Month>
+ <Day>01</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0031-9007</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>85</Volume>
+ <Issue>19</Issue>
+ <PubDate>
+ <Year>2000</Year>
+ <Month>Nov</Month>
+ <Day>06</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Physical review letters</Title>
+ <ISOAbbreviation>Phys. Rev. Lett.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Dislocated epitaxial islands.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>4088-91</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Dislocation networks observed in CoSi (2) islands grown epitaxially on Si are compared with the results of dislocation-dynamics calculations. The calculations make use of the fact that image forces play a relatively minor role compared to line tension forces and dislocation-dislocation interactions. Remarkable agreement is achieved, demonstrating that this approach can be applied more generally to study dislocations in other mesostructures.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Liu</LastName>
+ <ForeName>X H</ForeName>
+ <Initials>XH</Initials>
+ <AffiliationInfo>
+ <Affiliation>IBM Watson Research Center, P.O. Box 218, Yorktown Heights, New York 10598, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ross</LastName>
+ <ForeName>F M</ForeName>
+ <Initials>FM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Schwarz</LastName>
+ <ForeName>K W</ForeName>
+ <Initials>KW</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Phys Rev Lett</MedlineTA>
+ <NlmUniqueID>0401141</NlmUniqueID>
+ <ISSNLinking>0031-9007</ISSNLinking>
+ </MedlineJournalInfo>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>2000</Year>
+ <Month>07</Month>
+ <Day>17</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2000</Year>
+ <Month>11</Month>
+ <Day>1</Day>
+ <Hour>11</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2000</Year>
+ <Month>11</Month>
+ <Day>1</Day>
+ <Hour>11</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2000</Year>
+ <Month>11</Month>
+ <Day>1</Day>
+ <Hour>11</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11056631</ArticleId>
+ <ArticleId IdType="doi">10.1103/PhysRevLett.85.4088</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11238657</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>05</Month>
+ <Day>17</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>30</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0022-1767</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>166</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Mar</Month>
+ <Day>15</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal of immunology (Baltimore, Md. : 1950)</Title>
+ <ISOAbbreviation>J. Immunol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>4083-91</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Increasing evidence suggests that a continuous release of histamine from mast cells occurs in the airways of asthmatic patients and that histamine may modulate functions of other inflammatory cells such as macrophages. In the present study histamine (10(-9)-10(-6) M) increased in a concentration-dependent fashion the basal release of beta-glucuronidase (EC(50) = 8.2 +/- 3.5 x 10(-9) M) and IL-6 (EC(50) = 9.3 +/- 2.9 x 10(-8) M) from human lung macrophages. Enhancement of beta-glucuronidase release induced by histamine was evident after 30 min and peaked at 90 min, whereas that of IL-6 required 2-6 h of incubation. These effects were reproduced by the H(1) agonist (6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptane carboxamide but not by the H(2) agonist dimaprit. Furthermore, histamine induced a concentration-dependent increase of intracellular Ca(2+) concentrations ([Ca(2+)](i)) that followed three types of response, one characterized by a rapid increase, a second in which [Ca(2+)](i) displays a slow but progressive increase, and a third characterized by an oscillatory pattern. Histamine-induced beta-glucuronidase and IL-6 release and [Ca(2+)](i) elevation were inhibited by the selective H(1) antagonist fexofenadine (10(-7)-10(-4) M), but not by the H(2) antagonist ranitidine. Inhibition of histamine-induced beta-glucuronidase and IL-6 release by fexofenadine was concentration dependent and displayed the characteristics of a competitive antagonism (K(d) = 89 nM). These data demonstrate that histamine induces exocytosis and IL-6 production from human macrophages by activating H(1) receptor and by increasing [Ca(2+)](i) and they suggest that histamine may play a relevant role in the long-term sustainment of allergic inflammation in the airways.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Triggiani</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy. triggian@unina.it</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Gentile</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Secondo</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Granata</LastName>
+ <ForeName>F</ForeName>
+ <Initials>F</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Oriente</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Taglialatela</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Annunziato</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Marone</LastName>
+ <ForeName>G</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Immunol</MedlineTA>
+ <NlmUniqueID>2985117R</NlmUniqueID>
+ <ISSNLinking>0022-1767</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D017442">Histamine Agonists</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D006634">Histamine H1 Antagonists</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D006635">Histamine H2 Antagonists</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D011969">Receptors, Histamine H1</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D014052">Toluidines</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>103827-15-2</RegistryNumber>
+ <NameOfSubstance UI="C081972">6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>820484N8I3</RegistryNumber>
+ <NameOfSubstance UI="D006632">Histamine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 3.2.1.31</RegistryNumber>
+ <NameOfSubstance UI="D005966">Glucuronidase</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>SY7Q814VUP</RegistryNumber>
+ <NameOfSubstance UI="D002118">Calcium</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>ZZQ699148P</RegistryNumber>
+ <NameOfSubstance UI="D017259">Dimaprit</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D002118" MajorTopicYN="N">Calcium</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003600" MajorTopicYN="N">Cytosol</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017259" MajorTopicYN="N">Dimaprit</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004306" MajorTopicYN="N">Dose-Response Relationship, Immunologic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005089" MajorTopicYN="N">Exocytosis</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005966" MajorTopicYN="N">Glucuronidase</DescriptorName>
+ <QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006632" MajorTopicYN="N">Histamine</DescriptorName>
+ <QualifierName UI="Q000031" MajorTopicYN="Y">analogs &amp; derivatives</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017442" MajorTopicYN="N">Histamine Agonists</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006634" MajorTopicYN="N">Histamine H1 Antagonists</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006635" MajorTopicYN="N">Histamine H2 Antagonists</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
+ <QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
+ <QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
+ <QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016676" MajorTopicYN="N">Macrophages, Alveolar</DescriptorName>
+ <QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ <QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
+ <QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011969" MajorTopicYN="N">Receptors, Histamine H1</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014052" MajorTopicYN="N">Toluidines</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>3</Month>
+ <Day>10</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>5</Month>
+ <Day>18</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>3</Month>
+ <Day>10</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11238657</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11243089</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>05</Month>
+ <Day>17</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0019-557X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>43</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <MedlineDate>1999 Jan-Mar</MedlineDate>
+ </PubDate>
+ </JournalIssue>
+ <Title>Indian journal of public health</Title>
+ <ISOAbbreviation>Indian J Public Health</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Nutritional status of pavement dweller children of Calcutta City.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>49-54</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Pavement dwelling is likely to aggravate malnutrition among its residents due to extreme poverty, lack of dwelling and access to food and their exposure to polluted environment. Paucity of information about nutritional status of street children compared to that among urban slum dwellers, squatters or rural/tribal population is quite evident. The present study revealed the magnitude of Protein Energy Malnutrition (PEM) and few associated factors among a sample of 435 underfives belonging to pavement dweller families and selected randomly from clusters of such families, from each of the five geographical sectors of Calcutta city. Overall prevalence of PEM was found almost similar (about 70%) to that among other 'urban poor' children viz. slum dwellers etc., but about 16% of them were found severely undernourished (Grade III &amp; V of IAP classification of PEM). About 35% and 70% of street dweller children had wasting and stunting respectively. Severe PEM (Grade III &amp; IV) was more prevalent among 12-23 months old, girl child, those belonged to illiterate parents and housewife mothers rather than wage earners. It also did increase with increase of birth rate of decrease of birth interval.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Ray</LastName>
+ <ForeName>S K</ForeName>
+ <Initials>SK</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Community Medicine, Medical College, Calcutta.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Mishra</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Biswas</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kumar</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Halder</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Chatterjee</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>India</Country>
+ <MedlineTA>Indian J Public Health</MedlineTA>
+ <NlmUniqueID>0400673</NlmUniqueID>
+ <ISSNLinking>0019-557X</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <CitationSubset>J</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004522" MajorTopicYN="N">Educational Status</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007194" MajorTopicYN="N" Type="Geographic">India</DescriptorName>
+ <QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009752" MajorTopicYN="Y">Nutritional Status</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011203" MajorTopicYN="N">Poverty</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011287" MajorTopicYN="N">Prejudice</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011502" MajorTopicYN="N">Protein-Energy Malnutrition</DescriptorName>
+ <QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="PIP">143717</OtherID>
+ <OtherID Source="POP">00288124</OtherID>
+ <OtherAbstract Type="PIP" Language="eng">
+ <AbstractText>This document presents a cross-sectional survey concerning the magnitude of protein energy malnutrition (PEM) and its associated factors among 435 under-5 pavement-dwelling children in Calcutta. Results revealed that 69.43% were undernourished and that 16% of them were suffering from severe malnutrition (grade III and IV of the Indian Academy of Pediatrics criteria for PEM). The 24-35 month age group had the highest prevalence of malnutrition (82.93%) followed by the 36-47 and 12-23 month age groups with prevalences of 76.19% and 74.03%, respectively. Prevalence of severe grade malnutrition was noted to be three times higher in females (24.76%) than males (8.45%), and among families it increased in direct proportion to birth rate and inverse proportion to birth interval. Moreover, children of illiterate parents and nonworking mothers had a higher incidence of severe PEM. Simple measures such as exclusive breast-feeding and timely complementary feeding as well as measures directed toward birth spacing and limiting family size should be implemented to solve the problem of malnutrition.</AbstractText>
+ </OtherAbstract>
+ <KeywordList Owner="PIP">
+ <Keyword MajorTopicYN="N">Age Factors</Keyword>
+ <Keyword MajorTopicYN="N">Asia</Keyword>
+ <Keyword MajorTopicYN="Y">Child</Keyword>
+ <Keyword MajorTopicYN="Y">Child Nutrition</Keyword>
+ <Keyword MajorTopicYN="N">Demographic Factors</Keyword>
+ <Keyword MajorTopicYN="N">Developing Countries</Keyword>
+ <Keyword MajorTopicYN="N">Diseases</Keyword>
+ <Keyword MajorTopicYN="N">Geographic Factors</Keyword>
+ <Keyword MajorTopicYN="N">Health</Keyword>
+ <Keyword MajorTopicYN="Y">Homeless Persons</Keyword>
+ <Keyword MajorTopicYN="N">India</Keyword>
+ <Keyword MajorTopicYN="Y">Malnutrition</Keyword>
+ <Keyword MajorTopicYN="N">Nutrition</Keyword>
+ <Keyword MajorTopicYN="N">Nutrition Disorders</Keyword>
+ <Keyword MajorTopicYN="N">Population</Keyword>
+ <Keyword MajorTopicYN="N">Population Characteristics</Keyword>
+ <Keyword MajorTopicYN="N">Research Methodology</Keyword>
+ <Keyword MajorTopicYN="Y">Research Report</Keyword>
+ <Keyword MajorTopicYN="N">Residence Characteristics</Keyword>
+ <Keyword MajorTopicYN="N">Sampling Studies</Keyword>
+ <Keyword MajorTopicYN="N">Southern Asia</Keyword>
+ <Keyword MajorTopicYN="N">Spatial Distribution</Keyword>
+ <Keyword MajorTopicYN="N">Studies</Keyword>
+ <Keyword MajorTopicYN="Y">Surveys</Keyword>
+ <Keyword MajorTopicYN="Y">Urban Population</Keyword>
+ <Keyword MajorTopicYN="N">Youth</Keyword>
+ </KeywordList>
+ <GeneralNote Owner="PIP">TJ: INDIAN JOURNAL OF PUBLIC HEALTH.</GeneralNote>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>3</Month>
+ <Day>13</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>5</Month>
+ <Day>18</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>3</Month>
+ <Day>13</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11243089</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11279676</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>12</Month>
+ <Day>07</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2014</Year>
+ <Month>11</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1469-493X</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Cochrane database of systematic reviews</Title>
+ <ISOAbbreviation>Cochrane Database Syst Rev</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Elective versus selective caesarean section for delivery of the small baby.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>CD000078</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Elective caesarean delivery for women in preterm labour might reduce the chances of fetal or neonatal death, but it might also increase the risk of maternal morbidity.</AbstractText>
+ <AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To assess the effects of a policy of elective caesarean delivery versus selective caesarean delivery for women in preterm labour.</AbstractText>
+ <AbstractText Label="SEARCH STRATEGY" NlmCategory="METHODS">The Cochrane Pregnancy and Childbirth Group trials register was searched. Date of last search: September 2000.</AbstractText>
+ <AbstractText Label="SELECTION CRITERIA" NlmCategory="METHODS">Randomised trials comparing a policy of elective caesarean delivery versus expectant management with recourse to caesarean section.</AbstractText>
+ <AbstractText Label="DATA COLLECTION AND ANALYSIS" NlmCategory="METHODS">One reviewer assessed eligibility and trial quality, and both contributed to the update.</AbstractText>
+ <AbstractText Label="MAIN RESULTS" NlmCategory="RESULTS">Six studies involving 122 women were included. All trials reported recruiting difficulties. No significant differences between elective and selective policies for caesarean delivery were found for fetal, neonatal or maternal outcomes.</AbstractText>
+ <AbstractText Label="REVIEWER'S CONCLUSIONS" NlmCategory="CONCLUSIONS">There is not enough evidence to evaluate the use of a policy for elective caesarean delivery for small babies. Randomised trials in this area are likely to continue to experience recruitment problems. However, it still may be possible to investigate elective caesarean delivery in preterm babies with cephalic presentations.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Grant</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Health Services Research Unit, The Polwarth Building, Foresterhill, Aberdeen, UK, AB9 2ZD. a.grant@abdn.ac.uk</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Glazener</LastName>
+ <ForeName>C M</ForeName>
+ <Initials>CM</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Cochrane Database Syst Rev</MedlineTA>
+ <NlmUniqueID>100909747</NlmUniqueID>
+ <ISSNLinking>1361-6137</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="UpdateOf">
+ <RefSource>Cochrane Database Syst Rev. 2000;(2):CD000078</RefSource>
+ <PMID Version="1">10796117</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="UpdateIn">
+ <RefSource>Cochrane Database Syst Rev. 2001;(2):CD000078</RefSource>
+ <PMID Version="1">11405950</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D002585" MajorTopicYN="Y">Cesarean Section</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017558" MajorTopicYN="Y">Elective Surgical Procedures</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007234" MajorTopicYN="N">Infant, Premature</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007752" MajorTopicYN="Y">Obstetric Labor, Premature</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>21</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>5</Month>
+ <Day>2</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>1</Month>
+ <Day>5</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>5</Month>
+ <Day>2</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11279676</ArticleId>
+ <ArticleId IdType="pii">CD000078</ArticleId>
+ <ArticleId IdType="doi">10.1002/14651858.CD000078</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11406024</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>02</Month>
+ <Day>28</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>06</Month>
+ <Day>28</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1469-493X</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Issue>2</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Cochrane database of systematic reviews</Title>
+ <ISOAbbreviation>Cochrane Database Syst Rev</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Parent-training programmes for improving maternal psychosocial health.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>CD002020</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Mental health problems are common, and there is evidence from a range of studies to suggest that a number of factors relating to maternal psychosocial health can have a significant effect on the mother-infant relationship, and that this can have consequences for both the short and long-term psychological health of the child. The use of parenting programmes is increasing in the UK and evidence of their effectiveness in improving outcomes for mothers is now required.</AbstractText>
+ <AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The objective of this review is to address whether group-based parenting programmes are effective in improving maternal psychosocial health including anxiety, depression, and self-esteem.</AbstractText>
+ <AbstractText Label="SEARCH STRATEGY" NlmCategory="METHODS">A range of biomedical, social science, educational and general reference electronic databases were searched including MEDLINE, EMBASE CINAHL, PsychLIT, ERIC, ASSIA, Sociofile and the Social Science Citation Index. Other sources of information included the Cochrane Library (SPECTR, CENTRAL), and the National Research Register (NRR).</AbstractText>
+ <AbstractText Label="SELECTION CRITERIA" NlmCategory="METHODS">Only randomised controlled trials were included in which participants had been randomly allocated to an experimental and a control group, the latter being either a waiting-list, no-treatment or a placebo control group. Studies had to include at least one group-based parenting programme, and one standardised instrument measuring maternal psychosocial health.</AbstractText>
+ <AbstractText Label="DATA COLLECTION AND ANALYSIS" NlmCategory="METHODS">A systematic critical appraisal of all included studies was undertaken using a modified version of the Journal of the American Medical Association (JAMA) published criteria. The treatment effect for each outcome in each study was standardised by dividing the mean difference in post-intervention scores for the intervention and treatment group, by the pooled standard deviation, to produce an effect size. Where appropriate the results were then combined in a meta-analysis using a fixed-effect model, and 95% confidence intervals were used to assess the significance of the findings.</AbstractText>
+ <AbstractText Label="MAIN RESULTS" NlmCategory="RESULTS">A total of 23 studies were included in the review but only 17 provided sufficient data to calculate effect sizes. The 17 studies provided a total of 59 assessments of outcome on a range of aspects of psychosocial functioning including depression, anxiety, stress, self-esteem, social competence, social support, guilt, mood, automatic thoughts, dyadic adjustment, psychiatric morbidity, irrationality, anger and aggression, mood, attitude, personality, and beliefs. There was only sufficient data, however, on five outcomes (depression; anxiety/stress; self-esteem; social support; and relationship with spouse/marital adjustment) to combine the results in a meta-analysis. The meta-analyses show statistically significant results favouring the intervention group as regards depression; anxiety/stress; self-esteem; and relationship with spouse/marital adjustment. The meta-analysis of the social support data, however, showed no evidence of effectiveness. These results suggest that parenting programmes, irrespective of the type (or content) of programme, can be effective in improving important aspects of maternal psycho-social functioning. Of the data summarising the effectiveness of the different types of parenting programmes, which it was not possible to combine in a meta-analysis, approximately 22% of the outcomes measured, showed significant differences between the intervention group and the control group. A further 40% showed medium to large non-significant differences favouring the intervention group. Approximately one-third of outcomes showed small non-significant differences or no evidence of effectiveness. A meta-analysis of the follow-up data on three outcomes was also conducted - depression, self-esteem and relationship with spouse/marital adjustment. The results show that there was a continued improvement in self-esteem, depression and marital adjustment at follow-up, although the latter two findings were not statistically significant.</AbstractText>
+ <AbstractText Label="REVIEWER'S CONCLUSIONS" NlmCategory="CONCLUSIONS">It is suggested that parenting programmes can make a significant contribution to short-term psychosocial health in mothers, and that the limited follow-up data available suggest that these are maintained over time. However, the overall paucity of long-term follow-up data points to the need for further evidence concerning the long-term effectiveness of parenting programmes on maternal mental health. Furthermore, it is suggested that some caution should be exercised before the results are generalised to parents irrespective of the level of pathology present, and that further research is still required.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Barlow</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ <AffiliationInfo>
+ <Affiliation>Health Services Research Unit, University of Oxford, Institute of Health Sciences, Old Road, Headington, Oxford, UK, OX3 7LF. esther.coren@public-health.oxford.ac.uk</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Coren</LastName>
+ <ForeName>E</ForeName>
+ <Initials>E</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Cochrane Database Syst Rev</MedlineTA>
+ <NlmUniqueID>100909747</NlmUniqueID>
+ <ISSNLinking>1361-6137</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="UpdateOf">
+ <RefSource>Cochrane Database Syst Rev. 2000;(4):CD002020</RefSource>
+ <PMID Version="1">11034741</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="UpdateIn">
+ <RefSource>Cochrane Database Syst Rev. 2004;(1):CD002020</RefSource>
+ <PMID Version="1">14973981</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008425" MajorTopicYN="N">Maternal Behavior</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008429" MajorTopicYN="N">Maternal Welfare</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009034" MajorTopicYN="Y">Mother-Child Relations</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016487" MajorTopicYN="Y">Parenting</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015397" MajorTopicYN="Y">Program Evaluation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012649" MajorTopicYN="N">Self Concept</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>100</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>6</Month>
+ <Day>19</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>1</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>6</Month>
+ <Day>19</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11406024</ArticleId>
+ <ArticleId IdType="pii">CD002020</ArticleId>
+ <ArticleId IdType="doi">10.1002/14651858.CD002020</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11237011</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>03</Month>
+ <Day>22</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>25</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0028-0836</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>409</Volume>
+ <Issue>6822</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Feb</Month>
+ <Day>15</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Nature</Title>
+ <ISOAbbreviation>Nature</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Initial sequencing and analysis of the human genome.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>860-921</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Lander</LastName>
+ <ForeName>E S</ForeName>
+ <Initials>ES</Initials>
+ <AffiliationInfo>
+ <Affiliation>Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, MA 02142, USA. lander@genome.wi.mit.edu</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Linton</LastName>
+ <ForeName>L M</ForeName>
+ <Initials>LM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Birren</LastName>
+ <ForeName>B</ForeName>
+ <Initials>B</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Nusbaum</LastName>
+ <ForeName>C</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Zody</LastName>
+ <ForeName>M C</ForeName>
+ <Initials>MC</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Baldwin</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Devon</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dewar</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Doyle</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>FitzHugh</LastName>
+ <ForeName>W</ForeName>
+ <Initials>W</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Funke</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Gage</LastName>
+ <ForeName>D</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Harris</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Heaford</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Howland</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kann</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lehoczky</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>LeVine</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>McEwan</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>McKernan</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Meldrim</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Mesirov</LastName>
+ <ForeName>J P</ForeName>
+ <Initials>JP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Miranda</LastName>
+ <ForeName>C</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Morris</LastName>
+ <ForeName>W</ForeName>
+ <Initials>W</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Naylor</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Raymond</LastName>
+ <ForeName>C</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Rosetti</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Santos</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sheridan</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sougnez</LastName>
+ <ForeName>C</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Stange-Thomann</LastName>
+ <ForeName>Y</ForeName>
+ <Initials>Y</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Stojanovic</LastName>
+ <ForeName>N</ForeName>
+ <Initials>N</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Subramanian</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wyman</LastName>
+ <ForeName>D</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Rogers</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sulston</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ainscough</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Beck</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bentley</LastName>
+ <ForeName>D</ForeName>
+ <Initials>D</Initials>
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+ <ArticleId IdType="pubmed">11428848</ArticleId>
+ <ArticleId IdType="doi">10.1053/euhj.2001.2584</ArticleId>
+ <ArticleId IdType="pii">S0195668X01925849</ArticleId>
+ </ArticleIdList>
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+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">11431089</PMID>
+ <DateCompleted>
+ <Year>2005</Year>
+ <Month>06</Month>
+ <Day>08</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2004</Year>
+ <Month>04</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0924-7947</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>7</Volume>
+ <PubDate>
+ <Year>2001</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Archives of gerontology and geriatrics. Supplement</Title>
+ <ISOAbbreviation>Arch Gerontol Geriatr Suppl</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>An investigation on behavioral problems in centenarians.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>375-8</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Tafaro</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Aging Science, Policlinico Umberto I, University La Sapienza, Roma, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cicconetti</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Martella</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tedeschi</LastName>
+ <ForeName>G</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Zannino</LastName>
+ <ForeName>G</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Troisi</LastName>
+ <ForeName>G</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Pastena</LastName>
+ <ForeName>I</ForeName>
+ <Initials>I</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fioravanti</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Marigliano</LastName>
+ <ForeName>V</ForeName>
+ <Initials>V</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
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+ <Country>Ireland</Country>
+ <MedlineTA>Arch Gerontol Geriatr Suppl</MedlineTA>
+ <NlmUniqueID>8911786</NlmUniqueID>
+ <ISSNLinking>0924-7947</ISSNLinking>
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+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>6</Month>
+ <Day>30</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
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+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>6</Month>
+ <Day>30</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>6</Month>
+ <Day>30</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
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+ </History>
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+ <ArticleId IdType="pubmed">11431089</ArticleId>
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+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11441930</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>07</Month>
+ <Day>19</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2015</Year>
+ <Month>11</Month>
+ <Day>19</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0284-186X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>40</Volume>
+ <Issue>2-3</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Acta oncologica (Stockholm, Sweden)</Title>
+ <ISOAbbreviation>Acta Oncol</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Assessment of quality of life during chemotherapy.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>175-84</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Increasingly more aggressive chemotherapy together with expected small differences between treatments with respect to objective endpoints has heightened awareness about the importance of addressing how patients experience and value the impact that treatment has had on their overall life situation. Assessment of a patient's quality of life (QoL) is now conceptually viewed as an important complement to traditional objective evaluation measures. It was therefore considered important to review the basis for the assessment of this endpoint when The Swedish Council of Technology Assessment in Health Care (SBU) performed a systematic overview of chemotherapy effects in several tumour types. The group came to the following conclusions: QoL assessments, mostly by patient self-reporting in questionnaires, have come increasingly into use during the past decade. A number of general, cancer-specific and cancer diagnosis-specific instruments have been developed. There is at present little need for development of new cancer instruments, although specific treatment modalities and tumour types may need new additional modules. A predefined hypothesis should determine the instrument to be used. Since the selection of a QoL instrument in a specific study influences both the results and the conclusions, it is essential to carefully select the instrument or instruments that have the greatest likelihood of identifying relevant differences between treatment alternatives. Interpretation of QoL data is more difficult than interpretation of objective endpoints such as survival time, objective response rates or toxicity. Despite these difficulties, QoL analyses have provided new insights into the advantages and disadvantages of various treatments not provided by traditional end-points. Some palliative treatments seemingly increase patients' QoL despite side-effects or the lack of, or marginal, increases in survival. When using potentially curative chemotherapy, it is not a matter of when the treatment should be started, but rather when it should be concluded. When using less active chemotherapy, the expected small therapeutic gains must be weighed against the QoL costs of using the therapy: does the toxicity and/or the inconvenience of the proposed treatment justify the expected gain? When it is found that the strain on the patient is greater than the effects of the cancer, treatment must be discontinued. It is not possible to determine whether or not the advantages of palliative chemotherapy are worth their costs without knowledge about patients' personal values regarding the influence on factors of relevance for QoL. The mostly used QoL questionnaires do not consider individual preferences, which therefore need to be addressed in the dialogue with the patient. QoL assessment is clearly in need of further methodological improvement before this endpoint can be regarded as fully established with respect to ability to provide unequivocally useful data in clinical trials. The multitude of questionnaires, missing data, lack of pre-study hypotheses of relevant differences between treatments and data multiplicity giving a risk for chance findings are examples of serious methodological problems. Patient response-shifts over time further complicate the interpretation of the data. Thus, QoL data, also from seemingly well-performed clinical trials, have to be interpreted cautiously. The international development during recent years has aimed at creating increased standardization of QoL measures. This has created greater possibilities to compare results from different trials. Hopefully, this also implies that it will be possible to draw firmer conclusions from QoL measurements in recently completed or ongoing trials than has been the case previously. QoL assessments are resource demanding even when short standardized questionnaires are used. Since cancer patients also generally give priority to anticancer effects over toxicity and convenience, QoL assessments in clinical trials are motivated mainly in study settings comparing treatments without expected major differences of outcome in objective endpoints.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Gunnars</LastName>
+ <ForeName>B</ForeName>
+ <Initials>B</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Oncology, University Hospital, Lund, Sweden.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Nygren</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Glimelius</LastName>
+ <ForeName>B</ForeName>
+ <Initials>B</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <CollectiveName>SBU-group. Swedish Council of Technology Assessment in Health Care</CollectiveName>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Acta Oncol</MedlineTA>
+ <NlmUniqueID>8709065</NlmUniqueID>
+ <ISSNLinking>0284-186X</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName>
+ <QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D023381" MajorTopicYN="N">Endpoint Determination</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017063" MajorTopicYN="N">Outcome Assessment (Health Care)</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010166" MajorTopicYN="N">Palliative Care</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017060" MajorTopicYN="N">Patient Satisfaction</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011788" MajorTopicYN="Y">Quality of Life</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>112</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>7</Month>
+ <Day>10</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>7</Month>
+ <Day>20</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>7</Month>
+ <Day>10</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11441930</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11442735</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>04</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0303-6979</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>28</Volume>
+ <Issue>8</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Aug</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal of clinical periodontology</Title>
+ <ISOAbbreviation>J. Clin. Periodontol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>753-61</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="AIM" NlmCategory="OBJECTIVE">In the present 6-month multicentre trial, the outcome of 2 different approaches to non-surgical treatment of chronic periodontitis, both involving the use of a locally delivered controlled-release doxycycline, was evaluated.</AbstractText>
+ <AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">105 adult patients with moderately advanced chronic periodontitis from 3 centres participated in the trial. Each patient had to present with at least 8 periodontal sites in 2 jaw quadrants with a probing pocket depth (PPD) of &gt; or =5 mm and bleeding following pocket probing (BoP), out of which at least 2 sites had to be &gt; or =7 mm and a further 2 sites &gt; or =6 mm. Following a baseline examination, including assessments of plaque, PPD, clinical attachment level (CAL) and BoP, careful instruction in oral hygiene was given. The patients were then randomly assigned to one of two treatment groups: scaling/root planing (SRP) with local analgesia or debridement (supra- and subgingival ultrasonic instrumentation without analgesia). The "SRP" group received a single episode of full-mouth supra-/subgingival scaling and root planing under local analgesia. In addition, at a 3-month recall visit, a full-mouth supra-/subgingival debridement using ultrasonic instrumentation was provided. This was followed by subgingival application of an 8.5% w/w doxycycline polymer at sites with a remaining PPD of &gt; or =5 mm. The patients of the "debridement" group were initially subjected to a 45-minute full-mouth debridement with the use of an ultrasonic instrument and without administration of local analgesia, and followed by application of doxycycline in sites with a PPD of &gt; or =5 mm. At month 3, sites with a remaining PPD of &gt; or =5 mm were subjected to scaling and root planing. Clinical re-examinations were performed at 3 and 6 months.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">At 3 months, the proportion of sites showing PPD of &lt; or =4 mm was significantly higher in the "debridement" group than in the "SRP" group (58% versus 50%; p&lt;0.05). The CAL gain at 3 months amounted to 0.8 mm in the "debridement" group and 0.5 mm in the "SRP" group (p=0.064). The proportion of sites demonstrating a clinically significant CAL gain (&gt; or =2 mm) was higher in the "debridement" group than in the "SRP" group (38% versus 30%; p&lt;0.05). At the 6-month examination, no statistically significant differences in PPD or CAL were found between the two treatment groups. BoP was significantly lower for the "debridement" group than for the "SRP" group (p&lt;0.001) both at 3- and 6 months. The mean total treatment time (baseline and 3-month) for the "SRP" patients was 3:11 h, compared to 2:00 h for the patients in the "debridement" group (p&lt;0.001).</AbstractText>
+ <AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results indicate that simplified subgingival instrumentation combined with local application of doxycycline in deep periodontal sites can be considered as a justified approach for non-surgical treatment of chronic periodontitis.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Wennström</LastName>
+ <ForeName>J L</ForeName>
+ <Initials>JL</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Periodontology, Institute of Odontology, Göteborg University, SE 405 30 Göteborg, Sweden. wennstrom@odontologi.gu.se</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Newman</LastName>
+ <ForeName>H N</ForeName>
+ <Initials>HN</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>MacNeill</LastName>
+ <ForeName>S R</ForeName>
+ <Initials>SR</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Killoy</LastName>
+ <ForeName>W J</ForeName>
+ <Initials>WJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Griffiths</LastName>
+ <ForeName>G S</ForeName>
+ <Initials>GS</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Gillam</LastName>
+ <ForeName>D G</ForeName>
+ <Initials>DG</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Krok</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Needleman</LastName>
+ <ForeName>I G</ForeName>
+ <Initials>IG</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Weiss</LastName>
+ <ForeName>G</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Garrett</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <Language>fre</Language>
+ <Language>ger</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016430">Clinical Trial</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016448">Multicenter Study</PublicationType>
+ <PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Clin Periodontol</MedlineTA>
+ <NlmUniqueID>0425123</NlmUniqueID>
+ <ISSNLinking>0303-6979</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>N12000U13O</RegistryNumber>
+ <NameOfSubstance UI="D004318">Doxycycline</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>D</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="Y">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002985" MajorTopicYN="N">Clinical Protocols</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003362" MajorTopicYN="N">Cost-Benefit Analysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003646" MajorTopicYN="N">Debridement</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012534" MajorTopicYN="N">Dental Scaling</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004318" MajorTopicYN="N">Doxycycline</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="Y">administration &amp; dosage</QualifierName>
+ <QualifierName UI="Q000031" MajorTopicYN="N">analogs &amp; derivatives</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004339" MajorTopicYN="N">Drug Compounding</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005884" MajorTopicYN="N">Gingival Hemorrhage</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010514" MajorTopicYN="N">Periodontal Pocket</DescriptorName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016745" MajorTopicYN="N">Root Planing</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016037" MajorTopicYN="N">Single-Blind Method</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>7</Month>
+ <Day>10</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>5</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>7</Month>
+ <Day>10</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11442735</ArticleId>
+ <ArticleId IdType="pii">cpe280806</ArticleId>
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+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11473127</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>11</Month>
+ <Day>01</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Print">0021-9258</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>276</Volume>
+ <Issue>39</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Sep</Month>
+ <Day>28</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Journal of biological chemistry</Title>
+ <ISOAbbreviation>J. Biol. Chem.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>36520-9</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>We have used the highly selective alpha(4)beta(1) inhibitor 2S-[(1-benzenesulfonyl-pyrrolidine-2S-carbonyl)-amino]-4-[4-methyl-2S-(methyl-[2-[4-(3-o-tolyl-ureido)-phenyl]-acetyl]-amino)-pentanoylamino]-butyric acid (BIO7662) as a model ligand to study alpha(4)beta(1) integrin-ligand interactions on Jurkat cells. Binding of [(35)S]BIO7662 to Jurkat cells was dependent on the presence of divalent cations and could be blocked by treatment with an excess of unlabeled inhibitor or with EDTA. K(D) values for the binding of BIO7662 to Mn(2+)-activated alpha(4)beta(1) and to the nonactivated state of the integrin that exists in 1 mm Mg(2+), 1 mm Ca(2+) were &lt;10 pm, indicating that it has a high affinity for both activated and nonactivated integrin. No binding was observed on alpha(4)beta(1) negative cells. Through an analysis of the metal ion dependences of ligand binding, several unexpected findings about alpha(4)beta(1) function were made. First, we observed that Ca(2+) binding to alpha(4)beta(1) was stimulated by the addition of BIO7662. From solution binding studies on purified alpha(4)beta(1), two types of Ca(2+)-binding sites were identified, one dependent upon and the other independent of BIO7662 binding. Second, we observed that the metal ion dependence of ligand binding was affected by the affinity of the ligand for alpha(4)beta(1). ED(50) values for the metal ion dependence of the binding of BIO7762 and the binding of a lower affinity ligand, BIO1211, differed by 2-fold for Mn(2+), 30-fold for Mg(2+), and &gt;1000-fold for Ca(2+). Low Ca(2+) (ED(50) = 5-10 microm) stimulated the binding of BIO7662 to alpha(4)beta(1). The effects of microm Ca(2+) closely resembled the effects of Mn(2+) on alpha(4)beta(1) function. Third, we observed that the rate of BIO7662 binding was dependent on the metal ion concentration and that the ED(50) for the metal ion dependence of BIO7662 binding was affected by the concentration of the BIO7662. These studies point to an even more complex interplay between metal ion and ligand binding than previously appreciated and provide evidence for a three-component coupled equilibrium model for metal ion-dependent binding of ligands to alpha(4)beta(1).</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Chen</LastName>
+ <ForeName>L L</ForeName>
+ <Initials>LL</Initials>
+ <AffiliationInfo>
+ <Affiliation>Biogen, Inc., Cambridge, Massachusetts 02142, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Whitty</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Scott</LastName>
+ <ForeName>D</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lee</LastName>
+ <ForeName>W C</ForeName>
+ <Initials>WC</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cornebise</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Adams</LastName>
+ <ForeName>S P</ForeName>
+ <Initials>SP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Petter</LastName>
+ <ForeName>R C</ForeName>
+ <Initials>RC</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lobb</LastName>
+ <ForeName>R R</ForeName>
+ <Initials>RR</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Pepinsky</LastName>
+ <ForeName>R B</ForeName>
+ <Initials>RB</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2001</Year>
+ <Month>07</Month>
+ <Day>25</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Biol Chem</MedlineTA>
+ <NlmUniqueID>2985121R</NlmUniqueID>
+ <ISSNLinking>0021-9258</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C438014">2-((1-benzenesulfonylpyrrolidine-2-carbonyl)amino)-4-(4-methyl-2-(methyl-(2-(4-(3-o-tolylureido)phenyl)acetyl)amino)pentanoylamino)butyric acid</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D001565">Benzoates</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D002412">Cations</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D004151">Dipeptides</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D039041">Integrin alpha4beta1</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D016023">Integrins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D007477">Ions</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D008024">Ligands</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D010671">Phenylurea Compounds</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D016201">Receptors, Lymphocyte Homing</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>42Z2K6ZL8P</RegistryNumber>
+ <NameOfSubstance UI="D008345">Manganese</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>9G34HU7RV0</RegistryNumber>
+ <NameOfSubstance UI="D004492">Edetic Acid</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>I38ZP9992A</RegistryNumber>
+ <NameOfSubstance UI="D008274">Magnesium</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>SY7Q814VUP</RegistryNumber>
+ <NameOfSubstance UI="D002118">Calcium</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001565" MajorTopicYN="N">Benzoates</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002118" MajorTopicYN="N">Calcium</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002412" MajorTopicYN="N">Cations</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004151" MajorTopicYN="N">Dipeptides</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004492" MajorTopicYN="N">Edetic Acid</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D039041" MajorTopicYN="N">Integrin alpha4beta1</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016023" MajorTopicYN="N">Integrins</DescriptorName>
+ <QualifierName UI="Q000037" MajorTopicYN="N">antagonists &amp; inhibitors</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007477" MajorTopicYN="Y">Ions</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019169" MajorTopicYN="N">Jurkat Cells</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008024" MajorTopicYN="Y">Ligands</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008274" MajorTopicYN="N">Magnesium</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008345" MajorTopicYN="N">Manganese</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008956" MajorTopicYN="N">Models, Chemical</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010671" MajorTopicYN="N">Phenylurea Compounds</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016201" MajorTopicYN="N">Receptors, Lymphocyte Homing</DescriptorName>
+ <QualifierName UI="Q000037" MajorTopicYN="N">antagonists &amp; inhibitors</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>7</Month>
+ <Day>27</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>11</Month>
+ <Day>3</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>7</Month>
+ <Day>27</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11473127</ArticleId>
+ <ArticleId IdType="doi">10.1074/jbc.M106216200</ArticleId>
+ <ArticleId IdType="pii">M106216200</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11488864</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0905-7161</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>12</Volume>
+ <Issue>4</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Aug</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Clinical oral implants research</Title>
+ <ISOAbbreviation>Clin Oral Implants Res</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Early endosseous integration enhanced by dual acid etching of titanium: a torque removal study in the rabbit.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>350-7</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Textured implant surfaces are thought to enhance endosseous integration. Torque removal forces have been used as a biomechanical measure of anchorage, or endosseous integration, in which the greater forces required to remove implants may be interpreted as an increase in the strength of bony integration. The purpose of this study was to compare the torque resistance to removal of screw-shaped titanium implants having a dual acid-etched surface (Osseotite) with implants having either a machined surface, or a titanium plasma spray surface that exhibited a significantly more complex surface topography. Three custom screw-shaped implant types - machined, dual acid-etched (DAE), and titanium plasma sprayed (TPS) - were used in this study. Each implant surface was characterized by scanning electron microscopy and optical profilometry. One DAE implant was placed into each distal femur of eighteen adult New Zealand White rabbits along with one of the other implant types. Thus, each rabbit received two DAE implants and one each of the machined, or TPS, implants. All implants measured 3.25 mm in diameter x 4.00 mm in length without holes, grooves or slots to resist rotation. Eighteen rabbits were used for reverse torque measurements. Groups of six rabbits were sacrificed following one, two and three month healing periods. Implants were removed by reverse torque rotation with a digital torque-measuring device. Three implants with the machined surface preparation failed to achieve endosseous integration. All other implants were anchored by bone. Mean torque values for machined, DAE and TPS implants at one, two and three months were 6.00+/-0.64 N-cm, 9.07+/-0.67 N-cm and 6.73+/-0.95 N-cm; 21.86+/-1.37 N-cm, 27.63+/-3.41 N-cm and 27.40+/-3.89 N-cm; and 27.48+/-1.61 N-cm, 44.28+/-4.53 N-cm and 59.23+/-3.88 N-cm, respectively. Clearly, at the earliest time point the stability of DAE implants was comparable to that of TPS implants, while that of the machined implants was an order of magnitude lower. The TPS implants increased resistance to reverse torque removal over the three-month period. The results of this study confirm our previous results that demonstrated enhanced bony anchorage to dual acid-etched implants as compared to machined implants. Furthermore, the present results indicate that dual acid etching of titanium enhances early endosseous integration to a level which is comparable to that achieved by the topographically more complex TPS surfaces.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Klokkevold</LastName>
+ <ForeName>P R</ForeName>
+ <Initials>PR</Initials>
+ <AffiliationInfo>
+ <Affiliation>Division of Associated Specialties, Section of Periodontics, UCLA School of Dentistry, Los Angeles, CA 90095, USA. pklok@ucla.edu</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Johnson</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dadgostari</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Caputo</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Davies</LastName>
+ <ForeName>J E</ForeName>
+ <Initials>JE</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Nishimura</LastName>
+ <ForeName>R D</ForeName>
+ <Initials>RD</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <Language>fre</Language>
