top down approach: start with data, do stats, make predictions see also Ma'ayan coursera course, "Network Analysis in Systems Bio" bottom up approach: start with a model, run simulations to make predictions scope: ODE, dynamics beyond: parameter estimations, PDE, stochastics 7 weeks, 25 lectures, 20 minutes each, 3-4 a week questions at the end of lectures, "just for self" 5x homework assignments, required will discuss neuron firing a bit impression: will be very motivated