time to heat up domestic water: pasta pot, hot tub, etc function of starting temperature, environmental temperature, insulation, volume/surface area ## Paper read: "The impact of mathematical modeling languages on model quality in systems biology" The impact of mathematical modeling languages on model quality in systems biology: A software engineering perspective Christopher Sch¨olzel1, Valeria Blesius, Gernot Ernst, and Andreas Dominik https://www.biorxiv.org/content/10.1101/2019.12.16.875260v3 Interesting refs: - [A long journey into reproducible computational neuroscience](https://www.frontiersin.org/articles/10.3389/fncom.2015.00030/full) - Guidelines for Reproducibly Building and Simulating Systems Biology Models - Is My Model Good Enough? Best Practices for Verification and Validation of Musculoskeletal Models and Simulations of Movement - Antimony: A Modular Model Definition Language - SimuPy: A Python Framework for Modeling and Simulating Dynamical Systems - Systems Modeling and Programming in a Unified Environment Based on Julia - Recent advances in biomedical simulations: a manifesto for model engineering > [...] Guyton model, which is probably among the most complicated monolithic models in systems biology [...] ## Modia: Modelica-like in Julia Slides: https://modiasim.github.io/Modia.jl/slides/Systems-Modeling-and-Programming-Slides.pdf Code: https://github.com/ModiaSim/Modia.jl Expresses a strong interest in visual representation. ## Lean / mathlib ## Other Had not heard of "SimScape", a component of MATLAB along side Simulink. There is a somewhat arbitrary list of "100 theorems" used to compare systems like Lean and Coq: . What would a model or physical systems equivalent include? Interchange-like format for Modelica: What features should next modelthing iteration have? - s-expr native syntax - modularity/hierarchy - "hybrid" (including discrete) - input: mathml - output: c, wasm, julia, modelica, mathml, latex, text - some datastore, with ability to fetch code from website/API What are the type systems and data model of computer algebra systems?