+ <Language>ger</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D003160">Comparative Study</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Denmark</Country>
+ <MedlineTA>Clin Oral Implants Res</MedlineTA>
+ <NlmUniqueID>9105713</NlmUniqueID>
+ <ISSNLinking>0905-7161</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D020099">Coated Materials, Biocompatible</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D013464">Sulfuric Acids</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>D1JT611TNE</RegistryNumber>
+ <NameOfSubstance UI="D014025">Titanium</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>O40UQP6WCF</RegistryNumber>
+ <NameOfSubstance UI="C033158">sulfuric acid</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>QTT17582CB</RegistryNumber>
+ <NameOfSubstance UI="D006851">Hydrochloric Acid</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>D</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020099" MajorTopicYN="N">Coated Materials, Biocompatible</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003758" MajorTopicYN="N">Dental Implantation, Endosseous</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015921" MajorTopicYN="Y">Dental Implants</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003775" MajorTopicYN="N">Dental Polishing</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017267" MajorTopicYN="Y">Dental Prosthesis Design</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020878" MajorTopicYN="N">Device Removal</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005269" MajorTopicYN="N">Femur</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006851" MajorTopicYN="N">Hydrochloric Acid</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020007" MajorTopicYN="Y">Implants, Experimental</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008669" MajorTopicYN="N">Metallurgy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016348" MajorTopicYN="Y">Osseointegration</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013464" MajorTopicYN="N">Sulfuric Acids</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013499" MajorTopicYN="N">Surface Properties</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014025" MajorTopicYN="Y">Titanium</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019415" MajorTopicYN="N">Torque</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>8</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>26</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>8</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11488864</ArticleId>
+ <ArticleId IdType="pii">clr120409</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11488868</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2012</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0905-7161</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>12</Volume>
+ <Issue>4</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Aug</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Clinical oral implants research</Title>
+ <ISOAbbreviation>Clin Oral Implants Res</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Histology of human alveolar bone regeneration with a porous tricalcium phosphate. A report of two cases.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>379-84</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Porous beta-phase tricalcium phosphate particles (pTCP) (Cerasorb) were used in two patients to restore or augment alveolar bone prior to the placement of dental implants. In one patient, pTCP was used to fill a large alveolar defect in the posterior mandible after the removal of a residual cyst, and in another patient to augment the sinus floor. Biopsies were taken at the time of implant placement, 9.5 and 8 months after grafting, respectively, and processed for hard tissue histology. Goldner-stained histological sections showed considerable replacement of the bone substitute by bone and bone marrow. In the 9.5 months biopsy of the mandible, 34% of the biopsy consisted of mineralised bone tissue and 29% of remaining pTCP, while the biopsy at 8 months after sinus floor augmentation consisted of 20% mineralised bone and 44% remaining pTCP. Bone and osteoid were lying in close contact with the remaining pTCP and were also seen within the micropores of the grafted particles. Tartrate resistant-acid phosphatase (TRAP) multinuclear cells, presumably osteoclasts, were found surrounding, within and in close contact with the pTCP particles, suggesting active resorption of the bone substitute. Remodelling of immature woven bone into mature lamellar bone was also found. No histological signs of inflammation were detected. The limited data presented from these two cases suggest that this graft material, possibly by virtue of its porosity and chemical nature, may be a suitable bone substitute that can biodegrade and be replaced by new mineralising bone tissue.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Zerbo</LastName>
+ <ForeName>I R</ForeName>
+ <Initials>IR</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Oral Cell Biology, ACTA, Vrije Universiteit, Vander Boechorststraat 7, 1081 BT Amsterdam, Netherlands. IR.Zerbo.Ocb.ACTA@med.vu.nl</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bronckers</LastName>
+ <ForeName>A L</ForeName>
+ <Initials>AL</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>de Lange</LastName>
+ <ForeName>G L</ForeName>
+ <Initials>GL</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>van Beek</LastName>
+ <ForeName>G J</ForeName>
+ <Initials>GJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Burger</LastName>
+ <ForeName>E H</ForeName>
+ <Initials>EH</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D002363">Case Reports</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Denmark</Country>
+ <MedlineTA>Clin Oral Implants Res</MedlineTA>
+ <NlmUniqueID>9105713</NlmUniqueID>
+ <ISSNLinking>0905-7161</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D018786">Bone Substitutes</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D002130">Calcium Phosphates</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C485817">beta-tricalcium phosphate</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>K4C08XP666</RegistryNumber>
+ <NameOfSubstance UI="C018392">tricalcium phosphate</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>D</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D020341" MajorTopicYN="N">Absorbable Implants</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000540" MajorTopicYN="N">Alveolar Ridge Augmentation</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001861" MajorTopicYN="N">Bone Regeneration</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018786" MajorTopicYN="N">Bone Substitutes</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002130" MajorTopicYN="N">Calcium Phosphates</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008334" MajorTopicYN="N">Mandible</DescriptorName>
+ <QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008443" MajorTopicYN="N">Maxillary Sinus</DescriptorName>
+ <QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013516" MajorTopicYN="Y">Oral Surgical Procedures, Preprosthetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016062" MajorTopicYN="N">Porosity</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>8</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
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+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>26</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>8</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
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+ <ArticleId IdType="pubmed">11488868</ArticleId>
+ <ArticleId IdType="pii">clr120413</ArticleId>
+ </ArticleIdList>
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+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11520209</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>09</Month>
+ <Day>27</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0022-2623</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>44</Volume>
+ <Issue>18</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Aug</Month>
+ <Day>30</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal of medicinal chemistry</Title>
+ <ISOAbbreviation>J. Med. Chem.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>3001-13</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>This paper describes the synthesis of a series of azo compounds able to deliver 5-aminosalicylic acid (5-ASA) and a potent platelet activating factor (PAF) antagonist in a colon-specific manner for the purpose of treating ulcerative colitis. We found it possible to add an amino group on the aromatic moiety of our reported 1-[(1-acyl-4-piperidyl)methyl]-1H-2-methylimidazo[4,5-c]pyridine derivatives or on British Biotech compounds BB-882 and BB-823 maintaining a high level of activity as PAF antagonist. A selected compound UR-12715 (49c) showed an IC(50) of 8 nM in the in vitro PAF-induced aggregation assay, and an ID(50) of 29 microg/kg in the in vivo PAF-induced hypotension test in normotensive rats. Through attachment of 49c to the 5-ASA via azo functionality we obtained UR-12746 (70). Pharmacokinetics experiments with [14C]-70 allow us to reach the following conclusions, critical in the design of these new prodrugs of 5-ASA. Neither the whole molecule 70 nor the carrier 49c were absorbed after oral administration of [14C]-70 in rat as was demonstrated by the absence of plasma levels of radioactivity and the high recovery of it in feces. Effective cleavage of azo bond (84%) by microflora in the colon is achieved. These facts ensure high topical concentrations of 5-ASA and 49c in the colon. Additionally, 70 exhibited a potent anticolitic effect in the trinitrobenzenesulfonic acid-induced colitis model in the rat. This profile suggests that UR-12746 (70) provides an attractive new approach to the treatment of ulcerative colitis.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Carceller</LastName>
+ <ForeName>E</ForeName>
+ <Initials>E</Initials>
+ <AffiliationInfo>
+ <Affiliation>Research Center, J. Uriach &amp; Cía.S.A., Degà Bahí 59-67, 08026 Barcelona, Spain. chem-carceller@uriach.com</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Salas</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Merlos</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Giral</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ferrando</LastName>
+ <ForeName>R</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Escamilla</LastName>
+ <ForeName>I</ForeName>
+ <Initials>I</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ramis</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>García-Rafanell</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Forn</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Med Chem</MedlineTA>
+ <NlmUniqueID>9716531</NlmUniqueID>
+ <ISSNLinking>0022-2623</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C435198">1-((1-(3-(4-aminophenyl)-3-phenylpropenoyl)-4-piperidyl)methyl)-1H-2-methylimidazo(4,5-c)pyridine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000588">Amines</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000636">Aminosalicylic Acids</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000894">Anti-Inflammatory Agents, Non-Steroidal</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D001372">Aza Compounds</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D001391">Azo Compounds</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D007093">Imidazoles</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D010972">Platelet Activating Factor</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D011355">Prodrugs</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D011725">Pyridines</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C419382">UR 12746</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>4Q81I59GXC</RegistryNumber>
+ <NameOfSubstance UI="D019804">Mesalamine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>8T3HQG2ZC4</RegistryNumber>
+ <NameOfSubstance UI="D014302">Trinitrobenzenesulfonic Acid</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000588" MajorTopicYN="N">Amines</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000636" MajorTopicYN="N">Aminosalicylic Acids</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000894" MajorTopicYN="N">Anti-Inflammatory Agents, Non-Steroidal</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001372" MajorTopicYN="N">Aza Compounds</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001391" MajorTopicYN="N">Azo Compounds</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003093" MajorTopicYN="N">Colitis, Ulcerative</DescriptorName>
+ <QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004353" MajorTopicYN="N">Drug Evaluation, Preclinical</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007022" MajorTopicYN="N">Hypotension</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007093" MajorTopicYN="N">Imidazoles</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019804" MajorTopicYN="N">Mesalamine</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010972" MajorTopicYN="N">Platelet Activating Factor</DescriptorName>
+ <QualifierName UI="Q000037" MajorTopicYN="Y">antagonists &amp; inhibitors</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010974" MajorTopicYN="N">Platelet Aggregation</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011355" MajorTopicYN="N">Prodrugs</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011725" MajorTopicYN="N">Pyridines</DescriptorName>
+ <QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013237" MajorTopicYN="N">Stereoisomerism</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014302" MajorTopicYN="N">Trinitrobenzenesulfonic Acid</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>25</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>28</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>25</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11520209</ArticleId>
+ <ArticleId IdType="pii">jm010852p</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11524736</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>12</Month>
+ <Day>12</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>11</Month>
+ <Day>24</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1098-1004</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>18</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Sep</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Human mutation</Title>
+ <ISOAbbreviation>Hum. Mutat.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Detection of six novel FBN1 mutations in British patients affected by Marfan syndrome.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>251</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Marfan syndrome (MFS), an autosomal dominant disorder of the extracellular matrix, is due to mutations in fibrillin-1 (FBN1) gene. Investigations carried out in the last decade, unveiled the unpredictability of the site of the mutation, which could be anywhere in the gene. FBN1 mutations have been reported in a spectrum of diseases related to MFS, with no clear evidence for a phenotype-genotype correlation. In this paper we analysed 10 British patients affected by MFS and we were able to characterise five novel missense mutations (C474W, C1402Y, G1987R, C2153Y, G2536R), one novel frameshift mutation (7926delC), one already described mutation (P1424A) and one FBN1 variant (P1148A) classified as a polymorphism in the Asian population. Four out of the five novel missense mutations involved either cysteines or an amino acid conserved in the domain structure. The mutation yield in this study is calculated at 80.0% (8/10), thus indicating that SSCA is a reliable and cost-effective technique for the screening of such a large gene. Our results suggest that this method is reliable to search for FBN1 mutations and that FBN1 screening could be a helpful tool to confirm and possibly anticipate the clinical diagnosis in familial cases. Hum Mutat 18:251, 2001.</AbstractText>
+ <CopyrightInformation>Copyright 2001 Wiley-Liss, Inc.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Comeglio</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK. p.comeglio@sghms.ac.uk</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Evans</LastName>
+ <ForeName>A L</ForeName>
+ <Initials>AL</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Brice</LastName>
+ <ForeName>G W</ForeName>
+ <Initials>GW</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Child</LastName>
+ <ForeName>A H</ForeName>
+ <Initials>AH</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Hum Mutat</MedlineTA>
+ <NlmUniqueID>9215429</NlmUniqueID>
+ <ISSNLinking>1059-7794</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C000605722">FBN1 protein, human</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000071838">Fibrillin-1</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000071837">Fibrillins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D008840">Microfilament Proteins</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="RepublishedIn">
+ <RefSource>Hum Mutat. 2001 Dec;18(6):546-7</RefSource>
+ <PMID Version="1">11748851</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000071838" MajorTopicYN="N">Fibrillin-1</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000071837" MajorTopicYN="N">Fibrillins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016368" MajorTopicYN="N">Frameshift Mutation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008382" MajorTopicYN="N">Marfan Syndrome</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008840" MajorTopicYN="N">Microfilament Proteins</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020125" MajorTopicYN="N">Mutation, Missense</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017384" MajorTopicYN="N">Sequence Deletion</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006113" MajorTopicYN="N">United Kingdom</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>29</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>1</Month>
+ <Day>5</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>29</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11524736</ArticleId>
+ <ArticleId IdType="pii">10.1002/humu.1181</ArticleId>
+ <ArticleId IdType="doi">10.1002/humu.1181</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11525160</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
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+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>30</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0250-5525</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>124</Volume>
+ <PubDate>
+ <Year>2000</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Schweizerische medizinische Wochenschrift. Supplementum</Title>
+ <ISOAbbreviation>Schweiz Med Wochenschr Suppl</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>32nd Annual meeting of the Swiss Society of Nephrology. Lausanne, 14-15 December 2000. Abstracts.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1S-20S</MedlinePgn>
+ </Pagination>
+ <Language>eng</Language>
+ <Language>fre</Language>
+ <Language>ger</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016423">Congress</PublicationType>
+ <PublicationType UI="D016424">Overall</PublicationType>
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+ <Country>Switzerland</Country>
+ <MedlineTA>Schweiz Med Wochenschr Suppl</MedlineTA>
+ <NlmUniqueID>7708316</NlmUniqueID>
+ <ISSNLinking>0250-5525</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007674" MajorTopicYN="Y">Kidney Diseases</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009398" MajorTopicYN="Y">Nephrology</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>8</Month>
+ <Day>30</Day>
+ <Hour>10</Hour>
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+ <PubMedPubDate PubStatus="medline">
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+ <Day>31</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
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+ <PubMedPubDate PubStatus="entrez">
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+ <Month>8</Month>
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+ <PMID Version="1">11537092</PMID>
+ <DateCompleted>
+ <Year>1995</Year>
+ <Month>06</Month>
+ <Day>16</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0033-183X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>163</Volume>
+ <PubDate>
+ <Year>1991</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Protoplasma</Title>
+ <ISOAbbreviation>Protoplasma</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Cytoplasmic calcium levels in protoplasts from the cap and elongation zone of maize roots.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>181-8</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Calcium has been implicated as a key component in the signal transduction process of root gravitropism. We measured cytoplasmic free calcium in protoplasts isolated from the elongation zone and cap of primary roots of light-grown, vertically oriented seedlings of Zea mays L. Protoplasts were loaded with the penta-potassium salts of fura-2 and indo-1 by incubation in acidic solutions of these calcium indicators. Loading increased with decreasing pH but the pH dependence was stronger for indo-1 than for fura-2. In the case of fura-2, loading was enhanced only at the lowest pH (4.5) tested. Dyes loaded in this manner were distributed predominantly in the cytoplasm as indicated by fluorescence patterns. As an alternative method of loading, protoplasts were incubated with the acetoxymethylesters of fura-2 and indo-1. Protoplasts loaded by this method exhibited fluorescence both in the cytoplasm and in association with various organelles. Cytoplasmic calcium levels measured using spectrofluorometry, were found to be 160 +/- 40 nM and 257 +/- 27 nM, respectively, in populations of protoplasts from the root cap and elongation zone. Cytoplasmic free calcium did not increase upon addition of calcium to the incubation medium, indicating that the passive permeability to calcium was low.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Kiss</LastName>
+ <ForeName>H G</ForeName>
+ <Initials>HG</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Plant Biology, Ohio State University, Columbus.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Evans</LastName>
+ <ForeName>M L</ForeName>
+ <Initials>ML</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Johnson</LastName>
+ <ForeName>J D</ForeName>
+ <Initials>JD</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <GrantList CompleteYN="Y">
+ <Grant>
+ <GrantID>DMB 8608673</GrantID>
+ <Acronym>MB</Acronym>
+ <Agency>BHP HRSA HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ </GrantList>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Austria</Country>
+ <MedlineTA>Protoplasma</MedlineTA>
+ <NlmUniqueID>9806853</NlmUniqueID>
+ <ISSNLinking>0033-183X</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D005456">Fluorescent Dyes</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D007211">Indoles</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>N18RMK75W1</RegistryNumber>
+ <NameOfSubstance UI="C048960">indo-1</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>SY7Q814VUP</RegistryNumber>
+ <NameOfSubstance UI="D002118">Calcium</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>TSN3DL106G</RegistryNumber>
+ <NameOfSubstance UI="D016257">Fura-2</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>S</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D002118" MajorTopicYN="N">Calcium</DescriptorName>
+ <QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003593" MajorTopicYN="N">Cytoplasm</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005456" MajorTopicYN="N">Fluorescent Dyes</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016257" MajorTopicYN="N">Fura-2</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018522" MajorTopicYN="N">Gravitropism</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018466" MajorTopicYN="N">Gravity Sensing</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007211" MajorTopicYN="N">Indoles</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018518" MajorTopicYN="N">Plant Root Cap</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
+ <QualifierName UI="Q000254" MajorTopicYN="N">growth &amp; development</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018517" MajorTopicYN="N">Plant Roots</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
+ <QualifierName UI="Q000254" MajorTopicYN="Y">growth &amp; development</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011523" MajorTopicYN="N">Protoplasts</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003313" MajorTopicYN="N">Zea mays</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
+ <QualifierName UI="Q000254" MajorTopicYN="N">growth &amp; development</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="NASA">00015446</OtherID>
+ <KeywordList Owner="NASA">
+ <Keyword MajorTopicYN="N">NASA Discipline Number 40-50</Keyword>
+ <Keyword MajorTopicYN="N">NASA Discipline Plant Biology</Keyword>
+ <Keyword MajorTopicYN="N">NASA Program Space Biology</Keyword>
+ <Keyword MajorTopicYN="N">Non-NASA Center</Keyword>
+ </KeywordList>
+ <InvestigatorList>
+ <Investigator ValidYN="Y">
+ <LastName>Evans</LastName>
+ <ForeName>M L</ForeName>
+ <Initials>ML</Initials>
+ <AffiliationInfo>
+ <Affiliation>Ohio St U, Columbus, Dept Physiological Chemistry</Affiliation>
+ </AffiliationInfo>
+ </Investigator>
+ </InvestigatorList>
+ <GeneralNote Owner="NASA">Grant numbers: NAGW 297</GeneralNote>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1991</Year>
+ <Month>1</Month>
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+ <Hour>10</Hour>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>1991</Year>
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+ <Citation>Plant Physiol. 1990;92:792-6</Citation>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11537998</ArticleId>
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+ </Reference>
+ <Reference>
+ <Citation>Plant Physiol. 1988;87:803-5</Citation>
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+ <ArticleId IdType="pubmed">11537876</ArticleId>
+ </ArticleIdList>
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+ <Reference>
+ <Citation>Plant Physiol. 1989;89:875-8</Citation>
+ <ArticleIdList>
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+ </Reference>
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+ </Reference>
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+ </Reference>
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+ </ArticleIdList>
+ </Reference>
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+ <Citation>Planta. 1984;160:536-43</Citation>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>Plant Physiol. 1988;86:885-9</Citation>
+ <ArticleIdList>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>Plant Physiol. 1990 Jul;93(3):841-5</Citation>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
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+ <ArticleIdList>
+ <ArticleId IdType="pubmed">17730651</ArticleId>
+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>CRC Crit Rev Plant Sci. 1987;6(1):47-103</Citation>
+ <ArticleIdList>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
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+ <Citation>Plant Physiol. 1989 Jun;90(2):482-91</Citation>
+ <ArticleIdList>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>Planta. 1988 Dec;174(4):495-9</Citation>
+ <ArticleIdList>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
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+ <ArticleIdList>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>Sci Am. 1986 Dec;255(6):112-9</Citation>
+ <ArticleIdList>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
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+ <ArticleIdList>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>Plant Physiol. 1981 Aug;68(2):435-8</Citation>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>Plant Physiol. 1984 Oct;76(2):342-6</Citation>
+ <ArticleIdList>
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+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>Nature. 1990 Jun 7;345:528-30</Citation>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11540625</ArticleId>
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+ </PubmedData>
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+ <MedlineCitation Status="MEDLINE" Owner="NASA">
+ <PMID Version="1">11540070</PMID>
+ <DateCompleted>
+ <Year>1995</Year>
+ <Month>12</Month>
+ <Day>11</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0735-2689</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>6</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1987</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Critical reviews in plant sciences</Title>
+ <ISOAbbreviation>CRC Crit Rev Plant Sci</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Calcium messenger system in plants.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>47-103</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Poovaiah</LastName>
+ <ForeName>B W</ForeName>
+ <Initials>BW</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Horticulture, Washington State University, Pullman, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Reddy</LastName>
+ <ForeName>A S</ForeName>
+ <Initials>AS</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <GrantList CompleteYN="Y">
+ <Grant>
+ <GrantID>DCB-8502215</GrantID>
+ <Acronym>DC</Acronym>
+ <Agency>NIDCD NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ </GrantList>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
+ <PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>CRC Crit Rev Plant Sci</MedlineTA>
+ <NlmUniqueID>9889759</NlmUniqueID>
+ <ISSNLinking>0735-2689</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D002135">Calcium-Binding Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D002147">Calmodulin</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D010937">Plant Growth Regulators</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 2.7.11.17</RegistryNumber>
+ <NameOfSubstance UI="D017871">Calcium-Calmodulin-Dependent Protein Kinases</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>SY7Q814VUP</RegistryNumber>
+ <NameOfSubstance UI="D002118">Calcium</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>S</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002118" MajorTopicYN="N">Calcium</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002135" MajorTopicYN="N">Calcium-Binding Proteins</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017871" MajorTopicYN="N">Calcium-Calmodulin-Dependent Protein Kinases</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002147" MajorTopicYN="N">Calmodulin</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018506" MajorTopicYN="Y">Gene Expression Regulation, Plant</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018522" MajorTopicYN="N">Gravitropism</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D059828" MajorTopicYN="N">Plant Cells</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010937" MajorTopicYN="N">Plant Growth Regulators</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018521" MajorTopicYN="Y">Plant Physiological Phenomena</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010944" MajorTopicYN="N">Plants</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015290" MajorTopicYN="Y">Second Messenger Systems</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>363</NumberOfReferences>
+ <OtherID Source="NASA">00012050</OtherID>
+ <OtherAbstract Type="NASA" Language="eng">
+ <AbstractText>The purpose of this review is to delineate the ubiquitous and pivotal role of Ca2+ in diverse physiological processes. Emphasis will be given to the role of Ca2+ in stimulus-response coupling. In addition to reviewing the present status of research, our intention is to critically evaluate the existing data and describe the newly developing areas of Ca2+ research in plants.</AbstractText>
+ </OtherAbstract>
+ <KeywordList Owner="NASA">
+ <Keyword MajorTopicYN="N">NASA Discipline Number 40-30</Keyword>
+ <Keyword MajorTopicYN="N">NASA Discipline Plant Biology</Keyword>
+ <Keyword MajorTopicYN="N">NASA Program Space Biology</Keyword>
+ <Keyword MajorTopicYN="N">Non-NASA Center</Keyword>
+ </KeywordList>
+ <InvestigatorList>
+ <Investigator ValidYN="Y">
+ <LastName>Poovaiah</LastName>
+ <ForeName>B W</ForeName>
+ <Initials>BW</Initials>
+ <AffiliationInfo>
+ <Affiliation>WA St U, Pullman, Dept Horticulture</Affiliation>
+ </AffiliationInfo>
+ </Investigator>
+ </InvestigatorList>
+ <GeneralNote Owner="NASA">Grant numbers: NAG-10-0032</GeneralNote>
+ </MedlineCitation>
+ <PubmedData>
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+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1987</Year>
+ <Month>1</Month>
+ <Day>1</Day>
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+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>11</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>1987</Year>
+ <Month>1</Month>
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+ <ArticleId IdType="doi">10.1080/07352688709382247</ArticleId>
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+ </PubmedArticle>
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+ <Year>2001</Year>
+ <Month>09</Month>
+ <Day>27</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2011</Year>
+ <Month>11</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0198-8859</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>62</Volume>
+ <Issue>9</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Sep</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Human immunology</Title>
+ <ISOAbbreviation>Hum. Immunol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>The origin of Palestinians and their genetic relatedness with other Mediterranean populations.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>889-900</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The genetic profile of Palestinians has, for the first time, been studied by using human leukocyte antigen (HLA) gene variability and haplotypes. The comparison with other Mediterranean populations by using neighbor-joining dendrograms and correspondence analyses reveal that Palestinians are genetically very close to Jews and other Middle East populations, including Turks (Anatolians), Lebanese, Egyptians, Armenians, and Iranians. Archaeologic and genetic data support that both Jews and Palestinians came from the ancient Canaanites, who extensively mixed with Egyptians, Mesopotamian, and Anatolian peoples in ancient times. Thus, Palestinian-Jewish rivalry is based in cultural and religious, but not in genetic, differences. The relatively close relatedness of both Jews and Palestinians to western Mediterranean populations reflects the continuous circum-Mediterranean cultural and gene flow that have occurred in prehistoric and historic times. This flow overtly contradicts the demic diffusion model of western Mediterranean populations substitution by agriculturalists coming from the Middle East in the Mesolithic-Neolithic transition.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Arnaiz-Villena</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid, Spain. aarnaiz@eucmax.sim.ucm.es</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Elaiwa</LastName>
+ <ForeName>N</ForeName>
+ <Initials>N</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Silvera</LastName>
+ <ForeName>C</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Rostom</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Moscoso</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Gómez-Casado</LastName>
+ <ForeName>E</ForeName>
+ <Initials>E</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Allende</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Varela</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Martínez-Laso</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D003160">Comparative Study</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ <PublicationType UI="D016441">Retracted Publication</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Hum Immunol</MedlineTA>
+ <NlmUniqueID>8010936</NlmUniqueID>
+ <ISSNLinking>0198-8859</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D006680">HLA Antigens</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D015234">HLA-A Antigens</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D015235">HLA-B Antigens</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D006683">HLA-DQ Antigens</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D059866">HLA-DQ beta-Chains</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C069051">HLA-DQB1 antigen</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D006684">HLA-DR Antigens</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D059811">HLA-DRB1 Chains</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Hum Immunol. 2001 Oct;62(10):1064</RefSource>
+ <PMID Version="1">11600211</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="RetractionIn">
+ <RefSource>Suciu-Foca N, Lewis R. Hum Immunol. 2001 Oct;62(10):1063</RefSource>
+ <PMID Version="1">11600210</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018912" MajorTopicYN="N">Arabs</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006115" MajorTopicYN="N" Type="Geographic">Greece</DescriptorName>
+ <QualifierName UI="Q000208" MajorTopicYN="N">ethnology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006680" MajorTopicYN="N">HLA Antigens</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015234" MajorTopicYN="N">HLA-A Antigens</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015235" MajorTopicYN="N">HLA-B Antigens</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006683" MajorTopicYN="N">HLA-DQ Antigens</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D059866" MajorTopicYN="N">HLA-DQ beta-Chains</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006684" MajorTopicYN="N">HLA-DR Antigens</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D059811" MajorTopicYN="N">HLA-DRB1 Chains</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006239" MajorTopicYN="N">Haplotypes</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007514" MajorTopicYN="N">Islam</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007557" MajorTopicYN="N" Type="Geographic">Israel</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007585" MajorTopicYN="N">Jews</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015810" MajorTopicYN="N">Linkage Disequilibrium</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019083" MajorTopicYN="N" Type="Geographic">Mediterranean Region</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008877" MajorTopicYN="N" Type="Geographic">Middle East</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>7</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>28</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>7</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11543891</ArticleId>
+ <ArticleId IdType="pii">S0198885901002889</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11562649</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>02</Month>
+ <Day>22</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2014</Year>
+ <Month>11</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0891-5245</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>15</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <MedlineDate>2001 Sep-Oct</MedlineDate>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates &amp; Practitioners</Title>
+ <ISOAbbreviation>J Pediatr Health Care</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Educating parents about normal stool pattern changes in infants.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>269-74</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Arias</LastName>
+ <ForeName>A</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Pediatric Nurse Practitioner Program at Ohio State University College of Nursing, Columbus, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bennison</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Justus</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Thurman</LastName>
+ <ForeName>D</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Pediatr Health Care</MedlineTA>
+ <NlmUniqueID>8709735</NlmUniqueID>
+ <ISSNLinking>0891-5245</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>N</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="SummaryForPatientsIn">
+ <RefSource>J Pediatr Health Care. 2001 Sep-Oct;15(5):270-1</RefSource>
+ <PMID Version="1">11858131</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003258" MajorTopicYN="N">Consumer Behavior</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003672" MajorTopicYN="Y">Defecation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005243" MajorTopicYN="Y">Feces</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006266" MajorTopicYN="N">Health Education</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009820" MajorTopicYN="N" Type="Geographic">Ohio</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016487" MajorTopicYN="Y">Parenting</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>13</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>20</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>2</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>20</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11562649</ArticleId>
+ <ArticleId IdType="pii">S0891-5245(01)91970-4</ArticleId>
+ <ArticleId IdType="doi">10.1067/mph.2000.118432</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">11567133</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>04</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2007</Year>
+ <Month>03</Month>
+ <Day>19</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0036-8075</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>293</Volume>
+ <Issue>5538</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Sep</Month>
+ <Day>21</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Science (New York, N.Y.)</Title>
+ <ISOAbbreviation>Science</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Changes in seismic anisotropy after volcanic eruptions: evidence from Mount Ruapehu.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>2231-3</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The eruptions of andesite volcanoes are explosively catastrophic and notoriously difficult to predict. Yet changes in shear waveforms observed after an eruption of Mount Ruapehu, New Zealand, suggest that forces generated by such volcanoes are powerful and dynamic enough to locally overprint the regional stress regime, which suggests a new method of monitoring volcanoes for future eruptions. These results show a change in shear-wave polarization with time and are interpreted as being due to a localized stress regime caused by the volcano, with a release in pressure after the eruption.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Miller</LastName>
+ <ForeName>V</ForeName>
+ <Initials>V</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Geophysics, Victoria University of Wellington, Wellington, New Zealand.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Savage</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Science</MedlineTA>
+ <NlmUniqueID>0404511</NlmUniqueID>
+ <ISSNLinking>0036-8075</ISSNLinking>
+ </MedlineJournalInfo>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>22</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>22</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>9</Month>
+ <Day>22</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11567133</ArticleId>
+ <ArticleId IdType="doi">10.1126/science.1063463</ArticleId>
+ <ArticleId IdType="pii">293/5538/2231</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11580607</PMID>
+ <DateCompleted>
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Print">0031-9007</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>87</Volume>
+ <Issue>13</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Sep</Month>
+ <Day>24</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Physical review letters</Title>
+ <ISOAbbreviation>Phys. Rev. Lett.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Maximal height scaling of kinetically growing surfaces.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>136101</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The scaling properties of the maximal height of a growing self-affine surface with a lateral extent L are considered. In the late-time regime its value measured relative to the evolving average height scales like the roughness: h*(L) approximately L alpha. For large values its distribution obeys logP(h*(L)) approximately (-)A(h*(L)/L(alpha))(a). In the early-time regime where the roughness grows as t(beta), we find h*(L) approximately t(beta)[lnL-(beta/alpha)lnt+C](1/b), where either b = a or b is the corresponding exponent of the velocity distribution. These properties are derived from scaling and extreme-value arguments. They are corroborated by numerical simulations and supported by exact results for surfaces in 1D with the asymptotic behavior of a Brownian path.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Raychaudhuri</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cranston</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Przybyla</LastName>
+ <ForeName>C</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Shapir</LastName>
+ <ForeName>Y</ForeName>
+ <Initials>Y</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2001</Year>
+ <Month>09</Month>
+ <Day>05</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Phys Rev Lett</MedlineTA>
+ <NlmUniqueID>0401141</NlmUniqueID>
+ <ISSNLinking>0031-9007</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001419" MajorTopicYN="N">Bacteria</DescriptorName>
+ <QualifierName UI="Q000254" MajorTopicYN="N">growth &amp; development</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003460" MajorTopicYN="N">Crystallization</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008962" MajorTopicYN="Y">Models, Theoretical</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013499" MajorTopicYN="N">Surface Properties</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>2001</Year>
+ <Month>05</Month>
+ <Day>07</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>3</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>26</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2001</Year>
+ <Month>10</Month>
+ <Day>3</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11580607</ArticleId>
+ <ArticleId IdType="doi">10.1103/PhysRevLett.87.136101</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11600210</PMID>
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+ <DescriptorName UI="D016462" MajorTopicYN="N">Mammaplasty</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
+ <QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
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+ <DescriptorName UI="D008408" MajorTopicYN="N">Mastectomy</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
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+ <ISSN IssnType="Print">8756-2057</ISSN>
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+ <Title>Reporter on human reproduction and the law</Title>
+ <ISOAbbreviation>Report Hum Reprod Law</ISOAbbreviation>
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+ <ArticleTitle>The dilemma of the Webster decision: deconstitutionalizing the trimester system.</ArticleTitle>
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+ <LastName>Kindregan</LastName>
+ <ForeName>Charles P</ForeName>
+ <Initials>CP</Initials>
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+ <Language>eng</Language>
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+ <DescriptorName UI="D000025" MajorTopicYN="N">Abortion, Eugenic</DescriptorName>
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+ <DescriptorName UI="D000028" MajorTopicYN="Y">Abortion, Induced</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D000032" MajorTopicYN="N">Abortion, Therapeutic</DescriptorName>
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+ <DescriptorName UI="D033421" MajorTopicYN="N">Beginning of Human Life</DescriptorName>
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+ <DescriptorName UI="D002961" MajorTopicYN="N">Civil Rights</DescriptorName>
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+ <DescriptorName UI="D005328" MajorTopicYN="Y">Fetal Viability</DescriptorName>
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+ <DescriptorName UI="D005333" MajorTopicYN="N">Fetus</DescriptorName>
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+ <DescriptorName UI="D033161" MajorTopicYN="Y">Government Regulation</DescriptorName>
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+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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+ <DescriptorName UI="D007391" MajorTopicYN="N">International Cooperation</DescriptorName>
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+ <DescriptorName UI="D038622" MajorTopicYN="N">Internationality</DescriptorName>
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+ <DescriptorName UI="D007603" MajorTopicYN="Y">Jurisprudence</DescriptorName>
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+ <DescriptorName UI="D007878" MajorTopicYN="Y">Legislation as Topic</DescriptorName>
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+ <Keyword MajorTopicYN="N">Genetics and Reproduction</Keyword>
+ <Keyword MajorTopicYN="N">Legal Approach</Keyword>
+ <Keyword MajorTopicYN="Y">Roe v. Wade</Keyword>
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+ <GeneralNote Owner="KIE">63 fn.</GeneralNote>
+ <GeneralNote Owner="KIE">KIE BoB Subject Heading: abortion/legal aspects</GeneralNote>
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+ <Year>2018</Year>
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+ <ISSN IssnType="Print">0031-7012</ISSN>
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+ <Volume>64</Volume>
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+ <Month>Jan</Month>
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+ <Title>Pharmacology</Title>
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+ <ArticleTitle>Progress in the search for ideal drugs.</ArticleTitle>
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+ <AbstractText>The search for ideal drugs to improve patient care requires applications of modern scientific methods to both discovery and development. Using these modern methods, the pharmaceutical industry with strong academic and government collaboration has introduced in the last 25 years many new drugs that approach the ideal. After reviewing Björnsson's classification of drug action and the notion of contributory causality, this commentary defines an ideal drug from the perspectives of pharmacodynamics, pharmacokinetics, and therapeutics. Examples of new drugs for hypertension, heart disease, stroke, osteoporosis, asthma, ulcer, and migraine headaches are described. Finally, the profound implications of progress in developing ideal drugs not only for the patient but also for the academic, educational, and regulatory establishments are briefly reviewed.</AbstractText>
+ <CopyrightInformation>Copyright 2002 S. Karger AG, Basel</CopyrightInformation>
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+ <LastName>Spector</LastName>
+ <ForeName>Reynold</ForeName>
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+ <Affiliation>Department of Medicine, Robert Wood Johnson Medical School, Piscataway, NJ, USA.</Affiliation>
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+ <ISSN IssnType="Print">0028-4793</ISSN>
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+ <Title>The New England journal of medicine</Title>
+ <ISOAbbreviation>N. Engl. J. Med.</ISOAbbreviation>
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+ <ArticleTitle>Recognition and management of anthrax--an update.</ArticleTitle>
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+ <RefSource>N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5</RefSource>
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+ <RefSource>N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5</RefSource>
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+ <RefSource>N Engl J Med 2002 Feb 21;346(8):634</RefSource>
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+ <RefSource>N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5</RefSource>
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+ <DescriptorName UI="D000881" MajorTopicYN="Y">Anthrax</DescriptorName>
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+ <QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
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+ <DescriptorName UI="D017053" MajorTopicYN="N">Infection Control</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
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+ <DescriptorName UI="D016920" MajorTopicYN="N">Meningitis, Bacterial</DescriptorName>
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+ <DescriptorName UI="D010406" MajorTopicYN="N">Penicillins</DescriptorName>
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+ <DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName>
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+ <Title>Malpractice digest</Title>
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+ <LastName>Bower</LastName>
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+ <DescriptorName UI="D032962" MajorTopicYN="N">Consent Forms</DescriptorName>
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+ <Volume>120</Volume>
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+ <Month>Feb</Month>
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+ <Title>Archives of ophthalmology (Chicago, Ill. : 1960)</Title>
+ <ISOAbbreviation>Arch. Ophthalmol.</ISOAbbreviation>
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+ <ArticleTitle>Republication of color figures.</ArticleTitle>
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+ <Author ValidYN="Y">
+ <LastName>Dushku</LastName>
+ <ForeName>Nicholas</ForeName>
+ <Initials>N</Initials>
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+ <Author ValidYN="Y">
+ <LastName>John</LastName>
+ <ForeName>Molykutty K</ForeName>
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+ <LastName>Schultz</LastName>
+ <ForeName>Gregory S</ForeName>
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+ <LastName>Reid</LastName>
+ <ForeName>Ted W</ForeName>
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+ <MedlineTA>Arch Ophthalmol</MedlineTA>
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+ <ISSNLinking>0003-9950</ISSNLinking>
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+ <NameOfSubstance UI="D020782">Matrix Metalloproteinases</NameOfSubstance>
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+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
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+ <CommentsCorrections RefType="CommentOn">
+ <RefSource>Arch Ophthalmol. 2001 May;119(5):695-706</RefSource>
+ <PMID Version="1">11346397</PMID>
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+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName>
+ <QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName>
+ <QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007124" MajorTopicYN="N">Immunoenzyme Techniques</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016850" MajorTopicYN="N">Limbus Corneae</DescriptorName>
+ <QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020782" MajorTopicYN="N">Matrix Metalloproteinases</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011625" MajorTopicYN="N">Pterygium</DescriptorName>
+ <QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
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+ <Month>03</Month>
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+ <DateRevised>
+ <Year>2016</Year>
+ <Month>11</Month>
+ <Day>24</Day>
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+ <Journal>
+ <ISSN IssnType="Electronic">1098-1004</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>18</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Dec</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Human mutation</Title>
+ <ISOAbbreviation>Hum. Mutat.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Erratum: Detection of six novel FBN1 mutations in British patients affected by Marfan syndrome.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>546-7</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Marfan syndrome (MFS), an autosomal dominant disorder of the extracellular matrix, is due to mutations in fibrillin-1 (FBN1) gene. Investigations carried out in the last decade, unveiled the unpredictability of the site of the mutation, which could be anywhere in the gene. FBN1 mutations have been reported in a spectrum of diseases related to MFS, with no clear evidence for a phenotype-genotype correlation. In this paper we analysed 10 British patients affected by MFS and we were able to characterise five novel missense mutations (C474W, C1402Y, G1987R, C2153Y, G2536R), one novel frameshift mutation (7926delC), one already described mutation (P1424A) and one FBN1 variant (P1148A) classified as a polymorphism in the Asian population. Four out of the five novel missense mutations involved either cysteines or an amino acid conserved in the domain structure. The mutation yield in this study is calculated at 80.0% (8/10), thus indicating that SSCA is a reliable and cost-effective technique for the screening of such a large gene. Our results suggest that this method is reliable to search for FBN1 mutations and that FBN1 screening could be a helpful tool to confirm and possibly anticipate the clinical diagnosis in familial cases.</AbstractText>
+ <CopyrightInformation>Copyright 2001 Wiley-Liss, Inc.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Comeglio</LastName>
+ <ForeName>P</ForeName>
+ <Initials>P</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK. p.comeglio@sghms.ac.uk</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Evans</LastName>
+ <ForeName>A L</ForeName>
+ <Initials>AL</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Brice</LastName>
+ <ForeName>G W</ForeName>
+ <Initials>GW</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Child</LastName>
+ <ForeName>A H</ForeName>
+ <Initials>AH</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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+ </Article>
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+ <Country>United States</Country>
+ <MedlineTA>Hum Mutat</MedlineTA>
+ <NlmUniqueID>9215429</NlmUniqueID>
+ <ISSNLinking>1059-7794</ISSNLinking>
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+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C000605722">FBN1 protein, human</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000071838">Fibrillin-1</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000071837">Fibrillins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D008840">Microfilament Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>9007-49-2</RegistryNumber>
+ <NameOfSubstance UI="D004247">DNA</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="RepublishedFrom">
+ <RefSource>Hum Mutat. 2001 Sep;18(3):251</RefSource>
+ <PMID Version="1">11524736</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004252" MajorTopicYN="N">DNA Mutational Analysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000071838" MajorTopicYN="N">Fibrillin-1</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000071837" MajorTopicYN="N">Fibrillins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016368" MajorTopicYN="N">Frameshift Mutation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008382" MajorTopicYN="N">Marfan Syndrome</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008840" MajorTopicYN="N">Microfilament Proteins</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D020125" MajorTopicYN="N">Mutation, Missense</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018807" MajorTopicYN="N">Polymorphism, Single-Stranded Conformational</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006113" MajorTopicYN="N">United Kingdom</DescriptorName>
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+ <Year>2002</Year>
+ <Month>3</Month>
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+ <ArticleId IdType="pii">10.1002/humu.1235</ArticleId>
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+ <Year>2002</Year>
+ <Month>03</Month>
+ <Day>07</Day>
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+ <Year>2016</Year>
+ <Month>11</Month>
+ <Day>24</Day>
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+ <Journal>
+ <ISSN IssnType="Electronic">1098-1004</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>18</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Dec</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Human mutation</Title>
+ <ISOAbbreviation>Hum. Mutat.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Eight novel germline MLH1 and MSH2 mutations in hereditary non-polyposis colorectal cancer families from Spain.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>549</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Germline mutations in the MLH1 and MSH2 genes, account for the majority of HNPCC families. We have screened such families from Spain by using DGGE analysis and subsequent direct sequencing techniques. In eight families we identified six novel MLH1 and two novel MSH2 mutations comprising one frame shift mutation (c.1420 del C), two missense mutations (L622H and R687W), two splice site mutations (c.1990-1 G&gt;A and c.453+2 T&gt;C and one nonsense mutation (K329X) in the MLH1 gene as well as two frame shift mutations (c.1979-1980 del AT and c.1704-1705 del AG) in the MSH2 gene. Our analysis contributes to the further characterization of the mutational spectrum of MLH1 and MSH2 genes in HNPCC families.</AbstractText>
+ <CopyrightInformation>Copyright 2001 Wiley-Liss, Inc.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Godino</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratory of Molecular Oncology, San Carlos University Hospital, 28040 Madrid, Spain.</Affiliation>
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+ <Author ValidYN="Y">
+ <LastName>de La Hoya</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
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+ <Author ValidYN="Y">
+ <LastName>Diaz-Rubio</LastName>
+ <ForeName>E</ForeName>
+ <Initials>E</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Benito</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Caldés</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
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+ <Language>eng</Language>
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+ <MedlineTA>Hum Mutat</MedlineTA>
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+ <NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance>
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+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance>
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+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C501486">MLH1 protein, human</NameOfSubstance>
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+ <NameOfSubstance UI="D009363">Neoplasm Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
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+ <NameOfSubstance UI="D009687">Nuclear Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D011518">Proto-Oncogene Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>9007-49-2</RegistryNumber>
+ <NameOfSubstance UI="D004247">DNA</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 3.6.1.3</RegistryNumber>
+ <NameOfSubstance UI="C497172">MSH2 protein, human</NameOfSubstance>
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+ <Chemical>
+ <RegistryNumber>EC 3.6.1.3</RegistryNumber>
+ <NameOfSubstance UI="D000070957">MutL Protein Homolog 1</NameOfSubstance>
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+ <Chemical>
+ <RegistryNumber>EC 3.6.1.3</RegistryNumber>
+ <NameOfSubstance UI="D051718">MutS Homolog 2 Protein</NameOfSubstance>
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+ <CitationSubset>IM</CitationSubset>
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+ <DescriptorName UI="D048868" MajorTopicYN="N">Adaptor Proteins, Signal Transducing</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003123" MajorTopicYN="N">Colorectal Neoplasms, Hereditary Nonpolyposis</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004252" MajorTopicYN="N">DNA Mutational Analysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004268" MajorTopicYN="Y">DNA-Binding Proteins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005192" MajorTopicYN="N">Family Health</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018095" MajorTopicYN="Y">Germ-Line Mutation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000070957" MajorTopicYN="N">MutL Protein Homolog 1</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051718" MajorTopicYN="N">MutS Homolog 2 Protein</DescriptorName>
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+ <DescriptorName UI="D009363" MajorTopicYN="N">Neoplasm Proteins</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D009687" MajorTopicYN="N">Nuclear Proteins</DescriptorName>
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+ <DescriptorName UI="D011518" MajorTopicYN="N">Proto-Oncogene Proteins</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
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+ <DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName>
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+ <ArticleId IdType="pii">10.1002/humu.1240</ArticleId>
+ <ArticleId IdType="doi">10.1002/humu.1240</ArticleId>
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+ <Year>2002</Year>
+ <Month>02</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>30</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0023-7205</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>99</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Jan</Month>
+ <Day>17</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Lakartidningen</Title>
+ <ISOAbbreviation>Lakartidningen</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[Unequal distribution of health resources. Research is not supported with consideration to the global significance of the diseases].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>148-9</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Milerad</LastName>
+ <ForeName>Josef</ForeName>
+ <Initials>J</Initials>
+ <AffiliationInfo>
+ <Affiliation>josef.milerad@lakartidningen.se</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>swe</Language>
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+ <PublicationType UI="D016456">Historical Article</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D019477">Portrait</PublicationType>
+ </PublicationTypeList>
+ <VernacularTitle>Ojämn fördelning av hälsoresurser. Forskningspengar satsas inte i proportion till sjukdomars globala betydelse.</VernacularTitle>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Sweden</Country>
+ <MedlineTA>Lakartidningen</MedlineTA>
+ <NlmUniqueID>0027707</NlmUniqueID>
+ <ISSNLinking>0023-7205</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
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+ <DescriptorName UI="D014943" MajorTopicYN="Y">Global Health</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015276" MajorTopicYN="N">Health Care Rationing</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D049673" MajorTopicYN="N">History, 20th Century</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009613" MajorTopicYN="Y">Nobel Prize</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012109" MajorTopicYN="Y">Research Support as Topic</DescriptorName>
+ <QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName>
+ <QualifierName UI="Q000458" MajorTopicYN="N">organization &amp; administration</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013548" MajorTopicYN="N" Type="Geographic">Sweden</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
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+ <PersonalNameSubject>
+ <LastName>Varmus</LastName>
+ <ForeName>Harold</ForeName>
+ <Initials>H</Initials>
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+ </MedlineCitation>
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+ </DateCompleted>
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+ <Year>2004</Year>
+ <Month>11</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0002-838X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>65</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Feb</Month>
+ <Day>01</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>American family physician</Title>
+ <ISOAbbreviation>Am Fam Physician</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Information from your family doctor. Exercise for the elderly.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>427-8</MedlinePgn>
+ </Pagination>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D029282">Patient Education Handout</PublicationType>
+ </PublicationTypeList>
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+ <Country>United States</Country>
+ <MedlineTA>Am Fam Physician</MedlineTA>
+ <NlmUniqueID>1272646</NlmUniqueID>
+ <ISSNLinking>0002-838X</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
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+ <RefSource>Am Fam Physician. 2002 Feb 1;65(3):419-26</RefSource>
+ <PMID Version="1">11858624</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015444" MajorTopicYN="Y">Exercise</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005194" MajorTopicYN="N">Family Practice</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006293" MajorTopicYN="Y">Health Promotion</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>2</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
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+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>7</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>2</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11858625</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NASA">
+ <PMID Version="1">11858276</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>03</Month>
+ <Day>28</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2008</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0094-5765</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>48</Volume>
+ <Issue>5-12</Issue>
+ <PubDate>
+ <MedlineDate>2001 Mar-Jun</MedlineDate>
+ </PubDate>
+ </JournalIssue>
+ <Title>Acta astronautica</Title>
+ <ISOAbbreviation>Acta Astronaut</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Phase 1 research program overview.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>845-51</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The Phase 1 research program was unprecedented in its scope and ambitious in its objectives. The National Aeronautics and Space Administration committed to conducting a multidisciplinary long-duration research program on a platform whose capabilities were not well known, not to mention belonging to another country. For the United States, it provided the first opportunity to conduct research in a long-duration space flight environment since the Skylab program in the 1970's. Multiple technical as well as cultural challenges were successfully overcome through the dedicated efforts of a relatively small cadre of individuals. The program developed processes to successfully plan, train for and execute research in a long-duration environment, with significant differences identified from short-duration space flight science operations. Between August 1994 and June 1998, thousands of kilograms of research hardware was prepared and launched to Mir, and thousands of kilograms of hardware and data products were returned to Earth. More than 150 Principal Investigators from eight countries were involved in the program in seven major research disciplines: Advanced Technology; Earth Sciences; Fundamental Biology; Human Life Sciences; International Space Station Risk Mitigation; Microgravity; and Space Sciences. Approximately 75 long-duration investigations were completed on Mir, with additional investigations performed on the Shuttle flights that docked with Mir. The flight phase included the participation of seven US astronauts and 20 Russian cosmonauts. The successful completion of the Phase 1 research program not only resulted in high quality science return but also in numerous lessons learned to make the ISS experience more productive. The cooperation developed during the program was instrumental in its success.</AbstractText>
+ <CopyrightInformation>c2001 AIAA. Published by Elsevier Science Ltd.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Uri</LastName>
+ <ForeName>J J</ForeName>
+ <Initials>JJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>NASA Johnson Space Center, Houston, TX, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lebedev</LastName>
+ <ForeName>O N</ForeName>
+ <Initials>ON</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Acta Astronaut</MedlineTA>
+ <NlmUniqueID>9890631</NlmUniqueID>
+ <ISSNLinking>0094-5765</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>S</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001690" MajorTopicYN="N">Biological Science Disciplines</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004867" MajorTopicYN="N">Equipment Design</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018559" MajorTopicYN="N">Exobiology</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005118" MajorTopicYN="N">Extraterrestrial Environment</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007391" MajorTopicYN="Y">International Cooperation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015397" MajorTopicYN="Y">Program Evaluation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012106" MajorTopicYN="N">Research</DescriptorName>
+ <QualifierName UI="Q000295" MajorTopicYN="N">instrumentation</QualifierName>
+ <QualifierName UI="Q000458" MajorTopicYN="Y">organization &amp; administration</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012426" MajorTopicYN="N" Type="Geographic">Russia</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013026" MajorTopicYN="N">Space Flight</DescriptorName>
+ <QualifierName UI="Q000295" MajorTopicYN="N">instrumentation</QualifierName>
+ <QualifierName UI="Q000458" MajorTopicYN="Y">organization &amp; administration</QualifierName>
+ <QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018531" MajorTopicYN="N">Spacecraft</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014586" MajorTopicYN="N" Type="Geographic">USSR</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018557" MajorTopicYN="N">United States National Aeronautics and Space Administration</DescriptorName>
+ <QualifierName UI="Q000458" MajorTopicYN="Y">organization &amp; administration</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014893" MajorTopicYN="Y">Weightlessness</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="NASA">00027286</OtherID>
+ <SpaceFlightMission>Flight Experiment</SpaceFlightMission>
+ <SpaceFlightMission>Mir Project</SpaceFlightMission>
+ <SpaceFlightMission>STS Shuttle Project</SpaceFlightMission>
+ <SpaceFlightMission>long duration</SpaceFlightMission>
+ <SpaceFlightMission>manned</SpaceFlightMission>
+ <SpaceFlightMission>short duration</SpaceFlightMission>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>2</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>29</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>2</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
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+ <ArticleId IdType="pubmed">11858276</ArticleId>
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+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11869993</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>03</Month>
+ <Day>22</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1052-1577</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>27</Volume>
+ <Issue>4</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Feb</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Harvard health letter</Title>
+ <ISOAbbreviation>Harv Health Lett</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>By the way doctor... I'm 72 and was recently told that I am losing a bit of my sight because of macular degeneration. My doctor assured me that it was progressing very slowly, but also said there wasn't really anything to do about it. But I read that zinc or vitamins might help. Should I be taking them?</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>8</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Lee</LastName>
+ <ForeName>Thomas H</ForeName>
+ <Initials>TH</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Harv Health Lett</MedlineTA>
+ <NlmUniqueID>9425764</NlmUniqueID>
+ <ISSNLinking>1052-1577</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D014815">Vitamins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>J41CSQ7QDS</RegistryNumber>
+ <NameOfSubstance UI="D015032">Zinc</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>K</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008268" MajorTopicYN="N">Macular Degeneration</DescriptorName>
+ <QualifierName UI="Q000517" MajorTopicYN="Y">prevention &amp; control</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014815" MajorTopicYN="N">Vitamins</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015032" MajorTopicYN="N">Zinc</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>1</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>1</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11869993</ArticleId>
+ <ArticleId IdType="pii">L0202i</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NASA">
+ <PMID Version="1">11876201</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>03</Month>
+ <Day>22</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>11</Month>
+ <Day>24</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1069-9422</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>5</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>1998</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Life support &amp; biosphere science : international journal of earth space</Title>
+ <ISOAbbreviation>Life Support Biosph Sci</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Consumer acceptance of vegetarian sweet potato products intended for space missions.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>339-46</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Sweet potato is one of the crops selected for NASA's Advanced Life Support Program for potential long-duration lunar/Mars missions. This article presents recipes of products made from sweet potato and determines the consumer acceptability of products containing from 6% to 20% sweet potato on a dry weight basis. These products were developed for use in nutritious and palatable meals for future space explorers. Sensory evaluation (appearance/color, aroma, texture, flavor/taste, and overall acceptability) studies were conducted to determine the consumer acceptability of vegetarian products made with sweet potato using panelists at NASA/Johnson Space Center in Houston, TX. None of these products including the controls, contained any ingredient of animal origin with the exception of sweet potato pie. A 9-point hedonic scale (9 being like extremely and 1 being dislike extremely) was used to evaluate 10 products and compare them to similar commercially available products used as controls. The products tested were pancakes, waffles, tortillas, bread, pie, pound cake, pasta, vegetable patties, doughnuts, and pretzels. All of the products were either liked moderately or liked slightly with the exception of the sweet potato vegetable patties, which were neither liked nor disliked. Mean comparisons of sensory scores of sweet potato recipes and their controls were accomplished by using the Student t-test. Because of their nutritional adequacy and consumer acceptability, these products are being recommended to NASA's Advanced Life Support Program for inclusion in a vegetarian menu plan designed for lunar/Mars space missions.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Wilson</LastName>
+ <ForeName>C D</ForeName>
+ <Initials>CD</Initials>
+ <AffiliationInfo>
+ <Affiliation>Center for Food and Environmental Systems for Human Exploration of Space, George Washington Carver Agricultural Experiment Station, Tuskegee University, Tuskegee, AL 36088, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Pace</LastName>
+ <ForeName>R D</ForeName>
+ <Initials>RD</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bromfield</LastName>
+ <ForeName>E</ForeName>
+ <Initials>E</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Jones</LastName>
+ <ForeName>G</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lu</LastName>
+ <ForeName>J Y</ForeName>
+ <Initials>JY</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Life Support Biosph Sci</MedlineTA>
+ <NlmUniqueID>9431217</NlmUniqueID>
+ <ISSNLinking>1069-9422</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>S</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D014676" MajorTopicYN="N">Diet, Vegetarian</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018504" MajorTopicYN="N">Ecological Systems, Closed</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005069" MajorTopicYN="N">Evaluation Studies as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005247" MajorTopicYN="N">Feeding Behavior</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005518" MajorTopicYN="N">Food Preferences</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005524" MajorTopicYN="N">Food Technology</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D027723" MajorTopicYN="Y">Ipomoea batatas</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008021" MajorTopicYN="N">Life Support Systems</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008612" MajorTopicYN="Y">Menu Planning</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009753" MajorTopicYN="N">Nutritive Value</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013026" MajorTopicYN="Y">Space Flight</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N">United States</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018557" MajorTopicYN="N">United States National Aeronautics and Space Administration</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014893" MajorTopicYN="N">Weightlessness</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="NASA">00027330</OtherID>
+ <KeywordList Owner="NASA">
+ <Keyword MajorTopicYN="N">NASA Discipline Life Support Systems</Keyword>
+ <Keyword MajorTopicYN="N">Non-NASA Center</Keyword>
+ </KeywordList>
+ <InvestigatorList>
+ <Investigator ValidYN="Y">
+ <LastName>Mortley</LastName>
+ <ForeName>D G</ForeName>
+ <Initials>DG</Initials>
+ <AffiliationInfo>
+ <Affiliation>Tuskegee U, AL</Affiliation>
+ </AffiliationInfo>
+ </Investigator>
+ </InvestigatorList>
+ <GeneralNote Owner="NASA">Grant numbers: NCC 9-51, ALX-FS-2.</GeneralNote>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>6</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>6</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11876201</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11885531</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>04</Month>
+ <Day>08</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0028-2200</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>99</Volume>
+ <Issue>7</Issue>
+ <PubDate>
+ <Year>1992</Year>
+ <Month>Jul</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Nederlands tijdschrift voor tandheelkunde</Title>
+ <ISOAbbreviation>Ned Tijdschr Tandheelkd</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[Microbiological diagnostics in periodontal treatment].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>245-6</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Periodontal diseases are bacterial infections. The rationale for the use of microbiological diagnostics in periodontal treatment of severe periodontitis patients is discussed as well as the use of adjunct antimicrobial therapy for the elimination of specific bacterial species.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>de Graaff</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ <AffiliationInfo>
+ <Affiliation>Uit de vakgroep Orale Microbiologie van het Academisch Centrum Tandheelkunde Amsterdam (ACTA).</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>van Winkelhoff</LastName>
+ <ForeName>A J</ForeName>
+ <Initials>AJ</Initials>
+ </Author>
+ </AuthorList>
+ <Language>dut</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D004740">English Abstract</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ <VernacularTitle>Microbiologische diagnostiek in de paradontologie.</VernacularTitle>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Netherlands</Country>
+ <MedlineTA>Ned Tijdschr Tandheelkd</MedlineTA>
+ <NlmUniqueID>0400771</NlmUniqueID>
+ <ISSNLinking>0028-2200</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>D</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000193" MajorTopicYN="N">Actinomycetales Infections</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006920" MajorTopicYN="N">Hygiene</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010510" MajorTopicYN="N">Periodontal Diseases</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>6</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1992</Year>
+ <Month>7</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>4</Month>
+ <Day>9</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1992</Year>
+ <Month>7</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11885531</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11892742</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>03</Month>
+ <Day>18</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2017</Year>
+ <Month>12</Month>
+ <Day>28</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0012-1606</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>242</Volume>
+ <Issue>2</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Feb</Month>
+ <Day>15</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Developmental biology</Title>
+ <ISOAbbreviation>Dev. Biol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>The major subacrosomal occupant of bull spermatozoa is a novel histone H2B variant associated with the forming acrosome during spermiogenesis.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>376-87</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Recent studies on the structural composition of mammalian sperm heads have shown a congregate of unidentified proteins occupying the periphery of the mammalian sperm nucleus, forming a layer of condensed cytosol. These proteins are the perinuclear theca (PT) and can be categorized into SDS-soluble and SDS-insoluble components. The present study focused on identifying the major SDS-insoluble PT protein, which we localized to the subacrosomal layer of bovine spermatozoa and cloned by immunoscreening a bull testicular cDNA library. The isolated clones encode a protein of 122 amino acids that bears 67% similarity with histone H2B and contains a predicted histone fold motif. The novel amino terminus of the protein contains a potential bipartite nuclear targeting sequence. Hence, we identified this prominent subacrosomal component as a novel H2B variant, SubH2Bv. Northern blot analyses of SubH2Bv mRNA expression showed that it is testis-specific and is also present in murid testes. Immunocytochemical analysis showed SubH2Bv intimately associates, temporally and spatially, with acrosome formation. While the molecular features of SubH2Bv are common to nuclear proteins, it is never seen developmentally within the nucleus of the spermatid. Considering its developmental and molecular characteristics, we have postulated roles of SubH2Bv in acrosome assembly and acrosome-nuclear docking.</AbstractText>
+ <CopyrightInformation>Copyright 2001 Academic Press.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Aul</LastName>
+ <ForeName>Ritu B</ForeName>
+ <Initials>RB</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada, K7L 3N6.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Oko</LastName>
+ <ForeName>Richard J</ForeName>
+ <Initials>RJ</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016439">Corrected and Republished Article</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Dev Biol</MedlineTA>
+ <NlmUniqueID>0372762</NlmUniqueID>
+ <ISSNLinking>0012-1606</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D018076">DNA, Complementary</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D006657">Histones</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>63231-63-0</RegistryNumber>
+ <NameOfSubstance UI="D012313">RNA</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="RepublishedFrom">
+ <RefSource>Dev Biol. 2001 Nov 15;239(2):376-87</RefSource>
+ <PMID Version="1">11784042</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000177" MajorTopicYN="N">Acrosome</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ <QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020816" MajorTopicYN="N">Amino Acid Motifs</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015152" MajorTopicYN="N">Blotting, Northern</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018076" MajorTopicYN="N">DNA, Complementary</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004591" MajorTopicYN="N">Electrophoresis, Polyacrylamide Gel</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006657" MajorTopicYN="N">Histones</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015151" MajorTopicYN="N">Immunoblotting</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012313" MajorTopicYN="N">RNA</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012670" MajorTopicYN="N">Seminiferous Epithelium</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017386" MajorTopicYN="N">Sequence Homology, Amino Acid</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013091" MajorTopicYN="N">Spermatogenesis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013094" MajorTopicYN="N">Spermatozoa</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013737" MajorTopicYN="N">Testis</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>15</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>19</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>15</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11892742</ArticleId>
+ <ArticleId IdType="pii">S0012-1606(02)90575-0</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11916658</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>04</Month>
+ <Day>15</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>11</Month>
+ <Day>24</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1070-910X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>9</Volume>
+ <Issue>7</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Mar</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Harvard women's health watch</Title>
+ <ISOAbbreviation>Harv Womens Health Watch</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>By the way, doctor. A few months ago, I was surprised to read that a new study has raised a question about the value of screening mammograms. Is that true? I thought the importance of having such mammograms was well-established. I'm 52 and have been getting annual mammograms for 10 years. Should I stop?</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>8</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Robb-Nicholson</LastName>
+ <ForeName>Celeste</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Harv Womens Health Watch</MedlineTA>
+ <NlmUniqueID>9423147</NlmUniqueID>
+ <ISSNLinking>1070-910X</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>K</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
+ <QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002986" MajorTopicYN="N">Clinical Trials as Topic</DescriptorName>
+ <QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008327" MajorTopicYN="Y">Mammography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010353" MajorTopicYN="N">Patient Education as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012107" MajorTopicYN="N">Research Design</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>28</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>4</Month>
+ <Day>16</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>3</Month>
+ <Day>28</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11916658</ArticleId>
+ <ArticleId IdType="pii">W0302f</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11953811</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>05</Month>
+ <Day>24</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1432-2218</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>16</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>May</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Surgical endoscopy</Title>
+ <ISOAbbreviation>Surg Endosc</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Disruptive visions: surgeon responsibility during the era of change.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>733-4</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Satava</LastName>
+ <ForeName>R M</ForeName>
+ <Initials>RM</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016421">Editorial</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Germany</Country>
+ <MedlineTA>Surg Endosc</MedlineTA>
+ <NlmUniqueID>8806653</NlmUniqueID>
+ <ISSNLinking>0930-2794</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D020811" MajorTopicYN="Y">Biomedical Technology</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003132" MajorTopicYN="N">Commerce</DescriptorName>
+ <QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003695" MajorTopicYN="N">Delivery of Health Care</DescriptorName>
+ <QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013502" MajorTopicYN="N">General Surgery</DescriptorName>
+ <QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
+ <QualifierName UI="Q000639" MajorTopicYN="Y">trends</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006301" MajorTopicYN="N">Health Services Needs and Demand</DescriptorName>
+ <QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>4</Month>
+ <Day>16</Day>
+ <Hour>10</Hour>
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+ <ArticleId IdType="pubmed">11953811</ArticleId>
+ <ArticleId IdType="doi">10.1007/s00464-002-0005-2</ArticleId>
+ </ArticleIdList>
+ <ReferenceList>
+ <Reference>
+ <Citation>Surg Endosc. 2000 May;14(5):417-8</Citation>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">10858462</ArticleId>
+ </ArticleIdList>
+ </Reference>
+ </ReferenceList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NASA">
+ <PMID Version="1">12038483</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>07</Month>
+ <Day>26</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0273-1177</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>26</Volume>
+ <Issue>12</Issue>
+ <PubDate>
+ <Year>2000</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Advances in space research : the official journal of the Committee on Space Research (COSPAR)</Title>
+ <ISOAbbreviation>Adv Space Res</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Planetary protection issues for Mars sample acquisition flight projects.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1911-6</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The planned NASA sample acquisition flight missions to Mars pose several interesting planetary protection issues. In addition to the usual forward contamination procedures for the adequate protection of Mars for the sake of future missions, there are reasons to ensure that the sample is not contaminated by terrestrial microbes from the acquisition mission. Recent recommendations by the Space Studies Board (SSB) of the National Research Council (United States), would indicate that the scientific integrity of the sample is a planetary protection concern (SSB, 1997). Also, as a practical matter, a contaminated sample would interfere with the process for its release from quarantine after return for distribution to the interested scientists. These matters are discussed in terms of the first planned acquisition mission.</AbstractText>
+ <CopyrightInformation>c2001 COSPAR Published by Elsevier Science Ltd. All rights reserved.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Barengoltz</LastName>
+ <ForeName>J B</ForeName>
+ <Initials>JB</Initials>
+ <AffiliationInfo>
+ <Affiliation>Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Adv Space Res</MedlineTA>
+ <NlmUniqueID>9878935</NlmUniqueID>
+ <ISSNLinking>0273-1177</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>BBX060AN9V</RegistryNumber>
+ <NameOfSubstance UI="D006861">Hydrogen Peroxide</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>S</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D003264" MajorTopicYN="Y">Containment of Biohazards</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004783" MajorTopicYN="N">Environmental Microbiology</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005118" MajorTopicYN="N">Extraterrestrial Environment</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006358" MajorTopicYN="N">Hot Temperature</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006861" MajorTopicYN="N">Hydrogen Peroxide</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018535" MajorTopicYN="Y">Mars</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013026" MajorTopicYN="N">Space Flight</DescriptorName>
+ <QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018531" MajorTopicYN="N">Spacecraft</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013048" MajorTopicYN="Y">Specimen Handling</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013242" MajorTopicYN="N">Sterilization</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018557" MajorTopicYN="N">United States National Aeronautics and Space Administration</DescriptorName>
+ <QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="NASA">00027913</OtherID>
+ <KeywordList Owner="NASA">
+ <Keyword MajorTopicYN="N">NASA Center JPL</Keyword>
+ <Keyword MajorTopicYN="N">NASA Discipline Exobiology</Keyword>
+ </KeywordList>
+ <InvestigatorList>
+ <Investigator ValidYN="Y">
+ <LastName>Barengoltz</LastName>
+ <ForeName>J B</ForeName>
+ <Initials>JB</Initials>
+ <AffiliationInfo>
+ <Affiliation>JPL</Affiliation>
+ </AffiliationInfo>
+ </Investigator>
+ </InvestigatorList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>6</Month>
+ <Day>1</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>7</Month>
+ <Day>27</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>6</Month>
+ <Day>1</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">12038483</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">11966386</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>05</Month>
+ <Day>02</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0098-7484</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>287</Volume>
+ <Issue>16</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Apr</Month>
+ <Day>24</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>JAMA</Title>
+ <ISOAbbreviation>JAMA</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>The 2001 Bethesda System: terminology for reporting results of cervical cytology.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>2114-9</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The Bethesda 2001 Workshop was convened to evaluate and update the 1991 Bethesda System terminology for reporting the results of cervical cytology. A primary objective was to develop a new approach to broaden participation in the consensus process.</AbstractText>
+ <AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Forum groups composed of 6 to 10 individuals were responsible for developing recommendations for discussion at the workshop. Each forum group included at least 1 cytopathologist, cytotechnologist, clinician, and international representative to ensure a broad range of views and interests. More than 400 cytopathologists, cytotechnologists, histopathologists, family practitioners, gynecologists, public health physicians, epidemiologists, patient advocates, and attorneys participated in the workshop, which was convened by the National Cancer Institute and cosponsored by 44 professional societies. More than 20 countries were represented.</AbstractText>
+ <AbstractText Label="EVIDENCE" NlmCategory="METHODS">Literature review, expert opinion, and input from an Internet bulletin board were all considered in developing recommendations. The strength of evidence of the scientific data was considered of paramount importance.</AbstractText>
+ <AbstractText Label="CONSENSUS PROCESS" NlmCategory="METHODS">Bethesda 2001 was a year-long iterative review process. An Internet bulletin board was used for discussion of issues and drafts of recommendations. More than 1000 comments were posted to the bulletin board over the course of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to the public. Postworkshop recommendations were posted on the bulletin board for a last round of critical review prior to finalizing the terminology.</AbstractText>
+ <AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Bethesda 2001 was developed with broad participation in the consensus process. The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Solomon</LastName>
+ <ForeName>Diane</ForeName>
+ <Initials>D</Initials>
+ <AffiliationInfo>
+ <Affiliation>EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA. ds87v@nih.gov</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Davey</LastName>
+ <ForeName>Diane</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kurman</LastName>
+ <ForeName>Robert</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Moriarty</LastName>
+ <ForeName>Ann</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>O'Connor</LastName>
+ <ForeName>Dennis</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Prey</LastName>
+ <ForeName>Marianne</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Raab</LastName>
+ <ForeName>Stephen</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sherman</LastName>
+ <ForeName>Mark</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wilbur</LastName>
+ <ForeName>David</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wright</LastName>
+ <ForeName>Thomas</ForeName>
+ <Initials>T</Initials>
+ <Suffix>Jr</Suffix>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Young</LastName>
+ <ForeName>Nancy</ForeName>
+ <Initials>N</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <CollectiveName>Forum Group Members</CollectiveName>
+ </Author>
+ <Author ValidYN="Y">
+ <CollectiveName>Bethesda 2001 Workshop</CollectiveName>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016446">Consensus Development Conference</PublicationType>
+ <PublicationType UI="D016447">Consensus Development Conference, NIH</PublicationType>
+ <PublicationType UI="D016431">Guideline</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>JAMA</MedlineTA>
+ <NlmUniqueID>7501160</NlmUniqueID>
+ <ISSNLinking>0098-7484</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>JAMA. 2002 Apr 24;287(16):2140-1</RefSource>
+ <PMID Version="1">11966390</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D018290" MajorTopicYN="N">Cervical Intraepithelial Neoplasia</DescriptorName>
+ <QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007753" MajorTopicYN="N">Laboratories</DescriptorName>
+ <QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011786" MajorTopicYN="N">Quality Control</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009626" MajorTopicYN="N">Terminology as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002578" MajorTopicYN="N">Uterine Cervical Dysplasia</DescriptorName>
+ <QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002583" MajorTopicYN="N">Uterine Cervical Neoplasms</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014626" MajorTopicYN="N">Vaginal Smears</DescriptorName>
+ <QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
+ <QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>28</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>4</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>5</Month>
+ <Day>3</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>4</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11966386</ArticleId>
+ <ArticleId IdType="pii">jst10014</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">12101218</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>08</Month>
+ <Day>12</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Print">0021-9258</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>277</Volume>
+ <Issue>28</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Jul</Month>
+ <Day>12</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Journal of biological chemistry</Title>
+ <ISOAbbreviation>J. Biol. Chem.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Interaction between FtsZ and FtsW of Mycobacterium tuberculosis.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>24983-7</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The recruitment of FtsZ to the septum and its subsequent interaction with other cell division proteins in a spatially and temporally controlled manner are the keys to bacterial cell division. In the present study, we have tested the hypothesis that FtsZ and FtsW of Mycobacterium tuberculosis could be binding partners. Using gel renaturation, pull-down, and solid-phase assays, we confirm that FtsZ and FtsW interact through their C-terminal tails, which carry extensions absent in their Escherichia coli counterparts. Crucial to these interactions is the cluster of aspartate residues Asp(367) to Asp(370) of FtsZ, which most likely interact with a cluster of positively charged residues in the C-terminal tail of FtsW. Mutations of the aspartate residues 367-370 showed that changing three aspartate residues to alanine resulted in complete loss of interaction. This is the first demonstration of the direct interaction between FtsZ and FtsW. We speculate that this interaction between FtsZ and FtsW could serve to anchor FtsZ to the membrane and link septum formation to peptidoglycan synthesis in M. tuberculosis. The findings assume particular significance in view of the global efforts to explore new targets in M. tuberculosis for chemotherapeutic intervention.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Datta</LastName>
+ <ForeName>Pratik</ForeName>
+ <Initials>P</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009, India.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dasgupta</LastName>
+ <ForeName>Arunava</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bhakta</LastName>
+ <ForeName>Sanjib</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Basu</LastName>
+ <ForeName>Joyoti</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2002</Year>
+ <Month>05</Month>
+ <Day>06</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Biol Chem</MedlineTA>
+ <NlmUniqueID>2985121R</NlmUniqueID>
+ <ISSNLinking>0021-9258</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D003598">Cytoskeletal Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D017931">DNA Primers</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C071525">FtsZ protein, Bacteria</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>125724-13-2</RegistryNumber>
+ <NameOfSubstance UI="C061684">FtsW protein, Bacteria</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001426" MajorTopicYN="N">Bacterial Proteins</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003598" MajorTopicYN="Y">Cytoskeletal Proteins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017931" MajorTopicYN="N">DNA Primers</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008565" MajorTopicYN="Y">Membrane Proteins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009169" MajorTopicYN="N">Mycobacterium tuberculosis</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>7</Month>
+ <Day>9</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>8</Month>
+ <Day>13</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>7</Month>
+ <Day>9</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">12101218</ArticleId>
+ <ArticleId IdType="doi">10.1074/jbc.M203847200</ArticleId>
+ <ArticleId IdType="pii">M203847200</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">12145319</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>09</Month>
+ <Day>16</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>30</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Print">0021-9258</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>277</Volume>
+ <Issue>31</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Aug</Month>
+ <Day>02</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Journal of biological chemistry</Title>
+ <ISOAbbreviation>J. Biol. Chem.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>28271-9</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The regulation of SNARE complex assembly likely plays an important role in governing the specificity as well as the timing of membrane fusion. Here we identify a novel brain-enriched protein, amisyn, with a tomosyn- and VAMP-like coiled-coil-forming domain that binds specifically to syntaxin 1a and syntaxin 4 both in vitro and in vivo, as assessed by co-immunoprecipitation from rat brain. Amisyn is mostly cytosolic, but a fraction co-sediments with membranes. The amisyn coil domain can form SNARE complexes of greater thermostability than can VAMP2 with syntaxin 1a and SNAP-25 in vitro, but it lacks a transmembrane anchor and so cannot act as a v-SNARE in this complex. The amisyn coil domain prevents the SNAP-25 C-terminally mediated rescue of botulinum neurotoxin E inhibition of norepinephrine exocytosis in permeabilized PC12 cells to a greater extent than it prevents the regular exocytosis of these vesicles. We propose that amisyn forms nonfusogenic complexes with syntaxin 1a and SNAP-25, holding them in a conformation ready for VAMP2 to replace it to mediate the membrane fusion event, thereby contributing to the regulation of SNARE complex formation.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Scales</LastName>
+ <ForeName>Suzie J</ForeName>
+ <Initials>SJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305-5345, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hesser</LastName>
+ <ForeName>Boris A</ForeName>
+ <Initials>BA</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Masuda</LastName>
+ <ForeName>Esteban S</ForeName>
+ <Initials>ES</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Scheller</LastName>
+ <ForeName>Richard H</ForeName>
+ <Initials>RH</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <DataBankList CompleteYN="Y">
+ <DataBank>
+ <DataBankName>GENBANK</DataBankName>
+ <AccessionNumberList>
+ <AccessionNumber>AF391153</AccessionNumber>
+ </AccessionNumberList>
+ </DataBank>
+ </DataBankList>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2002</Year>
+ <Month>05</Month>
+ <Day>24</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Biol Chem</MedlineTA>
+ <NlmUniqueID>2985121R</NlmUniqueID>
+ <ISSNLinking>0021-9258</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D009419">Nerve Tissue Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D050765">Qa-SNARE Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D011993">Recombinant Fusion Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C494208">SNAP25 protein, human</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D050600">SNARE Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C494212">STX1A protein, human</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C465215">STXBP6 protein, human</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C494210">Snap25 protein, rat</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C494213">Stx1a protein, rat</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D050825">Synaptosomal-Associated Protein 25</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D050827">Syntaxin 1</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D033921">Vesicular Transport Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 2.5.1.18</RegistryNumber>
+ <NameOfSubstance UI="D005982">Glutathione Transferase</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>X4W3ENH1CV</RegistryNumber>
+ <NameOfSubstance UI="D009638">Norepinephrine</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001665" MajorTopicYN="N">Binding Sites</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005089" MajorTopicYN="N">Exocytosis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005982" MajorTopicYN="N">Glutathione Transferase</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009419" MajorTopicYN="N">Nerve Tissue Proteins</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009638" MajorTopicYN="N">Norepinephrine</DescriptorName>
+ <QualifierName UI="Q000037" MajorTopicYN="N">antagonists &amp; inhibitors</QualifierName>
+ <QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016716" MajorTopicYN="N">PC12 Cells</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010673" MajorTopicYN="N">Pheochromocytoma</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017433" MajorTopicYN="N">Protein Structure, Secondary</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D050765" MajorTopicYN="N">Qa-SNARE Proteins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011993" MajorTopicYN="N">Recombinant Fusion Proteins</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D050600" MajorTopicYN="N">SNARE Proteins</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017386" MajorTopicYN="N">Sequence Homology, Amino Acid</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D050825" MajorTopicYN="N">Synaptosomal-Associated Protein 25</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D050827" MajorTopicYN="N">Syntaxin 1</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013816" MajorTopicYN="N">Thermodynamics</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D033921" MajorTopicYN="Y">Vesicular Transport Proteins</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>7</Month>
+ <Day>30</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
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+ <Year>2002</Year>
+ <Month>9</Month>
+ <Day>17</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>7</Month>
+ <Day>30</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">12145319</ArticleId>
+ <ArticleId IdType="doi">10.1074/jbc.M204929200</ArticleId>
+ <ArticleId IdType="pii">M204929200</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="KIE">
+ <PMID Version="1">12159900</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>08</Month>
+ <Day>22</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>06</Month>
+ <Day>07</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0362-4331</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Jul</Month>
+ <Day>02</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>The New York times on the Web</Title>
+ <ISOAbbreviation>N Y Times Web</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Weighing medical ethics for many years to come: a conversation with Harold Shapiro. Interview by Howard Markel.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>F6</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Shapiro</LastName>
+ <ForeName>Harold</ForeName>
+ <Initials>H</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D017203">Interview</PublicationType>
+ <PublicationType UI="D018431">Newspaper Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>N Y Times Web</MedlineTA>
+ <NlmUniqueID>9877126</NlmUniqueID>
+ <ISSNLinking>0362-4331</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>E</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D026683" MajorTopicYN="N">Advisory Committees</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D026688" MajorTopicYN="Y">Bioethical Issues</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D035843" MajorTopicYN="N">Biomedical Research</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001709" MajorTopicYN="N">Biotechnology</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019976" MajorTopicYN="N">Cloning, Organism</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016265" MajorTopicYN="N">Conflict of Interest</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D033041" MajorTopicYN="N">Embryo Research</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004622" MajorTopicYN="N">Embryo, Mammalian</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005380" MajorTopicYN="N">Financing, Government</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006292" MajorTopicYN="N">Health Priorities</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006805" MajorTopicYN="N">Human Experimentation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012109" MajorTopicYN="N">Research Support as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013234" MajorTopicYN="N">Stem Cells</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="KIE">103061</OtherID>
+ <OtherID Source="NRCBL">VF 2.1</OtherID>
+ <KeywordList Owner="KIE">
+ <Keyword MajorTopicYN="N">Bioethics and Professional Ethics</Keyword>
+ <Keyword MajorTopicYN="N">National Bioethics Advisory Commission</Keyword>
+ <Keyword MajorTopicYN="N">Popular Approach/Source</Keyword>
+ </KeywordList>
+ <GeneralNote Owner="KIE">KIE Bib: bioethics</GeneralNote>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>8</Month>
+ <Day>6</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
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+ <Year>2002</Year>
+ <Month>8</Month>
+ <Day>23</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>8</Month>
+ <Day>6</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">12159900</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="KIE">
+ <PMID Version="1">12174865</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>08</Month>
+ <Day>21</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2004</Year>
+ <Month>11</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1145-0762</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>11</Volume>
+ <Issue>2</Issue>
+ <PubDate>
+ <Year>2000</Year>
+ <Month>Jun</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal international de bioethique = International journal of bioethics</Title>
+ <ISOAbbreviation>J Int Bioethique</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Physicians' attitudes towards medical ethics issues in Turkey.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>57-67</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Pelin</LastName>
+ <ForeName>S S</ForeName>
+ <Initials>SS</Initials>
+ <AffiliationInfo>
+ <Affiliation>Dept. of Deontology, Faculty of Medicine, University of Ankara, Tip. Fak. Dekanligi, Morfoloji Terleskesi, Anakara, Sihhiye - 06100 Turkey.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Arda</LastName>
+ <ForeName>B</ForeName>
+ <Initials>B</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>France</Country>
+ <MedlineTA>J Int Bioethique</MedlineTA>
+ <NlmUniqueID>9015754</NlmUniqueID>
+ <ISSNLinking>1145-0762</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>E</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000028" MajorTopicYN="N">Abortion, Induced</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D032761" MajorTopicYN="N">Animal Experimentation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001291" MajorTopicYN="Y">Attitude of Health Personnel</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D026688" MajorTopicYN="Y">Bioethical Issues</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D035843" MajorTopicYN="N">Biomedical Research</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000529" MajorTopicYN="N">Complementary Therapies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003219" MajorTopicYN="N">Confidentiality</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003625" MajorTopicYN="N">Data Collection</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004992" MajorTopicYN="Y">Ethics, Medical</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D032984" MajorTopicYN="N">Ethics, Research</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005065" MajorTopicYN="N">Euthanasia</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010817" MajorTopicYN="N">Physician-Patient Relations</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010820" MajorTopicYN="Y">Physicians</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011287" MajorTopicYN="N">Prejudice</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D027724" MajorTopicYN="N">Reproductive Techniques, Assisted</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014342" MajorTopicYN="N">Truth Disclosure</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014421" MajorTopicYN="N" Type="Geographic">Turkey</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="KIE">102894</OtherID>
+ <KeywordList Owner="KIE">
+ <Keyword MajorTopicYN="N">Bioethics and Professional Ethics</Keyword>
+ <Keyword MajorTopicYN="N">Empirical Approach</Keyword>
+ </KeywordList>
+ <GeneralNote Owner="KIE">Pelin, Serap Sahinoglu; Arda, Berna</GeneralNote>
+ <GeneralNote Owner="KIE">KIE Bib: bioethics; medical ethics</GeneralNote>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>8</Month>
+ <Day>15</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>8</Month>
+ <Day>22</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>8</Month>
+ <Day>15</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">12174865</ArticleId>
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+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NASA">
+ <PMID Version="1">12192682</PMID>
+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>09</Month>
+ <Day>09</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0018-9251</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>35</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>1999</Year>
+ <Month>Jul</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>IEEE transactions on aerospace and electronic systems</Title>
+ <ISOAbbreviation>IEEE Trans Aerosp Electron Syst</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Intelligent control of a planning system for astronaut training.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1055-70</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>This work intends to design, analyze and solve, from the systems control perspective, a complex, dynamic, and multiconstrained planning system for generating training plans for crew members of the NASA-led International Space Station. Various intelligent planning systems have been developed within the framework of artificial intelligence. These planning systems generally lack a rigorous mathematical formalism to allow a reliable and flexible methodology for their design, modeling, and performance analysis in a dynamical, time-critical, and multiconstrained environment. Formulating the planning problem in the domain of discrete-event systems under a unified framework such that it can be modeled, designed, and analyzed as a control system will provide a self-contained theory for such planning systems. This will also provide a means to certify various planning systems for operations in the dynamical and complex environments in space. The work presented here completes the design, development, and analysis of an intricate, large-scale, and representative mathematical formulation for intelligent control of a real planning system for Space Station crew training. This planning system has been tested and used at NASA-Johnson Space Center.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Ortiz</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ <AffiliationInfo>
+ <Affiliation>Johnson Space Center, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Chen</LastName>
+ <ForeName>G</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>IEEE Trans Aerosp Electron Syst</MedlineTA>
+ <NlmUniqueID>9876802</NlmUniqueID>
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+ <DescriptorName UI="D000465" MajorTopicYN="N">Algorithms</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D001185" MajorTopicYN="Y">Artificial Intelligence</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D018480" MajorTopicYN="N">Astronauts</DescriptorName>
+ <QualifierName UI="Q000193" MajorTopicYN="Y">education</QualifierName>
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+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D007318" MajorTopicYN="Y">Inservice Training</DescriptorName>
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+ <DescriptorName UI="D013026" MajorTopicYN="N">Space Flight</DescriptorName>
+ <QualifierName UI="Q000193" MajorTopicYN="Y">education</QualifierName>
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+ <DescriptorName UI="D018531" MajorTopicYN="N">Spacecraft</DescriptorName>
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+ <DescriptorName UI="D013597" MajorTopicYN="N">Systems Analysis</DescriptorName>
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+ <DescriptorName UI="D017748" MajorTopicYN="N">Time Management</DescriptorName>
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+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
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+ <DescriptorName UI="D018557" MajorTopicYN="N">United States National Aeronautics and Space Administration</DescriptorName>
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+ <GeneralNote Owner="NASA">Grant numbers: DAAG55-98-1-0198.</GeneralNote>
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+ <Month>12</Month>
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+ <Year>2018</Year>
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+ <Day>30</Day>
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+ <ISSN IssnType="Print">1226-0282</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>10</Volume>
+ <Issue>2</Issue>
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+ <Year>1990</Year>
+ <Month>Dec</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Pogon sahoe nonjip = Journal of population, health, and social welfare</Title>
+ <ISOAbbreviation>Bogeon sahoe nonjib</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Recent changes in the population control policy and its future directions in Korea.</ArticleTitle>
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+ <MedlinePgn>152-73</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
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+ <Initials>NH</Initials>
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+ <LastName>Seo</LastName>
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+ <LastName>Tan</LastName>
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+ <NlmUniqueID>9422396</NlmUniqueID>
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+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="Y">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001208" MajorTopicYN="N" Type="Geographic">Asia</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001723" MajorTopicYN="Y">Birth Rate</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003247" MajorTopicYN="N">Conservation of Natural Resources</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003267" MajorTopicYN="Y">Contraception</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003695" MajorTopicYN="N">Delivery of Health Care</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003710" MajorTopicYN="N">Demography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003858" MajorTopicYN="Y">Dependency (Psychology)</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003906" MajorTopicYN="N">Developing Countries</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004467" MajorTopicYN="Y">Economics</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D004651" MajorTopicYN="Y">Employment</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D004777" MajorTopicYN="N">Environment</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005193" MajorTopicYN="N">Family Planning Services</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005202" MajorTopicYN="N" Type="Geographic">Far East</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005298" MajorTopicYN="N">Fertility</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006262" MajorTopicYN="N">Health</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006280" MajorTopicYN="N">Health Manpower</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006285" MajorTopicYN="Y">Health Planning</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006296" MajorTopicYN="N">Health Services</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007723" MajorTopicYN="N" Type="Geographic">Korea</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008430" MajorTopicYN="Y">Maternal-Child Health Centers</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009934" MajorTopicYN="N">Organization and Administration</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011153" MajorTopicYN="N">Population</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011154" MajorTopicYN="N">Population Characteristics</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011156" MajorTopicYN="N">Population Density</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011157" MajorTopicYN="Y">Population Dynamics</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011158" MajorTopicYN="Y">Population Growth</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011320" MajorTopicYN="N">Primary Health Care</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015397" MajorTopicYN="Y">Program Evaluation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011640" MajorTopicYN="Y">Public Policy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017150" MajorTopicYN="Y">Public Sector</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012106" MajorTopicYN="Y">Research</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012946" MajorTopicYN="Y">Social Welfare</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D012959" MajorTopicYN="Y">Socioeconomic Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013245" MajorTopicYN="Y">Sterilization, Reproductive</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="PIP">067656</OtherID>
+ <OtherID Source="POP">00204408</OtherID>
+ <OtherAbstract Type="PIP" Language="eng">
+ <AbstractText>The total fertility rate (TFR) in Korea decreased from 6.0 to 1.6 over the period 1960-87. A national family planning program and socioeconomic development have played roles in this decline. Should this most recent TFR prevail, the nation's population will increase to 50.2 million by 2020, shifting to negative growth thereafter. Demographic aging and labor shortages will ensue. Future population policy should consider Korea's socioeconomic conditions and its burgeoning population in relation to the available land area, and aim to maintain a minimum positive population growth rate. In this context, this paper considers future population policy directions for Korea, acknowledging that its strategies and objectives must change. Postponing reaching the goal of zero population growth rate is suggested to allow a moderate population infusion of economically active individuals. These people will help facilitate greater economic development and work to improve the quality of life in Korea. Strengthened family planning/maternal-child health programs which encourage and support temporary contraceptive methods instead of sterilization will help to achieve this goal. Improving qualitative program aspects should be the center of attention in these programs. The paper also calls upon the Korea Institute for Health and Social Affairs to strengthen its research and evaluation capabilities.</AbstractText>
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+ <Keyword MajorTopicYN="N">Adult</Keyword>
+ <Keyword MajorTopicYN="N">Age Factors</Keyword>
+ <Keyword MajorTopicYN="Y">Aged</Keyword>
+ <Keyword MajorTopicYN="N">Asia</Keyword>
+ <Keyword MajorTopicYN="N">Birth Rate</Keyword>
+ <Keyword MajorTopicYN="N">Carrying Capacity</Keyword>
+ <Keyword MajorTopicYN="N">Contraception</Keyword>
+ <Keyword MajorTopicYN="Y">Contraceptive Methods</Keyword>
+ <Keyword MajorTopicYN="N">Delivery Of Health Care</Keyword>
+ <Keyword MajorTopicYN="Y">Demographic Aging</Keyword>
+ <Keyword MajorTopicYN="N">Demographic Factors</Keyword>
+ <Keyword MajorTopicYN="Y">Demographic Transition</Keyword>
+ <Keyword MajorTopicYN="Y">Dependency Burden</Keyword>
+ <Keyword MajorTopicYN="N">Developing Countries</Keyword>
+ <Keyword MajorTopicYN="N">Eastern Asia</Keyword>
+ <Keyword MajorTopicYN="Y">Economic Development</Keyword>
+ <Keyword MajorTopicYN="N">Economic Factors</Keyword>
+ <Keyword MajorTopicYN="N">Environment</Keyword>
+ <Keyword MajorTopicYN="N">Family Planning</Keyword>
+ <Keyword MajorTopicYN="Y">Family Planning Programs</Keyword>
+ <Keyword MajorTopicYN="N">Fertility</Keyword>
+ <Keyword MajorTopicYN="N">Fertility Measurements</Keyword>
+ <Keyword MajorTopicYN="N">Fertility Rate</Keyword>
+ <Keyword MajorTopicYN="N">Health</Keyword>
+ <Keyword MajorTopicYN="N">Health Services</Keyword>
+ <Keyword MajorTopicYN="N">Human Resources</Keyword>
+ <Keyword MajorTopicYN="N">Korea</Keyword>
+ <Keyword MajorTopicYN="Y">Labor Force</Keyword>
+ <Keyword MajorTopicYN="N">Macroeconomic Factors</Keyword>
+ <Keyword MajorTopicYN="Y">Maternal-child Health Services</Keyword>
+ <Keyword MajorTopicYN="N">Microeconomic Factors</Keyword>
+ <Keyword MajorTopicYN="N">Natural Resources</Keyword>
+ <Keyword MajorTopicYN="N">Organization And Administration</Keyword>
+ <Keyword MajorTopicYN="N">Policy</Keyword>
+ <Keyword MajorTopicYN="N">Population</Keyword>
+ <Keyword MajorTopicYN="N">Population Characteristics</Keyword>
+ <Keyword MajorTopicYN="Y">Population Decrease</Keyword>
+ <Keyword MajorTopicYN="N">Population Dynamics</Keyword>
+ <Keyword MajorTopicYN="Y">Population Growth</Keyword>
+ <Keyword MajorTopicYN="Y">Population Policy</Keyword>
+ <Keyword MajorTopicYN="Y">Population Pressure</Keyword>
+ <Keyword MajorTopicYN="N">Population Size</Keyword>
+ <Keyword MajorTopicYN="N">Primary Health Care</Keyword>
+ <Keyword MajorTopicYN="Y">Program Evaluation</Keyword>
+ <Keyword MajorTopicYN="N">Programs</Keyword>
+ <Keyword MajorTopicYN="Y">Public Sector</Keyword>
+ <Keyword MajorTopicYN="Y">Research Methodology</Keyword>
+ <Keyword MajorTopicYN="N">Social Policy</Keyword>
+ <Keyword MajorTopicYN="Y">Social Welfare</Keyword>
+ <Keyword MajorTopicYN="Y">Socioeconomic Factors</Keyword>
+ <Keyword MajorTopicYN="Y">Sterilization, Sexual</Keyword>
+ <Keyword MajorTopicYN="Y">Total Fertility Rate--changes</Keyword>
+ <Keyword MajorTopicYN="Y">Zero Population Growth</Keyword>
+ </KeywordList>
+ <GeneralNote Owner="PIP">TJ: JOURNAL OF POPULATION, HEALTH AND SOCIAL WELFARE</GeneralNote>
+ </MedlineCitation>
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+ <Day>1</Day>
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+ <Year>2002</Year>
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+ <Hour>4</Hour>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>1990</Year>
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+ <Year>2007</Year>
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+ <Day>19</Day>
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+ <ISSN IssnType="Electronic">1095-9203</ISSN>
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+ <Volume>297</Volume>
+ <Issue>5586</Issue>
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+ <Year>2002</Year>
+ <Month>Aug</Month>
+ <Day>30</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Science (New York, N.Y.)</Title>
+ <ISOAbbreviation>Science</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Mycobacterium leprae and demyelination.</ArticleTitle>
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+ <MedlinePgn>1475-6; author reply 1475-6</MedlinePgn>
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+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Ottenhoff</LastName>
+ <ForeName>Tom H M</ForeName>
+ <Initials>TH</Initials>
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+ <RefSource>Science. 2002 May 3;296(5569):927-31</RefSource>
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+ <DescriptorName UI="D001422" MajorTopicYN="N">Bacterial Adhesion</DescriptorName>
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+ <DescriptorName UI="D003711" MajorTopicYN="N">Demyelinating Diseases</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ <QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
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+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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+ <DescriptorName UI="D007918" MajorTopicYN="N">Leprosy</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ <QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009166" MajorTopicYN="N">Mycobacterium leprae</DescriptorName>
+ <QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012583" MajorTopicYN="N">Schwann Cells</DescriptorName>
+ <QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
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+ <Year>2002</Year>
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+ <Day>5</Day>
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+ <Minute>1</Minute>
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+ <Year>2002</Year>
+ <Month>09</Month>
+ <Day>13</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>11</Month>
+ <Day>24</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1225-505X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>10</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2001</Year>
+ <Month>Jun</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Ui sahak</Title>
+ <ISOAbbreviation>Uisahak</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Development of neurophysiology in the early twentieth century: Charles Scott Sherrington and The Integrative action of the nervous system.</ArticleTitle>
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+ <LastName>Kim</LastName>
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+ <Affiliation>Department of the Medical History and Medical Humanities, Seoul National University College of Medicine.</Affiliation>
+ </AffiliationInfo>
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+ <PublicationType UI="D016428">Journal Article</PublicationType>
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+ <DescriptorName UI="D049673" MajorTopicYN="N">History, 20th Century</DescriptorName>
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+ <DescriptorName UI="D006113" MajorTopicYN="N">United Kingdom</DescriptorName>
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+ <LastName>Sherrington</LastName>
+ <ForeName>C S</ForeName>
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+ <ISSN IssnType="Print">1054-6863</ISSN>
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+ <Volume>12</Volume>
+ <Issue>1</Issue>
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+ <Year>2002</Year>
+ <Month>Mar</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Kennedy Institute of Ethics journal</Title>
+ <ISOAbbreviation>Kennedy Inst Ethics J</ISOAbbreviation>
+ </Journal>
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+ </Pagination>
+ <Abstract>
+ <AbstractText>Gill and Sade, in the preceding article in this issue of the Kennedy Institute of Ethics Journal, argue that living individuals should be free from legal constraints against selling their organs. The present commentary responds to several of their claims. It explains why an analogy between kidneys and blood fails; why, as a matter of public policy, we prohibit the sale of human solid organs, yet allow the sale of blood; and why their attack on Kant's putative argument against the sale of human body parts is misplaced. Finally, it rejects the claim that the state is entitled to interfere with the actions of individuals only if such actions would harm others. We draw certain lines grounded in what Rawls has termed "public reason" beyond which we do not give effect to the autonomous self-regarding decisions of individuals. Public resistance to the sale of human body parts, no matter how voluntary or well informed, is grounded in the conviction that such a practice would diminish human dignity and our sense of solidarity. A system of organ donation, in contrast, conveys our respect for persons and honors our common humanity.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Cohen</LastName>
+ <ForeName>Cynthia B</ForeName>
+ <Initials>CB</Initials>
+ <AffiliationInfo>
+ <Affiliation>Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
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+ <Country>United States</Country>
+ <MedlineTA>Kennedy Inst Ethics J</MedlineTA>
+ <NlmUniqueID>9109135</NlmUniqueID>
+ <ISSNLinking>1054-6863</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>E</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001782" MajorTopicYN="Y">Blood Donors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D032821" MajorTopicYN="N">Commodification</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D026689" MajorTopicYN="Y">Ethical Analysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005249" MajorTopicYN="Y">Fees and Charges</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018594" MajorTopicYN="N">Human Body</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007668" MajorTopicYN="Y">Kidney</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016030" MajorTopicYN="N">Kidney Transplantation</DescriptorName>
+ <QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019520" MajorTopicYN="Y">Living Donors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011640" MajorTopicYN="Y">Public Policy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009927" MajorTopicYN="N">Tissue and Organ Procurement</DescriptorName>
+ <QualifierName UI="Q000191" MajorTopicYN="Y">economics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="KIE">103573</OtherID>
+ <KeywordList Owner="KIE">
+ <Keyword MajorTopicYN="N">Analytical Approach</Keyword>
+ <Keyword MajorTopicYN="N">Health Care and Public Health</Keyword>
+ </KeywordList>
+ <GeneralNote Owner="KIE">24 refs. 4 fn.</GeneralNote>
+ <GeneralNote Owner="KIE">KIE Bib: blood donation; organ and tissue donation</GeneralNote>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
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+ <Year>2002</Year>
+ <Month>9</Month>
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+ <Year>2002</Year>
+ <Month>09</Month>
+ <Day>13</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2004</Year>
+ <Month>11</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0269-8897</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>15</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Mar</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Science in context</Title>
+ <ISOAbbreviation>Sci Context</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Paracelsus, Paracelsianism, and the secularization of the worldview.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>9-27</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>This paper examines Paracelsus and Paracelsianism in the light of the ideas of Max Weber concerning the social consequences of the Reformation, with special reference to his theories of Entzauberung and secularization. He linked these tendencies both to the rise of capitalism and the growth of experimental science. The detailed case study of Paracelsus' account of diseases linked with saints, in common with his interpretation of many other conditions, demonstrates that he self-consciously extended the boundaries of medicine and eroded the role of magic and witchcraft associated with the church. On the other hand, Paracelsus adopted the Neoplatonic worldview, was immersed in popular magic, and evolved a system of medicine that self-consciously revolved around magic. These factors seem to place a distinct limit on his role in the demystification of knowledge. However, the magic of Paracelsus entailed a decisive break with the entrenched elitist and esoteric tradition of the occultists and hermeticists. It is argued that this reconstructed magic re-establishes the credentials of Paracelsus as a significant contributor to the disenchantment and secularization of the worldview.</AbstractText>
+ </Abstract>
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+ <Author ValidYN="Y">
+ <LastName>Webster</LastName>
+ <ForeName>Charles</ForeName>
+ <Initials>C</Initials>
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+ <Affiliation>All Souls College, Oxford.</Affiliation>
+ </AffiliationInfo>
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+ <Language>eng</Language>
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+ <PublicationType UI="D016456">Historical Article</PublicationType>
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+ <Country>England</Country>
+ <MedlineTA>Sci Context</MedlineTA>
+ <NlmUniqueID>8904113</NlmUniqueID>
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+ <DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D049670" MajorTopicYN="N">History, 17th Century</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D049673" MajorTopicYN="N">History, 20th Century</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D049692" MajorTopicYN="N">History, Early Modern 1451-1600</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008273" MajorTopicYN="N">Magic</DescriptorName>
+ <QualifierName UI="Q000266" MajorTopicYN="Y">history</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008511" MajorTopicYN="Y">Medicine</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010684" MajorTopicYN="N">Philosophy</DescriptorName>
+ <QualifierName UI="Q000266" MajorTopicYN="Y">history</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012068" MajorTopicYN="Y">Religion and Medicine</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012585" MajorTopicYN="N">Sciatica</DescriptorName>
+ <QualifierName UI="Q000266" MajorTopicYN="Y">history</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <PersonalNameSubjectList>
+ <PersonalNameSubject>
+ <LastName>Paracelsus</LastName>
+ </PersonalNameSubject>
+ <PersonalNameSubject>
+ <LastName>Weber</LastName>
+ <ForeName>Max</ForeName>
+ <Initials>M</Initials>
+ </PersonalNameSubject>
+ </PersonalNameSubjectList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>9</Month>
+ <Day>14</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
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+ <PubMedPubDate PubStatus="medline">
+ <Year>2002</Year>
+ <Month>9</Month>
+ <Day>14</Day>
+ <Hour>10</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>9</Month>
+ <Day>14</Day>
+ <Hour>10</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
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+ <ArticleIdList>
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+ <DateCompleted>
+ <Year>2002</Year>
+ <Month>09</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2005</Year>
+ <Month>11</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1539-3704</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>137</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>2002</Year>
+ <Month>Sep</Month>
+ <Day>17</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Annals of internal medicine</Title>
+ <ISOAbbreviation>Ann. Intern. Med.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Screening for osteoporosis in postmenopausal women: recommendations and rationale.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>526-8</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
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+ <CollectiveName>U.S. Preventive Services Task Force</CollectiveName>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
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+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D017065">Practice Guideline</PublicationType>
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+ <Country>United States</Country>
+ <MedlineTA>Ann Intern Med</MedlineTA>
+ <NlmUniqueID>0372351</NlmUniqueID>
+ <ISSNLinking>0003-4819</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Ann Intern Med. 2003 Apr 15;138(8):689; author reply 389-90</RefSource>
+ <PMID Version="1">12693905</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="SummaryForPatientsIn">
+ <RefSource>Ann Intern Med. 2002 Sep 17;137(6):I59</RefSource>
+ <PMID Version="1">12230384</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D050723" MajorTopicYN="N">Fractures, Bone</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000517" MajorTopicYN="N">prevention &amp; control</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008403" MajorTopicYN="Y">Mass Screening</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015663" MajorTopicYN="N">Osteoporosis, Postmenopausal</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
+ </MeshHeading>
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+ <Year>2002</Year>
+ <Month>9</Month>
+ <Day>17</Day>
+ <Hour>10</Hour>
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+ <Day>26</Day>
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+ <ArticleId IdType="pubmed">12230355</ArticleId>
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+ <Year>2002</Year>
+ <Month>09</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2005</Year>
+ <Month>11</Month>
+ <Day>17</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1539-3704</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>137</Volume>
+ <Issue>6</Issue>
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+ <Year>2002</Year>
+ <Month>Sep</Month>
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+ <Title>Annals of internal medicine</Title>
+ <ISOAbbreviation>Ann. Intern. Med.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Summaries for patients. Screening for osteoporosis: recommendations from the U.S. Preventive Services Task Force.</ArticleTitle>
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+ <MedlinePgn>I59</MedlinePgn>
+ </Pagination>
+ <Language>eng</Language>
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+ <RefSource>Ann Intern Med. 2002 Sep 17;137(6):529-41</RefSource>
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+ </MeshHeading>
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+ <DescriptorName UI="D015519" MajorTopicYN="N">Bone Density</DescriptorName>
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+ <DescriptorName UI="D019317" MajorTopicYN="Y">Evidence-Based Medicine</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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+ <DescriptorName UI="D050723" MajorTopicYN="N">Fractures, Bone</DescriptorName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000517" MajorTopicYN="N">prevention &amp; control</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008403" MajorTopicYN="Y">Mass Screening</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015663" MajorTopicYN="N">Osteoporosis, Postmenopausal</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
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+ <Day>17</Day>
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+ <Month>12</Month>
+ <Day>06</Day>
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+ <Year>2007</Year>
+ <Month>11</Month>
+ <Day>15</Day>
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+ <Year>2000</Year>
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+ <ArticleTitle>Gender and globalization. A century in retrospect.</ArticleTitle>
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+ <MedlinePgn>69-70</MedlinePgn>
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+ <MeshHeading>
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+ <MeshHeading>
+ <DescriptorName UI="D007398" MajorTopicYN="Y">Interpersonal Relations</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012922" MajorTopicYN="Y">Social Change</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012959" MajorTopicYN="N">Socioeconomic Factors</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D014933" MajorTopicYN="Y">Women's Rights</DescriptorName>
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+ <OtherID Source="PIP">152034</OtherID>
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+ <AbstractText>In the past, power structures of the nation-State have been organized around patriarchal assumptions, granting men monopoly over power, authority, and wealth. A number of structures have been erected to achieve this imbalance, which have disguised its inequity by making it appear as natural and universal. However, with globalization, this centralization of power within the Sovereign State has been fragmented. Although globalization opens up new spaces by weakening the nation-State, subsequently making possible the undermining of traditional gender hierarchies and devising new bases for gender relations, the reality that the State is no longer the sole institution that can define identity and belonging within it has denied women the space to assert their own claims to gendered self-determination. In this regard, globalization has impacted upon gender relations in complex and contradictory ways. This paper discusses such impacts of globalization on gender relations. Overall, it has become apparent that forms of inequality still exist regardless of a State's prevailing political ideology. Their manifestations may differ, but the reality of women's subordination remains constant.</AbstractText>
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+ <Keyword MajorTopicYN="Y">Social Change</Keyword>
+ <Keyword MajorTopicYN="N">Socioeconomic Factors</Keyword>
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+ <Keyword MajorTopicYN="Y">World</Keyword>
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+ <NumberOfReferences>10</NumberOfReferences>
+ <SpaceFlightMission>Cosmos 1129 Project</SpaceFlightMission>
+ <SpaceFlightMission>Cosmos 2044 Project</SpaceFlightMission>
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+ <DescriptorName UI="D026684" MajorTopicYN="N">Personal Autonomy</DescriptorName>
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+ <DescriptorName UI="D019727" MajorTopicYN="N">Proxy</DescriptorName>
+ <QualifierName UI="Q000331" MajorTopicYN="N">legislation &amp; jurisprudence</QualifierName>
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+ <DescriptorName UI="D011996" MajorTopicYN="N">Records as Topic</DescriptorName>
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+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
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+ <Keyword MajorTopicYN="N">Legal Approach</Keyword>
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+ <Keyword MajorTopicYN="Y">Uniform Rights of the Terminally Ill Act</Keyword>
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+ <GeneralNote Owner="KIE">Sabatino, Charles P</GeneralNote>
+ <GeneralNote Owner="KIE">102 fn.</GeneralNote>
+ <GeneralNote Owner="KIE">KIE Bib: advance directives</GeneralNote>
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+ <ArticleTitle>The right to refuse life-sustaining medical treatment: national trend and recent changes in Maryland law.</ArticleTitle>
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+ <LastName>Goldmeier</LastName>
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+ <DescriptorName UI="D003657" MajorTopicYN="Y">Decision Making</DescriptorName>
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+ <DescriptorName UI="D005066" MajorTopicYN="N">Euthanasia, Passive</DescriptorName>
+ <QualifierName UI="Q000331" MajorTopicYN="Y">legislation &amp; jurisprudence</QualifierName>
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+ <DescriptorName UI="D005190" MajorTopicYN="N">Family</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
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+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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+ <DescriptorName UI="D007872" MajorTopicYN="N">Legal Guardians</DescriptorName>
+ <QualifierName UI="Q000331" MajorTopicYN="Y">legislation &amp; jurisprudence</QualifierName>
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+ <DescriptorName UI="D008020" MajorTopicYN="Y">Life Support Care</DescriptorName>
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+ <DescriptorName UI="D008396" MajorTopicYN="N" Type="Geographic">Maryland</DescriptorName>
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+ <DescriptorName UI="D018458" MajorTopicYN="N">Persistent Vegetative State</DescriptorName>
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+ <DescriptorName UI="D012297" MajorTopicYN="N">Right to Die</DescriptorName>
+ <QualifierName UI="Q000331" MajorTopicYN="Y">legislation &amp; jurisprudence</QualifierName>
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+ <DescriptorName UI="D016312" MajorTopicYN="N">Treatment Refusal</DescriptorName>
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+ <Keyword MajorTopicYN="N">Death and Euthanasia</Keyword>
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+ <Keyword MajorTopicYN="N">Mack v. Mack</Keyword>
+ </KeywordList>
+ <GeneralNote Owner="KIE">Goldmeier, Karen E</GeneralNote>
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+ <GeneralNote Owner="KIE">KIE Bib: allowing to die/legal aspects; treatment refusal</GeneralNote>
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+ <MedlineCitation Status="MEDLINE" Owner="NLM">
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+ <Year>2003</Year>
+ <Month>04</Month>
+ <Day>01</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2015</Year>
+ <Month>11</Month>
+ <Day>19</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1528-9117</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>8</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <MedlineDate>2002 Sep-Oct</MedlineDate>
+ </PubDate>
+ </JournalIssue>
+ <Title>Cancer journal (Sudbury, Mass.)</Title>
+ <ISOAbbreviation>Cancer J</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Radiotherapy alone for lymphocyte-predominant Hodgkin's disease.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>377-83</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The purpose of the study was to analyze the results with radiotherapy alone in a select group of asymptomatic adults with nonbulky, early-stage lymphocyte-predominant Hodgkin's disease.</AbstractText>
+ <AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Between 1963 and 1995, 36 patients with nonbulky stage IA (N = 27) or IIA (N = 9) supradiaphragmatic (N = 27) or subdiaphragmatic (N = 9) lymphocyte-predominant Hodgkin's disease were treated with radiotherapy alone. Eleven of the patients underwent laparotomy. Limited-field radiotherapy involving only one side of the diaphragm and extended-field radiotherapy encompassing both sides of the diaphragm were used in 28 and 8 cases, respectively. Median dose to involved areas was 40.0 Gy given daily in 20 2.0-Gy fractions. Salvage treatmentconsisted of MOPP (mechlorethamine, vincristine, prednisone, procarbazine), CVPP/ABDIC (cyclophosphamide, vinblastine, procarbazine and prednisone/doxorubicin, bleomycin, dacarbazine, lomustine, and prednisone), or ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) chemotherapy and/or involved-field radiotherapy.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">Median follow-up was 8.8 years (range, 3.0-34.4 years). None of the 15 patients with supradiaphragmatic disease who received limited-field radiotherapy to regions that did not include the mediastinal or hilar nodes subsequently experienced relapse there. Only one of 20 patients who received supradiaphragmatic limited-field radiotherapy alone experienced relapse in the paraaortic nodes or spleen. The 5-year relapse-free and overall survival rates for the 20 patients with stage IA lymphocyte-predominant Hodgkin's disease treated with involved-field or regional radiotherapy were 95% and 100%, respectively. There were no cases of severe or life-threatening cardiac toxicity. No solid tumors have been observed in-field in patients treated with limited-field radiotherapy, even though they have been followed up longer than those treated with extended-field radiotherapy (median follow-up, 11.6 vs 5.5 years); two solid tumors have developed in-field in patients who received extended-field radiotherapy.</AbstractText>
+ <AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">Involved-field or regional radiotherapy alone may be adequate in stage IA lymphocyte-predominant Hodgkin's disease patients. Longer follow-up will help to more clearly define the risks of cardiac toxicity and solid tumors that result from involved-field or regional radiotherapy, which appear to be low based on follow-up to date.</AbstractText>
+ </Abstract>
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+ <LastName>Schlembach</LastName>
+ <ForeName>Pamela J</ForeName>
+ <Initials>PJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030-4009, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
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+ <LastName>Wilder</LastName>
+ <ForeName>Richard B</ForeName>
+ <Initials>RB</Initials>
+ </Author>
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+ <LastName>Jones</LastName>
+ <ForeName>Dan</ForeName>
+ <Initials>D</Initials>
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+ <Author ValidYN="Y">
+ <LastName>Ha</LastName>
+ <ForeName>Chul S</ForeName>
+ <Initials>CS</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fayad</LastName>
+ <ForeName>Luis E</ForeName>
+ <Initials>LE</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Younes</LastName>
+ <ForeName>Anas</ForeName>
+ <Initials>A</Initials>
+ </Author>
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+ <LastName>Hagemeister</LastName>
+ <ForeName>Fredrick</ForeName>
+ <Initials>F</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hess</LastName>
+ <ForeName>Mark</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cabanillas</LastName>
+ <ForeName>Fernando</ForeName>
+ <Initials>F</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cox</LastName>
+ <ForeName>James D</ForeName>
+ <Initials>JD</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <GrantList CompleteYN="Y">
+ <Grant>
+ <GrantID>CA 16672</GrantID>
+ <Acronym>CA</Acronym>
+ <Agency>NCI NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>CA 6294</GrantID>
+ <Acronym>CA</Acronym>
+ <Agency>NCI NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ </GrantList>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Cancer J</MedlineTA>
+ <NlmUniqueID>100931981</NlmUniqueID>
+ <ISSNLinking>1528-9117</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>11056-06-7</RegistryNumber>
+ <NameOfSubstance UI="D001761">Bleomycin</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>35S93Y190K</RegistryNumber>
+ <NameOfSubstance UI="D011344">Procarbazine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>50D9XSG0VR</RegistryNumber>
+ <NameOfSubstance UI="D008466">Mechlorethamine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>5J49Q6B70F</RegistryNumber>
+ <NameOfSubstance UI="D014750">Vincristine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>5V9KLZ54CY</RegistryNumber>
+ <NameOfSubstance UI="D014747">Vinblastine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>7BRF0Z81KG</RegistryNumber>
+ <NameOfSubstance UI="D008130">Lomustine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>7GR28W0FJI</RegistryNumber>
+ <NameOfSubstance UI="D003606">Dacarbazine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>80168379AG</RegistryNumber>
+ <NameOfSubstance UI="D004317">Doxorubicin</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>VB0R961HZT</RegistryNumber>
+ <NameOfSubstance UI="D011241">Prednisone</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <SupplMeshList>
+ <SupplMeshName Type="Protocol" UI="C040721">ABDIC protocol</SupplMeshName>
+ <SupplMeshName Type="Protocol" UI="C034632">ABVD protocol</SupplMeshName>
+ <SupplMeshName Type="Protocol" UI="C034078">CVPP protocol</SupplMeshName>
+ <SupplMeshName Type="Protocol" UI="C014553">MOPP protocol</SupplMeshName>
+ </SupplMeshList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Cancer J. 2002 Sep-Oct;8(5):367-8</RefSource>
+ <PMID Version="1">12416892</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000971" MajorTopicYN="N">Antineoplastic Combined Chemotherapy Protocols</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001761" MajorTopicYN="N">Bleomycin</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003606" MajorTopicYN="N">Dacarbazine</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004317" MajorTopicYN="N">Doxorubicin</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006689" MajorTopicYN="N">Hodgkin Disease</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008130" MajorTopicYN="N">Lomustine</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008466" MajorTopicYN="N">Mechlorethamine</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011241" MajorTopicYN="N">Prednisone</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011344" MajorTopicYN="N">Procarbazine</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011879" MajorTopicYN="N">Radiotherapy Dosage</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016879" MajorTopicYN="N">Salvage Therapy</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014747" MajorTopicYN="N">Vinblastine</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014750" MajorTopicYN="N">Vincristine</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2002</Year>
+ <Month>11</Month>
+ <Day>6</Day>
+ <Hour>4</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2003</Year>
+ <Month>4</Month>
+ <Day>2</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2002</Year>
+ <Month>11</Month>
+ <Day>6</Day>
+ <Hour>4</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">12416895</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">12742516</PMID>
+ <DateCompleted>
+ <Year>2009</Year>
+ <Month>02</Month>
+ <Day>27</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1879-0712</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>468</Volume>
+ <Issue>2</Issue>
+ <PubDate>
+ <Year>2003</Year>
+ <Month>May</Month>
+ <Day>09</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>European journal of pharmacology</Title>
+ <ISOAbbreviation>Eur. J. Pharmacol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>93-101</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Mitochondrial Ca(2+) accumulation can induce a sudden increase in the permeability of the inner membrane. This phenomenon is due to the generation of a large nonselective ion channel, termed the permeability transition pore (PTP), which contributes to cellular injury during ischemia and reperfusion. Inhibition of PTP generation constitutes a relevant pharmacological target to protect a cell from death. In this study, we examined the effect of S-15176 ((N-[(3,5-di-tertiobutyl-4-hydroxy-1-thiophenyl)]-3-propyl-N'-(2,3,4-trimethoxybenzyl)piperazine), a novel anti-ischemic agent, on PTP in rat liver mitochondria. S-15176 prevented PTP opening generated by various triggering agents, as attested by the concentration-dependent inhibition of mitochondrial swelling, of mitochondrial membrane potential dissipation and of NADPH oxidation. These effects were associated with an increase in the Ca(2+) loading capacity of mitochondria. S-15176 was a strong inhibitor of lipid peroxidation, but experiments with another trimetazidine derivative devoid of antioxidant activity indicated that this activity was not essential to the inhibitory effect. Binding studies demonstrated that [3H]S-15176 bound to mitochondrial binding sites, especially those localized in the inner membrane. These sites were shared by several well-known inhibitors of PTP opening. These results demonstrate that the mechanism by which S-15176 protects mitochondria against the deleterious effects of ischemia-reperfusion involves inhibition of PTP opening and provide evidence that the drug operates through low structural specificity binding sites located in the inner mitochondrial membrane.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Elimadi</LastName>
+ <ForeName>Aziz</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Département de Pharmacologie, Faculté de Médecine de Paris XII, Créteil, France</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Jullien</LastName>
+ <ForeName>Vincent</ForeName>
+ <Initials>V</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tillement</LastName>
+ <ForeName>Jean Paul</ForeName>
+ <Initials>JP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Morin</LastName>
+ <ForeName>Didier</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Netherlands</Country>
+ <MedlineTA>Eur J Pharmacol</MedlineTA>
+ <NlmUniqueID>1254354</NlmUniqueID>
+ <ISSNLinking>0014-2999</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D033681">Mitochondrial Membrane Transport Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D010879">Piperazines</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C416838">S 15176</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C120771">mitochondrial permeability transition pore</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>53-59-8</RegistryNumber>
+ <NameOfSubstance UI="D009249">NADP</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>SY7Q814VUP</RegistryNumber>
+ <NameOfSubstance UI="D002118">Calcium</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001665" MajorTopicYN="N">Binding Sites</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002118" MajorTopicYN="N">Calcium</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015227" MajorTopicYN="N">Lipid Peroxidation</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D053078" MajorTopicYN="N">Membrane Potential, Mitochondrial</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008930" MajorTopicYN="N">Mitochondria, Liver</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D033681" MajorTopicYN="N">Mitochondrial Membrane Transport Proteins</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009249" MajorTopicYN="N">NADP</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010879" MajorTopicYN="N">Piperazines</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2003</Year>
+ <Month>5</Month>
+ <Day>14</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2009</Year>
+ <Month>2</Month>
+ <Day>28</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2003</Year>
+ <Month>5</Month>
+ <Day>14</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">12742516</ArticleId>
+ <ArticleId IdType="pii">S0014299903016716</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">12742518</PMID>
+ <DateCompleted>
+ <Year>2009</Year>
+ <Month>02</Month>
+ <Day>27</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2014</Year>
+ <Month>11</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1879-0712</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>468</Volume>
+ <Issue>2</Issue>
+ <PubDate>
+ <Year>2003</Year>
+ <Month>May</Month>
+ <Day>09</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>European journal of pharmacology</Title>
+ <ISOAbbreviation>Eur. J. Pharmacol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Behavioral effects of rimcazole analogues alone and in combination with cocaine.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>109-19</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Several sigma receptor ligands have been reported to also have affinity for the dopamine transporter, among them rimcazole (9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole dihydrochloride). However, rimcazole lacks behavioral effects like those of other dopamine uptake inhibitors, such as cocaine and GBR 12909 (1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride). Because of this profile, the interactions with cocaine of rimcazole and several of its novel analogues were assessed. The compounds studied were rimcazole, its N-methyl analogue, SH 1-73 (9-[3-(cis-3,5-dimethyl-4-methyl-1-piperazinyl)-propyl]carbazole hydrobromide), the dibrominated analogue, SH 1-76 (3,6-dibromo-9-[3-(cis-3,5-dimethyl-1-piperazinyl)-propyl]carbazole hydrochloride), and the N-propylphenyl analogues, SH 3-24 ([3-(cis-3,5-dimethyl-4-[3-phenylpropyl]-1-piperazinyl)-propyl]diphenylamine hydrochloride) and SH 3-28 (9-[3-(cis-3,5-dimethyl-4-[3-phenylpropyl]-1-piperazinyl)-propyl]carbazole hydrobromide). The former has a diphenyl-amine group in place of the carbazole moiety of rimcazole, giving the compound additional structural similarity to GBR 12909. The rimcazole analogues produced dose-related decreases in locomotor activity, and also decreased cocaine-stimulated activity in mice. In rats trained to discriminate 10 mg/kg cocaine (i.p.) from saline injections, cocaine and GBR 12909 each produced a dose-related increase in cocaine-appropriate responding. Cocaine also increased rates of responding. SH 3-28 decreased cocaine-appropriate responding at the cocaine training dose to about 58% (SH 3-28) with two of five subjects selecting the cocaine response key. Neither rimcazole nor SH 3-24 produced a significant attenuation of the discriminative effects of cocaine. Rimcazole and its analogs all attenuated the increases in rates of responding produced by cocaine. In contrast to effects obtained with rimcazole analogs, GBR 12909 potentiated the cocaine-induced increases in locomotor activity and operant behavior, as well as the discriminative-stimulus effects of cocaine. The present results indicate that analogues of rimcazole can attenuate the behavioral effects of cocaine, and though the mechanism for these effects is not presently clear, it is possible that this attenuation maybe mediated by actions of the rimcazole analogues at the dopamine transporter and/or sigma receptors.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Katz</LastName>
+ <ForeName>Jonathan L</ForeName>
+ <Initials>JL</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Health and Human Services, Medications Discovery Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. jkatz@intra.nida.nih.gov</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Libby</LastName>
+ <ForeName>Therissa A</ForeName>
+ <Initials>TA</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kopajtic</LastName>
+ <ForeName>Theresa</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Husbands</LastName>
+ <ForeName>Stephen M</ForeName>
+ <Initials>SM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Newman</LastName>
+ <ForeName>Amy Hauck</ForeName>
+ <Initials>AH</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Netherlands</Country>
+ <MedlineTA>Eur J Pharmacol</MedlineTA>
+ <NlmUniqueID>1254354</NlmUniqueID>
+ <ISSNLinking>0014-2999</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D002227">Carbazoles</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D050483">Dopamine Plasma Membrane Transport Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D018765">Dopamine Uptake Inhibitors</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D017480">Receptors, sigma</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>C3N1PS8CX1</RegistryNumber>
+ <NameOfSubstance UI="C034931">rimcazole</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>I5Y540LHVR</RegistryNumber>
+ <NameOfSubstance UI="D003042">Cocaine</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001522" MajorTopicYN="N">Behavior, Animal</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002227" MajorTopicYN="N">Carbazoles</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ <QualifierName UI="Q000819" MajorTopicYN="N">agonists</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003042" MajorTopicYN="N">Cocaine</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003216" MajorTopicYN="N">Conditioning, Operant</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D050483" MajorTopicYN="N">Dopamine Plasma Membrane Transport Proteins</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018765" MajorTopicYN="N">Dopamine Uptake Inhibitors</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="N">administration &amp; dosage</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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+ <MeshHeading>
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+ <AbstractText>The branching fractions of the exclusive decays B0--&gt;K(*0)gamma and B+--&gt;K(*+)gamma are measured from a sample of (22.74+/-0.36)x10(6) BB decays collected with the BABAR detector at the PEP-II asymmetric e(+)e(-) collider. We find B (B0--&gt;K(*0)gamma) = [4.23+/-0.40(stat)+/-0.22(syst)]x10(-5), B(B+--&gt;K(*+)gamma) = [3.83+/-0.62(stat)+/-0.22(syst)]x10(-5) and constrain the CP-violating charge asymmetry to be -0.170&lt;A(CP)(B--&gt;K(*)gamma)&lt;0.082 at 90% C.L.</AbstractText>
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+ <Author ValidYN="Y">
+ <LastName>Murugappan</LastName>
+ <ForeName>Swaminathan</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ding</LastName>
+ <ForeName>Zhongren</ForeName>
+ <Initials>Z</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kunapuli</LastName>
+ <ForeName>Satya P</ForeName>
+ <Initials>SP</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Hematology</MedlineTA>
+ <NlmUniqueID>9708388</NlmUniqueID>
+ <ISSNLinking>1024-5332</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D010975">Platelet Aggregation Inhibitors</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D058921">Purinergic P2Y Receptor Antagonists</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D058925">Receptors, Purinergic P2Y12</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>A74586SNO7</RegistryNumber>
+ <NameOfSubstance UI="C055162">clopidogrel</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>OM90ZUW7M1</RegistryNumber>
+ <NameOfSubstance UI="D013988">Ticlopidine</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001792" MajorTopicYN="N">Blood Platelets</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010975" MajorTopicYN="N">Platelet Aggregation Inhibitors</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D058921" MajorTopicYN="N">Purinergic P2Y Receptor Antagonists</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D058925" MajorTopicYN="N">Receptors, Purinergic P2Y12</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013988" MajorTopicYN="N">Ticlopidine</DescriptorName>
+ <QualifierName UI="Q000031" MajorTopicYN="Y">analogs &amp; derivatives</QualifierName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2003</Year>
+ <Month>12</Month>
+ <Day>12</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2015</Year>
+ <Month>2</Month>
+ <Day>24</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2003</Year>
+ <Month>12</Month>
+ <Day>12</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">14668029</ArticleId>
+ <ArticleId IdType="doi">10.1080/10245330310001621260</ArticleId>
+ <ArticleId IdType="pii">3FQ445E3467ML63X</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">14668030</PMID>
+ <DateCompleted>
+ <Year>2015</Year>
+ <Month>02</Month>
+ <Day>20</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2003</Year>
+ <Month>12</Month>
+ <Day>11</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1607-8454</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>8</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>2003</Year>
+ <Month>Dec</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Hematology (Amsterdam, Netherlands)</Title>
+ <ISOAbbreviation>Hematology</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Platelet counts and interleukin-6 (IL-6) promoter polymorphism in patients with Gaucher disease.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>367-8</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The purpose of this study was to ascertain whether polymorphism of the IL-6 promoter gene affects platelet counts among patients with Gaucher disease since it has been shown that in healthy individuals, the CC genotype is correlated with lower platelet counts.</AbstractText>
+ <AbstractText Label="METHODS" NlmCategory="METHODS">Blood samples from all adult patients seen at a referral clinic during a 12 month period were taken for PCR analysis for the IL-6 promoter polymorphism. Platelet counts were culled from the records on date of presentation and prior to advent of enzyme replacement therapy where relevant.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 138 Ashkenazi Jewish patients, 31 patients had platelet counts &lt;60,000/mm&lt;PRE&gt;3&lt;/PRE&gt; and 37 patients had normal platelet counts (&gt;150,000/mm&lt;PRE&gt;3&lt;/PRE&gt;). Of the former group, 4/31 (13%) and of the latter group, 3/37 (8%), had the CC genotype. Although all seven patients had relatively mild Gaucher disease (only one required therapy), there was no statistically significant difference in allele frequency of the IL-6 promoter polymorphism in either group relative to healthy Ashkenazi Jews.</AbstractText>
+ <AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Whether comparing patients with Gaucher disease with normal platelet counts or with thrombocytopenia to healthy Ashkenazi Jews, there was no difference in frequency of the CC state. Thus, the IL-6 promoter polymorphism may not influence Gaucher disease to induce lower platelet counts as shown in other normal Caucasians.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Elstein</LastName>
+ <ForeName>Deborah</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Altarescu</LastName>
+ <ForeName>Gheona</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Zimran</LastName>
+ <ForeName>Ari</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Hematology</MedlineTA>
+ <NlmUniqueID>9708388</NlmUniqueID>
+ <ISSNLinking>1024-5332</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005776" MajorTopicYN="N">Gaucher Disease</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007585" MajorTopicYN="N">Jews</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010976" MajorTopicYN="N">Platelet Count</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013921" MajorTopicYN="N">Thrombocytopenia</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2003</Year>
+ <Month>12</Month>
+ <Day>12</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2015</Year>
+ <Month>2</Month>
+ <Day>24</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2003</Year>
+ <Month>12</Month>
+ <Day>12</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">14668030</ArticleId>
+ <ArticleId IdType="doi">10.1080/10245330310001621297</ArticleId>
+ <ArticleId IdType="pii">MAT9NVAB4BEMLX27</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">14695699</PMID>
+ <DateCompleted>
+ <Year>2005</Year>
+ <Month>04</Month>
+ <Day>12</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1226-0479</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>9</Volume>
+ <Issue>4</Issue>
+ <PubDate>
+ <Year>2003</Year>
+ <Month>Dec</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Taehan Kan Hakhoe chi = The Korean journal of hepatology</Title>
+ <ISOAbbreviation>Taehan Kan Hakhoe Chi</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[The significance of urine sodium measurement after furosemide administration in diuretics-unresponsive patients with liver cirrhosis].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>324-31</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="BACKGROUND/AIMS" NlmCategory="OBJECTIVE">The diagnosis of refractory ascites means a poor prognosis for patients with liver cirrhosis. The definition of refractory ascites has already been established, but using the dosage of diuretics that correlates with the definition of refractory ascites in an out-patient department will lower the compliance of the patient, as well as causing serious complications, such as hepatic encephalopathy and hyponatremia, as the dosage of diuretics is increased. Due to this fact, it is very difficult to apply this definition of refractory ascites to patients in a domestic out-patient department. In this study, in situations where there are difficulties in applying the diuretics dosage according to definition of refractory ascites, we tried to find out whether measuring the value of urine sodium after the administration of intravenous furosemide can be the standard in early differentiation of the response to diuretics treatment.</AbstractText>
+ <AbstractText Label="METHODS" NlmCategory="METHODS">We reviewed 16 cases of liver cirrhosis with ascites and classified them into two groups by the response to diuretics. The diuretics-responsive ascites group was 8 cases and the diuretics-unresponsive ascites group consisted of 8 cases. After admission, we examined the patients' CBC, biochemical liver function test, spot urine sodium, and 24 hour creatinine clearance. After the beginning of the experiment, all diuretic therapy was stopped for 3 days. Daily we examined the patients' CBC, biochemical liver function test, and in the 3rd experiment day, we measured 24-hour urine volume and sodium. In the 4th experiment day, after sampling for ADH, plasma renin activity and plasma aldosterone level, we administrated the furosemide 80 mg I.V, and measured the amount of 8 hour urine volume and sodium.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">The plasma aldosterone level was significantly higher in the diuretics- unresponsive ascites group than in the diuretics-responsive ascites group. In the 4th experiment day, the amount of urine volume and sodium was very significantly lower in the diuretics-unresponsive ascites group than in the diuretics-responsive ascites group (1297.5 +/-80.9 vs 2003.7 +/-114.6 ml, p&lt;0.005, 77.3 +/-8.2 vs 211.8 +/-12.6 mEq, p&lt;0.001).</AbstractText>
+ <AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In out-patient departments, the measurement of urine sodium 8 hours after administrating 80 mg of intravenous furosemide, will help in differentiating ascites patients with lower treatment response to diuretics.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Cho</LastName>
+ <ForeName>Hyun Seok</ForeName>
+ <Initials>HS</Initials>
+ <AffiliationInfo>
+ <Affiliation>Research Institute of Digestive Disease, Hanyang University College of Medicine, Seoul, Korea.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Park</LastName>
+ <ForeName>Geun Tae</ForeName>
+ <Initials>GT</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kim</LastName>
+ <ForeName>Young Hoon</ForeName>
+ <Initials>YH</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Shim</LastName>
+ <ForeName>Sung Gon</ForeName>
+ <Initials>SG</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kim</LastName>
+ <ForeName>Jin Bae</ForeName>
+ <Initials>JB</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lee</LastName>
+ <ForeName>Oh Young</ForeName>
+ <Initials>OY</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Choi</LastName>
+ <ForeName>Ho Soon</ForeName>
+ <Initials>HS</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hahm</LastName>
+ <ForeName>Joon Soo</ForeName>
+ <Initials>JS</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lee</LastName>
+ <ForeName>Min Ho</ForeName>
+ <Initials>MH</Initials>
+ </Author>
+ </AuthorList>
+ <Language>kor</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D004740">English Abstract</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Korea (South)</Country>
+ <MedlineTA>Taehan Kan Hakhoe Chi</MedlineTA>
+ <NlmUniqueID>9607534</NlmUniqueID>
+ <ISSNLinking>1226-0479</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D004232">Diuretics</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>7LXU5N7ZO5</RegistryNumber>
+ <NameOfSubstance UI="D005665">Furosemide</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>9NEZ333N27</RegistryNumber>
+ <NameOfSubstance UI="D012964">Sodium</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001201" MajorTopicYN="N">Ascites</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004232" MajorTopicYN="N">Diuretics</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="Y">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005665" MajorTopicYN="N">Furosemide</DescriptorName>
+ <QualifierName UI="Q000008" MajorTopicYN="Y">administration &amp; dosage</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007262" MajorTopicYN="N">Infusions, Intravenous</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008103" MajorTopicYN="N">Liver Cirrhosis</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012964" MajorTopicYN="N">Sodium</DescriptorName>
+ <QualifierName UI="Q000652" MajorTopicYN="Y">urine</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2003</Year>
+ <Month>12</Month>
+ <Day>27</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2005</Year>
+ <Month>4</Month>
+ <Day>13</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2003</Year>
+ <Month>12</Month>
+ <Day>27</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">14695699</ArticleId>
+ <ArticleId IdType="pii">200312324</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">14729922</PMID>
+ <DateCompleted>
+ <Year>2004</Year>
+ <Month>02</Month>
+ <Day>11</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Electronic-Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1362-4962</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>32</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2004</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Nucleic acids research</Title>
+ <ISOAbbreviation>Nucleic Acids Res.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Local homology recognition and distance measures in linear time using compressed amino acid alphabets.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>380-5</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Methods for discovery of local similarities and estimation of evolutionary distance by identifying k-mers (contiguous subsequences of length k) common to two sequences are described. Given unaligned sequences of length L, these methods have O(L) time complexity. The ability of compressed amino acid alphabets to extend these techniques to distantly related proteins was investigated. The performance of these algorithms was evaluated for different alphabets and choices of k using a test set of 1848 pairs of structurally alignable sequences selected from the FSSP database. Distance measures derived from k-mer counting were found to correlate well with percentage identity derived from sequence alignments. Compressed alphabets were seen to improve performance in local similarity discovery, but no evidence was found of improvements when applied to distance estimates. The performance of our local similarity discovery method was compared with the fast Fourier transform (FFT) used in MAFFT, which has O(L log L) time complexity. The method for achieving comparable coverage to FFT is revealed here, and is more than an order of magnitude faster. We suggest using k-mer distance for fast, approximate phylogenetic tree construction, and show that a speed improvement of more than three orders of magnitude can be achieved relative to standard distance methods, which require alignments.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Edgar</LastName>
+ <ForeName>Robert C</ForeName>
+ <Initials>RC</Initials>
+ <AffiliationInfo>
+ <Affiliation>bob@drive5.com</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2004</Year>
+ <Month>01</Month>
+ <Day>16</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Nucleic Acids Res</MedlineTA>
+ <NlmUniqueID>0411011</NlmUniqueID>
+ <ISSNLinking>0305-1048</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
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+ <LastName>Leslie</LastName>
+ <ForeName>Mitch</ForeName>
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+ <DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName>
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+ <QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
+ <QualifierName UI="Q000517" MajorTopicYN="Y">prevention &amp; control</QualifierName>
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+ <DescriptorName UI="D017202" MajorTopicYN="N">Myocardial Ischemia</DescriptorName>
+ <QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
+ <QualifierName UI="Q000517" MajorTopicYN="Y">prevention &amp; control</QualifierName>
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+ <QualifierName UI="Q000517" MajorTopicYN="Y">prevention &amp; control</QualifierName>
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+ <Month>02</Month>
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+ <Month>11</Month>
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+ <ISSN IssnType="Electronic">1362-4962</ISSN>
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+ <Volume>32</Volume>
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+ <Year>2004</Year>
+ <Month>Jan</Month>
+ <Day>15</Day>
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+ <Title>Nucleic acids research</Title>
+ <ISOAbbreviation>Nucleic Acids Res.</ISOAbbreviation>
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+ <ArticleTitle>Superior 5' homogeneity of RNA from ATP-initiated transcription under the T7 phi 2.5 promoter.</ArticleTitle>
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+ <MedlinePgn>e14</MedlinePgn>
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+ <Abstract>
+ <AbstractText>Transcription from the commonly used GTP- initiating T7 class III promoter phi6.5 frequently produces heterogeneous RNA at both 3' and 5' ends. We demonstrate here that RNA transcripts from the T7 class II promoter phi2.5 have superior 5' homogeneity over those from the phi6.5 promoter, with comparable total RNA yields. The overall homogeneity of RNA transcripts is improved to different degrees depending on RNA sequences, although transcription under phi2.5 does not affect the 3' heterogeneity of RNA. In combination with 3' RNA trimming by DNAzymes or ribozymes, this ATP- initiated transcription system based on the T7 phi2.5 promoter can provide excellent quality of RNA for applications requiring a high degree of RNA size homogeneity.</AbstractText>
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+ <Author ValidYN="Y">
+ <LastName>Coleman</LastName>
+ <ForeName>Tricia M</ForeName>
+ <Initials>TM</Initials>
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+ <Affiliation>Department of Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS 39406-5043, USA.</Affiliation>
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+ <LastName>Wang</LastName>
+ <ForeName>Guocan</ForeName>
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+ <LastName>Huang</LastName>
+ <ForeName>Faqing</ForeName>
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+ <Month>01</Month>
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+ <Country>England</Country>
+ <MedlineTA>Nucleic Acids Res</MedlineTA>
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+ <DescriptorName UI="D020413" MajorTopicYN="N">3' Untranslated Regions</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D020121" MajorTopicYN="N">5' Untranslated Regions</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D000255" MajorTopicYN="N">Adenosine Triphosphate</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017123" MajorTopicYN="N">Bacteriophage T7</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015967" MajorTopicYN="N">Gene Expression Regulation, Viral</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D008970" MajorTopicYN="N">Molecular Weight</DescriptorName>
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+ <DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName>
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+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
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+ <LastName>Reston</LastName>
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+ <LastName>Savva</LastName>
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+ <LastName>Richards</LastName>
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+ <Year>2004</Year>
+ <Month>02</Month>
+ <Day>26</Day>
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+ <DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
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+ <DescriptorName UI="D001859" MajorTopicYN="N">Bone Neoplasms</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D005269" MajorTopicYN="N">Femur</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
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+ <DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
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+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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+ <DescriptorName UI="D015831" MajorTopicYN="N">Osteochondroma</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
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+ <DescriptorName UI="D011859" MajorTopicYN="N">Radiography</DescriptorName>
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+ <ArticleId IdType="doi">10.1007/s00256-003-0739-5</ArticleId>
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+ <ArticleId IdType="pubmed">6238969</ArticleId>
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+ <Year>2004</Year>
+ <Month>May</Month>
+ <Day>15</Day>
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+ <Title>Bioorganic &amp; medicinal chemistry</Title>
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+ <ArticleTitle>Aminyl and iminyl radicals from arylhydrazones in the photo-induced DNA cleavage.</ArticleTitle>
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+ <MedlinePgn>2509-15</MedlinePgn>
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+ <Abstract>
+ <AbstractText>Photolytic cleavage of the nitrogen-nitrogen single bond in benzaldehyde phenylhydrazones produced aminyl (R2N*) and iminyl (R2C=N*) radicals. This photochemical property was utilized in the development of hydrazones as photo-induced DNA-cleaving agents. Irradiation with 350 nm UV light of arylhydrazones bearing substituents of various types in a phosphate buffer solution containing the supercoiled circular phiX174 RFI DNA at pH 6.0 resulted in single-strand cleavage of DNA. Attachment of the electron-donating OMe group to arylhydrazones increased their DNA-cleaving activity. Results from systematic studies indicate that both the aminyl and the iminyl radicals possessed DNA-cleaving ability.</AbstractText>
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+ <LastName>Hwu</LastName>
+ <ForeName>Jih Ru</ForeName>
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+ <LastName>King</LastName>
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+ <LastName>Tsay</LastName>
+ <ForeName>Shwu-Chen</ForeName>
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+ <Title>Journal of motor behavior</Title>
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+ <ArticleTitle>The First Conference on Motor Control in Down Syndrome.</ArticleTitle>
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+ <LastName>Latash</LastName>
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+ <Month>9</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15117668</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">15206831</PMID>
+ <DateCompleted>
+ <Year>2004</Year>
+ <Month>07</Month>
+ <Day>29</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2007</Year>
+ <Month>11</Month>
+ <Day>14</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0896-4289</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>29</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>2003</Year>
+ <Season>Fall</Season>
+ </PubDate>
+ </JournalIssue>
+ <Title>Behavioral medicine (Washington, D.C.)</Title>
+ <ISOAbbreviation>Behav Med</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Warm partner contact is related to lower cardiovascular reactivity.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>123-30</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The authors investigated the relationship between brief warm social and physical contact among cohabitating couples and blood pressure (BP) reactivity to stress in a sample of healthy adults (66 African American, 117 Caucasian; 74 women, 109 men). Prior to stress, the warm contact group underwent a 10-minute period of handholding while viewing a romantic video. Followed by a 20-second hug with their partner, while the no contact group rested quietly for 10 minutes and 20 seconds. In response to a public speaking task, individuals receiving prestress partner contact demonstrated lower systolic BP diastolic BP, and heart rate increases compared with the no contact group. The effects of warm contact were comparable for men and women and were greater for African Americans compared with Caucasians. These findings suggest that affectionate relationships with a supportive partner may contribute to lower reactivity to stressful life events and may partially mediate the benefit of marital support on better cardiovascular health.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Grewen</LastName>
+ <ForeName>Karen M</ForeName>
+ <Initials>KM</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Psychiatry, University of North Carolina at Chapel Hill, 27599-7175, USA. karen_grewen@med.unc.edu</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Anderson</LastName>
+ <ForeName>Bobbi J</ForeName>
+ <Initials>BJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Girdler</LastName>
+ <ForeName>Susan S</ForeName>
+ <Initials>SS</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Light</LastName>
+ <ForeName>Kathleen C</ForeName>
+ <Initials>KC</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <GrantList CompleteYN="Y">
+ <Grant>
+ <GrantID>HL64927</GrantID>
+ <Acronym>HL</Acronym>
+ <Agency>NHLBI NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>RR00046</GrantID>
+ <Acronym>RR</Acronym>
+ <Agency>NCRR NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ </GrantList>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Behav Med</MedlineTA>
+ <NlmUniqueID>8804264</NlmUniqueID>
+ <ISSNLinking>0896-4289</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000339" MajorTopicYN="N">Affect</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001831" MajorTopicYN="Y">Body Temperature</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008016" MajorTopicYN="N">Life Change Events</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008393" MajorTopicYN="N">Marriage</DescriptorName>
+ <QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013060" MajorTopicYN="N">Speech</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018454" MajorTopicYN="Y">Spouses</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014110" MajorTopicYN="N">Touch</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2004</Year>
+ <Month>6</Month>
+ <Day>23</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2004</Year>
+ <Month>7</Month>
+ <Day>30</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2004</Year>
+ <Month>6</Month>
+ <Day>23</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15206831</ArticleId>
+ <ArticleId IdType="doi">10.1080/08964280309596065</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">15228064</PMID>
+ <DateCompleted>
+ <Year>2004</Year>
+ <Month>08</Month>
+ <Day>06</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>06</Month>
+ <Day>29</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1080-6032</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>15</Volume>
+ <Issue>2</Issue>
+ <PubDate>
+ <Year>2004</Year>
+ <Season>Summer</Season>
+ </PubDate>
+ </JournalIssue>
+ <Title>Wilderness &amp; environmental medicine</Title>
+ <ISOAbbreviation>Wilderness Environ Med</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Acute coronary ischemia following centipede envenomation: case report and review of the literature.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>109-12</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>This is the first known case report of electrocardiographic (ECG) changes suggestive of coronary vasospasm following a centipede envenomation. A 60-year-old man presented to the emergency department (ED) 1 hour after being stung by a 12-cm centipede. He complained of right great toe pain that did not radiate to his leg. The patient had no known ischemic heart disease. He did not describe any exertional symptoms but admitted experiencing weakness. During the ED course, concurrent with obtaining peripheral intravenous access, the patient experienced diaphoresis, dizziness, hypotension, and bradycardia. His ECG showed new ST-T wave changes, which suggested an acute ischemic process. The patient's blood pressure was 89/60 mm Hg, his pulse rate was 47 beats/min, and his respiration rate was 28 breaths/min. In the following hours, ECG findings returned to baseline. His blood pressure improved gradually with fluid resuscitation after approximately 5 hours. Cardiac markers returned to normal in the 13th hour after the event, and the patient underwent exercise stress testing, which was negative. The patient was discharged with cardiology follow-up. Adult patients with centipede envenomation should be closely monitored in anticipation of possible myocardial ischemia due to vasospasm, hypotension, and myocardial toxic effects of the venom. A child receiving the same amount of venom would be potentially at greater risk.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Ozsarac</LastName>
+ <ForeName>Murat</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Dokuz Eylul University School of Medicine, Department of Emergency Medicine, Inciralti, Izmir, Turkey. mozsarac@hotmail.com</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Karcioglu</LastName>
+ <ForeName>Ozgur</ForeName>
+ <Initials>O</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ayrik</LastName>
+ <ForeName>Cuneyt</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Somuncu</LastName>
+ <ForeName>Fatih</ForeName>
+ <Initials>F</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Gumrukcu</LastName>
+ <ForeName>Serhat</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D002363">Case Reports</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016454">Review</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Wilderness Environ Med</MedlineTA>
+ <NlmUniqueID>9505185</NlmUniqueID>
+ <ISSNLinking>1080-6032</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001181" MajorTopicYN="Y">Arthropods</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004562" MajorTopicYN="N">Electrocardiography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004638" MajorTopicYN="N">Emergency Treatment</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017202" MajorTopicYN="N">Myocardial Ischemia</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001098" MajorTopicYN="N">Spider Bites</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <NumberOfReferences>18</NumberOfReferences>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2004</Year>
+ <Month>7</Month>
+ <Day>2</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2004</Year>
+ <Month>8</Month>
+ <Day>7</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2004</Year>
+ <Month>7</Month>
+ <Day>2</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15228064</ArticleId>
+ <ArticleId IdType="pii">S1080-6032(04)70455-X</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">15278624</PMID>
+ <DateCompleted>
+ <Year>2005</Year>
+ <Month>02</Month>
+ <Day>07</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0913-8668</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>5</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>1991</Year>
+ <Month>Jul</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal of anesthesia</Title>
+ <ISOAbbreviation>J Anesth</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Hypoxic ventilatory response in cats lightly anesthetized with ketamine: effects of halothane and sevoflurane in low concentrations.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>233-8</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The effect of low concentration sevoflurane and halothane on the ventilatory response to isocapnic hypoxia was studied in sixteen cats. The cats were divided into two groups, sevoflurane group and halothane group, of eight subjects each. As parameters of the hypoxic ventilatory response, A value [the slope of the hyperbolic curve, V(E) = V(0) + A/(Pa(O)(2)-32)] and ratio of V(50) (the minute volume obtained from the hyperbolic equation when Pa(O)(2) = 50 mmHg) to V(0) were studied. These two parameters were examined at three states, sedative state with ketamine as the control, ketamine plus 0.1 MAC inhalation anesthetic, and ketamine plus 0.5 MAC inhalation anesthetic. In the sevoflurane group, the A values were 4789 +/- 1518, 2187 +/- 1214, 1730 +/- 880 (mean +/- SE. ml.min(-1).mmHg) at the control state, 0.1 MAC and 0.5 MAC, respectively. In the halothane group, the A values were 6411 +/- 2368, 2529 +/- 842 and 2372 +/- 545, respectively. The ratios of V(50) to V(0) were 1.32 +/- 0.09, 1.22 +/- 0.09, 1.25 +/- 0.08 in the sevoflurane group, 1.47 +/- 0.18, 1.32 +/- 0.11, 1.54 +/- 0.18 in the halothane group, respectively. The A value at 0.1 MAC of the halothane group was less than the control value significantly. This proved that even low concentration halothane depressed the hypoxic ventilatory responses. The depression of hypoxic ventilatory response could cause postanesthetic hypoventilation. On the other hand, we could not find significant depression on the hypoxic ventilatory response in the sevoflurane group, but we should notice that variances of the hypoxic ventilatory response were large.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Tamura</LastName>
+ <ForeName>C</ForeName>
+ <Initials>C</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Anesthesiology and Critical Care Medicine, Hamamatsu University School of Medicine, Japan.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Doi</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ikeda</LastName>
+ <ForeName>K</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Japan</Country>
+ <MedlineTA>J Anesth</MedlineTA>
+ <NlmUniqueID>8905667</NlmUniqueID>
+ <ISSNLinking>0913-8668</ISSNLinking>
+ </MedlineJournalInfo>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>1990</Year>
+ <Month>07</Month>
+ <Day>19</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="accepted">
+ <Year>1990</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1991</Year>
+ <Month>7</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
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+ <PubMedPubDate PubStatus="medline">
+ <Year>1991</Year>
+ <Month>7</Month>
+ <Day>1</Day>
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+ <Minute>1</Minute>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>1991</Year>
+ <Month>7</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15278624</ArticleId>
+ <ArticleId IdType="doi">10.1007/s0054010050233</ArticleId>
+ </ArticleIdList>
+ <ReferenceList>
+ <Reference>
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+ </ArticleIdList>
+ </Reference>
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+ </Reference>
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+ </Reference>
+ <Reference>
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+ <ArticleIdList>
+ <ArticleId IdType="pubmed">697078</ArticleId>
+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>Respir Physiol. 1975 Mar;23(2):181-99</Citation>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">1144940</ArticleId>
+ </ArticleIdList>
+ </Reference>
+ </ReferenceList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">15284444</PMID>
+ <DateCompleted>
+ <Year>2004</Year>
+ <Month>09</Month>
+ <Day>29</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Print">0027-8424</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>101</Volume>
+ <Issue>32</Issue>
+ <PubDate>
+ <Year>2004</Year>
+ <Month>Aug</Month>
+ <Day>10</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
+ <ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Tubular precipitation and redox gradients on a bubbling template.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>11537-41</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Tubular structures created by precipitation abound in nature, from chimneys at hydrothermal vents to soda straws in caves. Their formation is controlled by chemical gradients within which precipitation occurs, defining a surface that templates the growing structure. We report a self-organized periodic templating mechanism producing tubular structures electrochemically in iron-ammonium-sulfate solutions; iron oxides precipitate on the surface of bubbles that linger at the tube rim and then detach, leaving behind a ring of material. The acid-base and redox gradients spontaneously generated by diffusion of ammonia from the bubble into solution organize radial compositional layering within the tube wall, a mechanism studied on a larger scale by complex Liesegang patterns of iron oxides formed as ammonia diffuses through a gel containing FeSO(4). When magnetite forms within the wall, a tube may grow curved in an external magnetic field. Connections with free-boundary problems in speleothem formation are emphasized.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Stone</LastName>
+ <ForeName>David A</ForeName>
+ <Initials>DA</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Soil, Water, and Environmental Science, Program in Applied Mathematics, University of Arizona, Tucson, AZ 85721, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Goldstein</LastName>
+ <ForeName>Raymond E</ForeName>
+ <Initials>RE</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2004</Year>
+ <Month>07</Month>
+ <Day>29</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Proc Natl Acad Sci U S A</MedlineTA>
+ <NlmUniqueID>7505876</NlmUniqueID>
+ <ISSNLinking>0027-8424</ISSNLinking>
+ </MedlineJournalInfo>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2004</Year>
+ <Month>7</Month>
+ <Day>31</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2004</Year>
+ <Month>7</Month>
+ <Day>31</Day>
+ <Hour>5</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2004</Year>
+ <Month>7</Month>
+ <Day>31</Day>
+ <Hour>5</Hour>
+ <Minute>0</Minute>
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+ </History>
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+ <PMID Version="1">15611660</PMID>
+ <DateCompleted>
+ <Year>2006</Year>
+ <Month>03</Month>
+ <Day>23</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2017</Year>
+ <Month>11</Month>
+ <Day>16</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">1551-4005</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>4</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2005</Year>
+ <Month>Jan</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Cell cycle (Georgetown, Tex.)</Title>
+ <ISOAbbreviation>Cell Cycle</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>3-5</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Understanding the biological mechanisms underlying aging and cancer predisposition remains a fundamentally important goal in biomedicine. The generation of a PASG hypomorphic mutant mouse model shows that PASG, an SNF2 family member, is essential for properly maintaining normal DNA methylation and gene expression patterns. Disruption of PASG leads to decreased incorporation of BrdU, accumulation of senescence-associated tumor suppressor genes, and increased senescence-associated beta-galactosidase as well as age-related phenotypes. These observations demonstrate that PASG plays a critical role in maintenance of tissue homeostasis, normal growth and longevity.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Sun</LastName>
+ <ForeName>Lin-Quan</ForeName>
+ <Initials>LQ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Arceci</LastName>
+ <ForeName>Robert J</ForeName>
+ <Initials>RJ</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2005</Year>
+ <Month>01</Month>
+ <Day>03</Day>
+ </ArticleDate>
+ </Article>
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+ <Country>United States</Country>
+ <MedlineTA>Cell Cycle</MedlineTA>
+ <NlmUniqueID>101137841</NlmUniqueID>
+ <ISSNLinking>1551-4005</ISSNLinking>
+ </MedlineJournalInfo>
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+ <Chemical>
+ <RegistryNumber>9007-49-2</RegistryNumber>
+ <NameOfSubstance UI="D004247">DNA</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 2.1.1.-</RegistryNumber>
+ <NameOfSubstance UI="D008780">Methyltransferases</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 3.2.1.23</RegistryNumber>
+ <NameOfSubstance UI="D001616">beta-Galactosidase</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 3.6.4.-</RegistryNumber>
+ <NameOfSubstance UI="D004265">DNA Helicases</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 5.99.-</RegistryNumber>
+ <NameOfSubstance UI="C487055">Hells protein, mouse</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>G34N38R2N1</RegistryNumber>
+ <NameOfSubstance UI="D001973">Bromodeoxyuridine</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001973" MajorTopicYN="N">Bromodeoxyuridine</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002453" MajorTopicYN="N">Cell Cycle</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016922" MajorTopicYN="Y">Cellular Senescence</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004265" MajorTopicYN="N">DNA Helicases</DescriptorName>
+ <QualifierName UI="Q000037" MajorTopicYN="N">antagonists &amp; inhibitors</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019175" MajorTopicYN="N">DNA Methylation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D044127" MajorTopicYN="Y">Epigenesis, Genetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018507" MajorTopicYN="N">Gene Expression Regulation, Developmental</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008136" MajorTopicYN="Y">Longevity</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008780" MajorTopicYN="N">Methyltransferases</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008817" MajorTopicYN="N">Mice, Mutant Strains</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001616" MajorTopicYN="N">beta-Galactosidase</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2004</Year>
+ <Month>12</Month>
+ <Day>22</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2006</Year>
+ <Month>3</Month>
+ <Day>24</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2004</Year>
+ <Month>12</Month>
+ <Day>22</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15611660</ArticleId>
+ <ArticleId IdType="pii">1341</ArticleId>
+ <ArticleId IdType="doi">10.4161/cc.4.1.1341</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">15611661</PMID>
+ <DateCompleted>
+ <Year>2006</Year>
+ <Month>03</Month>
+ <Day>23</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2009</Year>
+ <Month>11</Month>
+ <Day>19</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">1551-4005</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>4</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2005</Year>
+ <Month>Jan</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Cell cycle (Georgetown, Tex.)</Title>
+ <ISOAbbreviation>Cell Cycle</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>TrkAIII. A novel hypoxia-regulated alternative TrkA splice variant of potential physiological and pathological importance.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>8-9</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Nerve growth factor receptor TrkA is critical for development and maturation of central and peripheral nervous systems, regulating proliferation, differentiation and apoptosis. In cancer, TrkA frequently exhibits suppressor activity in nonmutated form and oncogenic activity upon mutation. Our identification of a novel hypoxia-regulated alternative TrkAIII splice variant, expressed by neural crest-derived neuroblastic tumors, that exhibits neuroblastoma tumor promoting activity, adds significantly to our understanding of potential TrkA involvement in cancer. Our observation that hypoxia, which characterizes the tumor micro-environment, stimulates alternative TrkAIII splicing, provides a way by which TrkA tumor suppressing signals may convert to tumor promoting signals during progression and is consistent with conservation and pathological subversion by neural crest-derived neuroblastic tumors of a mechanism of potential physiological importance to normal neural stem/neural crest progenitors.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Tacconelli</LastName>
+ <ForeName>Antonella</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Farina</LastName>
+ <ForeName>Antonietta R</ForeName>
+ <Initials>AR</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cappabianca</LastName>
+ <ForeName>Lucia</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Gulino</LastName>
+ <ForeName>Alberto</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Mackay</LastName>
+ <ForeName>Andrew R</ForeName>
+ <Initials>AR</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2005</Year>
+ <Month>01</Month>
+ <Day>05</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Cell Cycle</MedlineTA>
+ <NlmUniqueID>101137841</NlmUniqueID>
+ <ISSNLinking>1551-4005</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D004273">DNA, Neoplasm</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 2.7.10.1</RegistryNumber>
+ <NameOfSubstance UI="D020917">Receptor, trkA</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D017398" MajorTopicYN="Y">Alternative Splicing</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015687" MajorTopicYN="Y">Cell Hypoxia</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004273" MajorTopicYN="N">DNA, Neoplasm</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015972" MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014411" MajorTopicYN="N">Neoplastic Stem Cells</DescriptorName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009432" MajorTopicYN="N">Neural Crest</DescriptorName>
+ <QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009447" MajorTopicYN="N">Neuroblastoma</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ <QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020917" MajorTopicYN="N">Receptor, trkA</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2004</Year>
+ <Month>12</Month>
+ <Day>22</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2006</Year>
+ <Month>3</Month>
+ <Day>24</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2004</Year>
+ <Month>12</Month>
+ <Day>22</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15611661</ArticleId>
+ <ArticleId IdType="pii">1349</ArticleId>
+ <ArticleId IdType="doi">10.4161/cc.4.1.1349</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">15611667</PMID>
+ <DateCompleted>
+ <Year>2006</Year>
+ <Month>03</Month>
+ <Day>23</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">1551-4005</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>4</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2005</Year>
+ <Month>Jan</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Cell cycle (Georgetown, Tex.)</Title>
+ <ISOAbbreviation>Cell Cycle</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Replication timing of human chromosome 6.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>172-6</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Genomic microarrays have been used to assess DNA replication timing in a variety of eukaryotic organisms. A replication timing map of the human genome has already been published at a 1Mb resolution. Here we describe how the same method can be used to assess the replication timing of chromosome 6 with a greater resolution using an array of overlapping tile path clones. We report the replication timing map of the whole of chromosome 6 in general, and the MHC region in particular. Positive correlations are observed between replication timing and a number of genomic features including GC content, repeat content and transcriptional activity.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Woodfine</LastName>
+ <ForeName>Kathryn</ForeName>
+ <Initials>K</Initials>
+ <AffiliationInfo>
+ <Affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Beare</LastName>
+ <ForeName>David M</ForeName>
+ <Initials>DM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ichimura</LastName>
+ <ForeName>Koichi</ForeName>
+ <Initials>K</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Debernardi</LastName>
+ <ForeName>Silvana</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Mungall</LastName>
+ <ForeName>Andrew J</ForeName>
+ <Initials>AJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fiegler</LastName>
+ <ForeName>Heike</ForeName>
+ <Initials>H</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Collins</LastName>
+ <ForeName>V Peter</ForeName>
+ <Initials>VP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Carter</LastName>
+ <ForeName>Nigel P</ForeName>
+ <Initials>NP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dunham</LastName>
+ <ForeName>Ian</ForeName>
+ <Initials>I</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2005</Year>
+ <Month>01</Month>
+ <Day>05</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Cell Cycle</MedlineTA>
+ <NlmUniqueID>101137841</NlmUniqueID>
+ <ISSNLinking>1551-4005</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>5Z93L87A1R</RegistryNumber>
+ <NameOfSubstance UI="D006147">Guanine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>8J337D1HZY</RegistryNumber>
+ <NameOfSubstance UI="D003596">Cytosine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>9007-49-2</RegistryNumber>
+ <NameOfSubstance UI="D004247">DNA</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002874" MajorTopicYN="N">Chromosome Mapping</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002896" MajorTopicYN="N">Chromosomes, Human, Pair 6</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003596" MajorTopicYN="N">Cytosine</DescriptorName>
+ <QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D042622" MajorTopicYN="N">DNA Repeat Expansion</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D042522" MajorTopicYN="Y">DNA Replication Timing</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D044127" MajorTopicYN="N">Epigenesis, Genetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016193" MajorTopicYN="N">G1 Phase</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006147" MajorTopicYN="N">Guanine</DescriptorName>
+ <QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008285" MajorTopicYN="N">Major Histocompatibility Complex</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020411" MajorTopicYN="N">Oligonucleotide Array Sequence Analysis</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016196" MajorTopicYN="N">S Phase</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2004</Year>
+ <Month>12</Month>
+ <Day>22</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
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+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
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+ <Month>12</Month>
+ <Day>22</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15611667</ArticleId>
+ <ArticleId IdType="pii">1350</ArticleId>
+ <ArticleId IdType="doi">10.4161/cc.4.1.1350</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">15739502</PMID>
+ <DateCompleted>
+ <Year>2010</Year>
+ <Month>04</Month>
+ <Day>15</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>18</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1000-8713</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>15</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <Year>1997</Year>
+ <Month>Sep</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Se pu = Chinese journal of chromatography</Title>
+ <ISOAbbreviation>Se Pu</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[The determination of olaquindox in feeds by HPLC].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>440-1</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>A liquid chromatographic procedure for the determination of olaquindox in feeds is described. Chromatography was performed on a PC8-10/S2504 (4.0 mm i.d. x 250 mm, 10 microm, Shimadzu Co.) column at 30 degrees C by using a mobile phase of methanol:water (20:80, V/V ) with a flow rate of 0.8 mL/min and UV detection at 260 nm. Acetanilide was used as internal standard. Olaquindox was extracted with dimethylformamide (DMF) from the feeds. The average recoveries of olaquindox were 98.58%-101.63% and the relative standard deviations were 2.67%-4.25%. The method is simple, rapid, reliable and inexpensive.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Li</LastName>
+ <ForeName>L</ForeName>
+ <Initials>L</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Applied Chemistry, Nanchang University, Nanchang, 330047.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Qiu</LastName>
+ <ForeName>S</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ </AuthorList>
+ <Language>chi</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D004740">English Abstract</PublicationType>
+ <PublicationType UI="D023362">Evaluation Studies</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>China</Country>
+ <MedlineTA>Se Pu</MedlineTA>
+ <NlmUniqueID>9424804</NlmUniqueID>
+ <ISSNLinking>1000-8713</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D005503">Food Additives</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D011810">Quinoxalines</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>G3LAW9U88T</RegistryNumber>
+ <NameOfSubstance UI="C013168">olaquindox</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000821" MajorTopicYN="N">Animal Feed</DescriptorName>
+ <QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005503" MajorTopicYN="N">Food Additives</DescriptorName>
+ <QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011810" MajorTopicYN="N">Quinoxalines</DescriptorName>
+ <QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2005</Year>
+ <Month>3</Month>
+ <Day>3</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2010</Year>
+ <Month>4</Month>
+ <Day>16</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2005</Year>
+ <Month>3</Month>
+ <Day>3</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15739502</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">15810377</PMID>
+ <DateCompleted>
+ <Year>2010</Year>
+ <Month>05</Month>
+ <Day>21</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2005</Year>
+ <Month>04</Month>
+ <Day>06</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1000-0593</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>17</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <Year>1997</Year>
+ <Month>Oct</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Guang pu xue yu guang pu fen xi = Guang pu</Title>
+ <ISOAbbreviation>Guang Pu Xue Yu Guang Pu Fen Xi</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>[Study on cleavage mechanisms of dimer (t-Bu)2NO in several solvent phases].</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>124-7</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>In this paper, we studied the cleavage products of dimer t-BuNO in aqueous and organic solutions using method of 1HNMR and UV-Vis, analyzed the reactive kinetics, put forward that dimer (t-Bu)2NO homolytically cleavaged in nonpolar organic solution, and that dimer (t-Bu)2NO homolytically and heterolyticall cleavaged in a competitive manner in polar aqueous solution.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Ma</LastName>
+ <ForeName>X</ForeName>
+ <Initials>X</Initials>
+ <AffiliationInfo>
+ <Affiliation>Cancer Research Institute, Hunan Medical University, Changsha.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tang</LastName>
+ <ForeName>J</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ </AuthorList>
+ <Language>chi</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D004740">English Abstract</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>China</Country>
+ <MedlineTA>Guang Pu Xue Yu Guang Pu Fen Xi</MedlineTA>
+ <NlmUniqueID>9424805</NlmUniqueID>
+ <ISSNLinking>1000-0593</ISSNLinking>
+ </MedlineJournalInfo>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2005</Year>
+ <Month>4</Month>
+ <Day>7</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2005</Year>
+ <Month>4</Month>
+ <Day>7</Day>
+ <Hour>9</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2005</Year>
+ <Month>4</Month>
+ <Day>7</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15810377</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">15968009</PMID>
+ <DateCompleted>
+ <Year>2005</Year>
+ <Month>06</Month>
+ <Day>27</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2014</Year>
+ <Month>07</Month>
+ <Day>29</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1539-3704</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>142</Volume>
+ <Issue>12 Pt 1</Issue>
+ <PubDate>
+ <Year>2005</Year>
+ <Month>Jun</Month>
+ <Day>21</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Annals of internal medicine</Title>
+ <ISOAbbreviation>Ann. Intern. Med.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>953-62</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">There is concern that exogenous female hormones may worsen disease activity in women with systemic lupus erythematosus (SLE).</AbstractText>
+ <AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate the effect of hormone replacement therapy (HRT) on disease activity in postmenopausal women with SLE.</AbstractText>
+ <AbstractText Label="DESIGN" NlmCategory="METHODS">Randomized, double-blind, placebo-controlled noninferiority trial conducted from March 1996 to June 2002.</AbstractText>
+ <AbstractText Label="SETTING" NlmCategory="METHODS">16 university-affiliated rheumatology clinics or practices in 11 U.S. states.</AbstractText>
+ <AbstractText Label="PATIENTS" NlmCategory="METHODS">351 menopausal patients (mean age, 50 years) with inactive (81.5%) or stable-active (18.5%) SLE.</AbstractText>
+ <AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">12 months of treatment with active drug (0.625 mg of conjugated estrogen daily, plus 5 mg of medroxyprogesterone for 12 days per month) or placebo. The 12-month follow-up rate was 82% for the HRT group and 87% for the placebo group.</AbstractText>
+ <AbstractText Label="MEASUREMENTS" NlmCategory="METHODS">The primary end point was occurrence of a severe flare as defined by Safety of Estrogens in Lupus Erythematosus, National Assessment-Systemic Lupus Erythematosus Disease Activity Index composite.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">Severe flare was rare in both treatment groups: The 12-month severe flare rate was 0.081 for the HRT group and 0.049 for the placebo group, yielding an estimated difference of 0.033 (P = 0.23). The upper limit of the 1-sided 95% CI for the treatment difference was 0.078, within the prespecified margin of 9% for noninferiority. Mild to moderate flares were significantly increased in the HRT group: 1.14 flares/person-year for HRT and 0.86 flare/person-year for placebo (relative risk, 1.34; P = 0.01). The probability of any type of flare by 12 months was 0.64 for the HRT group and 0.51 for the placebo group (P = 0.01). In the HRT group, there were 1 death, 1 stroke, 2 cases of deep venous thrombosis, and 1 case of thrombosis in an arteriovenous graft; in the placebo group, 1 patient developed deep venous thrombosis.</AbstractText>
+ <AbstractText Label="LIMITATIONS" NlmCategory="CONCLUSIONS">Findings are not generalizable to women with high-titer anticardiolipin antibodies, lupus anticoagulant, or previous thrombosis.</AbstractText>
+ <AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Adding a short course of HRT is associated with a small risk for increasing the natural flare rate of lupus. Most of these flares are mild to moderate. The benefits of HRT can be balanced against the risk for flare because HRT did not significantly increase the risk for severe flare compared with placebo.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Buyon</LastName>
+ <ForeName>Jill P</ForeName>
+ <Initials>JP</Initials>
+ <AffiliationInfo>
+ <Affiliation>Hospital for Joint Diseases, New York University School of Medicine, New York, New York, USA. jill.buyon@nyumc.org</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Petri</LastName>
+ <ForeName>Michelle A</ForeName>
+ <Initials>MA</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kim</LastName>
+ <ForeName>Mimi Y</ForeName>
+ <Initials>MY</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kalunian</LastName>
+ <ForeName>Kenneth C</ForeName>
+ <Initials>KC</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Grossman</LastName>
+ <ForeName>Jennifer</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hahn</LastName>
+ <ForeName>Bevra H</ForeName>
+ <Initials>BH</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Merrill</LastName>
+ <ForeName>Joan T</ForeName>
+ <Initials>JT</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sammaritano</LastName>
+ <ForeName>Lisa</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lockshin</LastName>
+ <ForeName>Michael</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Alarcón</LastName>
+ <ForeName>Graciela S</ForeName>
+ <Initials>GS</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Manzi</LastName>
+ <ForeName>Susan</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Belmont</LastName>
+ <ForeName>H Michael</ForeName>
+ <Initials>HM</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Askanase</LastName>
+ <ForeName>Anca D</ForeName>
+ <Initials>AD</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sigler</LastName>
+ <ForeName>Lisa</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dooley</LastName>
+ <ForeName>Mary Anne</ForeName>
+ <Initials>MA</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Von Feldt</LastName>
+ <ForeName>Joan</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>McCune</LastName>
+ <ForeName>W Joseph</ForeName>
+ <Initials>WJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Friedman</LastName>
+ <ForeName>Alan</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wachs</LastName>
+ <ForeName>Jane</ForeName>
+ <Initials>J</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cronin</LastName>
+ <ForeName>Mary</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hearth-Holmes</LastName>
+ <ForeName>Michelene</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tan</LastName>
+ <ForeName>Mark</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Licciardi</LastName>
+ <ForeName>Frederick</ForeName>
+ <Initials>F</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <DataBankList CompleteYN="Y">
+ <DataBank>
+ <DataBankName>ClinicalTrials.gov</DataBankName>
+ <AccessionNumberList>
+ <AccessionNumber>NCT00000419</AccessionNumber>
+ </AccessionNumberList>
+ </DataBank>
+ </DataBankList>
+ <GrantList CompleteYN="Y">
+ <Grant>
+ <GrantID>AR 43727</GrantID>
+ <Acronym>AR</Acronym>
+ <Agency>NIAMS NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>M01 RR00052</GrantID>
+ <Acronym>RR</Acronym>
+ <Agency>NCRR NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>M01 RR00096</GrantID>
+ <Acronym>RR</Acronym>
+ <Agency>NCRR NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ <Grant>
+ <GrantID>U01 AR42540</GrantID>
+ <Acronym>AR</Acronym>
+ <Agency>NIAMS NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ </GrantList>
+ <PublicationTypeList>
+ <PublicationType UI="D016430">Clinical Trial</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D016448">Multicenter Study</PublicationType>
+ <PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
+ <PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
+ <PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Ann Intern Med</MedlineTA>
+ <NlmUniqueID>0372351</NlmUniqueID>
+ <ISSNLinking>0003-4819</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D004966">Estrogens, Conjugated (USP)</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>HSU1C9YRES</RegistryNumber>
+ <NameOfSubstance UI="D008525">Medroxyprogesterone</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="SummaryForPatientsIn">
+ <RefSource>Ann Intern Med. 2005 Jun 21;142(12 Pt 1):I22</RefSource>
+ <PMID Version="1">15968006</PMID>
+ </CommentsCorrections>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Ann Intern Med. 2005 Jun 21;142(12 Pt 1):1014-5</RefSource>
+ <PMID Version="1">15968016</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015914" MajorTopicYN="N">Estrogen Replacement Therapy</DescriptorName>
+ <QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004966" MajorTopicYN="N">Estrogens, Conjugated (USP)</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008180" MajorTopicYN="N">Lupus Erythematosus, Systemic</DescriptorName>
+ <QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008525" MajorTopicYN="N">Medroxyprogesterone</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017698" MajorTopicYN="Y">Postmenopause</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2005</Year>
+ <Month>6</Month>
+ <Day>22</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2005</Year>
+ <Month>6</Month>
+ <Day>28</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2005</Year>
+ <Month>6</Month>
+ <Day>22</Day>
+ <Hour>9</Hour>
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+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">15968009</ArticleId>
+ <ArticleId IdType="pii">142/12_Part_1/953</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">16776646</PMID>
+ <DateCompleted>
+ <Year>2006</Year>
+ <Month>08</Month>
+ <Day>09</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0248-4900</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>98</Volume>
+ <Issue>7</Issue>
+ <PubDate>
+ <Year>2006</Year>
+ <Month>Jul</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Biology of the cell</Title>
+ <ISOAbbreviation>Biol. Cell</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Books for free? How can this be? - A PubMed resource you may be overlooking.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>439-43</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The NCBI (National Center for Biotechnology Information) at the National Institutes of Health collects a wide range of molecular biological data, and develops tools and databases to analyse and disseminate this information. Many life scientists are familiar with the website maintained by the NCBI (http://www.ncbi.nlm.nih.gov), because they use it to search GenBank for homologues of their genes of interest or to search the PubMed database for scientific literature of interest. There is also a database called the Bookshelf that includes searchable popular life science textbooks, medical and research reference books and NCBI reference materials. The Bookshelf can be useful for researchers and educators to find basic biological information. This article includes a representative list of the resources currently available on the Bookshelf, as well as instructions on how to access the information in these resources.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Corsi</LastName>
+ <ForeName>Ann K</ForeName>
+ <Initials>AK</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Biology, The Catholic University of America, Washington, DC 20064, USA. corsi@cua.edu</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
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+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
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+ <Country>England</Country>
+ <MedlineTA>Biol Cell</MedlineTA>
+ <NlmUniqueID>8108529</NlmUniqueID>
+ <ISSNLinking>0248-4900</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001690" MajorTopicYN="Y">Biological Science Disciplines</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001877" MajorTopicYN="Y">Books</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020407" MajorTopicYN="Y">Internet</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009317" MajorTopicYN="N">National Library of Medicine (U.S.)</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D039781" MajorTopicYN="Y">PubMed</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012013" MajorTopicYN="N">Reference Books</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012014" MajorTopicYN="Y">Reference Books, Medical</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013782" MajorTopicYN="N">Textbooks as Topic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2006</Year>
+ <Month>6</Month>
+ <Day>17</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
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+ <PubMedPubDate PubStatus="medline">
+ <Year>2006</Year>
+ <Month>8</Month>
+ <Day>10</Day>
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+ <Year>2006</Year>
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+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">16776646</ArticleId>
+ <ArticleId IdType="pii">BC20050093</ArticleId>
+ <ArticleId IdType="doi">10.1042/BC20050093</ArticleId>
+ </ArticleIdList>
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+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">16779244</PMID>
+ <DateCompleted>
+ <Year>2007</Year>
+ <Month>02</Month>
+ <Day>15</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1942-597X</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <PubDate>
+ <Year>2005</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>AMIA ... Annual Symposium proceedings. AMIA Symposium</Title>
+ <ISOAbbreviation>AMIA Annu Symp Proc</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>MeSH Speller + askMEDLINE: auto-completes MeSH terms then searches MEDLINE/PubMed via free-text, natural language queries.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>957</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Medical terminology is challenging even for healthcare personnel. Spelling errors can make searching MEDLINE/PubMed ineffective. We developed a utility that provides MeSH term and Specialist Lexicon Vocabulary suggestions as it is typed on a search page. The correctly spelled term can be incorporated into a free-text, natural language search or used as a clinical queries search.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Fontelo</LastName>
+ <ForeName>Paul</ForeName>
+ <Initials>P</Initials>
+ <AffiliationInfo>
+ <Affiliation>Office of High Performance Computing and Communications, National Library of Medicine, 8600 Rockville Pike, Bethesda, Maryland 20894, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Liu</LastName>
+ <ForeName>Fang</ForeName>
+ <Initials>F</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ackerman</LastName>
+ <ForeName>Michael</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <GrantList CompleteYN="Y">
+ <Grant>
+ <GrantID>Z99 LM999999</GrantID>
+ <Acronym>NULL</Acronym>
+ <Agency>Intramural NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
+ </GrantList>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
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+ <Country>United States</Country>
+ <MedlineTA>AMIA Annu Symp Proc</MedlineTA>
+ <NlmUniqueID>101209213</NlmUniqueID>
+ <ISSNLinking>1559-4076</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D016247" MajorTopicYN="N">Information Storage and Retrieval</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D046650" MajorTopicYN="Y">Medical Subject Headings</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009323" MajorTopicYN="Y">Natural Language Processing</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D039781" MajorTopicYN="Y">PubMed</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
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+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2006</Year>
+ <Month>6</Month>
+ <Day>17</Day>
+ <Hour>9</Hour>
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+ <Year>2007</Year>
+ <Month>2</Month>
+ <Day>16</Day>
+ <Hour>9</Hour>
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+ <Year>2006</Year>
+ <Month>6</Month>
+ <Day>17</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">16779244</ArticleId>
+ <ArticleId IdType="pii">57378</ArticleId>
+ <ArticleId IdType="pmc">PMC1513542</ArticleId>
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+ <ReferenceList>
+ <Reference>
+ <Citation>JAMA. 1998 Oct 21;280(15):1336-8</Citation>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">9794314</ArticleId>
+ </ArticleIdList>
+ </Reference>
+ <Reference>
+ <Citation>J Med Internet Res. 2003 Dec 11;5(4):e31</Citation>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">14713659</ArticleId>
+ </ArticleIdList>
+ </Reference>
+ </ReferenceList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">16888359</PMID>
+ <DateCompleted>
+ <Year>2006</Year>
+ <Month>09</Month>
+ <Day>28</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1064-3745</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>338</Volume>
+ <PubDate>
+ <Year>2006</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Methods in molecular biology (Clifton, N.J.)</Title>
+ <ISOAbbreviation>Methods Mol. Biol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Mining microarray data at NCBI's Gene Expression Omnibus (GEO)*.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>175-90</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) has emerged as the leading fully public repository for gene expression data. This chapter describes how to use Web-based interfaces, applications, and graphics to effectively explore, visualize, and interpret the hundreds of microarray studies and millions of gene expression patterns stored in GEO. Data can be examined from both experiment-centric and gene-centric perspectives using user-friendly tools that do not require specialized expertise in microarray analysis or time-consuming download of massive data sets. The GEO database is publicly accessible through the World Wide Web at http://www.ncbi.nlm.nih.gov/geo.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Barrett</LastName>
+ <ForeName>Tanya</ForeName>
+ <Initials>T</Initials>
+ <AffiliationInfo>
+ <Affiliation>National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Edgar</LastName>
+ <ForeName>Ron</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
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+ <Country>United States</Country>
+ <MedlineTA>Methods Mol Biol</MedlineTA>
+ <NlmUniqueID>9214969</NlmUniqueID>
+ <ISSNLinking>1064-3745</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000465" MajorTopicYN="N">Algorithms</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003627" MajorTopicYN="N">Data Interpretation, Statistical</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D030541" MajorTopicYN="Y">Databases, Genetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName>
+ <QualifierName UI="Q000706" MajorTopicYN="Y">statistics &amp; numerical data</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016247" MajorTopicYN="N">Information Storage and Retrieval</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020407" MajorTopicYN="N">Internet</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009317" MajorTopicYN="N">National Library of Medicine (U.S.)</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020411" MajorTopicYN="N">Oligonucleotide Array Sequence Analysis</DescriptorName>
+ <QualifierName UI="Q000706" MajorTopicYN="Y">statistics &amp; numerical data</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012984" MajorTopicYN="N">Software</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
+ </MeshHeading>
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+ </MedlineCitation>
+ <PubmedData>
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+ <Year>2006</Year>
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+ <ArticleId IdType="pii">1-59745-097-9:175</ArticleId>
+ <ArticleId IdType="doi">10.1385/1-59745-097-9:175</ArticleId>
+ <ArticleId IdType="pmc">PMC1619899</ArticleId>
+ <ArticleId IdType="mid">NIHMS12705</ArticleId>
+ </ArticleIdList>
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+ </Reference>
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+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">16923641</PMID>
+ <DateCompleted>
+ <Year>2007</Year>
+ <Month>01</Month>
+ <Day>25</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>08</Month>
+ <Day>22</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0803-9488</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>60</Volume>
+ <Issue>4</Issue>
+ <PubDate>
+ <Year>2006</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Nordic journal of psychiatry</Title>
+ <ISOAbbreviation>Nord J Psychiatry</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>The use of PubMed/Medline in psychiatry. 3: Searching PubMed.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>310-5</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>This paper is the third in a series of three, intended as a tutorial in the use of PubMed/Medline for an inexperienced user. The papers have the following contents: I--a description of NLM, Medline, PubMed and the system of Medical Subject Headings (MeSH), which form the basis for the indexing of scientific articles, books and other items at NLM. II--A description and a tutorial of the PubMed search window. III--The present article deals mainly with the searching for references in PubMed. Ways of restricting and concentrating the search are presented, and exercises are proposed. A reader may also find guidance for a search for medical books in the NLM Catalog, and in the use of tools like Related Articles, Bookshelf, and Index. With eating disorders as an example, more information is presented on the use of MeSH terms.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Theander</LastName>
+ <ForeName>Sten S</ForeName>
+ <Initials>SS</Initials>
+ <AffiliationInfo>
+ <Affiliation>Division of Psychiatry, Department of Clinical Neuroscience, Lund University, Sweden. sten.theander@med.lu.se</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Nord J Psychiatry</MedlineTA>
+ <NlmUniqueID>100927567</NlmUniqueID>
+ <ISSNLinking>0803-9488</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D016239" MajorTopicYN="N">MEDLINE</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D046650" MajorTopicYN="N">Medical Subject Headings</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011570" MajorTopicYN="Y">Psychiatry</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D039781" MajorTopicYN="Y">PubMed</DescriptorName>
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+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2006</Year>
+ <Month>8</Month>
+ <Day>23</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2007</Year>
+ <Month>1</Month>
+ <Day>26</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>2006</Year>
+ <Month>8</Month>
+ <Day>23</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
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+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">16923641</ArticleId>
+ <ArticleId IdType="pii">P37WU15215LX0170</ArticleId>
+ <ArticleId IdType="doi">10.1080/08039480600790481</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">16949478</PMID>
+ <DateCompleted>
+ <Year>2006</Year>
+ <Month>09</Month>
+ <Day>21</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2006</Year>
+ <Month>09</Month>
+ <Day>04</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1558-3597</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>48</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <Year>2006</Year>
+ <Month>Sep</Month>
+ <Day>05</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Journal of the American College of Cardiology</Title>
+ <ISOAbbreviation>J. Am. Coll. Cardiol.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death).</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>e247-346</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <CollectiveName>European Heart Rhythm Association</CollectiveName>
+ </Author>
+ <Author ValidYN="Y">
+ <CollectiveName>Heart Rhythm Society</CollectiveName>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Zipes</LastName>
+ <ForeName>Douglas P</ForeName>
+ <Initials>DP</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Camm</LastName>
+ <ForeName>A John</ForeName>
+ <Initials>AJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Borggrefe</LastName>
+ <ForeName>Martin</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Buxton</LastName>
+ <ForeName>Alfred E</ForeName>
+ <Initials>AE</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Chaitman</LastName>
+ <ForeName>Bernard</ForeName>
+ <Initials>B</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fromer</LastName>
+ <ForeName>Martin</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Gregoratos</LastName>
+ <ForeName>Gabriel</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Klein</LastName>
+ <ForeName>George</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Moss</LastName>
+ <ForeName>Arthur J</ForeName>
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+ <Title>Surgical endoscopy</Title>
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+ <Title>Alimentary pharmacology &amp; therapeutics</Title>
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+ <ArticleTitle>Effectiveness of an 'half elemental diet' as maintenance therapy for Crohn's disease: A randomized-controlled trial.</ArticleTitle>
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+ <Abstract>
+ <AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Although thiopurines have a proven role in maintenance therapy for Crohn's disease, an alternative therapy is needed for patients intolerant or resistant to thiopurines.</AbstractText>
+ <AbstractText Label="AIM" NlmCategory="OBJECTIVE">To evaluate the effectiveness of home enteral nutrition as a maintenance therapy regimen in which half of the daily calorie requirement is provided by an elemental diet and the remaining half by a free diet. We refer to this home enteral nutrition therapy as 'half elemental diet'.</AbstractText>
+ <AbstractText Label="METHODS" NlmCategory="METHODS">Between 2002 and 2005, 51 patients in remission from two hospitals were randomly assigned to a half elemental diet group (n = 26) or a free diet group (n = 25). The primary outcome measure of this study was the occurrence of relapse over the 2-year period.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">The relapse rate in the half elemental diet group was significantly lower [34.6% vs. 64.0%; multivariate hazard ratio 0.40 (95% CI: 0.16-0.98)] than that in the free diet group after a mean follow-up of 11.9 months. Compliance was similar in the two groups. No adverse event occurred in any of the patients throughout the study.</AbstractText>
+ <AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This randomized-controlled trial shows the effectiveness of an half elemental diet, which is a promising maintenance therapy for Crohn's disease patients.</AbstractText>
+ </Abstract>
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+ <LastName>Takagi</LastName>
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+ <Affiliation>Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. stakagi@int3.med.tohoku.ac.jp</Affiliation>
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+ <MedlineTA>Aliment Pharmacol Ther</MedlineTA>
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+ <QualifierName UI="Q000178" MajorTopicYN="Y">diet therapy</QualifierName>
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+ <MeshHeading>
+ <DescriptorName UI="D010288" MajorTopicYN="N">Parenteral Nutrition</DescriptorName>
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+ <Day>25</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2007</Year>
+ <Month>5</Month>
+ <Day>8</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2006</Year>
+ <Month>10</Month>
+ <Day>25</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">17059514</ArticleId>
+ <ArticleId IdType="pii">APT3120</ArticleId>
+ <ArticleId IdType="doi">10.1111/j.1365-2036.2006.03120.x</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">17713168</PMID>
+ <DateCompleted>
+ <Year>2007</Year>
+ <Month>10</Month>
+ <Day>19</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2007</Year>
+ <Month>11</Month>
+ <Day>30</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1359-6535</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>12</Volume>
+ <Issue>5</Issue>
+ <PubDate>
+ <Year>2007</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Antiviral therapy</Title>
+ <ISOAbbreviation>Antivir. Ther. (Lond.)</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Declining prevalence of HIV-1 drug resistance in treatment-failing patients: a clinical cohort study.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>835-9</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">A major barrier to successful viral suppression in HIV type 1 (HIV-1)-infected individuals is the emergence of virus resistant to antiretroviral drugs. We explored the evolution of genotypic drug resistance prevalence in treatment-failing patients from 1999 to 2005 in a clinical cohort.</AbstractText>
+ <AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Prevalence of major International AIDS Society-USA HIV-1 drug resistance mutations was measured over calendar years in a population with treatment failure and undergoing resistance testing. Predictors of the presence of resistance mutations were analysed by logistic regression.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">Significant reductions of the prevalence of resistance to all three drug classes examined were observed. This was accompanied by a reduction in the proportion of treatment-failing patients. Independent predictors of drug resistance were the earlier calendar year, prior use of suboptimal nucleoside analogue therapy, male sex and higher CD4 levels at testing.</AbstractText>
+ <AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In a single clinical cohort, we observed a decrease in the prevalence of resistance to all three examined antiretroviral drug classes over time. If this finding is confirmed in multicentre cohorts it may translate into reduced transmission of drug-resistant virus from treated patients.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Di Giambenedetto</LastName>
+ <ForeName>Simona</ForeName>
+ <Initials>S</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy. simona.digiambenedetto@rm.unicatt.it</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bracciale</LastName>
+ <ForeName>Laura</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Colafigli</LastName>
+ <ForeName>Manuela</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="N">
+ <LastName>Colatigli</LastName>
+ <ForeName>Manuela</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cattani</LastName>
+ <ForeName>Paola</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Pinnetti</LastName>
+ <ForeName>Carmen</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="N">
+ <LastName>Pannetti</LastName>
+ <ForeName>Carmen</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bacarelli</LastName>
+ <ForeName>Alessandro</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Prosperi</LastName>
+ <ForeName>Mattia</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fadda</LastName>
+ <ForeName>Giovanni</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cauda</LastName>
+ <ForeName>Roberto</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>De Luca</LastName>
+ <ForeName>Andrea</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Antivir Ther</MedlineTA>
+ <NlmUniqueID>9815705</NlmUniqueID>
+ <ISSNLinking>1359-6535</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="ErratumIn">
+ <RefSource>Antivir Ther. 2007;12(7):1145</RefSource>
+ <Note>Colatigli, Manuela [corrected to Colafigli, Manuela; Cattani, Paola [added]; Pannetti, Carmen [corrected to Pinnetti, Carmen]</Note>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV Agents</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D023241" MajorTopicYN="N">Antiretroviral Therapy, Highly Active</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018791" MajorTopicYN="N">CD4 Lymphocyte Count</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D024882" MajorTopicYN="N">Drug Resistance, Viral</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
+ <QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
+ <QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
+ <QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011159" MajorTopicYN="N">Population Surveillance</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012367" MajorTopicYN="Y">RNA, Viral</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017211" MajorTopicYN="N">Treatment Failure</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2007</Year>
+ <Month>8</Month>
+ <Day>24</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2007</Year>
+ <Month>10</Month>
+ <Day>20</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2007</Year>
+ <Month>8</Month>
+ <Day>24</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">17713168</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">17823161</PMID>
+ <DateCompleted>
+ <Year>2007</Year>
+ <Month>09</Month>
+ <Day>17</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1756-1833</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>335</Volume>
+ <Issue>7618</Issue>
+ <PubDate>
+ <Year>2007</Year>
+ <Month>Sep</Month>
+ <Day>08</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>BMJ (Clinical research ed.)</Title>
+ <ISOAbbreviation>BMJ</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Agency warns about dosing error for amphotericin after patients with cancer die.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>467</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Hawkes</LastName>
+ <ForeName>Nigel</ForeName>
+ <Initials>N</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016433">News</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>BMJ</MedlineTA>
+ <NlmUniqueID>8900488</NlmUniqueID>
+ <ISSNLinking>0959-8138</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>7XU7A7DROE</RegistryNumber>
+ <NameOfSubstance UI="D000666">Amphotericin B</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>AIM</CitationSubset>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="ErratumIn">
+ <RefSource>BMJ. 2008 Jan 12;336(7635). doi: 10.1136/bmj.39454.454676.AD</RefSource>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000666" MajorTopicYN="N">Amphotericin B</DescriptorName>
+ <QualifierName UI="Q000506" MajorTopicYN="Y">poisoning</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName>
+ <QualifierName UI="Q000506" MajorTopicYN="Y">poisoning</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004739" MajorTopicYN="N" Type="Geographic">England</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008508" MajorTopicYN="Y">Medication Errors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009181" MajorTopicYN="N">Mycoses</DescriptorName>
+ <QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName>
+ <QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2007</Year>
+ <Month>9</Month>
+ <Day>8</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2007</Year>
+ <Month>9</Month>
+ <Day>18</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2007</Year>
+ <Month>9</Month>
+ <Day>8</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">17823161</ArticleId>
+ <ArticleId IdType="pii">335/7618/467</ArticleId>
+ <ArticleId IdType="doi">10.1136/bmj.39329.504757.DB</ArticleId>
+ <ArticleId IdType="pmc">PMC1971151</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">17926191</PMID>
+ <DateCompleted>
+ <Year>2008</Year>
+ <Month>04</Month>
+ <Day>09</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2013</Year>
+ <Month>11</Month>
+ <Day>21</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1042-8194</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>48</Volume>
+ <Issue>11</Issue>
+ <PubDate>
+ <Year>2007</Year>
+ <Month>Nov</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Leukemia &amp; lymphoma</Title>
+ <ISOAbbreviation>Leuk. Lymphoma</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Advanced age and high initial WBC influence the outcome of inv(3) (q21q26)/t(3;3) (q21;q26) positive AML.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>2145-51</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>AML with inv(3)/t(3;3) are generally considered of having a poor prognosis. For further insight in this rare entity the outcome of 65 inv(3)/t(3;3) positive AML cases were examined with special emphasis o n patient a nd disease related factors at diagnosis. Survival data were available from 35 patients. A hematological CR was achieved in 16/35 patients (46%). Eight patients (50%) relapsed. The median duration of remission was 177 days. Probability of OS was 23% at 2 years. Advanced age and high initial WBC count were associated with shorter OS (p = 0.021 and p = 0.005, respectively). Loss of chromosome 7 was the most frequent additional aberration (n = 34; 52%), followed complex aberrant aberrations (n = 5). Cases with monosomy 7 or the presence of FLT3-length mutations (FLT3-LM)--detected in 13% of cases--were not associated with an even more inferior outcome. Allogeneic stem cell translplantation, performed in 12 cases, resulted in a probability of OS of 62% at 2 years. Our data (1) confirm that inv(3)/t(3;3) AML has a poor prognosis (2) show that age and initial WBC are risk factors for prognosis; (3) suggest that this group may benefit from allogeneic stem cell transplantation.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Weisser</LastName>
+ <ForeName>Martin</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Medical Department III, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany. martin.weisser@gmx.de</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Haferlach</LastName>
+ <ForeName>Claudia</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Haferlach</LastName>
+ <ForeName>Torsten</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Schnittger</LastName>
+ <ForeName>Susanne</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D023362">Evaluation Studies</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Leuk Lymphoma</MedlineTA>
+ <NlmUniqueID>9007422</NlmUniqueID>
+ <ISSNLinking>1026-8022</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>04079A1RDZ</RegistryNumber>
+ <NameOfSubstance UI="D003561">Cytarabine</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>094ZI81Y45</RegistryNumber>
+ <NameOfSubstance UI="D013629">Tamoxifen</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0O54ZQ14I9</RegistryNumber>
+ <NameOfSubstance UI="D000616">Aminoglutethimide</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>BZ114NVM5P</RegistryNumber>
+ <NameOfSubstance UI="D008942">Mitoxantrone</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>N29QWW3BUO</RegistryNumber>
+ <NameOfSubstance UI="D003613">Danazol</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <SupplMeshList>
+ <SupplMeshName Type="Protocol" UI="C435907">MAC chemotherapy protocol</SupplMeshName>
+ <SupplMeshName Type="Protocol" UI="C035360">TAD protocol</SupplMeshName>
+ </SupplMeshList>
+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentIn">
+ <RefSource>Leuk Lymphoma. 2007 Nov;48(11):2096-7</RefSource>
+ <PMID Version="1">17990175</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="Y">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000616" MajorTopicYN="N">Aminoglutethimide</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000971" MajorTopicYN="N">Antineoplastic Combined Chemotherapy Protocols</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007446" MajorTopicYN="Y">Chromosome Inversion</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002893" MajorTopicYN="Y">Chromosomes, Human, Pair 3</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003561" MajorTopicYN="N">Cytarabine</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003613" MajorTopicYN="N">Danazol</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018380" MajorTopicYN="N">Hematopoietic Stem Cell Transplantation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007621" MajorTopicYN="N">Karyotyping</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015470" MajorTopicYN="N">Leukemia, Myeloid, Acute</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007958" MajorTopicYN="Y">Leukocyte Count</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008942" MajorTopicYN="N">Mitoxantrone</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013629" MajorTopicYN="N">Tamoxifen</DescriptorName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014178" MajorTopicYN="Y">Translocation, Genetic</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
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+ <Year>2007</Year>
+ <Month>10</Month>
+ <Day>11</Day>
+ <Hour>9</Hour>
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+ <PubMedPubDate PubStatus="medline">
+ <Year>2008</Year>
+ <Month>4</Month>
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+ <PubMedPubDate PubStatus="entrez">
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+ <PublicationStatus>ppublish</PublicationStatus>
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+ <ArticleId IdType="pubmed">17926191</ArticleId>
+ <ArticleId IdType="pii">782923449</ArticleId>
+ <ArticleId IdType="doi">10.1080/10428190701632848</ArticleId>
+ </ArticleIdList>
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+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">18243949</PMID>
+ <DateCompleted>
+ <Year>2012</Year>
+ <Month>10</Month>
+ <Day>02</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2008</Year>
+ <Month>02</Month>
+ <Day>04</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0278-0062</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>4</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>1985</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>IEEE transactions on medical imaging</Title>
+ <ISOAbbreviation>IEEE Trans Med Imaging</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Electrophoretic recording of electronically stored radiographs.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>39-43</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Continuous tone hard copies of electronically stored radiographs are recorded on transparent film with a silverless conductive coating by electrophoretic deposition of toner particles. A stationary experimental print head with a row of 320 electrodes (eight electrodes per mm) was employed. The performance of the recording process with regard to the most important parameters, i.e., toner concentration, width of the gap between recording medium and electrodes, recording voltage, and speed will be described. The process exhibits continuous tone characteristics, because the optical density can be varied continuously by the recording voltage. The image resolution which can be achieved is characterized by a modulation transfer function.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Hinz</LastName>
+ <ForeName>H D</ForeName>
+ <Initials>HD</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lobl</LastName>
+ <ForeName>H</ForeName>
+ <Initials>H</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>IEEE Trans Med Imaging</MedlineTA>
+ <NlmUniqueID>8310780</NlmUniqueID>
+ <ISSNLinking>0278-0062</ISSNLinking>
+ </MedlineJournalInfo>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1985</Year>
+ <Month>1</Month>
+ <Day>1</Day>
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+ <PubMedPubDate PubStatus="medline">
+ <Year>1985</Year>
+ <Month>1</Month>
+ <Day>1</Day>
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+ <Minute>1</Minute>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>1985</Year>
+ <Month>1</Month>
+ <Day>1</Day>
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+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">18243949</ArticleId>
+ <ArticleId IdType="doi">10.1109/TMI.1985.4307691</ArticleId>
+ </ArticleIdList>
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+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM">
+ <PMID Version="1">18122624</PMID>
+ <DateCompleted>
+ <Year>2007</Year>
+ <Month>12</Month>
+ <Day>27</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>12</Month>
+ <Day>01</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0891-3633</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>59 (1 vol.)</Volume>
+ <PubDate>
+ <MedlineDate>1947-1948</MedlineDate>
+ </PubDate>
+ </JournalIssue>
+ <Title>Transactions of the Southern Surgical Association. Southern Surgical Association (U.S.)</Title>
+ <ISOAbbreviation>Trans South Surg Assoc</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Mesenteric vascular occlusion.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>136-55</MedlinePgn>
+ </Pagination>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>RIVES</LastName>
+ <ForeName>J D</ForeName>
+ <Initials>JD</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>STRUG</LastName>
+ <ForeName>L H</ForeName>
+ <Initials>LH</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>ESSRIG</LastName>
+ <ForeName>I M</ForeName>
+ <Initials>IM</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Trans South Surg Assoc</MedlineTA>
+ <NlmUniqueID>20930080R</NlmUniqueID>
+ <ISSNLinking>0891-3633</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>OM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008641" MajorTopicYN="Y">Mesenteric Vascular Occlusion</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008643" MajorTopicYN="Y">Mesentery</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014652" MajorTopicYN="Y">Vascular Diseases</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherID Source="CLML">4916:397a1</OtherID>
+ <KeywordList Owner="NLM">
+ <Keyword MajorTopicYN="Y">MESENTERY/occlusion</Keyword>
+ </KeywordList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1947</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2018</Year>
+ <Month>12</Month>
+ <Day>4</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1947</Year>
+ <Month>1</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">18122624</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM">
+ <PMID Version="1">18311089</PMID>
+ <DateCompleted>
+ <Year>2016</Year>
+ <Month>04</Month>
+ <Day>23</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>12</Month>
+ <Day>01</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">1091-0220</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>12</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>2008</Year>
+ <Month>Mar</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Mayo Clinic women's healthsource</Title>
+ <ISOAbbreviation>Mayo Clin Womens Healthsource</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Cancer death rates have fallen faster since 2002.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>3</MedlinePgn>
+ </Pagination>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Mayo Clin Womens Healthsource</MedlineTA>
+ <NlmUniqueID>9891120</NlmUniqueID>
+ <ISSNLinking>1091-0220</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>K</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D002423" MajorTopicYN="Y">Cause of Death</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2008</Year>
+ <Month>3</Month>
+ <Day>4</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2016</Year>
+ <Month>4</Month>
+ <Day>24</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2008</Year>
+ <Month>3</Month>
+ <Day>4</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">18311089</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">18964660</PMID>
+ <DateCompleted>
+ <Year>2012</Year>
+ <Month>10</Month>
+ <Day>02</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2008</Year>
+ <Month>10</Month>
+ <Day>30</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0039-9140</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>35</Volume>
+ <Issue>12</Issue>
+ <PubDate>
+ <Year>1988</Year>
+ <Month>Dec</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Talanta</Title>
+ <ISOAbbreviation>Talanta</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Multiparametric curve fitting-XIII Reliability of formation constants determined by analysis of potentiometric titration data.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>981-91</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>The formation (protonation) constants log K(i), of the acid H(j)L are determined by regression analysis of potentiometric titration data when common parameters (log K(i), i = 1,..., j) and group parameters (E(0)', L(0), H(T)) are refined. The influence of three kinds of error on the protonation constants has been investigated: error from the strategy of minimization, random error, and error from uncertain estimates of group parameters. An analysis of variance of the log K(i), matrix was made for 7 identical titrations and 8 computational strategies, or of 7 identical titrations and 8 different options of group parameters to be refined. The influence of the standard potential E(0) of the glass-electrode cell on the systematic error in log K is greater than that of the acid concentration (L(0)) or the concentration of titrant used (H(T)). The ill-conditioned group parameters should be refined together with the common parameters (K(i)), otherwise the estimates of log K(i), are not accurate enough. Two ways of calibrating the glass electrode cell were compared. Internal calibration (performed during titration) was more accurate than external calibration done separately. Of the programs tested ESAB and ACBA are the most powerful because they permit refinement of group parameters and internal calibration. Citric acid was chosen as model substance.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Meloun</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Analytical Chemistry, College of Chemical Technology, CS-532 10 Pardubice, Czechoslovakia.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bartos</LastName>
+ <ForeName>M</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Högfeldt</LastName>
+ <ForeName>E</ForeName>
+ <Initials>E</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Netherlands</Country>
+ <MedlineTA>Talanta</MedlineTA>
+ <NlmUniqueID>2984816R</NlmUniqueID>
+ <ISSNLinking>0039-9140</ISSNLinking>
+ </MedlineJournalInfo>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>1987</Year>
+ <Month>04</Month>
+ <Day>24</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="revised">
+ <Year>1988</Year>
+ <Month>06</Month>
+ <Day>29</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="accepted">
+ <Year>1988</Year>
+ <Month>08</Month>
+ <Day>12</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1988</Year>
+ <Month>12</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1988</Year>
+ <Month>12</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>1988</Year>
+ <Month>12</Month>
+ <Day>1</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">18964660</ArticleId>
+ <ArticleId IdType="pii">0039-9140(88)80233-9</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">18941263</PMID>
+ <DateCompleted>
+ <Year>2015</Year>
+ <Month>07</Month>
+ <Day>23</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>01</Month>
+ <Day>12</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1833-3575</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>37</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <MedlineDate>2008</MedlineDate>
+ </PubDate>
+ </JournalIssue>
+ <Title>Health information management : journal of the Health Information Management Association of Australia</Title>
+ <ISOAbbreviation>Health Inf Manag</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Issues in the measurement of social determinants of health.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>26-32</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>This article focuses on the measurement of the social determinants of health, and specifically on issues relating to two key variables relevant to the analysis of public health information: poverty and inequality. Although the paper has been written from the perspective of economics, the discipline of the two authors, it is also of relevance to researchers in other disciplines. It is argued that there is a need to ensure that, when considering measurement in this largely neglected area of research, sufficient thought is given to the relationships that are being examined or assessed. We argue further that any attempt at measurement in this area must take into account the historical backdrop and the complex nature of the relationships between these key variables.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Mooney</LastName>
+ <ForeName>Gavin</ForeName>
+ <Initials>G</Initials>
+ <AffiliationInfo>
+ <Affiliation>Curtin University of Technology, Perth, Western Australia. g.mooney@curtin.edu.au</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fohtung</LastName>
+ <ForeName>Nubong G</ForeName>
+ <Initials>NG</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Australia</Country>
+ <MedlineTA>Health Inf Manag</MedlineTA>
+ <NlmUniqueID>9438200</NlmUniqueID>
+ <ISSNLinking>1833-3583</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>H</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001315" MajorTopicYN="N" Type="Geographic">Australia</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006301" MajorTopicYN="N">Health Services Needs and Demand</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011203" MajorTopicYN="Y">Poverty</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011634" MajorTopicYN="N">Public Health</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012923" MajorTopicYN="N">Social Class</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D064890" MajorTopicYN="Y">Social Determinants of Health</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012959" MajorTopicYN="Y">Socioeconomic Factors</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2008</Year>
+ <Month>10</Month>
+ <Day>23</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2015</Year>
+ <Month>7</Month>
+ <Day>24</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2008</Year>
+ <Month>10</Month>
+ <Day>23</Day>
+ <Hour>9</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">18941263</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">19771122</PMID>
+ <DateCompleted>
+ <Year>2009</Year>
+ <Month>12</Month>
+ <Day>11</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2009</Year>
+ <Month>09</Month>
+ <Day>22</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Print">0146-9592</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>15</Volume>
+ <Issue>24</Issue>
+ <PubDate>
+ <Year>1990</Year>
+ <Month>Dec</Month>
+ <Day>15</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Optics letters</Title>
+ <ISOAbbreviation>Opt Lett</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Ultrashort-laser-pulse amplification in a XeF[C --&gt; A] excimer amplifier.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1461-3</MedlinePgn>
+ </Pagination>
+ <Abstract>
+ <AbstractText>Tunable blue-green subpicosecond laser pulses have been amplified in an electron-beam-pumped XeF(C --&gt; A) excimer amplifier. Small-signal gains of 3.5% cm(-1) were measured using a 50-cm active gain length. At output energy densities as high as 170 mJ/cm(2), only a small degree of saturation occurred, resulting in a gain of 2.5% cm(-1).</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Sharp</LastName>
+ <ForeName>T E</ForeName>
+ <Initials>TE</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Electrical and Computer Engineering, Rice University, P.O. Box 1892, Houston, Texas 77251, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hofmann</LastName>
+ <ForeName>T</ForeName>
+ <Initials>T</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Dane</LastName>
+ <ForeName>C B</ForeName>
+ <Initials>CB</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wilson</LastName>
+ <ForeName>W L</ForeName>
+ <Initials>WL</Initials>
+ <Suffix>Jr</Suffix>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tittel</LastName>
+ <ForeName>F K</ForeName>
+ <Initials>FK</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wisoff</LastName>
+ <ForeName>P J</ForeName>
+ <Initials>PJ</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Szabó</LastName>
+ <ForeName>G</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Opt Lett</MedlineTA>
+ <NlmUniqueID>7708433</NlmUniqueID>
+ <ISSNLinking>0146-9592</ISSNLinking>
+ </MedlineJournalInfo>
+ </MedlineCitation>
+ <PubmedData>
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+ <PubMedPubDate PubStatus="entrez">
+ <Year>2009</Year>
+ <Month>9</Month>
+ <Day>23</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>1990</Year>
+ <Month>12</Month>
+ <Day>15</Day>
+ <Hour>0</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>1990</Year>
+ <Month>12</Month>
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+ <Volume>337</Volume>
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+ <Title>BMJ (Clinical research ed.)</Title>
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+ <ArticleTitle>Health related quality of life after combined hormone replacement therapy: randomised controlled trial.</ArticleTitle>
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+ <AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the effect of combined hormone replacement therapy (HRT) on health related quality of life.</AbstractText>
+ <AbstractText Label="DESIGN" NlmCategory="METHODS">Randomised placebo controlled double blind trial.</AbstractText>
+ <AbstractText Label="SETTING" NlmCategory="METHODS">General practices in United Kingdom (384), Australia (94), and New Zealand (24).</AbstractText>
+ <AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Postmenopausal women aged 50-69 at randomisation; 3721 women with a uterus were randomised to combined oestrogen and progestogen (n=1862) or placebo (n=1859). Data on health related quality of life at one year were available from 1043 and 1087 women, respectively.</AbstractText>
+ <AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Conjugated equine oestrogen 0.625 mg plus medroxyprogesterone acetate 2.5/5.0 mg or matched placebo orally daily for one year.</AbstractText>
+ <AbstractText Label="MAIN OUTCOME MEASURES" NlmCategory="METHODS">Health related quality of life and psychological wellbeing as measured by the women's health questionnaire. Changes in emotional and physical menopausal symptoms as measured by a symptoms questionnaire and depression by the Centre for Epidemiological Studies depression scale (CES-D). Overall health related quality of life and overall quality of life as measured by the European quality of life instrument (EuroQol) and visual analogue scale, respectively.</AbstractText>
+ <AbstractText Label="RESULTS" NlmCategory="RESULTS">After one year small but significant improvements were observed in three of nine components of the women's health questionnaire for those taking combined HRT compared with those taking placebo: vasomotor symptoms (P&lt;0.001), sexual functioning (P&lt;0.001), and sleep problems (P&lt;0.001). Significantly fewer women in the combined HRT group reported hot flushes (P&lt;0.001), night sweats (P&lt;0.001), aching joints and muscles (P=0.001), insomnia (P&lt;0.001), and vaginal dryness (P&lt;0.001) than in the placebo group, but greater proportions reported breast tenderness (P&lt;0.001) or vaginal discharge (P&lt;0.001). Hot flushes were experienced in the combined HRT and placebo groups by 30% and 29% at trial entry and 9% and 25% at one year, respectively. No significant differences in other menopausal symptoms, depression, or overall quality of life were observed at one year.</AbstractText>
+ <AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Combined HRT started many years after the menopause can improve health related quality of life.</AbstractText>
+ <AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ISRCTN 63718836.</AbstractText>
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+ <AbstractText>The neural crest (NC) is a highly migratory multipotent cell population that forms at the interface between the neuroepithelium and the prospective epidermis of a developing embryo. Following extensive migration throughout the embryo, NC cells eventually settle to differentiate into multiple cell types, ranging from neurons and glial cells of the peripheral nervous system to pigment cells, fibroblasts to smooth muscle cells, and odontoblasts to adipocytes. NC cells migrate in large numbers and their migration is regulated by multiple mechanisms, including chemotaxis, contact-inhibition of locomotion and cell sorting. Here, we provide an overview of NC formation, differentiation and migration, highlighting the molecular mechanisms governing NC migration.</AbstractText>
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+ <LastName>Mayor</LastName>
+ <ForeName>Roberto</ForeName>
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+ <Affiliation>Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. r.mayor@ucl.ac.uk</Affiliation>
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+ <LastName>Theveneau</LastName>
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+ <Country>United Kingdom</Country>
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+ <Agency>Medical Research Council</Agency>
+ <Country>United Kingdom</Country>
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+ <DescriptorName UI="D002633" MajorTopicYN="N">Chemotaxis</DescriptorName>
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+ <DescriptorName UI="D058750" MajorTopicYN="N">Epithelial-Mesenchymal Transition</DescriptorName>
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+ <DescriptorName UI="D018507" MajorTopicYN="Y">Gene Expression Regulation, Developmental</DescriptorName>
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+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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+ <DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
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+ <DescriptorName UI="D009432" MajorTopicYN="N">Neural Crest</DescriptorName>
+ <QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName>
+ <QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
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+ <Keyword MajorTopicYN="N">Cell migration</Keyword>
+ <Keyword MajorTopicYN="N">Chemotaxis</Keyword>
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+ <Keyword MajorTopicYN="N">Neurocristopathies</Keyword>
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+ <Title>German medical science : GMS e-journal</Title>
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+ <ELocationID EIdType="doi" ValidYN="Y">10.3205/000169</ELocationID>
+ <Abstract>
+ <AbstractText>Although endovascular transcatheter embolization of arteriovenous fistulas is minimally invasive, the torrential flow prevailing within a fistula implies the risk of migration of the deployed embolization devices into the downstream venous and pulmonary circulation. We present the endovascular treatment of a giant postnephrectomy arteriovenous fistula between the right renal pedicle and the residual renal vein in a 63-year-old man. The purpose of this case report is to demonstrate that the Amplatzer vascular plug (AVP) can be safely positioned to embolize even relatively large arteriovenous fistulas (AVFs). Secondly, we illustrate that this occluder can even be introduced to the fistula via a transvenous catheter in cases where it is initially not possible to advance the deployment-catheter through a tortuous feeder artery. Migration of the vascular plug was ruled out at follow-up 4 months subsequently to the intervention. Thus, the Amplatzer vascular plug and the arteriovenous through-and-through guide wire access with subsequent transvenous deployment should be considered in similar cases.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Kayser</LastName>
+ <ForeName>Ole</ForeName>
+ <Initials>O</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Radiology, University Hospital Schleswig-Holstein, Kiel, Germany. o.kayser@rad.uni-kiel.de</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Schäfer</LastName>
+ <ForeName>Philipp</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D002363">Case Reports</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2013</Year>
+ <Month>01</Month>
+ <Day>14</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Germany</Country>
+ <MedlineTA>Ger Med Sci</MedlineTA>
+ <NlmUniqueID>101227686</NlmUniqueID>
+ <ISSNLinking>1612-3174</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000783" MajorTopicYN="N">Aneurysm</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001027" MajorTopicYN="N">Aortography</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001164" MajorTopicYN="N">Arteriovenous Fistula</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D042241" MajorTopicYN="N">Early Diagnosis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004621" MajorTopicYN="N">Embolization, Therapeutic</DescriptorName>
+ <QualifierName UI="Q000295" MajorTopicYN="Y">instrumentation</QualifierName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName>
+ <QualifierName UI="Q000293" MajorTopicYN="N">injuries</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009392" MajorTopicYN="Y">Nephrectomy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
+ <QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012077" MajorTopicYN="Y">Renal Artery</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D055989" MajorTopicYN="Y">Septal Occluder Device</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018616" MajorTopicYN="N">Ultrasonography, Doppler, Duplex</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014682" MajorTopicYN="Y">Vena Cava, Inferior</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <OtherAbstract Type="Publisher" Language="ger">
+ <AbstractText>Obwohl die endovaskuläre Katheter-Embolisation von arteriovenösen Fisteln minimal-invasiv ist, impliziert die, in der Fistel vorherrschende, hohe Strömungsgeschwindigkeit ein Risiko zur Migration des Embolisats in den nachgeschalteten venösen Abstrom und in den Lungenkreislauf. Wir beschreiben die endovaskuläre Behandlung einer großen arteriovenösen Fistel zwischen der rechten Nierenarterie und residueller Nierenvene nach Nephrektomie im Fall eines 63-jährigen Mannes.Dieser Fallbericht demonstriert, dass der Amplatzer vascular plug sicher innerhalb sogar relativ großkalibriger AVFs platziert werden kann. Zweitens zeigen wir, dass dieser "Occluder" sogar über einen transvenösen Katheter in die Fistel eingebracht werden kann, falls es initial nicht möglich ist, den Freisetzungs-Katheter über die (in unserem Fall) stark gewundene zuführende Arterie in die Fistel einzuführen. Migration des "vascular plug" wurde in der Verlaufskontrolle 4 Monate postinterventionell ausgeschlossen.Der hier vorgestellte kombiniert-arteriovenöse Zugangsweg mittels transfistulär durchgezogenem Führungsdraht und nachfolgender, transvenöser Freisetzung des Amplatzer vascular plugs sollte in ähnlichen Fällen berücksichtigt werden.</AbstractText>
+ </OtherAbstract>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">AV-fistula</Keyword>
+ <Keyword MajorTopicYN="N">Amplatzer vascular plug</Keyword>
+ <Keyword MajorTopicYN="N">arteriovenous access</Keyword>
+ <Keyword MajorTopicYN="N">arteriovenous fistula</Keyword>
+ <Keyword MajorTopicYN="N">embolisation</Keyword>
+ <Keyword MajorTopicYN="N">endovascular treatment</Keyword>
+ <Keyword MajorTopicYN="N">nephrectomy</Keyword>
+ <Keyword MajorTopicYN="N">through-and-through</Keyword>
+ <Keyword MajorTopicYN="N">transvenous access</Keyword>
+ </KeywordList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>2012</Year>
+ <Month>11</Month>
+ <Day>10</Day>
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+ <Year>2012</Year>
+ <Month>11</Month>
+ <Day>26</Day>
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+ <DateCompleted>
+ <Year>2013</Year>
+ <Month>07</Month>
+ <Day>01</Day>
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+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
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+ <Article PubModel="Electronic-eCollection">
+ <Journal>
+ <ISSN IssnType="Print">1662-4548</ISSN>
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+ <Volume>7</Volume>
+ <PubDate>
+ <Year>2013</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Frontiers in neuroscience</Title>
+ <ISOAbbreviation>Front Neurosci</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Improved blood velocity measurements with a hybrid image filtering and iterative Radon transform algorithm.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>106</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.3389/fnins.2013.00106</ELocationID>
+ <Abstract>
+ <AbstractText>Neural activity leads to hemodynamic changes which can be detected by functional magnetic resonance imaging (fMRI). The determination of blood flow changes in individual vessels is an important aspect of understanding these hemodynamic signals. Blood flow can be calculated from the measurements of vessel diameter and blood velocity. When using line-scan imaging, the movement of blood in the vessel leads to streaks in space-time images, where streak angle is a function of the blood velocity. A variety of methods have been proposed to determine blood velocity from such space-time image sequences. Of these, the Radon transform is relatively easy to implement and has fast data processing. However, the precision of the velocity measurements is dependent on the number of Radon transforms performed, which creates a trade-off between the processing speed and measurement precision. In addition, factors like image contrast, imaging depth, image acquisition speed, and movement artifacts especially in large mammals, can potentially lead to data acquisition that results in erroneous velocity measurements. Here we show that pre-processing the data with a Sobel filter and iterative application of Radon transforms address these issues and provide more accurate blood velocity measurements. Improved signal quality of the image as a result of Sobel filtering increases the accuracy and the iterative Radon transform offers both increased precision and an order of magnitude faster implementation of velocity measurements. This algorithm does not use a priori knowledge of angle information and therefore is sensitive to sudden changes in blood flow. It can be applied on any set of space-time images with red blood cell (RBC) streaks, commonly acquired through line-scan imaging or reconstructed from full-frame, time-lapse images of the vasculature. </AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Chhatbar</LastName>
+ <ForeName>Pratik Y</ForeName>
+ <Initials>PY</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Neurosciences, Medical University of South Carolina Charleston, SC, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kara</LastName>
+ <ForeName>Prakash</ForeName>
+ <Initials>P</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <GrantList CompleteYN="Y">
+ <Grant>
+ <GrantID>R01 EY017925</GrantID>
+ <Acronym>EY</Acronym>
+ <Agency>NEI NIH HHS</Agency>
+ <Country>United States</Country>
+ </Grant>
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+ <PublicationType UI="D016428">Journal Article</PublicationType>
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+ <Year>2013</Year>
+ <Month>06</Month>
+ <Day>18</Day>
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+ </Article>
+ <MedlineJournalInfo>
+ <Country>Switzerland</Country>
+ <MedlineTA>Front Neurosci</MedlineTA>
+ <NlmUniqueID>101478481</NlmUniqueID>
+ <ISSNLinking>1662-453X</ISSNLinking>
+ </MedlineJournalInfo>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">Sobel filtering</Keyword>
+ <Keyword MajorTopicYN="N">blood flow</Keyword>
+ <Keyword MajorTopicYN="N">line-scan</Keyword>
+ <Keyword MajorTopicYN="N">space-time images</Keyword>
+ <Keyword MajorTopicYN="N">two-photon imaging</Keyword>
+ <Keyword MajorTopicYN="N">velocity</Keyword>
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+ <Month>04</Month>
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+ <ArticleTitle>Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.</ArticleTitle>
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+ <MedlinePgn>1730-44</MedlinePgn>
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+ <Abstract>
+ <AbstractText>Actin-based remodelling underlies spine structural changes occurring during synaptic plasticity, the process that constantly reshapes the circuitry of the adult brain in response to external stimuli, leading to learning and memory formation. A positive correlation exists between spine shape and synaptic strength and, consistently, abnormalities in spine number and morphology have been described in a number of neurological disorders. In the present study, we demonstrate that the actin-regulating protein, Eps8, is recruited to the spine head during chemically induced long-term potentiation in culture and that inhibition of its actin-capping activity impairs spine enlargement and plasticity. Accordingly, mice lacking Eps8 display immature spines, which are unable to undergo potentiation, and are impaired in cognitive functions. Additionally, we found that reduction in the levels of Eps8 occurs in brains of patients affected by autism compared to controls. Our data reveal the key role of Eps8 actin-capping activity in spine morphogenesis and plasticity and indicate that reductions in actin-capping proteins may characterize forms of intellectual disabilities associated with spine defects.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Menna</LastName>
+ <ForeName>Elisabetta</ForeName>
+ <Initials>E</Initials>
+ <AffiliationInfo>
+ <Affiliation>CNR Institute of Neuroscience, Milano, Italy. e.menna@in.cnr.it</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Zambetti</LastName>
+ <ForeName>Stefania</ForeName>
+ <Initials>S</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Morini</LastName>
+ <ForeName>Raffaella</ForeName>
+ <Initials>R</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Donzelli</LastName>
+ <ForeName>Andrea</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Disanza</LastName>
+ <ForeName>Andrea</ForeName>
+ <Initials>A</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Calvigioni</LastName>
+ <ForeName>Daniela</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Braida</LastName>
+ <ForeName>Daniela</ForeName>
+ <Initials>D</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Nicolini</LastName>
+ <ForeName>Chiara</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Orlando</LastName>
+ <ForeName>Marta</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fossati</LastName>
+ <ForeName>Giuliana</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cristina Regondi</LastName>
+ <ForeName>Maria</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Pattini</LastName>
+ <ForeName>Linda</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Frassoni</LastName>
+ <ForeName>Carolina</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Francolini</LastName>
+ <ForeName>Maura</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Scita</LastName>
+ <ForeName>Giorgio</ForeName>
+ <Initials>G</Initials>
+ <Identifier Source="ORCID">0000000179841889</Identifier>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sala</LastName>
+ <ForeName>Mariaelvina</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fahnestock</LastName>
+ <ForeName>Margaret</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Matteoli</LastName>
+ <ForeName>Michela</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <GrantList CompleteYN="Y">
+ <Grant>
+ <GrantID>GGP12115</GrantID>
+ <Agency>Telethon</Agency>
+ <Country>Italy</Country>
+ </Grant>
+ </GrantList>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2013</Year>
+ <Month>05</Month>
+ <Day>17</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>EMBO J</MedlineTA>
+ <NlmUniqueID>8208664</NlmUniqueID>
+ <ISSNLinking>0261-4189</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000199">Actins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance>
+ </Chemical>
+ <Chemical>
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+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
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+ <DescriptorName UI="D000199" MajorTopicYN="N">Actins</DescriptorName>
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+ <MeshHeading>
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+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001321" MajorTopicYN="N">Autistic Disorder</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003071" MajorTopicYN="N">Cognition</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D049229" MajorTopicYN="N">Dendritic Spines</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017774" MajorTopicYN="N">Long-Term Potentiation</DescriptorName>
+ <QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
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+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013569" MajorTopicYN="N">Synapses</DescriptorName>
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+ <Month>07</Month>
+ <Day>15</Day>
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+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
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+ <ISSN IssnType="Electronic">2157-3999</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>5</Volume>
+ <PubDate>
+ <Year>2013</Year>
+ <Month>Jul</Month>
+ <Day>02</Day>
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+ <Title>PLoS currents</Title>
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+ <AbstractText>Immediately following the Boston Marathon attacks, individuals near the scene posted a deluge of data to social media sites. Previous work has shown that these data can be leveraged to provide rapid insight during natural disasters, disease outbreaks and ongoing conflicts that can assist in the public health and medical response. Here, we examine and discuss the social media messages posted immediately after and around the Boston Marathon bombings, and find that specific keywords appear frequently prior to official public safety and news media reports. Individuals immediately adjacent to the explosions posted messages within minutes via Twitter which identify the location and specifics of events, demonstrating a role for social media in the early recognition and characterization of emergency events. *Christopher Cassa and Rumi Chunara contributed equally to this work. </AbstractText>
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+ <LastName>Cassa</LastName>
+ <ForeName>Christopher A</ForeName>
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+ <Affiliation>Harvard Medical School Brigham and Women's Hospital.</Affiliation>
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+ <LastName>Chunara</LastName>
+ <ForeName>Rumi</ForeName>
+ <Initials>R</Initials>
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+ <LastName>Mandl</LastName>
+ <ForeName>Kenneth</ForeName>
+ <Initials>K</Initials>
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+ <LastName>Brownstein</LastName>
+ <ForeName>John S</ForeName>
+ <Initials>JS</Initials>
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+ <Reference>
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+ <ArticleIdList>
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+ </ArticleIdList>
+ </Reference>
+ </ReferenceList>
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+ <PMID Version="1">24090994</PMID>
+ <DateCompleted>
+ <Year>2014</Year>
+ <Month>06</Month>
+ <Day>02</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>07</Month>
+ <Day>10</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">1873-6971</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>91</Volume>
+ <PubDate>
+ <Year>2013</Year>
+ <Month>Dec</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Fitoterapia</Title>
+ <ISOAbbreviation>Fitoterapia</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Modulation of COX, LOX and NFκB activities by Xanthium spinosum L. root extract and ziniolide.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>284-289</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="pii" ValidYN="Y">S0367-326X(13)00260-8</ELocationID>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1016/j.fitote.2013.09.015</ELocationID>
+ <Abstract>
+ <AbstractText>Xanthium spinosum L. (Asteraceae) is a medicinal weed distributed worldwide. Many of its diverse ethnopharmacological uses - namely diarrhoea, inflammation, liver disorders, snake bite and fever - are linked - at least in part - to an uncontrolled release of arachidonic acid metabolites. The crude extract of X. spinosum roots from Jordanian origin dose-dependently inhibited the 5-LOX (IC50 is approximately equal to 10 μg/mL), COX-1(IC50 is approximately equal to 50 μg/mL), and 12-LOX (IC50 is approximately equal to 170 μg/mL) enzymatic pathways in intact pro-inflammatory cells. A direct activity at the level of PLA2 is not probable, but the extract induced the synthesis of the anti-inflammatory eicosanoid 15(S)-HETE, which may in turn inhibit this enzyme. 5-LOX bioguided fractionation of the crude extract led to the isolation of ziniolide, a known 12,8-guaianolide sesquiterpene lactone, from the hydro-alcoholic fraction of the n-hexane extract (IC50=69 μM). Both the plant extract and ziniolide are in vitro inhibitors of the phorbol-induced NFκB activation, a key regulator of the arachidonic pathway.</AbstractText>
+ <CopyrightInformation>© 2013.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Bader</LastName>
+ <ForeName>Ammar</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Giner</LastName>
+ <ForeName>Rosa M</ForeName>
+ <Initials>RM</Initials>
+ <AffiliationInfo>
+ <Affiliation>Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andrés Estellés, s/n. 46100 Burjassot, València, Spain.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Martini</LastName>
+ <ForeName>Francesca</ForeName>
+ <Initials>F</Initials>
+ <AffiliationInfo>
+ <Affiliation>Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andrés Estellés, s/n. 46100 Burjassot, València, Spain.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Schinella</LastName>
+ <ForeName>Guillermo R</ForeName>
+ <Initials>GR</Initials>
+ <AffiliationInfo>
+ <Affiliation>Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andrés Estellés, s/n. 46100 Burjassot, València, Spain; Cátedra de Farmacología Básica, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, CIC Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ríos</LastName>
+ <ForeName>José L</ForeName>
+ <Initials>JL</Initials>
+ <AffiliationInfo>
+ <Affiliation>Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andrés Estellés, s/n. 46100 Burjassot, València, Spain.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Braca</LastName>
+ <ForeName>Alessandra</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Dipartimento di Farmacia, Universita di Pisa, Via Bonanno 33, 56126 Pisa, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Prieto</LastName>
+ <ForeName>José M</ForeName>
+ <Initials>JM</Initials>
+ <AffiliationInfo>
+ <Affiliation>Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andrés Estellés, s/n. 46100 Burjassot, València, Spain; Centre for Pharmacognosy and Phytotherapy, University College London School of Pharmacy, 29-39 Brunswick Square, WC1N 1AX London, United Kingdom. Electronic address: j.prieto@ucl.ac.uk.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2013</Year>
+ <Month>10</Month>
+ <Day>01</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>Netherlands</Country>
+ <MedlineTA>Fitoterapia</MedlineTA>
+ <NlmUniqueID>16930290R</NlmUniqueID>
+ <ISSNLinking>0367-326X</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D016861">Cyclooxygenase Inhibitors</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D006893">Hydroxyeicosatetraenoic Acids</NameOfSubstance>
+ </Chemical>
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+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D016859">Lipoxygenase Inhibitors</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D010704">Phorbols</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D045789">Sesquiterpenes, Guaiane</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C000588656">ziniolide</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>73945-47-8</RegistryNumber>
+ <NameOfSubstance UI="C025984">15-hydroxy-5,8,11,13-eicosatetraenoic acid</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 1.13.11.-</RegistryNumber>
+ <NameOfSubstance UI="D058945">Lipoxygenases</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>EC 1.14.99.1</RegistryNumber>
+ <NameOfSubstance UI="D051545">Cyclooxygenase 1</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>XUZ76S9127</RegistryNumber>
+ <NameOfSubstance UI="C033085">phorbol</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName>
+ <QualifierName UI="Q000302" MajorTopicYN="N">isolation &amp; purification</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051545" MajorTopicYN="N">Cyclooxygenase 1</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016861" MajorTopicYN="N">Cyclooxygenase Inhibitors</DescriptorName>
+ <QualifierName UI="Q000302" MajorTopicYN="N">isolation &amp; purification</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006893" MajorTopicYN="N">Hydroxyeicosatetraenoic Acids</DescriptorName>
+ <QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
+ <QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D020128" MajorTopicYN="N">Inhibitory Concentration 50</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016859" MajorTopicYN="N">Lipoxygenase Inhibitors</DescriptorName>
+ <QualifierName UI="Q000302" MajorTopicYN="N">isolation &amp; purification</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D058945" MajorTopicYN="N">Lipoxygenases</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName>
+ <QualifierName UI="Q000037" MajorTopicYN="Y">antagonists &amp; inhibitors</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010704" MajorTopicYN="N">Phorbols</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008517" MajorTopicYN="N">Phytotherapy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018517" MajorTopicYN="N">Plant Roots</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D045789" MajorTopicYN="N">Sesquiterpenes, Guaiane</DescriptorName>
+ <QualifierName UI="Q000302" MajorTopicYN="N">isolation &amp; purification</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ <QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D031210" MajorTopicYN="N">Xanthium</DescriptorName>
+ <QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">Cyclooxygenase</Keyword>
+ <Keyword MajorTopicYN="N">Lipoxygenases</Keyword>
+ <Keyword MajorTopicYN="N">NF-κB</Keyword>
+ <Keyword MajorTopicYN="N">Sesquiterpene lactones</Keyword>
+ <Keyword MajorTopicYN="N">Xanthium spinosum</Keyword>
+ <Keyword MajorTopicYN="N">Ziniolide</Keyword>
+ </KeywordList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>2012</Year>
+ <Month>12</Month>
+ <Day>15</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="revised">
+ <Year>2013</Year>
+ <Month>09</Month>
+ <Day>15</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="accepted">
+ <Year>2013</Year>
+ <Month>09</Month>
+ <Day>22</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2013</Year>
+ <Month>10</Month>
+ <Day>5</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2013</Year>
+ <Month>10</Month>
+ <Day>5</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2014</Year>
+ <Month>6</Month>
+ <Day>3</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">24090994</ArticleId>
+ <ArticleId IdType="pii">S0367-326X(13)00260-8</ArticleId>
+ <ArticleId IdType="doi">10.1016/j.fitote.2013.09.015</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">25031417</PMID>
+ <DateCompleted>
+ <Year>2014</Year>
+ <Month>09</Month>
+ <Day>05</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2014</Year>
+ <Month>11</Month>
+ <Day>20</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1529-2401</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>34</Volume>
+ <Issue>29</Issue>
+ <PubDate>
+ <Year>2014</Year>
+ <Month>Jul</Month>
+ <Day>16</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>The Journal of neuroscience : the official journal of the Society for Neuroscience</Title>
+ <ISOAbbreviation>J. Neurosci.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>A new pathway mediating social effects on the endocrine system: female presence acting via norepinephrine release stimulates gonadotropin-inhibitory hormone in the paraventricular nucleus and suppresses luteinizing hormone in quail.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>9803-11</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1523/JNEUROSCI.3706-13.2014</ELocationID>
+ <Abstract>
+ <AbstractText>Rapid effects of social interactions on transient changes in hormonal levels are known in a wide variety of vertebrate taxa, ranging from fish to humans. Although these responses are mediated by the brain, neurochemical pathways that translate social signals into reproductive physiological changes are unclear. In this study, we analyzed how a female presence modifies synthesis and/or release of various neurochemicals, such as monoamines and neuropeptides, in the brain and downstream reproductive hormones in sexually active male Japanese quail. By viewing a female bird, sexually active males rapidly increased norepinephrine (NE) release in the paraventricular nucleus (PVN) of the hypothalamus, in which gonadotropin-inhibitory hormone (GnIH) neuronal cell bodies exist, increased GnIH precursor mRNA expression in the PVN, and decreased luteinizing hormone (LH) concentration in the plasma. GnIH is a hypothalamic neuropeptide that inhibits gonadotropin secretion from the pituitary. It was further shown that GnIH can rapidly suppress LH release after intravenous administration in this study. Centrally administered NE decreased plasma LH concentration in vivo. It was also shown that NE stimulated the release of GnIH from diencephalic tissue blocks in vitro. Fluorescence double-label immunohistochemistry indicated that GnIH neurons received noradrenergic innervations, and immunohistochemistry combined with in situ hybridization have further shown that GnIH neurons expressed α2A-adrenergic receptor mRNA. These results indicate that a female presence increases NE release in the PVN and stimulates GnIH release, resulting in the suppression of LH release in sexually active male quail. </AbstractText>
+ <CopyrightInformation>Copyright © 2014 the authors 0270-6474/14/349803-09$15.00/0.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Tobari</LastName>
+ <ForeName>Yasuko</ForeName>
+ <Initials>Y</Initials>
+ <Identifier Source="ORCID">http://orcid.org/0000-0003-0572-4123</Identifier>
+ <AffiliationInfo>
+ <Affiliation>Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan, and.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Son</LastName>
+ <ForeName>You Lee</ForeName>
+ <Initials>YL</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan, and.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ubuka</LastName>
+ <ForeName>Takayoshi</ForeName>
+ <Initials>T</Initials>
+ <Identifier Source="ORCID">http://orcid.org/0000-0002-4731-8118</Identifier>
+ <AffiliationInfo>
+ <Affiliation>Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan, and.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hasegawa</LastName>
+ <ForeName>Yoshihisa</ForeName>
+ <Initials>Y</Initials>
+ <AffiliationInfo>
+ <Affiliation>Experimental Animal Science, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori 034-8628, Japan.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tsutsui</LastName>
+ <ForeName>Kazuyoshi</ForeName>
+ <Initials>K</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan, and k-tsutsui@waseda.jp.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>J Neurosci</MedlineTA>
+ <NlmUniqueID>8102140</NlmUniqueID>
+ <ISSNLinking>0270-6474</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D030161">Avian Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D015306">Biogenic Monoamines</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D007028">Hypothalamic Hormones</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D018341">Receptors, Adrenergic, alpha-2</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="C413752">gonadotropin-inhibitory hormone, Coturnix japonica</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>33515-09-2</RegistryNumber>
+ <NameOfSubstance UI="D007987">Gonadotropin-Releasing Hormone</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>9002-67-9</RegistryNumber>
+ <NameOfSubstance UI="D007986">Luteinizing Hormone</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>X4W3ENH1CV</RegistryNumber>
+ <NameOfSubstance UI="D009638">Norepinephrine</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D030161" MajorTopicYN="N">Avian Proteins</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015306" MajorTopicYN="N">Biogenic Monoamines</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007987" MajorTopicYN="N">Gonadotropin-Releasing Hormone</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007028" MajorTopicYN="N">Hypothalamic Hormones</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007398" MajorTopicYN="N">Interpersonal Relations</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007986" MajorTopicYN="N">Luteinizing Hormone</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D017551" MajorTopicYN="N">Microdialysis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009638" MajorTopicYN="N">Norepinephrine</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009924" MajorTopicYN="N">Organ Culture Techniques</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010286" MajorTopicYN="N">Paraventricular Hypothalamic Nucleus</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011784" MajorTopicYN="N">Quail</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D018341" MajorTopicYN="N">Receptors, Adrenergic, alpha-2</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012726" MajorTopicYN="Y">Sexual Behavior, Animal</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">bird</Keyword>
+ <Keyword MajorTopicYN="N">monoamine</Keyword>
+ <Keyword MajorTopicYN="N">neurochemical pathway</Keyword>
+ <Keyword MajorTopicYN="N">neuropeptide</Keyword>
+ <Keyword MajorTopicYN="N">social signal</Keyword>
+ <Keyword MajorTopicYN="N">visual stimuli</Keyword>
+ </KeywordList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2014</Year>
+ <Month>7</Month>
+ <Day>18</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2014</Year>
+ <Month>7</Month>
+ <Day>18</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2014</Year>
+ <Month>9</Month>
+ <Day>6</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">25031417</ArticleId>
+ <ArticleId IdType="pii">34/29/9803</ArticleId>
+ <ArticleId IdType="doi">10.1523/JNEUROSCI.3706-13.2014</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM">
+ <PMID Version="1">27190381</PMID>
+ <DateCompleted>
+ <Year>2018</Year>
+ <Month>01</Month>
+ <Day>11</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>12</Month>
+ <Day>02</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1460-2385</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>32</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>2017</Year>
+ <Month>Jun</Month>
+ <Day>01</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association</Title>
+ <ISOAbbreviation>Nephrol. Dial. Transplant.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Prevalence of reduced kidney function and albuminuria in older adults: the Berlin Initiative Study.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>997-1005</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1093/ndt/gfw079</ELocationID>
+ <Abstract>
+ <AbstractText Label="Background" NlmCategory="UNASSIGNED">Although CKD is said to increase among older adults, epidemiologic data on kidney function in people ≥70 years of age are scarce. The Berlin Initiative Study (BIS) aims to fill this gap by evaluating the CKD burden in older adults.</AbstractText>
+ <AbstractText Label="Methods" NlmCategory="UNASSIGNED">The BIS is a prospective population-based cohort study whose participants are members of Germany's biggest insurance company. This cross-sectional analysis (i) gives a detailed baseline characterization of the participants, (ii) analyses the representativeness of the cohort's disease profile, (iii) assesses GFR and albuminuria levels across age categories, (iv) associates cardiovascular risk factors with GFR as well as albuminuria and (v) compares means of GFR values according to different estimating equations with measured GFR.</AbstractText>
+ <AbstractText Label="Results" NlmCategory="UNASSIGNED">A total of 2069 participants (52.6% female, mean age 80.4 years) were enrolled: 26.1% were diabetic, 78.8% were on antihypertensive medication, 8.7% had experienced a stroke, 14% a myocardial infarction, 22.6% had cancer, 17.8% were anaemic and 26.5% were obese. The distribution of comorbidities in the BIS cohort was very similar to that in the insurance 'source population'. Creatinine and cystatin C as well as the albumin:creatinine ratio (ACR) increased with increasing age. After multivariate adjustments, reduced GFR and elevated ACR were associated with most cardiovascular risk factors. The prevalence of a GFR &lt;60 mL/min/1.73 m 2 ranged from 38 to 62% depending on the estimation equation used.</AbstractText>
+ <AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">The BIS is a very well-characterized, representative cohort of older adults. Participants with an ACR ≥30 had significantly higher odds for most cardiovascular risk factors compared with an ACR &lt;30 mg/g. Kidney function declined and ACR rose with increasing age.</AbstractText>
+ <CopyrightInformation>© The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Ebert</LastName>
+ <ForeName>Natalie</ForeName>
+ <Initials>N</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Public Health, Charité University Medicine, Campus Virchow, Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Jakob</LastName>
+ <ForeName>Olga</ForeName>
+ <Initials>O</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute for Biostatistics and Clinical Epidemiology, Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Gaedeke</LastName>
+ <ForeName>Jens</ForeName>
+ <Initials>J</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Nephrology, Charité University Medicine, Campus Mitte Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>van der Giet</LastName>
+ <ForeName>Markus</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Nephrology, Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kuhlmann</LastName>
+ <ForeName>Martin K</ForeName>
+ <Initials>MK</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Nephrology, Vivantes Klinikum im Friedrichshain, Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Martus</LastName>
+ <ForeName>Peter</ForeName>
+ <Initials>P</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Clinical Epidemiology and Medical Biostatistics, Friedrich Karls-University, Tübingen, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Mielke</LastName>
+ <ForeName>Nina</ForeName>
+ <Initials>N</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Public Health, Charité University Medicine, Campus Virchow, Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Schuchardt</LastName>
+ <ForeName>Mirjam</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Nephrology, Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tölle</LastName>
+ <ForeName>Markus</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Nephrology, Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wenning</LastName>
+ <ForeName>Volker</ForeName>
+ <Initials>V</Initials>
+ <AffiliationInfo>
+ <Affiliation>AOK-Nordost - die Gesundheitskasse, Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Schaeffner</LastName>
+ <ForeName>Elke S</ForeName>
+ <Initials>ES</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Public Health, Charité University Medicine, Campus Virchow, Berlin, Germany.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>England</Country>
+ <MedlineTA>Nephrol Dial Transplant</MedlineTA>
+ <NlmUniqueID>8706402</NlmUniqueID>
+ <ISSNLinking>0931-0509</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D055316">Cystatin C</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>AYI8EX34EU</RegistryNumber>
+ <NameOfSubstance UI="D003404">Creatinine</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000419" MajorTopicYN="N">Albuminuria</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
+ <QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
+ <QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001604" MajorTopicYN="N">Berlin</DescriptorName>
+ <QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
+ <QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
+ <QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003404" MajorTopicYN="N">Creatinine</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D055316" MajorTopicYN="N">Cystatin C</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005919" MajorTopicYN="N">Glomerular Filtration Rate</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D051436" MajorTopicYN="N">Renal Insufficiency, Chronic</DescriptorName>
+ <QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
+ <QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
+ <QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">GFR</Keyword>
+ <Keyword MajorTopicYN="N">albuminuria</Keyword>
+ <Keyword MajorTopicYN="N">chronic kidney disease</Keyword>
+ <Keyword MajorTopicYN="N">cohort</Keyword>
+ <Keyword MajorTopicYN="N">older adults</Keyword>
+ </KeywordList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>2016</Year>
+ <Month>02</Month>
+ <Day>12</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="accepted">
+ <Year>2016</Year>
+ <Month>03</Month>
+ <Day>11</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2016</Year>
+ <Month>5</Month>
+ <Day>18</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2018</Year>
+ <Month>1</Month>
+ <Day>13</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2016</Year>
+ <Month>5</Month>
+ <Day>19</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">27190381</ArticleId>
+ <ArticleId IdType="pii">gfw079</ArticleId>
+ <ArticleId IdType="doi">10.1093/ndt/gfw079</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM">
+ <PMID Version="1">27687974</PMID>
+ <DateCompleted>
+ <Year>2018</Year>
+ <Month>01</Month>
+ <Day>16</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>12</Month>
+ <Day>02</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">1941-0611</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>9</Volume>
+ <PubDate>
+ <Year>2017</Year>
+ <Month>01</Month>
+ <Day>03</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Annual review of marine science</Title>
+ <ISOAbbreviation>Ann Rev Mar Sci</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>SAR11 Bacteria: The Most Abundant Plankton in the Oceans.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>231-255</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1146/annurev-marine-010814-015934</ELocationID>
+ <Abstract>
+ <AbstractText>SAR11 is a group of small, carbon-oxidizing bacteria that reach a global estimated population size of 2.4×10<sup>28</sup> cells-approximately 25% of all plankton. They are found throughout the oceans but reach their largest numbers in stratified, oligotrophic gyres, which are an expanding habitat in the warming oceans. SAR11 likely had a Precambrian origin and, over geological time, evolved into the niche of harvesting labile, low-molecular-weight dissolved organic matter (DOM). SAR11 cells are minimal in size and complexity, a phenomenon known as streamlining that is thought to benefit them by lowering the material costs of replication and maximizing transport functions that are essential to competition at ultralow nutrient concentrations. One of the surprises in SAR11 metabolism is their ability to both oxidize and produce a variety of volatile organic compounds that can diffuse into the atmosphere. SAR11 cells divide slowly and lack many forms of regulation commonly used by bacterial cells to adjust to changing environmental conditions. As a result of genome reduction, they require an unusual range of nutrients, which leads to complex biochemical interactions with other plankton. The study of SAR11 is providing insight into the biogeochemistry of labile DOM and is affecting microbiology beyond marine science by providing a model for understanding the evolution and function of streamlined cells.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Giovannoni</LastName>
+ <ForeName>Stephen J</ForeName>
+ <Initials>SJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Microbiology, Oregon State University, Corvallis, Oregon 97331; email: steve.giovannoni@oregonstate.edu.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2016</Year>
+ <Month>09</Month>
+ <Day>28</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Ann Rev Mar Sci</MedlineTA>
+ <NlmUniqueID>101536246</NlmUniqueID>
+ <ISSNLinking>1941-0611</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>7440-44-0</RegistryNumber>
+ <NameOfSubstance UI="D002244">Carbon</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D001419" MajorTopicYN="Y">Bacteria</DescriptorName>
+ <QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002244" MajorTopicYN="N">Carbon</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005798" MajorTopicYN="N">Genes, Bacterial</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009792" MajorTopicYN="N">Oceans and Seas</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010933" MajorTopicYN="Y">Plankton</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014871" MajorTopicYN="N">Water Microbiology</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="Y">carbon cycle</Keyword>
+ <Keyword MajorTopicYN="Y">dissolved organic matter</Keyword>
+ <Keyword MajorTopicYN="Y">proteorhodopsin</Keyword>
+ <Keyword MajorTopicYN="Y">streamlining</Keyword>
+ </KeywordList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>1</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2018</Year>
+ <Month>1</Month>
+ <Day>18</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>1</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">27687974</ArticleId>
+ <ArticleId IdType="doi">10.1146/annurev-marine-010814-015934</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">27529501</PMID>
+ <DateCompleted>
+ <Year>2017</Year>
+ <Month>02</Month>
+ <Day>13</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2017</Year>
+ <Month>02</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">2161-5063</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>6</Volume>
+ <Issue>1</Issue>
+ <PubDate>
+ <Year>2017</Year>
+ <Month>01</Month>
+ <Day>20</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>ACS synthetic biology</Title>
+ <ISOAbbreviation>ACS Synth Biol</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Short Synthetic Terminators for Assembly of Transcription Units in Vitro and Stable Chromosomal Integration in Yeast S. cerevisiae.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>130-138</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1021/acssynbio.6b00165</ELocationID>
+ <Abstract>
+ <AbstractText>Assembly of synthetic genetic circuits is central to synthetic biology. Yeast S. cerevisiae, in particular, has proven to be an ideal chassis for synthetic genome assemblies by exploiting its efficient homologous recombination. However, this property of efficient homologous recombination poses a problem for multigene assemblies in yeast, since repeated usage of standard parts, such as transcriptional terminators, can lead to rearrangements of the repeats in assembled DNA constructs in vivo. To address this issue in developing a library of orthogonal genetic components for yeast, we designed a set of short synthetic terminators based on a consensus sequence with random linkers to avoid repetitive sequences. We constructed a series of expression vectors with these synthetic terminators for efficient assembly of synthetic genes using Gateway recombination reactions. We also constructed two BAC (bacterial artificial chromosome) vectors for assembling multiple transcription units with the synthetic terminators in vitro and their integration in the yeast genome. The tandem array of synthetic genes integrated in the genome by this method is highly stable because there are few homologous segments in the synthetic constructs. Using this system of assembly and genomic integration of transcription units, we tested the synthetic terminators and their influence on the proximal transcription units. Although all the synthetic terminators have the common consensus with the identical length, they showed different activities and impacts on the neighboring transcription units.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>MacPherson</LastName>
+ <ForeName>Murray</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen , Aberdeen AB25 2ZD, U.K.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Saka</LastName>
+ <ForeName>Yasushi</ForeName>
+ <Initials>Y</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen , Aberdeen AB25 2ZD, U.K.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ <PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2016</Year>
+ <Month>08</Month>
+ <Day>25</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>ACS Synth Biol</MedlineTA>
+ <NlmUniqueID>101575075</NlmUniqueID>
+ <ISSNLinking>2161-5063</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D008164">Luminescent Proteins</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D022202" MajorTopicYN="N">Chromosomes, Artificial, Bacterial</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015825" MajorTopicYN="N">Chromosomes, Fungal</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005800" MajorTopicYN="N">Genes, Fungal</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005813" MajorTopicYN="Y">Genes, Synthetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005818" MajorTopicYN="N">Genetic Engineering</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D059765" MajorTopicYN="N">Homologous Recombination</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008164" MajorTopicYN="N">Luminescent Proteins</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D058615" MajorTopicYN="N">Synthetic Biology</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013728" MajorTopicYN="Y">Terminator Regions, Genetic</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">Saccharomyces cerevisiae</Keyword>
+ <Keyword MajorTopicYN="N">bacterial artificial chromosome</Keyword>
+ <Keyword MajorTopicYN="N">gene assembly</Keyword>
+ <Keyword MajorTopicYN="N">transcriptional terminator</Keyword>
+ <Keyword MajorTopicYN="N">yeast</Keyword>
+ </KeywordList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2016</Year>
+ <Month>8</Month>
+ <Day>17</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2017</Year>
+ <Month>2</Month>
+ <Day>14</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2016</Year>
+ <Month>8</Month>
+ <Day>17</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">27529501</ArticleId>
+ <ArticleId IdType="doi">10.1021/acssynbio.6b00165</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">27763809</PMID>
+ <DateCompleted>
+ <Year>2017</Year>
+ <Month>10</Month>
+ <Day>24</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">2164-554X</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>13</Volume>
+ <Issue>3</Issue>
+ <PubDate>
+ <Year>2017</Year>
+ <Month>03</Month>
+ <Day>04</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Human vaccines &amp; immunotherapeutics</Title>
+ <ISOAbbreviation>Hum Vaccin Immunother</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Do Australian immunoglobulin products meet international measles antibody titer standards?</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>607-612</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1080/21645515.2016.1234554</ELocationID>
+ <Abstract>
+ <AbstractText>The effectiveness of passive immunisation post-exposure to measles appears subject to a dose-response effect. New Zealand and the United Kingdom have increased the recommended dose of polyclonal human immunoglobulin for post-exposure prophylaxis within the last decade in response to concerns about decreasing levels of measles antibodies in these products. This study used the plaque-reduction neutralization test (PRNT) to measure the titer of measles-specific antibodies in Australian immunoglobulin products for post-exposure prophylaxis and compared the utility of an enzyme-linked immunosorbent assay (ELISA) to the PRNT in available Australian and international samples: Australian intramuscular (n = 10), Australian intravenous (n = 28), New Zealand intramuscular (n = 2), Hizentra (subcutaneous)(USA) (n = 3), and Privigen (intravenous)(USA) (n = 2). Measles titres in Australian IM and IV immunoglobulins ranged from 51 to 76 IU/mL and 6 to 24 IU/mL respectively, as measured by PRNT calibrated to the WHO 3<sup>rd</sup> international standard. ELISA titres were variable but higher than PRNT titres in all tested samples. Measles antibody titres in Australian immunoglobulin products meet consensus-prescribed international thresholds. Development of a convenient, standardized, readily accessible assay for determination of measles titres in immunoglobulin products would be useful for future studies and facilitate international comparisons.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Young</LastName>
+ <ForeName>Megan K</ForeName>
+ <Initials>MK</Initials>
+ <AffiliationInfo>
+ <Affiliation>a School of Medicine and Menzies Health Institute Queensland , Griffith University , Gold Coast , Australia.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bertolini</LastName>
+ <ForeName>Joseph</ForeName>
+ <Initials>J</Initials>
+ <AffiliationInfo>
+ <Affiliation>b CSL Behring (Australia) Pty Ltd , Broadmeadows , Australia.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kotharu</LastName>
+ <ForeName>Pushpa</ForeName>
+ <Initials>P</Initials>
+ <AffiliationInfo>
+ <Affiliation>b CSL Behring (Australia) Pty Ltd , Broadmeadows , Australia.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Maher</LastName>
+ <ForeName>Darryl</ForeName>
+ <Initials>D</Initials>
+ <AffiliationInfo>
+ <Affiliation>b CSL Behring (Australia) Pty Ltd , Broadmeadows , Australia.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cripps</LastName>
+ <ForeName>Allan W</ForeName>
+ <Initials>AW</Initials>
+ <AffiliationInfo>
+ <Affiliation>a School of Medicine and Menzies Health Institute Queensland , Griffith University , Gold Coast , Australia.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D003160">Comparative Study</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>20</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Hum Vaccin Immunother</MedlineTA>
+ <NlmUniqueID>101572652</NlmUniqueID>
+ <ISSNLinking>2164-5515</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D001688">Biological Products</NameOfSubstance>
+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
+ <QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001315" MajorTopicYN="N">Australia</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001688" MajorTopicYN="N">Biological Products</DescriptorName>
+ <QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007116" MajorTopicYN="N">Immunization, Passive</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008457" MajorTopicYN="N">Measles</DescriptorName>
+ <QualifierName UI="Q000517" MajorTopicYN="Y">prevention &amp; control</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D056990" MajorTopicYN="N">Post-Exposure Prophylaxis</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010948" MajorTopicYN="N">Viral Plaque Assay</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="Y">Australia</Keyword>
+ <Keyword MajorTopicYN="Y">blood products</Keyword>
+ <Keyword MajorTopicYN="Y">immunoglobulin</Keyword>
+ <Keyword MajorTopicYN="Y">measles</Keyword>
+ <Keyword MajorTopicYN="Y">prevention</Keyword>
+ </KeywordList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>21</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2017</Year>
+ <Month>10</Month>
+ <Day>25</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2016</Year>
+ <Month>10</Month>
+ <Day>21</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">27763809</ArticleId>
+ <ArticleId IdType="doi">10.1080/21645515.2016.1234554</ArticleId>
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+ <PMID Version="1">27687975</PMID>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">2045-2322</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>6</Volume>
+ <PubDate>
+ <Year>2016</Year>
+ <Month>Sep</Month>
+ <Day>30</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>Scientific reports</Title>
+ <ISOAbbreviation>Sci Rep</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Novel roles for the radial spoke head protein 9 in neural and neurosensory cilia.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>34437</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1038/srep34437</ELocationID>
+ <Abstract>
+ <AbstractText>Cilia are cell surface organelles with key roles in a range of cellular processes, including generation of fluid flow by motile cilia. The axonemes of motile cilia and immotile kinocilia contain 9 peripheral microtubule doublets, a central microtubule pair, and 9 connecting radial spokes. Aberrant radial spoke components RSPH1, 3, 4a and 9 have been linked with primary ciliary dyskinesia (PCD), a disorder characterized by ciliary dysmotility; yet, radial spoke functions remain unclear. Here we show that zebrafish Rsph9 is expressed in cells bearing motile cilia and kinocilia, and localizes to both 9 + 2 and 9 + 0 ciliary axonemes. Using CRISPR mutagenesis, we show that rsph9 is required for motility of presumptive 9 + 2 olfactory cilia and, unexpectedly, 9 + 0 neural cilia. rsph9 is also required for the structural integrity of 9 + 2 and 9 + 0 ciliary axonemes. rsph9 mutant larvae exhibit reduced initiation of the acoustic startle response consistent with hearing impairment, suggesting a novel role for Rsph9 in the kinocilia of the inner ear and/or lateral line neuromasts. These data identify novel roles for Rsph9 in 9 + 0 motile cilia and in sensory kinocilia, and establish a useful zebrafish PCD model.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Sedykh</LastName>
+ <ForeName>Irina</ForeName>
+ <Initials>I</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Zoology, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>TeSlaa</LastName>
+ <ForeName>Jessica J</ForeName>
+ <Initials>JJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Zoology, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Cellular and Molecular Biology Training Program, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tatarsky</LastName>
+ <ForeName>Rose L</ForeName>
+ <Initials>RL</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Zoology, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Keller</LastName>
+ <ForeName>Abigail N</ForeName>
+ <Initials>AN</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Zoology, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Toops</LastName>
+ <ForeName>Kimberly A</ForeName>
+ <Initials>KA</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>McPherson Eye Research Institute, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Lakkaraju</LastName>
+ <ForeName>Aparna</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>McPherson Eye Research Institute, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
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+ <Author ValidYN="Y">
+ <LastName>Nyholm</LastName>
+ <ForeName>Molly K</ForeName>
+ <Initials>MK</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Zoology, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
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+ <Author ValidYN="Y">
+ <LastName>Wolman</LastName>
+ <ForeName>Marc A</ForeName>
+ <Initials>MA</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Zoology, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
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+ <Author ValidYN="Y">
+ <LastName>Grinblat</LastName>
+ <ForeName>Yevgenya</ForeName>
+ <Initials>Y</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Zoology, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>McPherson Eye Research Institute, University of Wisconsin, Madison, WI, 53706, USA.</Affiliation>
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+ <Language>eng</Language>
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+ <Acronym>EY</Acronym>
+ <Agency>NEI NIH HHS</Agency>
+ <Country>United States</Country>
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+ <Grant>
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+ <Acronym>EY</Acronym>
+ <Agency>NEI NIH HHS</Agency>
+ <Country>United States</Country>
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+ <Year>2018</Year>
+ <Month>06</Month>
+ <Day>18</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">1439-0973</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>45</Volume>
+ <Issue>6</Issue>
+ <PubDate>
+ <Year>2017</Year>
+ <Month>Dec</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Infection</Title>
+ <ISOAbbreviation>Infection</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Respiratory diphtheria due to Corynebacterium ulcerans transmitted by a companion dog, Italy 2014.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>903-905</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1007/s15010-017-1040-1</ELocationID>
+ <Abstract>
+ <AbstractText>A serious respiratory tract infection due to Corynebacterium ulcerans was observed in a 70-year-old woman. Clinical presentation included pseudomembranes in the upper respiratory tract and lung involvement. C. ulcerans was recovered from the nose of the patient's dog. Both dog's and patient's isolates belonged to Sequence Type 331.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Monaco</LastName>
+ <ForeName>Monica</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Istituto Superiore di Sanità, Rome, Italy. monica.monaco@iss.it.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Sacchi</LastName>
+ <ForeName>Anna Rita</ForeName>
+ <Initials>AR</Initials>
+ <AffiliationInfo>
+ <Affiliation>Azienda Unità Sanitaria locale, Piacenza, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Scotti</LastName>
+ <ForeName>Marzia</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Ospedale Guglielmo da Saliceto, Piacenza, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Mancini</LastName>
+ <ForeName>Fabiola</ForeName>
+ <Initials>F</Initials>
+ <AffiliationInfo>
+ <Affiliation>Istituto Superiore di Sanità, Rome, Italy.</Affiliation>
+ </AffiliationInfo>
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+ <Author ValidYN="Y">
+ <LastName>Riccio</LastName>
+ <ForeName>Carlo</ForeName>
+ <Initials>C</Initials>
+ <AffiliationInfo>
+ <Affiliation>Azienda Unità Sanitaria locale, Piacenza, Italy.</Affiliation>
+ </AffiliationInfo>
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+ <Author ValidYN="Y">
+ <LastName>Errico</LastName>
+ <ForeName>Giulia</ForeName>
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+ <Affiliation>Istituto Superiore di Sanità, Rome, Italy.</Affiliation>
+ </AffiliationInfo>
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+ <Author ValidYN="Y">
+ <LastName>Ratti</LastName>
+ <ForeName>Giovanna</ForeName>
+ <Initials>G</Initials>
+ <AffiliationInfo>
+ <Affiliation>Ospedale Guglielmo da Saliceto, Piacenza, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Bondi</LastName>
+ <ForeName>Filippo</ForeName>
+ <Initials>F</Initials>
+ <AffiliationInfo>
+ <Affiliation>Ospedale Guglielmo da Saliceto, Piacenza, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ciervo</LastName>
+ <ForeName>Alessandra</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Istituto Superiore di Sanità, Rome, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Pantosti</LastName>
+ <ForeName>Annalisa</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Istituto Superiore di Sanità, Rome, Italy.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
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+ <Month>06</Month>
+ <Day>24</Day>
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+ <Country>Germany</Country>
+ <MedlineTA>Infection</MedlineTA>
+ <NlmUniqueID>0365307</NlmUniqueID>
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+ <CitationSubset>IM</CitationSubset>
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+ <RefSource>Infection. 2017 Dec;45(6):931</RefSource>
+ <PMID Version="1">28786003</PMID>
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+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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+ <MeshHeading>
+ <DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004165" MajorTopicYN="N">Diphtheria</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004283" MajorTopicYN="N">Dog Diseases</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
+ <QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007558" MajorTopicYN="N">Italy</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D015047" MajorTopicYN="N">Zoonoses</DescriptorName>
+ <QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
+ <QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
+ <QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">Corynebacterium ulcerans</Keyword>
+ <Keyword MajorTopicYN="N">Diphtheria toxin</Keyword>
+ <Keyword MajorTopicYN="N">Dog</Keyword>
+ <Keyword MajorTopicYN="N">Molecular typing</Keyword>
+ <Keyword MajorTopicYN="N">Respiratory diphtheria</Keyword>
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+ <DateCompleted>
+ <Year>2017</Year>
+ <Month>11</Month>
+ <Day>07</Day>
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+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Electronic-eCollection">
+ <Journal>
+ <ISSN IssnType="Electronic">1932-6203</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>12</Volume>
+ <Issue>10</Issue>
+ <PubDate>
+ <Year>2017</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>PloS one</Title>
+ <ISOAbbreviation>PLoS ONE</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>e0186401</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0186401</ELocationID>
+ <Abstract>
+ <AbstractText>Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide. The fatality gradually decreased with improved living standards and further alleviated when many immunization programs were introduced. However, numerous drug-resistant strains emerged recently that consequently decreased the efficacy of current therapeutics and vaccines, thereby obliging the scientific community to start investigating new therapeutic targets in pathogenic microorganisms. In this study, our contributions include the prediction of modelome of 13 C. diphtheriae strains, using the MHOLline workflow. A set of 463 conserved proteins were identified by combining the results of pangenomics based core-genome and core-modelome analyses. Further, using subtractive proteomics and modelomics approaches for target identification, a set of 23 proteins was selected as essential for the bacteria. Considering human as a host, eight of these proteins (glpX, nusB, rpsH, hisE, smpB, bioB, DIP1084, and DIP0983) were considered as essential and non-host homologs, and have been subjected to virtual screening using four different compound libraries (extracted from the ZINC database, plant-derived natural compounds and Di-terpenoid Iso-steviol derivatives). The proposed ligand molecules showed favorable interactions, lowered energy values and high complementarity with the predicted targets. Our proposed approach expedites the selection of C. diphtheriae putative proteins for broad-spectrum development of novel drugs and vaccines, owing to the fact that some of these targets have already been identified and validated in other organisms.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Jamal</LastName>
+ <ForeName>Syed Babar</ForeName>
+ <Initials>SB</Initials>
+ <AffiliationInfo>
+ <Affiliation>PG program in Bioinformatics (LGCM), Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hassan</LastName>
+ <ForeName>Syed Shah</ForeName>
+ <Initials>SS</Initials>
+ <AffiliationInfo>
+ <Affiliation>PG program in Bioinformatics (LGCM), Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Department of Chemistry, Islamia College University Peshawar, KPK, Pakistan.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Tiwari</LastName>
+ <ForeName>Sandeep</ForeName>
+ <Initials>S</Initials>
+ <AffiliationInfo>
+ <Affiliation>PG program in Bioinformatics (LGCM), Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Viana</LastName>
+ <ForeName>Marcus V</ForeName>
+ <Initials>MV</Initials>
+ <AffiliationInfo>
+ <Affiliation>PG program in Bioinformatics (LGCM), Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Benevides</LastName>
+ <ForeName>Leandro de Jesus</ForeName>
+ <Initials>LJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>PG program in Bioinformatics (LGCM), Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ullah</LastName>
+ <ForeName>Asad</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Chemistry, Islamia College University Peshawar, KPK, Pakistan.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Turjanski</LastName>
+ <ForeName>Adrián G</ForeName>
+ <Initials>AG</Initials>
+ <AffiliationInfo>
+ <Affiliation>Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Buenos Aires, Argentina.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Barh</LastName>
+ <ForeName>Debmalya</ForeName>
+ <Initials>D</Initials>
+ <AffiliationInfo>
+ <Affiliation>Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology, Nonakuri, Purba Medinipur, West Bengal, India.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ghosh</LastName>
+ <ForeName>Preetam</ForeName>
+ <Initials>P</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Computer Science, Virginia Commonwealth University, Richmond, VA, United States of America.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Costa</LastName>
+ <ForeName>Daniela Arruda</ForeName>
+ <Initials>DA</Initials>
+ <AffiliationInfo>
+ <Affiliation>PG program in Bioinformatics (LGCM), Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Silva</LastName>
+ <ForeName>Artur</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Institute of Biologic Sciences, Federal University of Para, Belém, PA, Brazil.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Röttger</LastName>
+ <ForeName>Richard</ForeName>
+ <Initials>R</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Baumbach</LastName>
+ <ForeName>Jan</ForeName>
+ <Initials>J</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Azevedo</LastName>
+ <ForeName>Vasco A C</ForeName>
+ <Initials>VAC</Initials>
+ <AffiliationInfo>
+ <Affiliation>PG program in Bioinformatics (LGCM), Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Department of General Biology (LGCM), Institute of Biologic Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
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+ <PublicationType UI="D023361">Validation Studies</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2017</Year>
+ <Month>10</Month>
+ <Day>19</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>PLoS One</MedlineTA>
+ <NlmUniqueID>101285081</NlmUniqueID>
+ <ISSNLinking>1932-6203</ISSNLinking>
+ </MedlineJournalInfo>
+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance>
+ </Chemical>
+ <Chemical>
+ <RegistryNumber>0</RegistryNumber>
+ <NameOfSubstance UI="D001428">Bacterial Vaccines</NameOfSubstance>
+ </Chemical>
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+ </Chemical>
+ </ChemicalList>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001426" MajorTopicYN="N">Bacterial Proteins</DescriptorName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001428" MajorTopicYN="N">Bacterial Vaccines</DescriptorName>
+ <QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003198" MajorTopicYN="N">Computer Simulation</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003353" MajorTopicYN="N">Corynebacterium diphtheriae</DescriptorName>
+ <QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
+ <QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
+ <QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016680" MajorTopicYN="N">Genome, Bacterial</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008024" MajorTopicYN="N">Ligands</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D062105" MajorTopicYN="N">Molecular Docking Simulation</DescriptorName>
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+ <Year>2017</Year>
+ <Month>09</Month>
+ <Day>29</Day>
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+ <DateCompleted>
+ <Year>2018</Year>
+ <Month>09</Month>
+ <Day>21</Day>
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+ <DateRevised>
+ <Year>2018</Year>
+ <Month>10</Month>
+ <Day>04</Day>
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+ <Article PubModel="Print-Electronic">
+ <Journal>
+ <ISSN IssnType="Electronic">1873-4499</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>49</Volume>
+ <PubDate>
+ <MedlineDate>2018 May - Jun</MedlineDate>
+ </PubDate>
+ </JournalIssue>
+ <Title>Clinical imaging</Title>
+ <ISOAbbreviation>Clin Imaging</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Bilateral absence of the cruciate ligaments with meniscal dysplasia: Unexpected diagnosis in a child with juvenile idiopathic arthritis.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>193-197</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="pii" ValidYN="Y">S0899-7071(18)30064-0</ELocationID>
+ <ELocationID EIdType="doi" ValidYN="Y">10.1016/j.clinimag.2018.03.015</ELocationID>
+ <Abstract>
+ <AbstractText>Bilateral agenesis of the cruciate ligaments is a rare congenital anomaly. We report a unique case of a young girl who had congenital short femur and diagnosed with polyarticular juvenile idiopathic arthritis (JIA) and later discovered to have congenital absence of both anterior and posterior cruciate ligaments and meniscal dysplasia in both the knees when MRI was performed at 11 years of age. The MRI was performed to evaluate knee laxity and persistent symptoms despite medical management and multiple steroid injections for arthritis treatment. This patient is one of the youngest with congenital absence of both the cruciate ligaments to be treated with ACL reconstruction. We highlight the unique radiographic imaging manifestations of congenital cruciate ligament agenesis and emphasize the role of MRI to confirm and depict additional intraarticular abnormalities.</AbstractText>
+ <CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Degnan</LastName>
+ <ForeName>Andrew J</ForeName>
+ <Initials>AJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Kietz</LastName>
+ <ForeName>Daniel A</ForeName>
+ <Initials>DA</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Grudziak</LastName>
+ <ForeName>Jan S</ForeName>
+ <Initials>JS</Initials>
+ <AffiliationInfo>
+ <Affiliation>Division of Orthopedics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Shah</LastName>
+ <ForeName>Amisha</ForeName>
+ <Initials>A</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States. Electronic address: shaha3@upmc.edu.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D002363">Case Reports</PublicationType>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2018</Year>
+ <Month>03</Month>
+ <Day>26</Day>
+ </ArticleDate>
+ </Article>
+ <MedlineJournalInfo>
+ <Country>United States</Country>
+ <MedlineTA>Clin Imaging</MedlineTA>
+ <NlmUniqueID>8911831</NlmUniqueID>
+ <ISSNLinking>0899-7071</ISSNLinking>
+ </MedlineJournalInfo>
+ <CitationSubset>IM</CitationSubset>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D016118" MajorTopicYN="N">Anterior Cruciate Ligament</DescriptorName>
+ <QualifierName UI="Q000002" MajorTopicYN="Y">abnormalities</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D001171" MajorTopicYN="N">Arthritis, Juvenile</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
+ <QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D005269" MajorTopicYN="N">Femur</DescriptorName>
+ <QualifierName UI="Q000002" MajorTopicYN="N">abnormalities</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007717" MajorTopicYN="N">Knee</DescriptorName>
+ <QualifierName UI="Q000002" MajorTopicYN="N">abnormalities</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007719" MajorTopicYN="N">Knee Joint</DescriptorName>
+ <QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName>
+ <QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008592" MajorTopicYN="N">Menisci, Tibial</DescriptorName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000072600" MajorTopicYN="N">Meniscus</DescriptorName>
+ <QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016119" MajorTopicYN="N">Posterior Cruciate Ligament</DescriptorName>
+ <QualifierName UI="Q000002" MajorTopicYN="Y">abnormalities</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D011859" MajorTopicYN="N">Radiography</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">Congenital</Keyword>
+ <Keyword MajorTopicYN="N">Cruciate ligament agenesis</Keyword>
+ <Keyword MajorTopicYN="N">Juvenile idiopathic arthritis</Keyword>
+ <Keyword MajorTopicYN="N">Meniscal dysplasia</Keyword>
+ </KeywordList>
+ </MedlineCitation>
+ <PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>2018</Year>
+ <Month>01</Month>
+ <Day>23</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="revised">
+ <Year>2018</Year>
+ <Month>03</Month>
+ <Day>21</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="accepted">
+ <Year>2018</Year>
+ <Month>03</Month>
+ <Day>23</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2018</Year>
+ <Month>4</Month>
+ <Day>11</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2018</Year>
+ <Month>9</Month>
+ <Day>22</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2018</Year>
+ <Month>4</Month>
+ <Day>11</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>ppublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">29635139</ArticleId>
+ <ArticleId IdType="pii">S0899-7071(18)30064-0</ArticleId>
+ <ArticleId IdType="doi">10.1016/j.clinimag.2018.03.015</ArticleId>
+ </ArticleIdList>
+ </PubmedData>
+ </PubmedArticle>
+ <PubmedArticle>
+ <MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM">
+ <PMID Version="1">29869631</PMID>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>14</Day>
+ </DateRevised>
+ <Article PubModel="Electronic-eCollection">
+ <Journal>
+ <ISSN IssnType="Print">2296-2646</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>6</Volume>
+ <PubDate>
+ <Year>2018</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Frontiers in chemistry</Title>
+ <ISOAbbreviation>Front Chem</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Discovery of the Linear Region of Near Infrared Diffuse Reflectance Spectra Using the Kubelka-Munk Theory.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>154</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.3389/fchem.2018.00154</ELocationID>
+ <Abstract>
+ <AbstractText>Particle size is of great importance for the quantitative model of the NIR diffuse reflectance. In this paper, the effect of sample particle size on the measurement of harpagoside in <i>Radix Scrophulariae</i> powder by near infrared diffuse (NIR) reflectance spectroscopy was explored. High-performance liquid chromatography (HPLC) was employed as a reference method to construct the quantitative particle size model. Several spectral preprocessing methods were compared, and particle size models obtained by different preprocessing methods for establishing the partial least-squares (PLS) models of harpagoside. Data showed that the particle size distribution of 125-150 μm for <i>Radix Scrophulariae</i> exhibited the best prediction ability with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML">
+ <mml:msubsup>
+ <mml:mrow>
+ <mml:mtext>R</mml:mtext>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mtext>pre</mml:mtext>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mn>2</mml:mn>
+ </mml:mrow>
+ </mml:msubsup>
+ </mml:math> = 0.9513, RMSEP = 0.1029 mg·g<sup>-1</sup>, and RPD = 4.78. For the hybrid granularity calibration model, the particle size distribution of 90-180 μm exhibited the best prediction ability with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML">
+ <mml:msubsup>
+ <mml:mrow>
+ <mml:mtext>R</mml:mtext>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mtext>pre</mml:mtext>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mn>2</mml:mn>
+ </mml:mrow>
+ </mml:msubsup>
+ </mml:math> = 0.8919, RMSEP = 0.1632 mg·g<sup>-1</sup>, and RPD = 3.09. Furthermore, the Kubelka-Munk theory was used to relate the absorption coefficient <i>k</i> (concentration-dependent) and scatter coefficient <i>s</i> (particle size-dependent). The scatter coefficient <i>s</i> was calculated based on the Kubelka-Munk theory to study the changes of <i>s</i> after being mathematically preprocessed. A linear relationship was observed between <i>k</i>/<i>s</i> and absorption <i>A</i> within a certain range and the value for <i>k</i>/<i>s</i> was &gt;4. According to this relationship, the model was more accurately constructed with the particle size distribution of 90-180 μm when <i>s</i> was kept constant or in a small linear region. This region provided a good reference for the linear modeling of diffuse reflectance spectroscopy. To establish a diffuse reflectance NIR model, further accurate assessment should be obtained in advance for a precise linear model.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Dai</LastName>
+ <ForeName>Shengyun</ForeName>
+ <Initials>S</Initials>
+ <AffiliationInfo>
+ <Affiliation>Key Laboratory of TCM-Information Engineering of State Administration of TCM, Pharmaceutical Engineering and New Drug Development of Traditional Chinese, Medicine of Ministry of Education, Beijing University of Chinese Medicine, Beijing, China.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Pan</LastName>
+ <ForeName>Xiaoning</ForeName>
+ <Initials>X</Initials>
+ <AffiliationInfo>
+ <Affiliation>Key Laboratory of TCM-Information Engineering of State Administration of TCM, Pharmaceutical Engineering and New Drug Development of Traditional Chinese, Medicine of Ministry of Education, Beijing University of Chinese Medicine, Beijing, China.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ma</LastName>
+ <ForeName>Lijuan</ForeName>
+ <Initials>L</Initials>
+ <AffiliationInfo>
+ <Affiliation>Key Laboratory of TCM-Information Engineering of State Administration of TCM, Pharmaceutical Engineering and New Drug Development of Traditional Chinese, Medicine of Ministry of Education, Beijing University of Chinese Medicine, Beijing, China.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Huang</LastName>
+ <ForeName>Xingguo</ForeName>
+ <Initials>X</Initials>
+ <AffiliationInfo>
+ <Affiliation>Key Laboratory of TCM-Information Engineering of State Administration of TCM, Pharmaceutical Engineering and New Drug Development of Traditional Chinese, Medicine of Ministry of Education, Beijing University of Chinese Medicine, Beijing, China.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Du</LastName>
+ <ForeName>Chenzhao</ForeName>
+ <Initials>C</Initials>
+ <AffiliationInfo>
+ <Affiliation>Key Laboratory of TCM-Information Engineering of State Administration of TCM, Pharmaceutical Engineering and New Drug Development of Traditional Chinese, Medicine of Ministry of Education, Beijing University of Chinese Medicine, Beijing, China.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Qiao</LastName>
+ <ForeName>Yanjiang</ForeName>
+ <Initials>Y</Initials>
+ <AffiliationInfo>
+ <Affiliation>Key Laboratory of TCM-Information Engineering of State Administration of TCM, Pharmaceutical Engineering and New Drug Development of Traditional Chinese, Medicine of Ministry of Education, Beijing University of Chinese Medicine, Beijing, China.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wu</LastName>
+ <ForeName>Zhisheng</ForeName>
+ <Initials>Z</Initials>
+ <AffiliationInfo>
+ <Affiliation>Key Laboratory of TCM-Information Engineering of State Administration of TCM, Pharmaceutical Engineering and New Drug Development of Traditional Chinese, Medicine of Ministry of Education, Beijing University of Chinese Medicine, Beijing, China.</Affiliation>
+ </AffiliationInfo>
+ </Author>
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+ <Language>eng</Language>
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+ <Month>05</Month>
+ <Day>07</Day>
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+ <Country>Switzerland</Country>
+ <MedlineTA>Front Chem</MedlineTA>
+ <NlmUniqueID>101627988</NlmUniqueID>
+ <ISSNLinking>2296-2646</ISSNLinking>
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+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">Kubelka-Munk theory</Keyword>
+ <Keyword MajorTopicYN="N">Near infrared (NIR) diffuse reflectance spectroscopy</Keyword>
+ <Keyword MajorTopicYN="N">PLS</Keyword>
+ <Keyword MajorTopicYN="N">Radix Scrophulariae</Keyword>
+ <Keyword MajorTopicYN="N">harpagoside</Keyword>
+ <Keyword MajorTopicYN="N">particle size</Keyword>
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+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>14</Day>
+ </PubDate>
+ </JournalIssue>
+ <Title>eLife</Title>
+ <ISOAbbreviation>Elife</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Closing the circle.</ArticleTitle>
+ <ELocationID EIdType="doi" ValidYN="Y">10.7554/eLife.42507</ELocationID>
+ <ELocationID EIdType="pii" ValidYN="Y">e42507</ELocationID>
+ <Abstract>
+ <AbstractText>In Chlamydomonas the different stages of the Calvin-Benson cycle take place in separate locations within the chloroplast.</AbstractText>
+ <CopyrightInformation>© 2018, Machingura et al.</CopyrightInformation>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Machingura</LastName>
+ <ForeName>Marylou C</ForeName>
+ <Initials>MC</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Biology, Georgia Southern University, Savannah, United States.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Moroney</LastName>
+ <ForeName>James V</ForeName>
+ <Initials>JV</Initials>
+ <Identifier Source="ORCID">https://orcid.org/0000-0002-3652-5293</Identifier>
+ <AffiliationInfo>
+ <Affiliation>Department of Biological Sciences, Louisiana State University, Baton Rouge, United States.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
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+ <PublicationType UI="D016428">Journal Article</PublicationType>
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+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>14</Day>
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+ <Country>England</Country>
+ <MedlineTA>Elife</MedlineTA>
+ <NlmUniqueID>101579614</NlmUniqueID>
+ <ISSNLinking>2050-084X</ISSNLinking>
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+ <ChemicalList>
+ <Chemical>
+ <RegistryNumber>EC 4.1.1.39</RegistryNumber>
+ <NameOfSubstance UI="D012273">Ribulose-Bisphosphate Carboxylase</NameOfSubstance>
+ </Chemical>
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+ <CitationSubset>IM</CitationSubset>
+ <CommentsCorrectionsList>
+ <CommentsCorrections RefType="CommentOn">
+ <RefSource>Elife. 2018 Oct 11;7:null</RefSource>
+ <PMID Version="1">30306890</PMID>
+ </CommentsCorrections>
+ </CommentsCorrectionsList>
+ <MeshHeadingList>
+ <MeshHeading>
+ <DescriptorName UI="D002696" MajorTopicYN="N">Chlamydomonas</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D016825" MajorTopicYN="N">Chlamydomonas reinhardtii</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D002736" MajorTopicYN="Y">Chloroplasts</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010788" MajorTopicYN="Y">Photosynthesis</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012273" MajorTopicYN="N">Ribulose-Bisphosphate Carboxylase</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
+ <KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="Y">Chlamydomonas reinhardtii</Keyword>
+ <Keyword MajorTopicYN="Y">biochemistry</Keyword>
+ <Keyword MajorTopicYN="Y">carbon fixation</Keyword>
+ <Keyword MajorTopicYN="Y">chemical biology</Keyword>
+ <Keyword MajorTopicYN="Y">microcompartment</Keyword>
+ <Keyword MajorTopicYN="Y">photosynthesis</Keyword>
+ <Keyword MajorTopicYN="Y">plant biology</Keyword>
+ <Keyword MajorTopicYN="Y">pyrenoid</Keyword>
+ <Keyword MajorTopicYN="Y">rubisco</Keyword>
+ </KeywordList>
+ <CoiStatement>MM, JM No competing interests declared</CoiStatement>
+ </MedlineCitation>
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+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>06</Day>
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+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>15</Day>
+ <Hour>6</Hour>
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+ <Month>11</Month>
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+ <ArticleId IdType="pubmed">30426925</ArticleId>
+ <ArticleId IdType="doi">10.7554/eLife.42507</ArticleId>
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+ <PMID Version="1">29869639</PMID>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>14</Day>
+ </DateRevised>
+ <Article PubModel="Electronic-eCollection">
+ <Journal>
+ <ISSN IssnType="Print">1664-462X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>9</Volume>
+ <PubDate>
+ <Year>2018</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Frontiers in plant science</Title>
+ <ISOAbbreviation>Front Plant Sci</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Multivariate Analysis of Water Quality and Benthic Macrophyte Communities in Florida Bay, USA Reveals Hurricane Effects and Susceptibility to Seagrass Die-Off.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>630</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.3389/fpls.2018.00630</ELocationID>
+ <Abstract>
+ <AbstractText>Seagrass communities, dominated by <i>Thalassia testudinum</i>, form the principal benthic ecosystem within Florida Bay, Florida USA. The bay has had several large-scale seagrass die-offs in recent decades associated with drought and hypersaline conditions. In addition, three category-5 hurricanes passed in close proximity to the bay during the fall of 2005. This study investigated temporal and spatial trends in macrophyte abundance and water quality from 2006 to 2013 at 15 permanent transect sites, which were co-located with long-term water quality stations. Relationships, by year and by transect location (basin), between antecedent water quality (mean, minimum and maximum for a 6-month period) and benthic macrophyte communities were examined using multivariate analyses. Total phosphorus, salinity, pH, turbidity, dissolved inorganic nitrogen (DIN), DIN to phosphate ratio (DIN: <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML">
+ <mml:msubsup>
+ <mml:mrow>
+ <mml:mtext>PO</mml:mtext>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mn>4</mml:mn>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mo>-</mml:mo>
+ <mml:mn>3</mml:mn>
+ </mml:mrow>
+ </mml:msubsup>
+ </mml:math> ), chlorophyll <i>a</i>, and dissolved oxygen correlated with temporal and spatial variations in the macrophyte communities. Temporal analysis (MDS and LINKTREE) indicated that the fall 2005 hurricanes affected both water quality and macrophyte communities for approximately a 2-year period. Spatial analysis revealed that five basins, which subsequently exhibited a major seagrass die-off during summer 2015, significantly differed from the other ten basins in macrophyte community structure and water quality more than 2 years before this die-off event. High total phosphorus, high pH, low DIN, and low DIN: <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML">
+ <mml:msubsup>
+ <mml:mrow>
+ <mml:mtext>PO</mml:mtext>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mn>4</mml:mn>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mo>-</mml:mo>
+ <mml:mn>3</mml:mn>
+ </mml:mrow>
+ </mml:msubsup>
+ </mml:math> , in combination with deep sediments and high seagrass cover were characteristic of sites that subsequently exhibited severe die-off. Our results indicate basins with more mixed seagrass communities and higher macroalgae abundance are less susceptible to die-off, which is consistent with the management goals of promoting more heterogeneous benthic macrophyte communities.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Cole</LastName>
+ <ForeName>Amanda M</ForeName>
+ <Initials>AM</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Biology and Marine Biology, Center for Marine Science, The University of North Carolina Wilmington, Wilmington, NC, United States.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Durako</LastName>
+ <ForeName>Michael J</ForeName>
+ <Initials>MJ</Initials>
+ <AffiliationInfo>
+ <Affiliation>Department of Biology and Marine Biology, Center for Marine Science, The University of North Carolina Wilmington, Wilmington, NC, United States.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Hall</LastName>
+ <ForeName>Margaret O</ForeName>
+ <Initials>MO</Initials>
+ <AffiliationInfo>
+ <Affiliation>Florida Fish and Wildlife Research Institute, Florida Fish and Wildlife Conservation Commission, St. Petersburg, FL, United States.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ </AuthorList>
+ <Language>eng</Language>
+ <PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+ </PublicationTypeList>
+ <ArticleDate DateType="Electronic">
+ <Year>2018</Year>
+ <Month>05</Month>
+ <Day>08</Day>
+ </ArticleDate>
+</Article>
+<MedlineJournalInfo>
+ <Country>Switzerland</Country>
+ <MedlineTA>Front Plant Sci</MedlineTA>
+ <NlmUniqueID>101568200</NlmUniqueID>
+ <ISSNLinking>1664-462X</ISSNLinking>
+</MedlineJournalInfo>
+<KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">Florida Bay</Keyword>
+ <Keyword MajorTopicYN="N">die-off</Keyword>
+ <Keyword MajorTopicYN="N">hurricanes</Keyword>
+ <Keyword MajorTopicYN="N">macroalgae</Keyword>
+ <Keyword MajorTopicYN="N">multivariate analyses</Keyword>
+ <Keyword MajorTopicYN="N">seagrasses</Keyword>
+ <Keyword MajorTopicYN="N">water quality</Keyword>
+</KeywordList>
+</MedlineCitation>
+<PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>2017</Year>
+ <Month>08</Month>
+ <Day>28</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="accepted">
+ <Year>2018</Year>
+ <Month>04</Month>
+ <Day>20</Day>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="entrez">
+ <Year>2018</Year>
+ <Month>6</Month>
+ <Day>6</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="pubmed">
+ <Year>2018</Year>
+ <Month>6</Month>
+ <Day>6</Day>
+ <Hour>6</Hour>
+ <Minute>0</Minute>
+ </PubMedPubDate>
+ <PubMedPubDate PubStatus="medline">
+ <Year>2018</Year>
+ <Month>6</Month>
+ <Day>6</Day>
+ <Hour>6</Hour>
+ <Minute>1</Minute>
+ </PubMedPubDate>
+ </History>
+ <PublicationStatus>epublish</PublicationStatus>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">29869639</ArticleId>
+ <ArticleId IdType="doi">10.3389/fpls.2018.00630</ArticleId>
+ <ArticleId IdType="pmc">PMC5952043</ArticleId>
+ </ArticleIdList>
+ <ReferenceList>
+ <Reference>
+ <Citation>Science. 2000 Sep 22;289(5487):2068-74</Citation>
+ <ArticleIdList>
+ <ArticleId IdType="pubmed">11000103</ArticleId>
+ </ArticleIdList>
+ </Reference>
+ </ReferenceList>
+</PubmedData>
+</PubmedArticle>
+<PubmedArticle>
+ <MedlineCitation Status="MEDLINE" Owner="NLM">
+ <PMID Version="1">28726616</PMID>
+ <DateCompleted>
+ <Year>2018</Year>
+ <Month>04</Month>
+ <Day>11</Day>
+ </DateCompleted>
+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>13</Day>
+ </DateRevised>
+ <Article PubModel="Print">
+ <Journal>
+ <ISSN IssnType="Electronic">1080-6059</ISSN>
+ <JournalIssue CitedMedium="Internet">
+ <Volume>23</Volume>
+ <Issue>8</Issue>
+ <PubDate>
+ <Year>2017</Year>
+ <Month>08</Month>
+ </PubDate>
+ </JournalIssue>
+ <Title>Emerging infectious diseases</Title>
+ <ISOAbbreviation>Emerging Infect. Dis.</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March-June 2015.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>1308-1315</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.3201/eid2308.162039</ELocationID>
+ <Abstract>
+ <AbstractText>In 2015, a cluster of respiratory diphtheria cases was reported from KwaZulu-Natal Province in South Africa. By using whole-genome analysis, we characterized 21 Corynebacterium diphtheriae isolates collected from 20 patients and contacts during the outbreak (1 patient was infected with 2 variants of C. diphtheriae). In addition, we included 1 cutaneous isolate, 2 endocarditis isolates, and 2 archived clinical isolates (ca. 1980) for comparison. Two novel lineages were identified, namely, toxigenic sequence type (ST) ST-378 (n = 17) and nontoxigenic ST-395 (n = 3). One archived isolate and the cutaneous isolate were ST-395, suggesting ongoing circulation of this lineage for &gt;30 years. The absence of preexisting molecular sequence data limits drawing conclusions pertaining to the origin of these strains; however, these findings provide baseline genotypic data for future cases and outbreaks. Neither ST has been reported in any other country; this ST appears to be endemic only in South Africa.</AbstractText>
+ </Abstract>
+ <AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>du Plessis</LastName>
+ <ForeName>Mignon</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Wolter</LastName>
+ <ForeName>Nicole</ForeName>
+ <Initials>N</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Allam</LastName>
+ <ForeName>Mushal</ForeName>
+ <Initials>M</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>de Gouveia</LastName>
+ <ForeName>Linda</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Moosa</LastName>
+ <ForeName>Fahima</ForeName>
+ <Initials>F</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ntshoe</LastName>
+ <ForeName>Genevie</ForeName>
+ <Initials>G</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Blumberg</LastName>
+ <ForeName>Lucille</ForeName>
+ <Initials>L</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cohen</LastName>
+ <ForeName>Cheryl</ForeName>
+ <Initials>C</Initials>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Smith</LastName>
+ <ForeName>Marshagne</ForeName>
+ <Initials>M</Initials>
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+ <ForeName>Moherndran</ForeName>
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+ </Author>
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+ <LastName>Mahabeer</LastName>
+ <ForeName>Yesholata</ForeName>
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+ <LastName>Mahomed</LastName>
+ <ForeName>Saajida</ForeName>
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+ <ForeName>Koleka</ForeName>
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+ </Author>
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+ <LastName>McCarthy</LastName>
+ <ForeName>Kerrigan</ForeName>
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+ </Author>
+ <Author ValidYN="Y">
+ <LastName>von Gottberg</LastName>
+ <ForeName>Anne</ForeName>
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+ <DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D064113" MajorTopicYN="N">CRISPR-Cas Systems</DescriptorName>
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+ <DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
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+ <DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D003353" MajorTopicYN="N">Corynebacterium diphtheriae</DescriptorName>
+ <QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName>
+ <QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
+ <QualifierName UI="Q000302" MajorTopicYN="N">isolation &amp; purification</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D004165" MajorTopicYN="N">Diphtheria</DescriptorName>
+ <QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
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+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D058885" MajorTopicYN="N">Multilocus Sequence Typing</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D012042" MajorTopicYN="N">Registries</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D013019" MajorTopicYN="N">South Africa</DescriptorName>
+ <QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D000073336" MajorTopicYN="N">Whole Genome Sequencing</DescriptorName>
+ </MeshHeading>
+ <MeshHeading>
+ <DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
+ </MeshHeading>
+ </MeshHeadingList>
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+ <Keyword MajorTopicYN="Y">CRISPR</Keyword>
+ <Keyword MajorTopicYN="Y">Corynebacterium diphtheriae</Keyword>
+ <Keyword MajorTopicYN="Y">MLST</Keyword>
+ <Keyword MajorTopicYN="Y">South Africa</Keyword>
+ <Keyword MajorTopicYN="Y">bacteria</Keyword>
+ <Keyword MajorTopicYN="Y">cutaneous diphtheria</Keyword>
+ <Keyword MajorTopicYN="Y">diphtheria</Keyword>
+ <Keyword MajorTopicYN="Y">molecular epidemiology</Keyword>
+ <Keyword MajorTopicYN="Y">outbreak</Keyword>
+ <Keyword MajorTopicYN="Y">respiratory diphtheria</Keyword>
+ <Keyword MajorTopicYN="Y">respiratory infections</Keyword>
+ <Keyword MajorTopicYN="Y">sequence type</Keyword>
+ <Keyword MajorTopicYN="Y">whole-genome sequencing</Keyword>
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+ <DateRevised>
+ <Year>2018</Year>
+ <Month>11</Month>
+ <Day>14</Day>
+ </DateRevised>
+ <Article PubModel="Electronic-eCollection">
+ <Journal>
+ <ISSN IssnType="Print">1664-302X</ISSN>
+ <JournalIssue CitedMedium="Print">
+ <Volume>9</Volume>
+ <PubDate>
+ <Year>2018</Year>
+ </PubDate>
+ </JournalIssue>
+ <Title>Frontiers in microbiology</Title>
+ <ISOAbbreviation>Front Microbiol</ISOAbbreviation>
+ </Journal>
+ <ArticleTitle>Synthesis and Antibacterial Activity of Metal(loid) Nanostructures by Environmental Multi-Metal(loid) Resistant Bacteria and Metal(loid)-Reducing Flavoproteins.</ArticleTitle>
+ <Pagination>
+ <MedlinePgn>959</MedlinePgn>
+ </Pagination>
+ <ELocationID EIdType="doi" ValidYN="Y">10.3389/fmicb.2018.00959</ELocationID>
+ <Abstract>
+ <AbstractText>Microbes are suitable candidates to recover and decontaminate different environments from soluble metal ions, either via reduction or precipitation to generate insoluble, non-toxic derivatives. In general, microorganisms reduce toxic metal ions generating nanostructures (NS), which display great applicability in biotechnological processes. Since the molecular bases of bacterial reduction are still unknown, the search for new -environmentally safe and less expensive- methods to synthesize NS have made biological systems attractive candidates. Here, 47 microorganisms isolated from a number of environmental samples were analyzed for their tolerance or sensitivity to 19 metal(loid)s. Ten of them were highly tolerant to some of them and were assessed for their ability to reduce these toxicants <i>in vitro</i>. All isolates were analyzed by 16S rRNA gene sequencing, fatty acids composition, biochemical tests and electron microscopy. Results showed that they belong to the <i>Enterobacter, Staphylococcus, Acinetobacter</i>, and <i>Exiguobacterium</i> genera. Most strains displayed metal(loid)-reducing activity using either NADH or NADPH as cofactor. While <i>Acinetobacter schindleri</i> showed the highest tellurite ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML">
+ <mml:msubsup>
+ <mml:mrow>
+ <mml:mtext>TeO</mml:mtext>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mn>3</mml:mn>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mn>2</mml:mn>
+ <mml:mo>-</mml:mo>
+ </mml:mrow>
+ </mml:msubsup>
+ </mml:math> ) and tetrachloro aurate ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML">
+ <mml:msubsup>
+ <mml:mrow>
+ <mml:mtext>AuCl</mml:mtext>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mn>4</mml:mn>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mo>-</mml:mo>
+ </mml:mrow>
+ </mml:msubsup>
+ </mml:math> ) reducing activity, <i>Staphylococcus sciuri</i> and <i>Exiguobacterium acetylicum</i> exhibited selenite ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML">
+ <mml:msubsup>
+ <mml:mrow>
+ <mml:mtext>SeO</mml:mtext>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mn>3</mml:mn>
+ </mml:mrow>
+ <mml:mrow>
+ <mml:mn>2</mml:mn>
+ <mml:mo>-</mml:mo>
+ </mml:mrow>
+ </mml:msubsup>
+ </mml:math> ) and silver (Ag<sup>+</sup>) reducing activity, respectively. Based on these results, we used these bacteria to synthetize, <i>in vivo and in vitro</i> Te, Se, Au, and Ag-containing nanostructures. On the other hand, we also used purified <i>E. cloacae</i> glutathione reductase to synthesize <i>in vitro</i> Te-, Ag-, and Se-containing NS, whose morphology, size, composition, and chemical composition were evaluated. Finally, we assessed the putative anti-bacterial activity exhibited by the <i>in vitro</i> synthesized NS: Te-containing NS were more effective than Au-NS in inhibiting <i>Escherichia coli</i> and <i>Listeria monocytogenes</i> growth. Aerobically synthesized TeNS using MF09 crude extracts showed MICs of 45- and 66- μg/ml for <i>E. coli</i> and <i>L. monocytogenes</i>, respectively. Similar MIC values (40 and 82 μg/ml, respectively) were observed for TeNS generated using crude extracts from <i>gorA</i>-overexpressing <i>E. coli</i>. In turn, AuNS MICs for <i>E. coli</i> and <i>L. monocytogenes</i> were 64- and 68- μg/ml, respectively.</AbstractText>
+</Abstract>
+<AuthorList CompleteYN="Y">
+ <Author ValidYN="Y">
+ <LastName>Figueroa</LastName>
+ <ForeName>Maximiliano</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratorio Microbiología Molecular, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Fernandez</LastName>
+ <ForeName>Valentina</ForeName>
+ <Initials>V</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratorio Microbiología Molecular, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Arenas-Salinas</LastName>
+ <ForeName>Mauricio</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Ahumada</LastName>
+ <ForeName>Diego</ForeName>
+ <Initials>D</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratorio Microbiología Molecular, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Muñoz-Villagrán</LastName>
+ <ForeName>Claudia</ForeName>
+ <Initials>C</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratorio Microbiología Molecular, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Departamento de Ciencias Básicas, Facultad de Ciencia, Universidad Santo Tomas, Sede Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Cornejo</LastName>
+ <ForeName>Fabián</ForeName>
+ <Initials>F</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratorio Microbiología Molecular, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Vargas</LastName>
+ <ForeName>Esteban</ForeName>
+ <Initials>E</Initials>
+ <AffiliationInfo>
+ <Affiliation>Center for the Development of Nanoscience and Nanotechnology, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Latorre</LastName>
+ <ForeName>Mauricio</ForeName>
+ <Initials>M</Initials>
+ <AffiliationInfo>
+ <Affiliation>Mathomics, Centro de Modelamiento Matemático, Universidad de Chile, Beauchef, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Fondap-Center of Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Laboratorio de Bioinformática y Expresión Génica, INTA, Universidad de Chile, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ <AffiliationInfo>
+ <Affiliation>Instituto de Ciencias de la Ingeniería, Universidad de O'Higgins, Rancagua, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Morales</LastName>
+ <ForeName>Eduardo</ForeName>
+ <Initials>E</Initials>
+ <AffiliationInfo>
+ <Affiliation>uBiome, San Francisco, CA, United States.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Vásquez</LastName>
+ <ForeName>Claudio</ForeName>
+ <Initials>C</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratorio Microbiología Molecular, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+ <Author ValidYN="Y">
+ <LastName>Arenas</LastName>
+ <ForeName>Felipe</ForeName>
+ <Initials>F</Initials>
+ <AffiliationInfo>
+ <Affiliation>Laboratorio Microbiología Molecular, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.</Affiliation>
+ </AffiliationInfo>
+ </Author>
+</AuthorList>
+<Language>eng</Language>
+<PublicationTypeList>
+ <PublicationType UI="D016428">Journal Article</PublicationType>
+</PublicationTypeList>
+<ArticleDate DateType="Electronic">
+ <Year>2018</Year>
+ <Month>05</Month>
+ <Day>15</Day>
+</ArticleDate>
+</Article>
+<MedlineJournalInfo>
+ <Country>Switzerland</Country>
+ <MedlineTA>Front Microbiol</MedlineTA>
+ <NlmUniqueID>101548977</NlmUniqueID>
+ <ISSNLinking>1664-302X</ISSNLinking>
+</MedlineJournalInfo>
+<KeywordList Owner="NOTNLM">
+ <Keyword MajorTopicYN="N">bioremediation</Keyword>
+ <Keyword MajorTopicYN="N">environmental bacteria</Keyword>
+ <Keyword MajorTopicYN="N">flavoprotein</Keyword>
+ <Keyword MajorTopicYN="N">metal</Keyword>
+ <Keyword MajorTopicYN="N">metalloid</Keyword>
+ <Keyword MajorTopicYN="N">nanostructure</Keyword>
+ <Keyword MajorTopicYN="N">reduction</Keyword>
+ <Keyword MajorTopicYN="N">resistance</Keyword>
+</KeywordList>
+</MedlineCitation>
+<PubmedData>
+ <History>
+ <PubMedPubDate PubStatus="received">
+ <Year>2017</Year>
+ <Month>12</Month>
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